erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kwiatkowska B and Maślińska M | Macrolide therapy in chronic inflammatory diseases. | 2012 | Mediators Inflamm. | pmid:22969171 |
Mulholland S et al. | Antibiotics for community-acquired lower respiratory tract infections secondary to Mycoplasma pneumoniae in children. | 2012 | Cochrane Database Syst Rev | pmid:22972079 |
Hess TM and Chew HF | Successful treatment of acute ocular involvement in Stevens-Johnson syndrome with amniotic membrane transplantation: a case report. | 2012 | Can. J. Ophthalmol. | pmid:23217513 |
Wang L et al. | Persistence of resistance to erythromycin and tetracycline in swine manure during simulated composting and lagoon treatments. | 2012 | Microb. Ecol. | pmid:21811793 |
Mansouri-najand L et al. | Prevalence of multidrug resistance Campylobacter jejuni and Campylobacter coli in chickens slaughtered in selected markets, Malaysia. | 2012 | Trop Biomed | pmid:22735845 |
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KurinÄiÄ M et al. | Effects of efflux pump inhibitors on erythromycin, ciprofloxacin, and tetracycline resistance in Campylobacter spp. isolates. | 2012 | Microb. Drug Resist. | pmid:22741576 |
Tran TD et al. | Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22727643 |
Shi JG et al. | The effect of CYP3A4 inhibition or induction on the pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in healthy volunteers. | 2012 | J Clin Pharmacol | pmid:21602517 |
Gokmen T et al. | A controlled trial of erythromycin and UDCA in premature infants during parenteral nutrition in minimizing feeding intolerance and liver function abnormalities. | 2012 | J Perinatol | pmid:21566568 |
Wormser GP et al. | Failure of topical antibiotics to prevent disseminated Borrelia burgdorferi infection following a tick bite in C3H/HeJ mice. | 2012 | J. Infect. Dis. | pmid:21930606 |
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Vendrell D et al. | Accumulation and depletion kinetics of erythromycin in rainbow trout (Oncorhynchus mykiss). | 2012 | Prev. Vet. Med. | pmid:22436556 |
Yoon SB et al. | The effect of exenatide and erythromycin on postprandial symptoms and their relation to gastric functions. | 2012 | Digestion | pmid:22354133 |
Golparian D et al. | In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea? | 2012 | Antimicrob. Agents Chemother. | pmid:22354296 |
Devlin MJ et al. | Gastric emptying and symptoms of bulimia nervosa: effect of a prokinetic agent. | 2012 | Physiol. Behav. | pmid:22361261 |
Chini P et al. | Effect of azithromycin on small bowel motility in patients with gastrointestinal dysmotility. | 2012 | Scand. J. Gastroenterol. | pmid:22364597 |
Gazzola S et al. | Assessment of tetracycline and erythromycin resistance transfer during sausage fermentation by culture-dependent and -independent methods. | 2012 | Food Microbiol. | pmid:22365347 |
Palumbo Piccionello A et al. | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. | 2012 | Eur J Med Chem | pmid:22365410 |
Michael M et al. | Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C(14)-erythromycin breath test and the antipyrine clearance test. | 2012 | Cancer Chemother. Pharmacol. | pmid:21626050 |
Ohene-Agyei T et al. | Mutations in MexB that affect the efflux of antibiotics with cytoplasmic targets. | 2012 | FEMS Microbiol. Lett. | pmid:22568688 |
Chen C et al. | Isolation and characterization of LS1924A, a new analog of emycins. | 2012 | J. Antibiot. | pmid:22569162 |
Mandisodza O et al. | Arcobacter species in diarrhoeal faeces from humans in New Zealand. | 2012 | N. Z. Med. J. | pmid:22522270 |
Gao J et al. | Antibiotic resistance of Streptococcus agalactiae from cows with mastitis. | 2012 | Vet. J. | pmid:22627045 |
Zhou Y et al. | Erythromycin ameliorates cigarette-smoke-induced emphysema and inflammation in rats. | 2012 | Transl Res | pmid:22633097 |
Yu DJ et al. | Cornmeal-induced resistance to ciprofloxacin and erythromycin in enterococci. | 2012 | Chemosphere | pmid:22633859 |
Leung HW et al. | Distribution, fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong, South China. | 2012 | Environ Int | pmid:21450345 |
Giovanetti E et al. | ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements. | 2012 | Antimicrob. Agents Chemother. | pmid:21986826 |
PiÄ…tkowska E et al. | The strongest resistance of Staphylococcus aureus to erythromycin is caused by decreasing uptake of the antibiotic into the cells. | 2012 | Cell. Mol. Biol. Lett. | pmid:23001512 |
Leiding JW et al. | Successful sirolimus graded dose challenge in an erythromycin-allergic patient. | 2012 | Ann. Allergy Asthma Immunol. | pmid:23010239 |
Brill S et al. | Transforming a drug/H+ antiporter into a polyamine importer by a single mutation. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23035252 |
