erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vincent M and Brune J | [4 cases of Mycoplasma pneumoniae pneumonia]. | 1982 | Sem Hop | pmid:6297021 |
Colin JY et al. | [Acute perihepatitis of genital origin (Fitz Hugh-Curtis syndrome): 4 case reports]. | 1982 | Sem Hop | pmid:6297042 |
Becq-Giraudon B et al. | [Acute respiratory distress syndrome: indigenous Legionnaires' disease (author's transl)]. | 1981 Mar 8-15 | Sem Hop | pmid:6261396 |
CLUZEL R et al. | [Combination erythromycin-oleandomycin: favorable bactericidal effect on pathogenic staphylococci]. | 1959 | Sem Hop | pmid:13624776 |
Mozziconacci P and Attal C | [Treatment of rheumatic cardiopathies]. | 1968 | Sem Hop | pmid:4307324 |
Loire R et al. | [Present developmental aspect of infectious endocarditis. According to hospital statistics of 103 consecutive cases collected in the last 12 years]. | 1969 | Sem Hop | pmid:4308671 |
Amblard P et al. | [The association tretinoin-erythromycin base: a new topical treatment for acne. Results of a multicentric trial on 347 cases (authors transl)]. | 1980 May 8-15 | Sem Hop | pmid:6248979 |
RADERMECKER M and REGINSTER M | [STEVENS-JOHNSON SYNDROME AND ALLERGIC PAROTIDITIS. CONTRIBUTION TO ITS ETIOPATHOGENIC STUDY]. | 1964 | Sem Hop | pmid:14176724 |
Satgé P et al. | [Generalized infections by Candida albicans in children (apropos of 17 cases)]. | 1967 | Sem Hop | pmid:4296493 |
Adachi T and Morimoto S | [A new macrolide antibiotic, clarithromycin--synthesis, structure-activity relationship and metabolism]. | 1990 | Seikagaku | pmid:2150202 |
Cao Z et al. | [Analysis of erythromycin A oxime and its related compounds by RP-HPLC on base-deactivated column]. | 2007 | Se Pu | pmid:18257324 |
Avian tuberculosis. | 1968 | Scott Med J | pmid:4884700 | |
Williams RF | The problems, diagnosis and treatment of infection by Staphylococcus aureus. | 1979 | Scott Med J | pmid:493932 |
Ford MJ et al. | Mycoplasma pneumonia: failure of erythromycin therapy. | 1980 | Scott Med J | pmid:7455669 |
Lacey RW | Do bacteria mutate to erythromycin resistance? | 1977 | Scott Med J | pmid:23582 |
Jones GR and Stewart SM | A prospective study of the persistence of Mycoplasma pneumoniae antibody levels. | 1974 | Scott Med J | pmid:4597913 |
Watt B | Erythromycin and anaerobes: in vitro aspects. | 1977 | Scott Med J | pmid:341310 |
Gould JC | Erythromycin symposium: introduction. | 1977 | Scott Med J | pmid:601552 |
McC Murdoch J | A short review of erythromycin. | 1977 | Scott Med J | pmid:601553 |
Watson GI | The treatment of Mycoplasma pneumoniae infections. | 1977 | Scott Med J | pmid:601554 |
Forfar JO | Erythromycin resistance in neonatal staphylococcal infection: a long-term survey. | 1977 | Scott Med J | pmid:601556 |
Lambert HP | Erythromycin and anaerobic infection. | 1977 | Scott Med J | pmid:601557 |
Knothe H and Dette GA | Pharmakokinetics of erythromycin. | 1977 | Scott Med J | pmid:601558 |
Ruhrmann G and Holthusen W | Mycoplasma infection and erythromycin therapy in childhood. | 1977 | Scott Med J | pmid:601559 |
Grob PR | The use of erythromycin in a general practice. | 1977 | Scott Med J | pmid:601560 |
Oriel JD et al. | Comparison of erythromycin stearate and oxytetracycline in the treatment of non-gonococcal urethritis: their efficacy against Chlamydia trachomatis. | 1977 | Scott Med J | pmid:601555 |
MACCABE AF and GOULD JC | The epidemiology of an erythromycin resistant Staphylococcus. | 1956 | Scott Med J | pmid:13351658 |
Edmond E et al. | Avian tuberculosis. | 1968 | Scott Med J | pmid:5751239 |
SYME J et al. | Studies with monopropionyl erythromycin. | 1961 | Scott Med J | pmid:13774375 |
Gould JC | Erythromycin in respiratory tract infection. | 1977 | Scott Med J | pmid:414355 |
GIBSON GL | Erythromycin-resistant Staphylococcus pyogenes; report of five cases. | 1958 | Scott Med J | pmid:13529051 |
Hardie R and Hardie RA | Leg ulcer infection with an erythromycin-resistant Streptococcus pyogenes. | 1986 | Scott Med J | pmid:3515552 |
Shen Y et al. | Mitigative effect of erythromycin on PMMA challenged preosteoblastic MC3T3-E1 cells. | 2014 | ScientificWorldJournal | pmid:25110723 |
GOODGAL SH and POSTEL EH | NITROUS ACID MUTATION OF TRANSFORMING DNA: CONSIDERATION OF MODE OF ACTION. | 1965 | Science | pmid:14289610 |
Tanaka K et al. | Erythromycin-resistant mutant of Escherichia coli with altered ribosomal protein component. | 1968 | Science | pmid:4886608 |
Cortes J et al. | Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. | 1995 | Science | pmid:7770773 |
WOLFE AD and HAHN FE | ERYTHROMYCIN: MODE OF ACTION. | 1964 | Science | pmid:14107448 |
Mets LJ and Bogorad L | Mendelian and uniparental alterations in erythromycin binding by plastid ribosomes. | 1971 | Science | pmid:5123420 |
Donadio S et al. | Modular organization of genes required for complex polyketide biosynthesis. | 1991 | Science | pmid:2024119 |
Kao CM et al. | Engineered biosynthesis of a complete macrolactone in a heterologous host. | 1994 | Science | pmid:8036492 |
Jacobsen JR et al. | Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. | 1997 | Science | pmid:9219693 |
Service RF | Hijacking a cell's chemical paths to make new antibiotics. | 1997 | Science | pmid:9518361 |
Oldenburg M et al. | TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. | 2012 | Science | pmid:22821982 |
D'Costa VM et al. | Sampling the antibiotic resistome. | 2006 | Science | pmid:16424339 |
Pfeifer BA et al. | Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. | 2001 | Science | pmid:11230695 |
Weber JM et al. | An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea. | 1991 | Science | pmid:2011746 |
Feighner SD et al. | Receptor for motilin identified in the human gastrointestinal system. | 1999 | Science | pmid:10381885 |
Sachs MS and Geballe AP | Biochemistry. Sense and sensitivity--controlling the ribosome. | 2002 | Science | pmid:12228706 |
GRIFFITH LJ et al. | DRUG ANTAGONISM BETWEEN LINCOMYCIN AND ERYTHROMYCIN. | 1965 | Science | pmid:14242023 |
Marsden AF et al. | Engineering broader specificity into an antibiotic-producing polyketide synthase. | 1998 | Science | pmid:9422686 |