Itaconic acid

Itaconic acid is a lipid of Fatty Acyls (FA) class. Itaconic acid is associated with abnormalities such as Tuberculosis and Bacterial Infections. The involved functions are known as Metabolic Inhibition, Gene Expression, Anabolism, Citric Acid Cycle and physiological aspects. Itaconic acid often locates in Protoplasm and Chromosomes, Human, Pair 13. The associated genes with Itaconic acid are Homologous Gene, IRG1 gene and Genome, Human. The related lipids are Propionate and Lipopolysaccharides.

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Introduction

To understand associated biological information of Itaconic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Itaconic acid?

Itaconic acid is suspected in Tuberculosis, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Itaconic acid

PubChem Associated disorders and diseases

What pathways are associated with Itaconic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Itaconic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Itaconic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Itaconic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Itaconic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Itaconic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Itaconic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Itaconic acid

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Authors Title Published Journal PubMed Link
Boruta T and Bizukojc M Production of lovastatin and itaconic acid by Aspergillus terreus: a comparative perspective. 2017 World J. Microbiol. Biotechnol. pmid:28102516
Yin X et al. Pgas, a Low-pH-Induced Promoter, as a Tool for Dynamic Control of Gene Expression for Metabolic Engineering of Aspergillus niger. 2017 Appl. Environ. Microbiol. pmid:28087530
Shin WS et al. Enhanced Production of Itaconic Acid through Development of Transformed Fungal Strains of Aspergillus terreus. 2017 J. Microbiol. Biotechnol. pmid:27974733
Rau MH et al. Genome-wide Escherichia coli stress response and improved tolerance towards industrially relevant chemicals. 2016 Microb. Cell Fact. pmid:27737709
Luan HH and Medzhitov R Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense. 2016 Cell Metab. pmid:27626199
Hossain AH et al. Rewiring a secondary metabolite pathway towards itaconic acid production in Aspergillus niger. 2016 Microb. Cell Fact. pmid:27469970
Itaconate and Inflammation, miRs in Zebrafish Embryos, and SHP2 Inhibitor. 2016 Cell Chem Biol pmid:27447041
Lampropoulou V et al. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. 2016 Cell Metab. pmid:27374498
Jiménez-Quero A et al. Itaconic and Fumaric Acid Production from Biomass Hydrolysates by Aspergillus Strains. 2016 J. Microbiol. Biotechnol. pmid:27291673
Németh B et al. Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. 2016 FASEB J. pmid:26358042