erythromycin

erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with erythromycin?

erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with erythromycin

MeSH term MeSH ID Detail
Endocarditis, Subacute Bacterial D004698 1 associated lipids
Lacrimal Duct Obstruction D007767 1 associated lipids
Choanal Atresia D002754 1 associated lipids
Scarlet Fever D012541 1 associated lipids
Pilonidal Sinus D010864 1 associated lipids
Postoperative Nausea and Vomiting D020250 1 associated lipids
Vagus Nerve Injuries D061223 1 associated lipids
Focal Infection, Dental D005491 1 associated lipids
Maxillofacial Injuries D008446 1 associated lipids
Dacryocystitis D003607 1 associated lipids
Erythrasma D004894 1 associated lipids
Granuloma, Respiratory Tract D015769 1 associated lipids
Lymphoma, B-Cell, Marginal Zone D018442 1 associated lipids
Sialadenitis D012793 1 associated lipids
Jaw Abnormalities D007569 1 associated lipids
Actinomycosis, Cervicofacial D000197 1 associated lipids
Pericarditis, Constrictive D010494 1 associated lipids
Microphthalmos D008850 1 associated lipids
Peritonsillar Abscess D000039 1 associated lipids
Staphylococcal Scalded Skin Syndrome D013206 1 associated lipids
Skin Diseases, Vascular D017445 1 associated lipids
Angiomatosis D000798 1 associated lipids
Ophthalmia Neonatorum D009878 1 associated lipids
Peliosis Hepatis D010382 1 associated lipids
Epidural Abscess D020802 1 associated lipids
Typhus, Epidemic Louse-Borne D014438 1 associated lipids
Myiasis D009198 1 associated lipids
Keratoderma, Palmoplantar D007645 1 associated lipids
Syphilis, Cardiovascular D013589 1 associated lipids
Chalazion D017043 1 associated lipids
Parapsoriasis D010267 1 associated lipids
Stomatognathic Diseases D009057 1 associated lipids
Splenic Infarction D013159 1 associated lipids
Thyroid Crisis D013958 1 associated lipids
Trench Fever D014205 1 associated lipids
Digestive System Abnormalities D004065 1 associated lipids
Occupational Injuries D060051 1 associated lipids
Papillon-Lefevre Disease D010214 1 associated lipids
Meningitis, Listeria D008584 1 associated lipids
Hereditary Sensory and Autonomic Neuropathies D009477 1 associated lipids
Megacolon D008531 1 associated lipids
Choroiditis D002833 1 associated lipids
Syphilis, Cutaneous D013591 1 associated lipids
Pneumonia, Ventilator-Associated D053717 1 associated lipids
Spider Bites D001098 1 associated lipids
Heart Murmurs D006337 1 associated lipids
Epidermitis, Exudative, of Swine D004818 1 associated lipids
Fecal Incontinence D005242 1 associated lipids
Rat-Bite Fever D011906 1 associated lipids
Pelvic Infection D034161 1 associated lipids
Per page 10 20 50 100 | Total 442

PubChem Associated disorders and diseases

What pathways are associated with erythromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with erythromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with erythromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with erythromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with erythromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with erythromycin?

Mouse Model

Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).

