erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Stieler AL et al. | Macrolide-induced hyperthermia in foals: Role of impaired sweat responses. | 2016 | Equine Vet. J. | pmid:26174202 |
Kumpfmüller J et al. | Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26432460 |
Deloose E et al. | Higher plasma motilin levels in obese patients decrease after Roux-en-Y gastric bypass surgery and regulate hunger. | 2016 | Gut | pmid:25986945 |
Mombelli A et al. | Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci. | 2016 | J. Periodontol. | pmid:26654350 |
Ulanovsky I et al. | Erythromycin Prophylaxis for Neonatal Conjunctivitis: Ointment Versus Drops. | 2016 | Isr. Med. Assoc. J. | pmid:28471562 |
Sagkan-Ozturk A et al. | Prokinetics stimulate the increase of ghrelin in mice. | 2016 | Bratisl Lek Listy | pmid:28127970 |
Talebi M et al. | Determination of Characteristics of Erythromycin Resistant Streptococcus pneumoniae with Preferred PCV Usage in Iran. | 2016 | PLoS ONE | pmid:28033345 |
Ray D et al. | Molecular characterization and evaluation of the emerging antibiotic-resistant Streptococcus pyogenes from eastern India. | 2016 | BMC Infect. Dis. | pmid:27955635 |
Ma Y et al. | Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical isolates from a hospital in Shanghai, China. | 2016 | Front Med | pmid:27896620 |
Aslantaş Ö and Demir C | Investigation of the antibiotic resistance and biofilm-forming ability of Staphylococcus aureus from subclinical bovine mastitis cases. | 2016 | J. Dairy Sci. | pmid:27592437 |
Budha NR et al. | Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation. | 2016 | Clin Pharmacokinet | pmid:27225997 |
Wan TW et al. | Complete Circular Genome Sequence of Successful ST8/SCCmecIV Community-Associated Methicillin-Resistant Staphylococcus aureus (OC8) in Russia: One-Megabase Genomic Inversion, IS256's Spread, and Evolution of Russia ST8-IV. | 2016 | PLoS ONE | pmid:27741255 |
Hadjipanayis A et al. | Nasopharyngeal Pneumococcal Carriage among Healthy Children in Cyprus Post Widespread Simultaneous Implementation of PCV10 and PCV13 Vaccines. | 2016 | PLoS ONE | pmid:27706247 |
Krishnamoorthy G et al. | Breaking the Permeability Barrier of Escherichia coli by Controlled Hyperporination of the Outer Membrane. | 2016 | Antimicrob. Agents Chemother. | pmid:27697764 |
Li M et al. | Inducible Expression of both ermB and ermT Conferred High Macrolide Resistance in Streptococcus gallolyticus subsp. pasteurianus Isolates in China. | 2016 | Int J Mol Sci | pmid:27669217 |
Murchison L et al. | Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. | 2016 | Pediatr. Surg. Int. | pmid:27655365 |
Dzyubak E and Yap MN | The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling. | 2016 | Antimicrob. Agents Chemother. | pmid:27645242 |
Abreu AC et al. | Combinatorial approaches with selected phytochemicals to increase antibiotic efficacy against Staphylococcus aureus biofilms. | 2016 | Biofouling | pmid:27643487 |
Jurado-Tarifa E et al. | Genetic diversity and antimicrobial resistance of Campylobacter and Salmonella strains isolated from decoys and raptors. | 2016 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:27638115 |
Hu Z et al. | Short-term performance of enhanced biological phosphorus removal (EBPR) system exposed to erythromycin (ERY) and oxytetracycline (OTC). | 2016 | Bioresour. Technol. | pmid:27631889 |
Benamrouche N et al. | Microbiological and molecular characterization of Corynebacterium diphtheriae isolated in Algeria between 1992 and 2015. | 2016 | Clin. Microbiol. Infect. | pmid:27585941 |
Kang CH and So JS | Antibiotic and heavy metal resistance in Shewanella putrefaciens strains isolated from shellfishes collected from West Sea, Korea. | 2016 | Mar. Pollut. Bull. | pmid:27555484 |
Wu L et al. | Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells. | 2016 | PLoS ONE | pmid:27447724 |
Kwon JW | Environmental impact assessment of veterinary drug on fish aquaculture for food safety. | 2016 | Drug Test Anal | pmid:27443211 |
Aslan Bayhan S et al. | Effects of topical acne treatment on the ocular surface in patients with acne vulgaris. | 2016 | Cont Lens Anterior Eye | pmid:27422575 |
Li X et al. | Effects of Total Alkaloids of Sophora alopecuroides on Biofilm Formation in Staphylococcus epidermidis. | 2016 | Biomed Res Int | pmid:27413745 |