Kou X et al. | Synthesis, characterization and adsorption behavior of molecularly imprinted nanospheres for erythromycin using precipitation polymerization. | 2012 | J Nanosci Nanotechnol | pmid:23035481 |
Ashour S and Bayram R | Novel spectrophotometric method for determination of some macrolide antibiotics in pharmaceutical formulations using 1,2-naphthoquinone-4-sulphonate. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:23041925 |
Zhang H et al. | Improved E. coli erythromycin A production through the application of metabolic and bioprocess engineering. | 2012 Jan-Feb | Biotechnol. Prog. | pmid:21905273 |
Pehr K | Mycophenolate mofetil and erythromycin for bullous lupus erythematosus of childhood. | 2012 Jan-Feb | J Cutan Med Surg | pmid:22417996 |
Amatya A et al. | Comparative study of effectiveness of oral acyclovir with oral erythromycin in the treatment of Pityriasis rosea. | 2012 Jan-Mar | Kathmandu Univ Med J (KUMJ) | pmid:22971864 |
Kuhn M et al. | Feed restriction enhances the depressive effects of erythromycin on equine hindgut microbial metabolism in vitro. | 2012 Jul-Aug | Berl. Munch. Tierarztl. Wochenschr. | pmid:22919930 |
Jiang RS et al. | Efficacy of Chinese herbal medicine compared with a macrolide in the treatment of chronic rhinosinusitis without nasal polyps. | 2012 Jul-Aug | Am J Rhinol Allergy | pmid:22801017 |
Kuehne SA and Minton NP | ClosTron-mediated engineering of Clostridium. | 2012 Jul-Aug | Bioengineered | pmid:22750794 |
Miguel AI et al. | Pediatric ocular rosacea: 2 cases. | 2012 Jul-Aug | Eur J Ophthalmol | pmid:22267454 |
Clementson B and Smidt AC | Periorificial dermatitis due to systemic corticosteroids in children: report of two cases. | 2012 May-Jun | Pediatr Dermatol | pmid:22122785 |
Hapa A et al. | Childhood pityriasis lichenoides and oral erythromycin. | 2012 Nov-Dec | Pediatr Dermatol | pmid:22639857 |
Asai N et al. | A successfully treated case of parainfluenza virus 3 pneumonia mimicking influenza pneumonia. | 2012 Nov-Dec | J Bras Pneumol | pmid:23288130 |
Lian W et al. | Electrochemical sensor based on gold nanoparticles fabricated molecularly imprinted polymer film at chitosan-platinum nanoparticles/graphene-gold nanoparticles double nanocomposites modified electrode for detection of erythromycin. | 2012 Oct-Dec | Biosens Bioelectron | pmid:22683249 |
Heelan K et al. | Panton-Valentine leukocidin-producing Staphylococcal aureus: report of four siblings. | 2012 Sep-Oct | Pediatr Dermatol | pmid:21906149 |
Nie XP et al. | Toxic effects of erythromycin, ciprofloxacin and sulfamethoxazole exposure to the antioxidant system in Pseudokirchneriella subcapitata. | 2013 | Environ. Pollut. | pmid:22982550 |
Parrott N et al. | An unusual cause of persistent postpartum vaginal discharge. | 2013 | Int J STD AIDS | pmid:23970614 |
Pelchovich G et al. | The contribution of common rpsL mutations in Escherichia coli to sensitivity to ribosome targeting antibiotics. | 2013 | Int. J. Med. Microbiol. | pmid:23972615 |
Ishihara K et al. | Distribution of antimicrobial-resistant lactic acid bacteria in natural cheese in Japan. | 2013 | Microbiol. Immunol. | pmid:23930694 |
Pedersen JM et al. | Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). | 2013 | Toxicol. Sci. | pmid:24014644 |
Zhang L et al. | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23937982 |
Herath SC and Poole P | Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD). | 2013 | Cochrane Database Syst Rev | pmid:24288145 |
Liang JH and Han X | Structure-activity relationships and mechanism of action of macrolides derived from erythromycin as antibacterial agents. | 2013 | Curr Top Med Chem | pmid:24200358 |
Matejcek A and Goldman RD | Treatment and prevention of ophthalmia neonatorum. | 2013 | Can Fam Physician | pmid:24235191 |
Hirano E et al. | Erythromycin treatment suppresses myocardial injury in autoimmune myocarditis in rats via suppression of superoxide production. | 2013 | Int. J. Cardiol. | pmid:22727964 |
Wang HB et al. | Molecular epidemiological analysis of group A Streptococci isolated from children in Chaoyang District of Beijing, 2011: emm types, virulence factor genes and erythromycin resistant genes. | 2013 | Biomed. Environ. Sci. | pmid:24099615 |
Wang X et al. | Mesoporous titanium zirconium oxide nanospheres with potential for drug delivery applications. | 2013 | ACS Appl Mater Interfaces | pmid:24150740 |
Wu C et al. | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. | 2013 | J. Nat. Prod. | pmid:24164206 |
Arao M et al. | Clostridium difficile colitis induced by long-term low-dosage erythromycin. | 2013 | Pediatr. Infect. Dis. J. | pmid:24008746 |