Knock-out

Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with erythromycin

Download all related citations
Per page 10 20 50 100 | Total 13660
Authors Title Published Journal PubMed Link
Lakritz J et al. Effect of treatment with erythromycin on bronchoalveolar lavage fluid cell populations in foals. 1997 Am. J. Vet. Res. pmid:8989497
Nieto JE et al. In vitro effects of erythromycin, lidocaine, and metoclopramide on smooth muscle from the pyloric antrum, proximal portion of the duodenum, and middle portion of the jejunum of horses. 2000 Am. J. Vet. Res. pmid:10772106
Roussel AJ et al. Prokinetic effects of erythromycin on the ileum, cecum, and pelvic flexure of horses during the postoperative period. 2000 Am. J. Vet. Res. pmid:10772107
Bartlett JG et al. Antibiotic-induced lethal enterocolitis in hamsters: studies with eleven agents and evidence to support the pathogenic role of toxin-producing Clostridia. 1978 Am. J. Vet. Res. pmid:697162
Lester GD et al. Effect of erythromycin lactobionate on myoelectric activity of ileum, cecum, and right ventral colon, and cecal emptying of radiolabeled markers in clinically normal ponies. 1998 Am. J. Vet. Res. pmid:9522953
FLORESTANO HJ and BAHLER ME Chemotherapeutic properties of erythromycin alone and in combination with sulfamerazine. 1955 Am. J. Vet. Res. pmid:13228887
Regnery RL et al. Experimentally induced Bartonella henselae infections followed by challenge exposure and antimicrobial therapy in cats. 1996 Am. J. Vet. Res. pmid:8950424
Ringger NC et al. Effect of bethanechol or erythromycin on gastric emptying in horses. 1996 Am. J. Vet. Res. pmid:8950433
Nieto JE et al. Use of an extracorporeal circuit to evaluate effects of intraluminal distention and decompression on the equine jejunum. 2002 Am. J. Vet. Res. pmid:11843129
Stalheim OH Chemotherapy of renal leptospirosis in hamsters. 1966 Am. J. Vet. Res. pmid:4164020
Lakritz J et al. Pharmacokinetics of erythromycin estolate and erythromycin phosphate after intragastric administration to healthy foals. 2000 Am. J. Vet. Res. pmid:10951982
Ramstedt KL et al. Changes in gallbladder volume in healthy dogs after food was withheld for 12 hours followed by ingestion of a meal or a meal containing erythromycin. 2008 Am. J. Vet. Res. pmid:18447796
Lakritz J et al. Comparison of microbiologic and high-performance liquid chromatography assays to determine plasma concentrations, pharmacokinetics, and bioavailability of erythromycin base in plasma of foals after intravenous or intragastric administration. 1999 Am. J. Vet. Res. pmid:10211682
Ziv G et al. Mode of transfer of antibiotics from treated to nontreated quarters in dairy cows. 1974 Am. J. Vet. Res. pmid:4133826
Afshari GR et al. Effect of parenteral administration of ivermectin and erythromycin on abomasal emptying rate in suckling calves. 2009 Am. J. Vet. Res. pmid:19335110
Libal MC Comparison of minimal inhibitory concentration and disk-diffusion antimicrobic sensitivity testing of bacterial pathogens isolated from food animals. 1985 Am. J. Vet. Res. pmid:3159322
Cooper RF et al. Characterization of Listeria monocytogenes serotype 5. 1973 Am. J. Vet. Res. pmid:4198346
Koenig JB et al. Binding of radiolabeled porcine motilin and erythromycin lactobionate to smooth muscle membranes in various segments of the equine gastrointestinal tract. 2002 Am. J. Vet. Res. pmid:12428665
Wittek T and Constable PD Assessment of the effects of erythromycin, neostigmine, and metoclopramide on abomasal motility and emptying rate in calves. 2005 Am. J. Vet. Res. pmid:15822601
Wilson RC et al. Serum erythromycin concentration in sheep fed two diets. 1984 Am. J. Vet. Res. pmid:6742574
PEARSON CC et al. A study of the effect of three drugs on the multiplication of Anaplasma-infected bovine erythrocytes. 1962 Am. J. Vet. Res. pmid:14484757
