erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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McCune JS et al. | In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone. | 2000 | Clin. Pharmacol. Ther. | pmid:11061575 |
Vivrette SL et al. | Clinical application of a polymerase chain reaction assay in the diagnosis of pneumonia caused by Rhodococcus equi in a horse. | 2000 | J. Am. Vet. Med. Assoc. | pmid:11061388 |
Mant A | Choosing the most appropriate antibiotic for respiratory infections. | 2000 | Aust Fam Physician | pmid:11059087 |
Farmer RG | Preoperative preparation of the patients with carcinoma of the colon. | 1975 | Surg. Clin. North Am. | pmid:1105833 |
Condon RE and Nichols RL | The present position of the neomycin-erythromycin bowal prep. | 1975 | Surg. Clin. North Am. | pmid:1105832 |
Kazim M et al. | Schizontocidal activity of antibiotics against blood-induced Plasmodium gallinaceum infection. | 1979 | Chemotherapy | pmid:110541 |
See S | Is azithromycin monotherapy as efficacious as cefuroxime plus erythromycin for the treatment of community-acquired pneumonia in hospitalized patients? | 2000 | J Fam Pract | pmid:11052155 |
Guerrini AM et al. | Studies on a temperature sensitive nuclear petite mutant of Saccharomyces cerevisiae: phenotypic reversibility of the mitochondrial functions. | 1975 | Mol. Gen. Genet. | pmid:1105155 |
Wilkie D | Cytoplasmic inheritance and mitochondrial genetics in yeasts. | 1975 | Methods Cell Biol. | pmid:1105071 |
Jokinen MJ et al. | The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine. | 2000 | Anesth. Analg. | pmid:11049910 |
Syrogiannopoulos GA et al. | Antimicrobial use and colonization with erythromycin-resistant Streptococcus pneumoniae in Greece during the first 2 years of life. | 2000 | Clin. Infect. Dis. | pmid:11049766 |
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Ibrahim NG and Beattie DS | Regulation of mitochondrial protein synthesis at the polyribosomal level. | 1976 | J. Biol. Chem. | pmid:1104623 |
Birky CW | Effects of glucose repression of the transmission and recombination of mitochondrial genes in yeast (Saccharomyces cerevisiae). | 1975 | Genetics | pmid:1104405 |
Millar J | Excipient E110: a cause for complaint? | 2000 | Br J Gen Pract | pmid:11042924 |
McWhinney PH et al. | Failure to produce detectable antibodies to Legionella pneumophila by an immunocompetent adult. | 2000 | J. Infect. | pmid:11041710 |
Nawaz MS et al. | Comparative molecular analysis of erythromycin-resistance determinants in staphylococcal isolates of poultry and human origin. | 2000 | Mol. Cell. Probes | pmid:11040095 |
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Bemer-Melchior P et al. | In vitro activity of the new ketolide telithromycin compared with those of macrolides against Streptococcus pyogenes: influences of resistance mechanisms and methodological factors. | 2000 | Antimicrob. Agents Chemother. | pmid:11036012 |
Andrews JI et al. | Group B streptococci causing neonatal bloodstream infection: antimicrobial susceptibility and serotyping results from SENTRY centers in the Western Hemisphere. | 2000 | Am. J. Obstet. Gynecol. | pmid:11035326 |
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Kurek C | [Effect of antibiotics on hemolysin production by bacteria causing mastitis in cattle]. | 1975 | Pol Arch Weter | pmid:1103096 |
Forster JL and Kleese RA | The segregation of mitochondrial genes in yeast. II. Analysis of zygote pedigrees of drug-resistant X drug-sensitive crosses. | 1975 | Mol. Gen. Genet. | pmid:1102946 |
Gunge N | Genetic analysis of unequal transmission of the mitochondrial markers in Saccharomyces cerevisiae. | 1975 | Mol. Gen. Genet. | pmid:1102935 |
Isiadinso OA | Listeria sepsis and meningitis: A complication of renal transplantation. | 1975 | JAMA | pmid:1102738 |
