erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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TartakovskiÄ IS et al. | [The action of interferon preparations on strains of Legionella of various serogroups and species]. | 1988 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:2469268 |
Chimirov OB | [Sensitivity to the differential dose of erythromycin and oleandomycin of various holarctic strains of tularemia microbe isolated in the Kazakh SSR]. | 1978 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:150182 |
Ivashchenko VD | [Use of embryonic intestinal tissue culture, infected with dysentery bicilli, for study of the efficacy of chemotherapeutic preparations]. | 1973 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:4594209 |
Zueva VS and Linevich IuG | [Mechanism of disorders of transmission of extrachromosomal determinants of resistance in staphylococci]. | 1971 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:5135463 |
Zueva VS and Pavlov EP | [The prevalence of staphylococci with extrachromosomal drug resistance factors in different collectives]. | 1972 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:4563840 |
Wu DQ et al. | [The expression of transforming growth factor beta-1 in rat model of chronic obstructive pulmonary disease and the effects of early drugs intervention]. | 2004 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:15476327 |
Xu G | [Regulating effect of electro-acupuncture on dysrythmia of gastro-colonic electric activity induced by erythromycine in rabbits]. | 1994 | Zhen Ci Yan Jiu | pmid:7834859 |
Wang LQ et al. | [Pharmacokinetics of erythromycin stinoprate capsule]. | 2005 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:15898434 |
Lin XM et al. | [Influence of neferine and erythromycin on cellular GSH concentration in K562/A02 cell line]. | 2004 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:16136961 |
Xie L et al. | [Efficacy of low-dose oral erythromycin as an adjuvant therapy for cytomegalovirus infection]. | 2010 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:20199738 |
Yang Y | [Mechanism and clinical application of erythromycin as a gastrointestinal prokinetic agent in children]. | 2008 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:18289489 |
Thomas W and Speer CP | Prevention and therapy of bronchopulmonary dysplasia - evidence and clinical practice. | 2007 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:17582275 |
Yu M et al. | [Mechanism reversing MDR of K562/A02 by garlicin combined with erythromycin]. | 2008 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:18928592 |
Du Y and He Q | [The mechanism of alleviation of paraquat induced vascular endothelial permeability by erythromycin through adenosine 3'5'-cyclic monophosphate pathway]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19930884 |
Lu NF et al. | [Study of erythromycin and metoclopramide in treatment of feeding intolerance of critically ill patients in intensive care unit]. | 2010 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:20092709 |
Wang H et al. | Demethylation capacity of human fetal adrenal mitochondrial cytochrome P-450 in vitro. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452125 |
Huang SK et al. | [A combined perfusion-compartmental pharmacokinetic model used to estimate presystemic metabolism of erythromycin in dogs]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2954396 |
Ye H et al. | Antimycoplasmal activities of (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10 -[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid (YH-6) in comparison with other antibiotics in vitro. | 1999 | Zhongguo Yao Li Xue Bao | pmid:11270970 |
Lei PS et al. | [Advance in synthesis of ketolides, a new class of erythromycin derivatives]. | 2004 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:15379279 |
Sun XR et al. | [Effect of motilin receptor agonist-erythromycin on the glucose responsive neurons in hypothalamus of rats]. | 2005 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21162186 |