erythromycin is a lipid of Polyketides (PK) class. Erythromycin is associated with abnormalities such as Systemic Inflammatory Response Syndrome, Pneumonia, Infection, Pneumococcal Infections and Exanthema. The involved functions are known as Pharmacodynamics, Sterility, Agent, Drug Kinetics and Adjudication. Erythromycin often locates in Blood, peritoneal, Extracellular, Ribosomes and apicoplast. The associated genes with erythromycin are P4HTM gene, SLC33A1 gene, FAM3B gene, Operon and Homologous Gene. The related lipids are Hydroxytestosterones, Steroids, Propionate, Mycolic Acids and campesterol. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of erythromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
erythromycin is suspected in Pneumonia, Infection, Gonorrhea, Cystic Fibrosis, Respiratory Tract Infections, Influenza and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with erythromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.' (Falzari K et al., 2005) and Mouse Model are used in the study 'Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.' (Cynamon MH et al., 2000).
Knock-out are used in the study 'Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.' (McLaughlin LA et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Alexander RE and Grogan DM | Long-acting erythromycins: assessing their role in treating outpatient odontogenic infections. | 2009 | Tex Dent J | pmid:19472551 |
Kabir AR et al. | Management of bronchiolitis without antibiotics: a multicentre randomized control trial in Bangladesh. | 2009 | Acta Paediatr. | pmid:19572992 |
Ung D et al. | Metabolic interactions between prokinetic agents domperidone and erythromycin: an in vitro analysis. | 2009 | Xenobiotica | pmid:19575604 |
Dalisay DS et al. | Absolute configuration of the alpha,omega-bifunctionalized sphingolipid leucettamol A from Leucetta microrhaphis by deconvoluted exciton coupled CD. | 2009 | J. Nat. Prod. | pmid:19159253 |
Savino C et al. | Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate. | 2009 | J. Biol. Chem. | pmid:19625248 |
Arias CA et al. | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. | 2009 | Antimicrob. Agents Chemother. | pmid:19667280 |
Rukayadi Y et al. | In vitro activities of panduratin A against clinical Staphylococcus strains. | 2009 | Antimicrob. Agents Chemother. | pmid:19651906 |
Abu-Shandi KH | Determination of vancomycin in human plasma using high-performance liquid chromatography with fluorescence detection. | 2009 | Anal Bioanal Chem | pmid:19655128 |
Michaud L | Incision separation after eye rubbing on a postradial keratotomy cornea: a case report. | 2009 | Eye Contact Lens | pmid:19657280 |
Gomes T et al. | Macrolide-induced digoxin toxicity: a population-based study. | 2009 | Clin. Pharmacol. Ther. | pmid:19606089 |
Feld L et al. | Characterization of a small erythromycin resistance plasmid pLFE1 from the food-isolate Lactobacillus plantarum M345. | 2009 | Plasmid | pmid:19399991 |
Cheng YS et al. | Stress-induced cardiac insufficiency relating to abnormal leptin and FKBP12.6 is ameliorated by CPU0213, an endothelin receptor antagonist, which is not affected by the CYP3A suppressing effect of erythromycin. | 2009 | J. Pharm. Pharmacol. | pmid:19405994 |
Majumdar S et al. | Vitreal kinetics of quinidine in rabbits in the presence of topically coadministered P-glycoprotein substrates/modulators. | 2009 | Drug Metab. Dispos. | pmid:19406953 |
Zonenschain D et al. | Erythromycin- and tetracycline-resistant lactobacilli in Italian fermented dry sausages. | 2009 | J. Appl. Microbiol. | pmid:19426258 |
Bostan K et al. | Prevalence and antibiotic susceptibility of thermophilic Campylobacter species on beef, mutton, and chicken carcasses in Istanbul, Turkey. | 2009 | Microb. Drug Resist. | pmid:19432522 |
Pinheiro S et al. | Prevalence and mechanisms of erythromycin resistance in Streptococcus agalactiae from healthy pregnant women. | 2009 | Microb. Drug Resist. | pmid:19432524 |
Ahmed AB et al. | Strain measurement during antral contractions by ultrasound strain rate imaging: influence of erythromycin. | 2009 | Neurogastroenterol. Motil. | pmid:18086208 |
