erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Triolo R | [Nephrotoxicity of antibiotics]. | 1976 | Minerva Med. | pmid:934504 |
Klimek JJ et al. | Mycoplasma pneumoniae meningoencephalitis and transverse myelitis in association with low cerebrospinal fluid glucose. | 1976 | Pediatrics | pmid:934771 |
Lopardo HA et al. | Argentinian collaborative study on prevalence of erythromycin and penicillin susceptibility in Streptococcus pyogenes. The Argentinian Streptococcus Study Group. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9350412 |
Korgenski EK and Daly JA | Surveillance and detection of erythromycin resistance in Bordetella pertussis isolates recovered from a pediatric population in the Intermountain West region of the United States. | 1997 | J. Clin. Microbiol. | pmid:9350776 |
Pendland SL et al. | Comparison of charcoal- and starch-based media for testing susceptibilities of Legionella species to macrolides, azalides, and fluoroquinolones. | 1997 | J. Clin. Microbiol. | pmid:9350781 |
Roberts ES et al. | Inactivation of cytochrome P450s 2B1, 2B4, 2B6, and 2B11 by arylalkynes. | 1997 | Drug Metab. Dispos. | pmid:9351899 |
Villagrasa V et al. | Effects of erythromycin on chemoattractant-activated human polymorphonuclear leukocytes. | 1997 | Gen. Pharmacol. | pmid:9352310 |
Sánchez L et al. | The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump. | 1997 | J. Bacteriol. | pmid:9352940 |
Summers RG et al. | Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production. | 1997 | Microbiology (Reading, Engl.) | pmid:9353926 |
Lanouette JM et al. | Is inflammation on Papanicolaou smear a risk factor for preterm delivery? | 1997 Jul-Aug | Fetal. Diagn. Ther. | pmid:9354886 |
Vogt AW and Zollo RA | Long Q-T syndrome associated with oral erythromycin used in preoperative bowel preparation. | 1997 | Anesth. Analg. | pmid:9356092 |
Erythromycin resistance in Finland declines after reduction in macrolide use. | 1997 | Am J Health Syst Pharm | pmid:9359947 | |
Ekdahl K et al. | Eradication of penicillin-resistant pneumococci in the nasopharynx with antibiotic combinations including rifampicin: experiences from the South Swedish Pneumococcal Intervention Project. | 1997 | Scand. J. Infect. Dis. | pmid:9360252 |
Dasgupta MK et al. | The effects of macrolide and quinolone antibiotics in methicillin-resistant Staphylococcus aureus biofilm growth. | 1997 | Adv Perit Dial | pmid:9360684 |
Epler GR | Bronchiolar disorders with airflow obstruction. | 1996 | Curr Opin Pulm Med | pmid:9363129 |
Morey TE et al. | Ionic basis of the differential effects of intravenous anesthetics on erythromycin-induced prolongation of ventricular repolarization in the guinea pig heart. | 1997 | Anesthesiology | pmid:9366470 |
Malessa R et al. | Oligosymptomatic neurosyphilis with false negative CSF-VDRL in HIV-infected individuals? | 1996 | Eur. J. Med. Res. | pmid:9367943 |
Hueston WJ and Lenhart JG | A decision analysis to guide antibiotic selection for Chlamydia infection during pregnancy. | 1997 Nov-Dec | Arch Fam Med | pmid:9371049 |
Chan LY and Chan JC | Mycoplasma pneumoniae infection presenting as haemolytic anaemia. | 1997 Aug 20-Sep 2 | Br J Hosp Med | pmid:9373409 |
Weissman KJ et al. | The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase. | 1997 | Biochemistry | pmid:9374862 |
Rohner CD and Force RW | Lowering the rate of antibiotic resistance. | 1997 | J Fam Pract | pmid:9374954 |
Chuck JA et al. | Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. | 1997 | Chem. Biol. | pmid:9375254 |
Nawaz MS et al. | Detection of erythromycin resistant methylase gene by the polymerase chain reaction. | 1997 | Mol. Cell. Probes | pmid:9375290 |
Baraia-Etxaburu J et al. | [Pneumonia caused by Rhodococcus equi in patients with AIDS: difficulty in defining the most appropriate initial treatment]. | 1997 | Enferm. Infecc. Microbiol. Clin. | pmid:9376391 |
López-Yeste ML and Lite Lite J | [Loss of erythromycin sensitivity in strains of Staphylococcus aureus]. | 1997 | Enferm. Infecc. Microbiol. Clin. | pmid:9376396 |
Sollecito TP et al. | Elephantiasis nostras of the lips: a case report. | 1997 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:9377195 |
