erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kawamura-Sato K et al. | Postantibiotic suppression effect of macrolides on the expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis. | 2001 | J. Infect. Chemother. | pmid:11406758 |
Ng E and Shah V | Erythromycin for feeding intolerance in preterm infants. | 2001 | Cochrane Database Syst Rev | pmid:11406010 |
Takahashi T et al. | Erythromycin attenuates an experimental model of chronic bronchiolitis via augmenting monocyte chemoattractant protein-1. | 2001 | Eur. Respir. J. | pmid:11405512 |
PÃriz S et al. | Comparison of erythromycin and oxytetracycline for the treatment of ovine footrot. | 2001 | Acta Vet. Hung. | pmid:11402641 |
Butrous G and Siegel RL | Sildenafil (Viagra) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current. | 2001 | Circulation | pmid:11401951 |
Usary J and Champney WS | Erythromycin inhibition of 50S ribosomal subunit formation in Escherichia coli cells. | 2001 | Mol. Microbiol. | pmid:11401702 |
Lim J and Yun H | Postantibiotic effects and postantibiotic sub-MIC effects of erythromycin, roxithromycin, tilmicosin, and tylosin on Pasteurella multocida. | 2001 | Int. J. Antimicrob. Agents | pmid:11397617 |
Rospide MF et al. | Comparative antimicrobial activity of ABT-773, a novel ketolide, tested against drug-resistant Gram-positive cocci and Haemophilus influenzae. | 2001 | Int. J. Antimicrob. Agents | pmid:11397614 |
Svejda J and Richter J | [The hepatotoxic action of erythromycin (author's transl)]. | 1975 | Cas. Lek. Cesk. | pmid:1139592 |
Schuster-Bruce M | Gastric emptying in the critically ill. | 2001 | Crit. Care Med. | pmid:11395631 |
Sudden death in a traveler following halofantrine administration--Togo, 2000. | 2001 | MMWR Morb. Mortal. Wkly. Rep. | pmid:11393488 | |
Fox KK et al. | Gonorrhea in the HIV era: a reversal in trends among men who have sex with men. | 2001 | Am J Public Health | pmid:11392941 |
Kim C et al. | The role of serine-246 in cytochrome P450eryF-catalyzed hydroxylation of 6-deoxyerythronolide B. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11388449 |
Claesson K et al. | Sirolimus and erythromycin interaction: two cases. | 2001 | Transplant. Proc. | pmid:11377477 |
Whitehead TR and Cotta MA | Sequence analyses of a broad host-range plasmid containing ermT from a tylosin-resistant Lactobacillus sp. Isolated from swine feces. | 2001 | Curr. Microbiol. | pmid:11375658 |
Fardis M et al. | Synthesis of 14,15-dehydroerythromycin A ketolides: effects of the 13-substituent on erythromycin tautomerism. | 2001 | J. Antibiot. | pmid:11372784 |
Sambol SP et al. | Infection of hamsters with epidemiologically important strains of Clostridium difficile. | 2001 | J. Infect. Dis. | pmid:11372028 |
Takedomi S et al. | In-vivo kinetics of the interaction between midazolam and erythromycin in rats, taking account of metabolic intermediate complex formation. | 2001 | J. Pharm. Pharmacol. | pmid:11370704 |
Germaniskis L and Singer EJ | HIV and peripheral neuropathy. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362726 |
Ray RS et al. | Evaluation of UV-induced superoxide radical generation potential of some common antibiotics. | 2001 | Drug Chem Toxicol | pmid:11360435 |
Rowe CJ et al. | Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase. | 2001 | Chem. Biol. | pmid:11358694 |
Dujovne CA | Liver cell culture toxicity and surfactant potency of erythromycin derivatives. | 1975 | Toxicol. Appl. Pharmacol. | pmid:1135866 |
Marti GarcÃa JL et al. | [Rheumatic pneumonitis]. | 1975 | Rev Clin Esp | pmid:1135467 |
Bonnefoy A et al. | In vivo efficacy of the new ketolide telithromycin (HMR 3647) in murine infection models. | 2001 | Antimicrob. Agents Chemother. | pmid:11353612 |
Chitturi S and Farrell GC | Drug-induced cholestasis. | 2001 | Semin. Gastrointest. Dis. | pmid:11352118 |