Burrows GE et al. Serum and tissue concentrations of erythromycin in calves with induced pneumonic pasteurellosis. 1989 Am. J. Vet. Res. pmid:2774339
Smith JA et al. Inhibitory and lethal activities of rosaramicin, erythromycin, and clindamycin against Campylobacter fetus subsp jejuni and intestinalis. 1983 Am. J. Vet. Res. pmid:6625312
Kinoshita T et al. Impact of age-related alteration of plasma alpha 1-acid glycoprotein concentration on erythromycin pharmacokinetics in pigs. 1995 Am. J. Vet. Res. pmid:7771705
Nouri M and Constable PD Effect of parenteral administration of erythromycin, tilmicosin, and tylosin on abomasal emptying rate in suckling calves. 2007 Am. J. Vet. Res. pmid:18052746
JUNG RC et al. Fumagillin and erythromycin in the treatment of amebiasis. 1955 Am. J. Trop. Med. Hyg. pmid:13268803
MCHARDY G et al. Erythromycin in amebiasis. 1955 Am. J. Trop. Med. Hyg. pmid:13268804
NELSON TL et al. Amebic hepatitis; laboratory findings and treatment with erythromycin. 1955 Am. J. Trop. Med. Hyg. pmid:13259005
Hamel MJ et al. Efficacy of trimethoprim-sulfamethoxazole compared with sulfadoxine-pyrimethamine plus erythromycin for the treatment of uncomplicated malaria in children with integrated management of childhood illness dual classifications of malaria and pneumonia. 2005 Am. J. Trop. Med. Hyg. pmid:16172491
NOR EL-DIN G Erythromycin in the treatment of amebiasis. 1956 Am. J. Trop. Med. Hyg. pmid:13292653
Gingras BA and Jensen JB Activity of azithromycin (CP-62,993) and erythromycin against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro. 1992 Am. J. Trop. Med. Hyg. pmid:1326232
Robins-Browne RM et al. Treatment of acute nonspecific gastroenteritis of infants and young children with erythromycin. 1983 Am. J. Trop. Med. Hyg. pmid:6349401
WILMOT AJ et al. Erythromycin in amebic liver abscess. 1958 Am. J. Trop. Med. Hyg. pmid:13595213
ANDERSON HH et al. Erythromycin stearate against systemic amebiasis in Colombia. 1955 Am. J. Trop. Med. Hyg. pmid:13238724
VILLAREJOS VM Treatment of amebiasis with erythromycin. 1955 Am. J. Trop. Med. Hyg. pmid:13238725
Kelly DJ et al. Rickettsia tsutsugamushi infection in cell culture: antibiotic susceptibility determined by flow cytometry. 1995 Am. J. Trop. Med. Hyg. pmid:8561261
ANDERSON HH et al. Antibiotic synergism in amebiasis. 1954 Am. J. Trop. Med. Hyg. pmid:13138827
Hall KA et al. Characterization of counterfeit artesunate antimalarial tablets from southeast Asia. 2006 Am. J. Trop. Med. Hyg. pmid:17123969
Gingras BA and Jensen JB Antimalarial activity of azithromycin and erythromycin against Plasmodium berghei. 1993 Am. J. Trop. Med. Hyg. pmid:8394660
MCCOWEN MC et al. The effects of erythromycin (ilotycin, lilly) against certain parasitic organisms. 1953 Am. J. Trop. Med. Hyg. pmid:13040654
Crawford KA et al. Efficacy of amoscanate against experimental schistosomal infections in monkeys. 1983 Am. J. Trop. Med. Hyg. pmid:6625061
Perine PL and Teklu B Antibiotic treatment of louse-borne relapsing fever in Ethiopia: a report of 377 cases. 1983 Am. J. Trop. Med. Hyg. pmid:6625065
Vanaudenaerde BM et al. Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. 2007 Am. J. Transplant. pmid:17061983
Jones TR et al. Efficacy of an antibiotic mouthwash in contaminated head and neck surgery. 1989 Am. J. Surg. pmid:2802036
Brass C et al. The effect of metronidazole on the incidence of postoperative wound infection in elective colon surgery. 1978 Am. J. Surg. pmid:341733
LeVeen HH et al. Effects of prophylactic antibiotics on colonic healing. 1976 Am. J. Surg. pmid:1247153
Carlson RG et al. Erythromycin enhances delayed gastric emptying in dogs after Roux-Y antrectomy. 1991 Am. J. Surg. pmid:1987856
Nissan A et al. Direct inhibitory effect of erythromycin on human alimentary tract smooth muscle. 2002 Am. J. Surg. pmid:11975929