Abdelghaffar H et al. | Erythromycin A-derived macrolides modify the functional activities of human neutrophils by altering the phospholipase D-phosphatidate phosphohydrolase transduction pathway: L-cladinose is involved both in alterations of neutrophil functions and modulation of this transductional pathway. | 1997 | J. Immunol. | pmid:9378989 |
Syphilis: recommended treatment schedules, 1976. Recommendations established by the Venereal Disease Control Advisory Committee. | 1976 | Ann. Intern. Med. | pmid:937929 | |
Tanaka E and Yasuhara H | [Evaluation of liver function in liver diseases using drugs as indicators]. | 1997 | J Toxicol Sci | pmid:9379499 |
Salcedo Abizanda S et al. | [Administration of intrapartum erythromycin for the interruption of the vertical transmission of Ureaplasma urealyticum and its possible relation to the development of bronchopulmonary dysplasia in neonates with less than 32 weeks gestation. Multicenter study]. | 1997 | An. Esp. Pediatr. | pmid:9382274 |
Stephenson GA et al. | Solid-state investigations of erythromycin A dihydrate: structure, NMR spectroscopy, and hygroscopicity. | 1997 | J Pharm Sci | pmid:9383733 |
Zhao XJ and Ishizaki T | Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes. | 1997 | Br J Clin Pharmacol | pmid:9384469 |
Feng B et al. | [Acetaminophen absorption test for determination of diabetic gastroparesis and effects of erythromycin on gastric emptying]. | 1996 | Zhonghua Nei Ke Za Zhi | pmid:9387657 |
He Z and Li Y | [Diffuse panbronchiolitis]. | 1996 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:9388854 |
Jamis-Dow CA et al. | Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole. | 1997 | Am. J. Clin. Oncol. | pmid:9391548 |
Pelizza G et al. | Polymorphism of erythromycin studied by differential thermal analysis. | 1976 | Farmaco Sci | pmid:939324 |
Gaisser S et al. | Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. | 1997 | Mol. Gen. Genet. | pmid:9393448 |
Woodhouse C | Ulceration of a ring into a phalanx. | 1976 | Hand | pmid:939446 |
Maeda K et al. | [Effect of cessation of erythromycin therapy on diffuse panbronchiolitis]. | 1997 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:9396251 |
Pal D et al. | Reactivation of denatured proteins by domain V of bacterial 23S rRNA. | 1997 | Nucleic Acids Res. | pmid:9396814 |
Graham MY and Weisblum B | Altered methylation of adenine in 23 S ribosomal RNA associated with erythromycin resistance in Streptomyces erythreus and Streptococcus fecalis. | 1979 | Contrib. Microbiol. Immunol. | pmid:94004 |
Geerdes-Fenge HF et al. | Comparative pharmacokinetics of dirithromycin and erythromycin in normal volunteers with special regard to accumulation in polymorphonuclear leukocytes and in saliva. | 1997 | Eur. J. Clin. Pharmacol. | pmid:9403284 |
Koyama H and Geddes DM | Erythromycin and diffuse panbronchiolitis. | 1997 | Thorax | pmid:9404381 |
Barry AL et al. | In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9405952 |
Khan AM et al. | Neonatal diarrhea caused by Vibrio cholerae 0139 Bengal. | 1995 | Diagn. Microbiol. Infect. Dis. | pmid:9407221 |
Sacristán JA et al. | [Double-blind clinical trial comparing 5 days of dirithromycin versus 7 days of diacetylmidecamycin in acute bronchitis and acute exacerbations of chronic bronchitis]. | 1997 Aug-Sep | Enferm. Infecc. Microbiol. Clin. | pmid:9410047 |
Kiska DL and Cynamon MH | Photo quiz. Tinea barbae caused by Trichophyton verrucosum. | 1997 | Clin. Infect. Dis. | pmid:9410095 |
Sharrock WJ et al. | Protein synthesis in Bacillus subtilis. II. Selective translation of natural mRNAs and its possible relation to the species-specific inhibition of protein synthesis by lincomycin and erythromycin. | 1979 | J. Mol. Biol. | pmid:94104 |
Tsarev VN et al. | [A trial of the use of rulid, sumamed and makropen in the combined treatment of generalized periodontitis at a stage of exacerbation]. | 1997 | Stomatologiia (Mosk) | pmid:9411932 |
Strachynskił LS et al. | [Pharmacoepidemiology of antibiotics in the treatment of respiratory tract infections in pediatric outpatients]. | 1997 | Antibiot. Khimioter. | pmid:9412396 |