Tateda K | [New Actions of macrolides. General topics. Summary of discussion. (2)]. | 2009 | Jpn J Antibiot | pmid:22454853 |
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Lin HT et al. | MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA. | 2009 | J. Biol. Chem. | pmid:18955484 |
Crider KS et al. | Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. | 2009 | Arch Pediatr Adolesc Med | pmid:19884587 |
Paasche SR | Rhodococcus equi infection in a surgical wound. | 2009 | Clin Lab Sci | pmid:19827407 |
Beliaev AM et al. | Erythromycin-induced postprandial biliary colic. | 2009 | N. Z. Med. J. | pmid:19829393 |
Zhang X et al. | Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition. | 2009 | Drug Metab. Dispos. | pmid:18854379 |
Ri E et al. | [EM and EM703 suppress inflammatory cytokines formation by human respiratory epithelial cells provoked by diesel exhaust particles]. | 2009 | Jpn J Antibiot | pmid:22452046 |
Shimizu S et al. | [Action of EM900 on mucus secretion by the respiratory epithelial cells]. | 2009 | Jpn J Antibiot | pmid:22452047 |
Yamauchi Y et al. | [The effects of macrolides (EM900, clarithromycin and azithromycin) on IL-17-induced IL-8 production by airway epithelial cells]. | 2009 | Jpn J Antibiot | pmid:22452048 |
Inoue K et al. | [Suppression of endotoxic shock by macrolide derivative, EM900, and the mechanism involved in the process]. | 2009 | Jpn J Antibiot | pmid:22452050 |
Asano K | [Efficacy of EM900: summary of discussion]. | 2009 | Jpn J Antibiot | pmid:22452051 |
Yamauchi K et al. | [14-membered ring macrolides exaggerate IL-10 expression stimulated by LPS]. | 2009 | Jpn J Antibiot | pmid:22452057 |
Maruyama K et al. | [Analysis of the mechanism involved in the effects of erythromycin in suppressing the development of pseudomembranous colitis]. | 2009 | Jpn J Antibiot | pmid:22452058 |
Zhu Q et al. | Sesquiterpenoids and phenylpropanoids from pericarps of Illicium oligandrum. | 2009 | J. Nat. Prod. | pmid:19159273 |
Nash KA et al. | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. | 2009 | Antimicrob. Agents Chemother. | pmid:19171799 |
Renye JA and Somkuti GA | Insertion of a heterologous gene construct into a non-functional ORF of the Streptococcus thermophilus chromosome. | 2009 | Biotechnol. Lett. | pmid:19172230 |
Kim HC and Kang SH | Total synthesis of azithromycin. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19173267 |
Kawai K et al. | Serum protein binding displacement: theoretical analysis using a hypothetical radiopharmaceutical and experimental analysis with 123I-N-isopropyl-p-iodoamphetamine. | 2009 | Nucl. Med. Biol. | pmid:19181274 |
Blackman Northwood J et al. | Characterization of macrolide efflux pump mef subclasses detected in clinical isolates of Streptococcus pyogenes isolated between 1999 and 2005. | 2009 | Antimicrob. Agents Chemother. | pmid:19258262 |
Fan Y et al. | Preparation and characteristics of erythromycin microspheres for lung targeting. | 2009 | Drug Dev Ind Pharm | pmid:19259878 |
Markel DC et al. | Inhibitory effects of erythromycin on wear debris-induced VEGF/Flt-1 gene production and osteolysis. | 2009 | Inflamm. Res. | pmid:19262986 |
Zheng J et al. | Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin. | 2009 | J. Mol. Biol. | pmid:19265703 |
Zou X et al. | Oxygen uptake rate optimization with nitrogen regulation for erythromycin production and scale-up from 50 L to 372 m3 scale. | 2009 | Bioresour. Technol. | pmid:18929481 |
Chan JC et al. | Epidemiological analysis of Streptococcus pyogenes infections in Hong Kong. | 2009 | Pathology | pmid:20001348 |
Udayakumar D and Sanaullah M | Campylobacter cholecystitis. | 2009 | Int J Med Sci | pmid:19960123 |
Hariharan H et al. | Antimicrobial drug resistance as determined by the E-test in Campylobacter jejuni, C. coli, and C. lari isolates from the ceca of broiler and layer chickens in Grenada. | 2009 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:18329712 |
Umehara Y et al. | Campylobacter fetus meningitis in a patient with Crohn's disease. | 2009 | Inflamm. Bowel Dis. | pmid:18798576 |