Dillon ML and Bowling KA Effect of antibiotics on wound and stool cultures. Comparison of intravenous terramycin with other antibiotics. 1967 Am. J. Surg. pmid:5334435
Nakabayashi T et al. Gastropyloric motor activity and the effects of erythromycin given orally after esophagectomy. 2002 Am. J. Surg. pmid:11943134
COHN I and LONGACRE AB Erythromycin and erythromycin-neomycin for intestinal antisepsis. 1957 Am. J. Surg. pmid:13458603
Tzovaras G et al. The effect of intravenous erythromycin on esophageal motility in healthy subjects. 1996 Am. J. Surg. pmid:8615464
Gombert ME et al. Cavitary Legionnaires' pneumonia: nosocomial infection in renal transplant recipients. 1984 Am. J. Surg. pmid:6367506
Marshall W et al. Legionnaires' disease in renal transplant patients. 1981 Am. J. Surg. pmid:7013509
Pennathur A et al. Erythromycin strengthens the defective lower esophageal sphincter in patients with gastroesophageal reflux disease. 1994 Am. J. Surg. pmid:8311129
Fry DE Colon preparation and surgical site infection. 2011 Am. J. Surg. pmid:21429471
Weaver M et al. Oral neomycin and erythromycin compared with single-dose systemic metronidazole and ceftriaxone prophylaxis in elective colorectal surgery. 1986 Am. J. Surg. pmid:3083705
Baciewicz AM and Baciewicz FA Cyclosporine pharmacokinetic drug interactions. 1989 Am. J. Surg. pmid:2644865
EICHENWALD HF and SHINEFIELD HR RATIONAL USE OF ANTIBIOTICS. 1964 Am. J. Surg. pmid:14129331
Condon RE et al. Oral neomycin and erythromycin compared with single-dose systemic metronidazole and ceftriaxone prophylaxis in elective colorectal surgery. 1986 Am. J. Surg. pmid:3777340
Kudoh S et al. Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. 1998 Am. J. Respir. Crit. Care Med. pmid:9620913
Hayakawa H et al. Bronchiolar disease in rheumatoid arthritis. 1996 Am. J. Respir. Crit. Care Med. pmid:8912776
Carvalho P et al. Effects of erythromycin on the rabbit pleura: its potential role as a pleural sclerosant. 1995 Am. J. Respir. Crit. Care Med. pmid:7697257
Suzuki T et al. Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells. 2002 Am. J. Respir. Crit. Care Med. pmid:11956054
Tamaoki J et al. Effect of erythromycin on endotoxin-induced microvascular leakage in the rat trachea and lungs. 1995 Am. J. Respir. Crit. Care Med. pmid:7735618
Azuma M et al. Role of alpha1-acid glycoprotein in therapeutic antifibrotic effects of imatinib with macrolides in mice. 2007 Am. J. Respir. Crit. Care Med. pmid:17717205
Sato K et al. Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice. 1998 Am. J. Respir. Crit. Care Med. pmid:9517602
Takizawa H et al. Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells. 1997 Am. J. Respir. Crit. Care Med. pmid:9230759
Seemungal TA et al. Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations. 2008 Am. J. Respir. Crit. Care Med. pmid:18723437
Kunisaki KM and Niewoehner DE Antibiotic prophylaxis for chronic obstructive pulmonary disease: resurrecting an old idea. 2008 Am. J. Respir. Crit. Care Med. pmid:19023036
Kondo M et al. Erythromycin inhibits ATP-induced intracellular calcium responses in bovine tracheal epithelial cells. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9806744
Dakhama A et al. Induction of regulated upon activation, normal T cells expressed and secreted (RANTES) and transforming growth factor-beta 1 in airway epithelial cells by Mycoplasma pneumoniae. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12714377
Gorrini M et al. Inhibition of human neutrophil elastase by erythromycin and flurythromycin, two macrolide antibiotics. 2001 Am. J. Respir. Cell Mol. Biol. pmid:11694455
Sakahara S et al. Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus). 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20686171