Ziesenitz VC et al. | Cytochrome P450-3A phenotyping using midazolam is not altered by OATP1B1 polymorphisms. | 2013 | Clin. Pharmacol. Ther. | pmid:23549145 |
Kirm B et al. | SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea. | 2013 | Microb. Cell Fact. | pmid:24341557 |
Olender A et al. | The cause of Actinomyces canalictulis--a case study. | 2013 | Ann Agric Environ Med | pmid:24364446 |
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Prabu D and Menon T | Genotyping of erythromycin resistant group C & G streptococci isolated in Chennai, south India. | 2013 | Indian J. Med. Res. | pmid:23481067 |
Zhang Y et al. | Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23481648 |
Koulaouzidis A et al. | Do prokinetics influence the completion rate in small-bowel capsule endoscopy? A systematic review and meta-analysis. | 2013 | Curr Med Res Opin | pmid:23790243 |
Lin MH et al. | Penetration of erythromycin through Staphylococcus epidermidis biofilm. | 2013 | Chin. Med. J. | pmid:23876889 |
Winnicka K et al. | The effect of PAMAM dendrimers on the antibacterial activity of antibiotics with different water solubility. | 2013 | Molecules | pmid:23881050 |
Hennenberg M et al. | The cAMP effector EPAC activates Elk1 transcription factor in prostate smooth muscle, and is a minor regulator of α1-adrenergic contraction. | 2013 | J. Biomed. Sci. | pmid:23815815 |
Mu Y et al. | Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics. | 2013 | Antimicrob. Agents Chemother. | pmid:23817373 |
Mu X et al. | Effects of erythromycin and rifampicin on immunomodulatory gene expression and cellular function in human polymorphonuclear leukocytes. | 2013 | Chemotherapy | pmid:24852442 |
Sundermann U et al. | Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase. | 2013 | ACS Chem. Biol. | pmid:23181268 |
Everson GT et al. | Functional elements associated with hepatic regeneration in living donors after right hepatic lobectomy. | 2013 | Liver Transpl. | pmid:23239552 |
Kelmer G et al. | Evaluation of regional limb perfusion with erythromycin using the saphenous, cephalic, or palmar digital veins in standing horses. | 2013 | J. Vet. Pharmacol. Ther. | pmid:23240633 |
Oplinger RW and Wagner EJ | Control of Flavobacterium psychrophilum: tests of erythromycin, streptomycin, osmotic and thermal shocks, and rapid pH change. | 2013 | J. Aquat. Anim. Health | pmid:23241009 |
Li N et al. | Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus and Candida albicans. | 2013 | Phytother Res | pmid:23192753 |
Chae HS et al. | Use of a novel Escherichia coli-leuconostoc shuttle vector for metabolic engineering of Leuconostoc citreum to overproduce D-lactate. | 2013 | Appl. Environ. Microbiol. | pmid:23241984 |
Papapetropoulos N et al. | Abscesses and wound infections due to Staphylococcus lugdunensis: report of 16 cases. | 2013 | Infection | pmid:23242962 |
Berger A et al. | Two cases of cutaneous diphtheria associated with occupational pig contact in Germany. | 2013 | Zoonoses Public Health | pmid:23280311 |
Juntunen P et al. | Absence of tetracycline resistance in Campylobacter coli isolates from Finnish finishing pigs treated with chlortetracycline. | 2013 | J. Appl. Microbiol. | pmid:23282197 |
Boutouyrie-Dumont B | An aide memoire for model-based drug development--a new key for the interpretation of the erythromycin breath test--therapeutic index as a biomarker for smart drug development. | 2013 | Biomark Med | pmid:23387489 |
Liang JH et al. | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23375796 |
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Rams TE et al. | Antibiotic susceptibility of periodontal Enterococcus faecalis. | 2013 | J. Periodontol. | pmid:23106507 |
Osterman IA et al. | A nascent proteome study combining click chemistry with 2DE. | 2013 | Proteomics | pmid:23161590 |
Serisier DJ et al. | Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial. | 2013 | JAMA | pmid:23532242 |
Elborn JS and Tunney MM | Macrolides and bronchiectasis: clinical benefit with a resistance price. | 2013 | JAMA | pmid:23532247 |
Chan BC et al. | Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase. | 2013 | Phytomedicine | pmid:23541215 |
Tarran R et al. | Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23542952 |
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Moriya S et al. | Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells. | 2013 | Int. J. Oncol. | pmid:23546223 |
Akiyoshi T et al. | Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. | 2013 | Drug Metab. Pharmacokinet. | pmid:23514827 |
Müller W et al. | German Francisella tularensis isolates from European brown hares (Lepus europaeus) reveal genetic and phenotypic diversity. | 2013 | BMC Microbiol. | pmid:23517149 |