Ababou A and Koronakis V | Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate. | 2016 | PLoS ONE | pmid:27403665 |
Yuan QB et al. | Reductions of bacterial antibiotic resistance through five biological treatment processes treated municipal wastewater. | 2016 | Environ Sci Pollut Res Int | pmid:27384166 |
Karlsson E et al. | Clonality of erythromycin resistance in Francisella tularensis. | 2016 | J. Antimicrob. Chemother. | pmid:27334667 |
Changchien CH et al. | Antibiotic susceptibility and genomic variations in Staphylococcus aureus associated with Skin and Soft Tissue Infection (SSTI) disease groups. | 2016 | BMC Infect. Dis. | pmid:27287530 |
Waiser MJ et al. | Effects of erythromycin, trimethoprim and clindamycin on attached microbial communities from an effluent dominated prairie stream. | 2016 | Ecotoxicol. Environ. Saf. | pmid:27261880 |
KarniÄar K et al. | Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea. | 2016 | Microb. Cell Fact. | pmid:27255285 |
Ghosh S and Banerjee M | Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureus. | 2016 | Indian J. Med. Res. | pmid:27241651 |
Pignatello R et al. | Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides. | 2016 | Eur J Med Chem | pmid:27236014 |
Mushtaq A et al. | Differential Antimicrobial Susceptibilities of Granulicatella adiacens and Abiotrophia defectiva. | 2016 | Antimicrob. Agents Chemother. | pmid:27216060 |
Hong M et al. | Impacts of proline on the central metabolism of an industrial erythromycin-producing strain Saccharopolyspora erythraea via (13)C labeling experiments. | 2016 | J. Biotechnol. | pmid:27215341 |
StaceviÄienÄ— I et al. | Antibiotic resistance of Streptococcus pneumoniae, isolated from nasopharynx of preschool children with acute respiratory tract infection in Lithuania. | 2016 | BMC Infect. Dis. | pmid:27206423 |
Tatiya-Aphiradee N et al. | In vivo antibacterial activity of Garcinia mangostana pericarp extract against methicillin-resistant Staphylococcus aureus in a mouse superficial skin infection model. | 2016 | Pharm Biol | pmid:27180784 |
Trac MH et al. | Macrolide antibiotics and the risk of ventricular arrhythmia in older adults. | 2016 | CMAJ | pmid:26903359 |
He M et al. | Mechanism of synergy between SIPI-8294 and β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. | 2016 | Lett. Appl. Microbiol. | pmid:27173151 |
Patel MB et al. | Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. | 2016 | Bioorg. Med. Chem. | pmid:27166575 |
Taylor SJ et al. | A randomised controlled feasibility and proof-of-concept trial in delayed gastric emptying when metoclopramide fails: We should revisit nasointestinal feeding versus dual prokinetic treatment: Achieving goal nutrition in critical illness and delayed gastric emptying: Trial of nasointestinal feeding versus nasogastric feeding plus prokinetics. | 2016 | Clin Nutr ESPEN | pmid:28531392 |
Guo Q et al. | Controlling the feed rate of propanol to optimize erythromycin fermentation by on-line capacitance and oxygen uptake rate measurement. | 2016 | Bioprocess Biosyst Eng | pmid:26615414 |
Zhang A et al. | Molecular subtyping and erythromycin resistance of Campylobacter in China. | 2016 | J. Appl. Microbiol. | pmid:26999516 |
Mukai S et al. | Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. | 2016 | Int. J. Oncol. | pmid:26718641 |
Sousa M et al. | Genetic Diversity and Antibiotic Resistance Among Coagulase-Negative Staphylococci Recovered from Birds of Prey in Portugal. | 2016 | Microb. Drug Resist. | pmid:26990729 |
Morroni G et al. | Enterococcus faecium ST17 from Coastal Marine Sediment Carrying Transferable Multidrug Resistance Plasmids. | 2016 | Microb. Drug Resist. | pmid:26982016 |
Lenart-Boroń A et al. | Phenotypic and Molecular Antibiotic Resistance Determination of Airborne Coagulase Negative Staphylococcus spp. Strains from Healthcare Facilities in Southern Poland. | 2016 | Microb. Drug Resist. | pmid:26978225 |
Li X et al. | Macrolides use and the risk of sudden cardiac death. | 2016 | Expert Rev Anti Infect Ther | pmid:27086751 |
Diawara I et al. | Phenotypic and genotypic characterization of Streptococcus pneumoniae resistant to macrolide in Casablanca, Morocco. | 2016 | Infect. Genet. Evol. | pmid:26961592 |
Barros RR et al. | Polyclonal spread of Streptococcus agalactiae resistant to clindamycin among pregnant women in Brazil. | 2016 | J. Antimicrob. Chemother. | pmid:27029847 |