Accorinti M | Ocular bartonellosis. | 2009 | Int J Med Sci | pmid:19319232 |
Vila-Corcoles A et al. | Drug-resistance in Streptococcus pneumoniae isolates among Spanish middle aged and older adults with community-acquired pneumonia. | 2009 | BMC Infect. Dis. | pmid:19320989 |
Sader HS et al. | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. | 2009 | Antimicrob. Agents Chemother. | pmid:19289528 |
Razzaq A et al. | Erythromycin establishes early oral feeding in neonates operated for congenital intestinal atresias. | 2009 | Pediatr. Surg. Int. | pmid:19290531 |
Lindqvist M et al. | A clonal outbreak of methicillin-susceptible Staphylococcus aureus with concomitant resistance to erythromycin, clindamycin and tobramycin in a Swedish county. | 2009 | Scand. J. Infect. Dis. | pmid:19294581 |
Sambo N et al. | Effect of the aqueous extract of Psidium guajava on erythromycin-induced liver damage in rats. | 2009 | Niger J Physiol Sci | pmid:20234760 |
Kumar S et al. | Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection. | 2009 | Drug Metab. Dispos. | pmid:19299527 |
Picazo JJ | Management of antibiotic-resistant Streptococcus pneumoniae infections and the use of pneumococcal conjugate vaccines. | 2009 | Clin. Microbiol. Infect. | pmid:19366362 |
Sanger GJ et al. | GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility. | 2009 | Neurogastroenterol. Motil. | pmid:19374732 |
Graham JS et al. | A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. | 2009 | Cancer Chemother. Pharmacol. | pmid:18654747 |
Jiang LJ et al. | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. | 2009 | Antimicrob. Agents Chemother. | pmid:19223626 |
Camlar SA et al. | Chlamydia pneumonia mimicking miliary tuberculosis. | 2009 | Pediatr Emerg Care | pmid:19755900 |
Lutgen EM et al. | Antimicrobial resistance profiling and molecular subtyping of Campylobacter spp. from processed turkey. | 2009 | BMC Microbiol. | pmid:19772592 |
Poeta P et al. | Influence of oral hygiene in patients with fixed appliances in the oral carriage of antimicrobial-resistant Escherichia coli and Enterococcus isolates. | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:19778742 |
Fan C et al. | Influence of trace erythromycin and eryhthromycin-H2O on carbon and nutrients removal and on resistance selection in sequencing batch reactors (SBRs). | 2009 | Appl. Microbiol. Biotechnol. | pmid:19727707 |
Seville LA et al. | Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA. | 2009 | Microb. Drug Resist. | pmid:19728772 |
Du-Cuny L et al. | Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. | 2009 | Bioorg. Med. Chem. | pmid:19734051 |
Kelmer G and Hayes ME | Regional limb perfusion with erythromycin for treatment of septic physitis and arthritis caused by Rhodococcus equi. | 2009 | Vet. Rec. | pmid:19734562 |
May T et al. | Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. | 2009 | Antimicrob. Agents Chemother. | pmid:19721076 |
Ghosh P et al. | Modeling a macrocyclic bis[spirodiepoxide] strategy to erythronolide A. | 2009 | Org. Lett. | pmid:19725523 |
Marcellini L et al. | Esculentin-1b(1-18)--a membrane-active antimicrobial peptide that synergizes with antibiotics and modifies the expression level of a limited number of proteins in Escherichia coli. | 2009 | FEBS J. | pmid:19725877 |
Nam HM et al. | Antimicrobial resistance of streptococci isolated from mastitic bovine milk samples in Korea. | 2009 | J. Vet. Diagn. Invest. | pmid:19737768 |
Koomanachai P et al. | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. | 2009 | Antimicrob. Agents Chemother. | pmid:19738006 |
Arhin FF et al. | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. | 2009 | Antimicrob. Agents Chemother. | pmid:19738026 |
Xu P et al. | Synthesis and antibacterial activity of 11,12-carbamate-3-O-acyl erythromycin derivatives. | 2009 | J Asian Nat Prod Res | pmid:20183250 |
Tanaka H et al. | Problems associated with prophylactic use of erythromycin in 1566 staff to prevent hospital infection during the outbreak of pertussis. | 2009 | J Clin Pharm Ther | pmid:20175806 |
Roy K and Pratim Roy P | Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. | 2009 | Eur J Med Chem | pmid:19128860 |