Sun XJ et al. Combination of erythromycin and dexamethasone improves corticosteroid sensitivity induced by CSE through inhibiting PI3K-δ/Akt pathway and increasing GR expression. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:25957293
Zhao DM et al. Effect of erythromycin on ATP-induced intracellular calcium response in A549 cells. 2000 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:10749750
Ishizawa K et al. Erythromycin increases bactericidal activity of surface liquid in human airway epithelial cells. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16148051
Hodge S et al. Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases. 2017 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:28258107
Wyatt TA et al. cAMP-dependent protein kinase activation decreases cytokine release in bronchial epithelial cells. 2014 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:25150062
Tarran R et al. Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. 2013 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:23542952
Takagi Y et al. Erythromycin-induced CXCR4 expression on microvascular endothelial cells. 2009 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:19502290
Faas H et al. Pressure-geometry relationship in the antroduodenal region in humans. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11668030
Lemahieu WP et al. Measurement of hepatic and intestinal CYP3A4 and PGP activity by combined po + iv [14C]erythromycin breath and urine test. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12909563
Bryant LK et al. Stimulation of small intestinal burst activity in the postprandial state differentially affects lipid and glucose absorption in healthy adult humans. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15191881
Sarna SK et al. Enteric locus of action of prokinetics: ABT-229, motilin, and erythromycin. 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:10801267
Chen J et al. Effect of erythromycin on gastric myoelectrical activity in normal human subjects. 1992 Am. J. Physiol. pmid:1636712
Yamada K et al. Electrophysiological characterization of a motilin agonist, GM611, on rabbit duodenal smooth muscle. 1996 Am. J. Physiol. pmid:8997244
Holle GE et al. Effects of erythromycin in the dog upper gastrointestinal tract. 1992 Am. J. Physiol. pmid:1353302
Prather CM et al. Gastric axial forces in experimentally delayed and accelerated gastric emptying. 1993 Am. J. Physiol. pmid:8498519
Parkman HP et al. Gastrokinetic effects of erythromycin: myogenic and neurogenic mechanisms of action in rabbit stomach. 1995 Am. J. Physiol. pmid:7573453
Mathis C and Malbert CH Erythromycin gastrokinetic activity is partially vagally mediated. 1998 Am. J. Physiol. pmid:9458776
Hasler WL et al. Erythromycin contracts rabbit colon myocytes via occupation of motilin receptors. 1992 Am. J. Physiol. pmid:1733270
Otterson MF and Sarna SK Gastrointestinal motor effects of erythromycin. 1990 Am. J. Physiol. pmid:2399980
Irokawa T et al. Cholinomimetic action of macrolide antibiotics on airway gland electrolyte secretion. 1999 Am. J. Physiol. pmid:10362719
Itoh Z et al. Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog. 1984 Am. J. Physiol. pmid:6507625
Sun WM et al. Relationship between surface electrogastrography and antropyloric pressures. 1995 Am. J. Physiol. pmid:7900804
Liu YF et al. Sphincter of Oddi regulates flow by acting as a variable resistor to flow. 1992 Am. J. Physiol. pmid:1443142
Peeters T et al. Erythromycin is a motilin receptor agonist. 1989 Am. J. Physiol. pmid:2782416
Tanaka T et al. A new method to measure gastric emptying in conscious dogs: a validity study and effects of EM523 and L-NNA. 1997 Am. J. Physiol. pmid:9142925
Itoh Z et al. Structure-activity relation among macrolide antibiotics in initiation of interdigestive migrating contractions in the canine gastrointestinal tract. 1985 Am. J. Physiol. pmid:3976891