Akritopoulou-Zanze I and Sowin TJ | Solid-phase synthesis of macrolide analogues. | 2001 May-Jun | J Comb Chem | pmid:11350254 |
Dobbin CJ et al. | The efficacy of an antibiotic protocol for community-acquired pneumonia. | 2001 | Med. J. Aust. | pmid:11346105 |
Corcoran JW | S-adenosylmethionine:erythromycin C O-methyltransferase. | 1975 | Meth. Enzymol. | pmid:1134368 |
Wang M et al. | Prevalence and phenotypes of erythromycin-resistant Streptococcus pneumoniae in Shanghai, China. | 2001 | Diagn. Microbiol. Infect. Dis. | pmid:11337187 |
Samra Z et al. | In vitro susceptibility of recent clinical isolates of Chlamydia trachomatis to macrolides and tetracyclines. | 2001 | Diagn. Microbiol. Infect. Dis. | pmid:11337185 |
Rawlings BJ | Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis). | 2001 | Nat Prod Rep | pmid:11336289 |
Gintant GA et al. | The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis. | 2001 | J. Cardiovasc. Pharmacol. | pmid:11336111 |
Hondeghem LM et al. | Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia. | 2001 | Cardiovasc. Res. | pmid:11334838 |
Takiguchi Y et al. | Fulminant Mycoplasma pneumoniae pneumonia. | 2001 | Intern. Med. | pmid:11334397 |
Gharpure V et al. | Efficacy of erythromycin for postpyloric placement of feeding tubes in critically ill children: a randomized, double-blind, placebo controlled study. | 2001 May-Jun | JPEN J Parenter Enteral Nutr | pmid:11334066 |
Ibarrola M et al. | [Disseminated disease by Mycobacterium kansasii resistant to isoniazid and rifampin in patients] with AIDS]. | 2001 | Enferm. Infecc. Microbiol. Clin. | pmid:11333577 |
Hattori A et al. | [A case of Folliculitis barbae Candidomycetica]. | 2001 | Nihon Ishinkin Gakkai Zasshi | pmid:11331469 |
Zarantonelli L et al. | Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae. | 2001 | J. Antimicrob. Chemother. | pmid:11328778 |
Martin SJ et al. | The activity of 14-hydroxy clarithromycin, alone and in combination with clarithromycin, against penicillin- and erythromycin-resistant Streptococcus pneumoniae. | 2001 | J. Antimicrob. Chemother. | pmid:11328768 |
Curry JI et al. | Review article: erythromycin as a prokinetic agent in infants and children. | 2001 | Aliment. Pharmacol. Ther. | pmid:11328252 |
Tsuji SY et al. | Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. | 2001 | Biochemistry | pmid:11327852 |
Rivory LP et al. | The erythromycin breath test for the prediction of drug clearance. | 2001 | Clin Pharmacokinet | pmid:11327195 |
From the Centers for Disease Control and Prevention. Sudden death in a traveler following halofantrine administration--Togo, 2000. | 2001 | JAMA | pmid:11324646 | |
Weeda LW | Erythromycin and amoxicillin? | 2001 | J Tenn Dent Assoc | pmid:11324196 |
Kim HS et al. | Double-edged sword of chemosensitizer: increase of multidrug resistance protein (MRP) in leukemic cells by an MRP inhibitor probenecid. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11322768 |
Lanbeck P and Paulsen O | Short-term effects of four antibiotics on DNA synthesis in endothelial cells. | 2001 | Pharmacol. Toxicol. | pmid:11322179 |
Rouzica M and Filipová K | [On the article of J. Buchanec and V. Kdrajnák: Lesions of the liver during therapy with erythromycin in 3 children]. | 1975 | Cesk Pediatr | pmid:1132045 |
Ng PC et al. | Randomised controlled study of oral erythromycin for treatment of gastrointestinal dysmotility in preterm infants. | 2001 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:11320044 |
Fogarty CM et al. | Effectiveness of levofloxacin for adult community-acquired pneumonia caused by macrolide-resistant Streptococcus pneumoniae: integrated results from four open-label, multicenter, phase III clinical trials. | 2001 | Clin Ther | pmid:11318077 |
Ripa S et al. | SmaI macrorestriction analysis of Italian isolates of erythromycin-resistant Streptococcus pyogenes and correlations with macrolide-resistance phenotypes. | 2001 | Microb. Drug Resist. | pmid:11310805 |