MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
Carcinosarcoma | D002296 | 7 associated lipids |
Gastrointestinal Stromal Tumors | D046152 | 1 associated lipids |
Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.
To understand associated biological information of Epothilone B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone B is suspected in Peripheral Neuropathy, Myelosuppression, Neuropathy, Morphologically altered structure, Measurable Disease, Neutropenia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone B
MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
Carcinosarcoma | D002296 | 7 associated lipids |
Gastrointestinal Stromal Tumors | D046152 | 1 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005), Xenograft Model are used in the study 'Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.' (Hofstetter B et al., 2005) and Xenograft Model are used in the study 'In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.' (Peterson JK et al., 2005).
Mouse Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cheng H et al. | Synthesis and antitumor activity of epothilone B. | 2018 | Eur J Med Chem | pmid:30149324 |
Rogalska A and Marczak A | Therapeutic potential of patupilone in epithelial ovarian cancer and future directions. | 2018 | Life Sci. | pmid:29727613 |
Hsu CY et al. | Stabilization of microtubules restores barrier function after cytokine-induced defects in reconstructed human epidermis. | 2018 | J. Dermatol. Sci. | pmid:29691121 |
Zhu W et al. | Enhanced anti-proliferative efficacy of epothilone B loaded with Escherichia coli Nissle 1917 bacterial ghosts on the HeLa cells by mitochondrial pathway of apoptosis. | 2018 | Drug Dev Ind Pharm | pmid:29521115 |
Mao L et al. | Epothilone B impairs functional recovery after spinal cord injury by increasing secretion of macrophage colony-stimulating factor. | 2017 | Cell Death Dis | pmid:29095439 |
Shin DH and Kwon GS | Pre-clinical evaluation of a themosensitive gel containing epothilone B and mTOR/Hsp90 targeted agents in an ovarian tumor model. | 2017 | J Control Release | pmid:29056443 |
Park MN et al. | Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. | 2017 | Biomed Res Int | pmid:29181405 |
Lee JH et al. | The Application of REDOR NMR to Understand the Conformation of Epothilone B. | 2017 | Int J Mol Sci | pmid:28698492 |
Nicolaou KC et al. | 12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents. | 2017 | J. Am. Chem. Soc. | pmid:28513142 |
Shin DH and Kwon GS | Epothilone B-based 3-in-1 polymeric micelle for anticancer drug therapy. | 2017 | Int J Pharm | pmid:28062368 |