Sox CM et al. | The influence of types of decision support on physicians' decision making. | 2009 | Arch. Dis. Child. | pmid:19131417 |
Liu J et al. | Characterization of a novel macrolide efflux gene, mef(B), found linked to sul3 in porcine Escherichia coli. | 2009 | J. Antimicrob. Chemother. | pmid:19131424 |
Davies HM | Total synthesis: expanding the art of synthesis. | 2009 | Nat Chem | pmid:21378926 |
Azizia M and Ahmed M | Association between cerebral palsy and erythromycin. | 2009 | Lancet | pmid:19121711 |
Lamont RF | Association between cerebral palsy and erythromycin. | 2009 | Lancet | pmid:19121713 |
Cui L et al. | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. | 2009 | Antimicrob. Agents Chemother. | pmid:19124662 |
Biedenbach DJ et al. | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. | 2009 | Antimicrob. Agents Chemother. | pmid:19124664 |
Morgenstern K et al. | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. | 2009 | Antimicrob. Agents Chemother. | pmid:19075048 |
Jakeman DL et al. | Antimicrobial activities of jadomycin B and structurally related analogues. | 2009 | Antimicrob. Agents Chemother. | pmid:19075054 |
Bae S and Lee K | Distribution of capsular serotypes and macrolide resistance mechanisms among macrolide-resistant Streptococcus pneumoniae isolates in Korea. | 2009 | Diagn. Microbiol. Infect. Dis. | pmid:19097840 |
Chegaev K et al. | Synthesis of some novel organic nitrates and comparative in vitro study of their vasodilator profile. | 2009 | J. Med. Chem. | pmid:19438239 |
Del Grosso M et al. | New composite genetic element of the Tn916 family with dual macrolide resistance genes in a Streptococcus pneumoniae isolate belonging to clonal complex 271. | 2009 | Antimicrob. Agents Chemother. | pmid:19104015 |
Mackey-Lawrence NM et al. | Staphylococcus aureus immunodominant surface antigen B is a cell-surface associated nucleic acid binding protein. | 2009 | BMC Microbiol. | pmid:19323837 |
Helmetag V et al. | Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis. | 2009 | FEBS J. | pmid:19490124 |
Ilisz I et al. | Enantioseparation of beta-substituted tryptophan analogues with modified cyclodextrins by capillary zone electrophoresis. | 2009 | J Chromatogr A | pmid:19215927 |
Keiser J et al. | Mefloquine--an aminoalcohol with promising antischistosomal properties in mice. | 2009 | PLoS Negl Trop Dis | pmid:19125172 |
Pannicke U et al. | Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. | 2009 | Nat. Genet. | pmid:19043417 |
Shiina I et al. | Evaluation of the efficiency of the macrolactonization using MNBA in the synthesis of erythromycin A aglycon. | 2009 | Chem Rec | pmid:20041452 |
Purves GI et al. | Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels. | 2009 | J. Physiol. (Lond.) | pmid:19491242 |
Portilla-Arias JA et al. | Nanoparticles made of microbial poly(gamma-glutamate)s for encapsulation and delivery of drugs and proteins. | 2009 | J Biomater Sci Polym Ed | pmid:19454169 |
Bergseng H et al. | Molecular and phenotypic characterization of invasive group B streptococcus strains from infants in Norway 2006-2007. | 2009 | Clin. Microbiol. Infect. | pmid:19456824 |
Harnden A | Whooping cough. | 2009 | BMJ | pmid:19460804 |
Griffiths LM et al. | Mitochondrial DNA oxidative damage and mutagenesis in Saccharomyces cerevisiae. | 2009 | Methods Mol. Biol. | pmid:19513680 |
Henry F et al. | [Image of the month. Combined chancre, a soft chancroid and a syphilitic chancre]. | 2009 | Rev Med Liege | pmid:19514534 |
Wolff KA et al. | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. | 2009 | Antimicrob. Agents Chemother. | pmid:19528288 |
House B et al. | Acid-stress-induced changes in enterohaemorrhagic Escherichia coli O157 : H7 virulence. | 2009 | Microbiology (Reading, Engl.) | pmid:19497950 |
Wu L et al. | In vitro effects of erythromycin on RANKL and nuclear factor-kappa B by human TNF-alpha stimulated Jurkat cells. | 2009 | Int. Immunopharmacol. | pmid:19500694 |
Takagi Y et al. | Erythromycin-induced CXCR4 expression on microvascular endothelial cells. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19502290 |