Steward CD et al. | Ability of laboratories to detect emerging antimicrobial resistance in nosocomial pathogens: a survey of project ICARE laboratories. | 2000 | Diagn. Microbiol. Infect. Dis. | pmid:11025185 |
Ubukata K et al. | Transduction of drug resistance to tetracycline, chloramphenicol, macrolides, lincomycin and clindamycin with phages induced from Streptococcus pyogenes. | 1975 | J. Antibiot. | pmid:1102514 |
Gay K et al. | The emergence of Streptococcus pneumoniae resistant to macrolide antimicrobial agents: a 6-year population-based assessment. | 2000 | J. Infect. Dis. | pmid:11023465 |
Cunningham ET and Koehler JE | Ocular bartonellosis. | 2000 | Am. J. Ophthalmol. | pmid:11020414 |
Arvand M et al. | Antimicrobial resistance in Streptococcus pyogenes isolates in Berlin. | 2000 | J. Antimicrob. Chemother. | pmid:11020262 |
Takemura H et al. | Evaluation of a human monocytic cell line THP-1 model for assay of the intracellular activities of antimicrobial agents against Legionella pneumophila. | 2000 | J. Antimicrob. Chemother. | pmid:11020257 |
Sugita K et al. | [Antimicrobial susceptibility and serotypes of Streptococcus pneumoniae isolated from the patients with respiratory tract infections in Hokusetsu Area of Osaka]. | 2000 | Jpn J Antibiot | pmid:11019385 |
Sillerström E et al. | In vitro activity of ABT-773 against anaerobic bacteria. | 2000 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:11014629 |
Otaka T and Kaji A | Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1101261 |
Tay YK | Erythema nodosum in Singapore. | 2000 | Clin. Exp. Dermatol. | pmid:11012588 |
Westphal JF | Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin. | 2000 | Br J Clin Pharmacol | pmid:11012550 |
Tsubery H et al. | The functional association of polymyxin B with bacterial lipopolysaccharide is stereospecific: studies on polymyxin B nonapeptide. | 2000 | Biochemistry | pmid:11009595 |
Sugiura J et al. | [Clinical experience with amoxicillin in pediatric infections due to hemolytic streptococci (author's transl)]. | 1975 | Jpn J Antibiot | pmid:1100874 |
Rayner CK et al. | The stimulation of antral motility by erythromycin is attenuated by hyperglycemia. | 2000 | Am. J. Gastroenterol. | pmid:11007223 |
Schleifer KH and Kloos WE | A simple test system for the separation of staphylococci from micrococci. | 1975 | J. Clin. Microbiol. | pmid:1100662 |
Young RA and Perlman PS | "Killer" character does not influence the transmission of mitochondrial genes in Saccharomyces cerevisiae. | 1975 | J. Bacteriol. | pmid:1100604 |
Lan LB et al. | Mdr1 limits CYP3A metabolism in vivo. | 2000 | Mol. Pharmacol. | pmid:10999959 |
Rivory LP et al. | Optimizing the erythromycin breath test for use in cancer patients. | 2000 | Clin. Cancer Res. | pmid:10999732 |
Yamaya M and Sasaki H | [The pathogenesis and therapy of virus infection-induced senile bronchial asthma]. | 2000 | Nihon Ronen Igakkai Zasshi | pmid:10998927 |
Diekema DJ et al. | Antimicrobial-drug use and changes in resistance in Streptococcus pneumoniae. | 2000 Sep-Oct | Emerging Infect. Dis. | pmid:10998390 |
Mushiroda T et al. | The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. | 2000 | Drug Metab. Dispos. | pmid:10997945 |
Dinos GP and Kalpaxis DL | Kinetic studies on the interaction between a ribosomal complex active in peptide bond formation and the macrolide antibiotics tylosin and erythromycin. | 2000 | Biochemistry | pmid:10995229 |
Cynamon MH et al. | Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model. | 2000 | Antimicrob. Agents Chemother. | pmid:10991883 |
Marchese A et al. | Antibiotic susceptibility patterns and serotypes of antibiotic resistant and/or invasive Streptococcus pneumoniae strains circulating in Italy. | 2000 | Microb. Drug Resist. | pmid:10990272 |