Sierra-Arguello YM et al. | Fluoroquinolone and macrolide resistance in Campylobacter jejuni isolated from broiler slaughterhouses in southern Brazil. | 2016 | Avian Pathol. | pmid:26925976 |
Molina-Manso D et al. | Effect of different agents with potential antibiofilm activity on antimicrobial susceptibility of biofilms formed by Staphylococcus spp. isolated from implant-related infections. | 2016 | J. Antibiot. | pmid:26905757 |
Meng HL et al. | Construction of polyketide overproducing Escherichia coli strains via synthetic antisense RNAs based on in silico fluxome analysis and comparative transcriptome analysis. | 2016 | Biotechnol J | pmid:26709503 |
Madmanang S et al. | Constituents of Fagraea fragrans with Antimycobacterial Activity in Combination with Erythromycin. | 2016 | J. Nat. Prod. | pmid:26905094 |
Aydin S et al. | Assessment of anaerobic bacterial diversity and its effects on anaerobic system stability and the occurrence of antibiotic resistance genes. | 2016 | Bioresour. Technol. | pmid:26897411 |
Baek YS et al. | Antimicrobial resistance of Staphylococcus aureus isolated from skin infections and its implications in various clinical conditions in Korea. | 2016 | Int. J. Dermatol. | pmid:26892888 |
Chua SL et al. | Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms. | 2016 | Nat Commun | pmid:26892159 |
Liu H et al. | [A systematic review of the therapy for Mycoplasma pneumoniae infections in children]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:26875461 |
Poliquin V et al. | Preparedness for Implementing Change in Neonatal Ocular Prophylaxis Policies. | 2016 | J Obstet Gynaecol Can | pmid:26872748 |
Bouvet L et al. | Ultrasound Assessment of the Prokinetic Effect of Erythromycin in Trauma Patients with a Full Stomach: A Case Series. | 2016 | Anesth. Analg. | pmid:26859878 |
Moltó-GarcÃa B et al. | Molecular characterization and antimicrobial susceptibility of hemolytic Streptococcus agalactiae from post-menopausal women. | 2016 | Maturitas | pmid:26857873 |
Sari E et al. | Fabrication of surface plasmon resonance nanosensor for the selective determination of erythromycin via molecular imprinted nanoparticles. | 2016 | Talanta | pmid:26838449 |
Magnussen MD et al. | Antibacterial resistance in Streptococcus pyogenes (GAS) from healthy carriers and tonsillitis patients and association with antibacterial sale in the Faroe Islands. | 2016 | APMIS | pmid:26833774 |
Gupta P et al. | Nascent peptide assists the ribosome in recognizing chemically distinct small molecules. | 2016 | Nat. Chem. Biol. | pmid:26727240 |
Dréno B | Bacteriological resistance in acne: A call to action. | 2016 | Eur J Dermatol | pmid:26711531 |
Parhizgari N et al. | High frequency of multidrug-resistant Staphylococcus aureus with SCCmec type III and Spa types t037 and t631 isolated from burn patients in southwest of Iran. | 2016 | APMIS | pmid:26709106 |
Chuang MC et al. | Diffuse panbronchiolitis-The response and recurrence after erythromycin therapy. | 2016 | J. Formos. Med. Assoc. | pmid:26705139 |
Broad J et al. | RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions. | 2016 | J. Pharmacol. Sci. | pmid:26685754 |
Sayed Ahmed WA et al. | Maternal serum interleukin-6 in the management of patients with preterm premature rupture of membranes. | 2016 | J. Matern. Fetal. Neonatal. Med. | pmid:26669630 |
Caspi M et al. | A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents. | 2016 | J. Mol. Med. | pmid:26620677 |
Zhou J et al. | A seventeen-year observation of the antimicrobial susceptibility of clinical Campylobacter jejuni and the molecular mechanisms of erythromycin-resistant isolates in Beijing, China. | 2016 | Int. J. Infect. Dis. | pmid:26594011 |
Li J et al. | Rhubarb to Facilitate Placement of Nasojejunal Feeding Tubes in Patients in the Intensive Care Unit. | 2016 | Nutr Clin Pract | pmid:26459161 |
Shimizu T and Suzaki H | Past, present and future of macrolide therapy for chronic rhinosinusitis in Japan. | 2016 | Auris Nasus Larynx | pmid:26441370 |
Vitali LA et al. | Correlation between genetic features of the mef(A)-msr(D) locus and erythromycin resistance in Streptococcus pyogenes. | 2016 | Diagn. Microbiol. Infect. Dis. | pmid:26429294 |
Sugawara A et al. | Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model. | 2016 | J. Antibiot. | pmid:26419414 |
Feuillolay C et al. | A Myrtus communis extract enriched in myrtucummulones and ursolic acid reduces resistance of Propionibacterium acnes biofilms to antibiotics used in acne vulgaris. | 2016 | Phytomedicine | pmid:26969384 |
Ohbatake Y et al. | Elevated alpha1-acid glycoprotein in gastric cancer patients inhibits the anticancer effects of paclitaxel, effects restored by co-administration of erythromycin. | 2016 | Clin. Exp. Med. | pmid:26359244 |
Brunel R and Charpentier X | Trans-translation is essential in the human pathogen Legionella pneumophila. | 2016 | Sci Rep | pmid:27892503 |
Naik KM and Nandibewoor ST | Investigation into the interaction of methylparaben and erythromycin with human serum albumin using multispectroscopic methods. | 2016 | Luminescence | pmid:26239839 |
Yuan SF et al. | Levels of six antibiotics used in China estimated by means of wastewater-based epidemiology. | 2016 | Water Sci. Technol. | pmid:26901719 |
Jakkidi M et al. | An illusion of septic shock: acute generalised exanthematous pustulosis with multiorgan dysfunction. | 2017 | BMJ Case Rep | pmid:28768672 |
Jeong S et al. | Combined photodynamic and antibiotic therapy for skin disorder via lipase-sensitive liposomes with enhanced antimicrobial performance. | 2017 | Biomaterials | pmid:28697465 |
Lamari F et al. | Assessment of the correlation among antibiotic resistance, adherence to abiotic and biotic surfaces, invasion and cytotoxicity of Pseudomonas aeruginosa isolated from diseased gilthead sea bream. | 2017 | Colloids Surf B Biointerfaces | pmid:28697438 |
Kasetty G et al. | The Nonantibiotic Macrolide EM703 Improves Survival in a Model of Quinolone-Treated Pseudomonas aeruginosa Airway Infection. | 2017 | Antimicrob. Agents Chemother. | pmid:28652240 |
Mingmongkolchai S and Panbangred W | In vitro evaluation of candidate Bacillus spp. for animal feed. | 2017 | J. Gen. Appl. Microbiol. | pmid:28331163 |
Attaran B et al. | Effect of biofilm formation by clinical isolates of on the efflux-mediated resistance to commonly used antibiotics. | 2017 | World J. Gastroenterol. | pmid:28275296 |
Nowakiewicz A et al. | Determination of antimicrobial resistance of Enterococcus strains isolated from pigs and their genotypic characterization by method of amplification of DNA fragments surrounding rare restriction sites (ADSRRS fingerprinting). | 2017 | J. Med. Microbiol. | pmid:28260584 |
Waites KB et al. | In Vitro Activities of Lefamulin and Other Antimicrobial Agents against Macrolide-Susceptible and Macrolide-Resistant Mycoplasma pneumoniae from the United States, Europe, and China. | 2017 | Antimicrob. Agents Chemother. | pmid:27855075 |
Zhang W et al. | Isolation and characterization of a high-efficiency erythromycin A-degrading Ochrobactrum sp. strain. | 2017 | Mar. Pollut. Bull. | pmid:27863881 |
Li B et al. | Antimicrobial Resistance of Campylobacter Species Isolated from Broilers in Live Bird Markets in Shanghai, China. | 2017 | Foodborne Pathog. Dis. | pmid:27854542 |
Dolberg AM and Reichl S | Activity of Multidrug Resistance-Associated Proteins 1-5 (MRP1-5) in the RPMI 2650 Cell Line and Explants of Human Nasal Turbinate. | 2017 | Mol. Pharm. | pmid:28291371 |
Massip C et al. | Macrolide resistance in Legionella pneumophila: the role of LpeAB efflux pump. | 2017 | J. Antimicrob. Chemother. | pmid:28137939 |
GarcÃa-Iglesias P et al. | Management of non variceal upper gastrointestinal bleeding: position statement of the Catalan Society of Gastroenterology. | 2017 | Gastroenterol Hepatol | pmid:28109636 |
Argemi X et al. | VISLISI trial, a prospective clinical study allowing identification of a new metalloprotease and putative virulence factor from Staphylococcus lugdunensis. | 2017 | Clin. Microbiol. Infect. | pmid:28017792 |
Yi M et al. | Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis. | 2017 | Arch. Biochem. Biophys. | pmid:28347661 |
Zheng PX et al. | Highly prevalent emmSTG840.0 and emmSTC839.0 types of erythromycin non-susceptible group G Streptococcus isolated from bacteremia in southern Taiwan. | 2017 | J Microbiol Immunol Infect | pmid:28711431 |
Abreu AC et al. | Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA. | 2017 | Sci Rep | pmid:28630440 |
Feng L et al. | Removal of antibiotics during the anaerobic digestion of pig manure. | 2017 | Sci. Total Environ. | pmid:28628813 |
Tay JH et al. | Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis. | 2017 | J. Am. Chem. Soc. | pmid:28627172 |