Glabridin is a lipid of Polyketides (PK) class. Glabridin is associated with abnormalities such as Atherosclerosis, CNS disorder, Corn of toe, Fatty Liver and Obesity. The involved functions are known as Energy Absorption, Oxidation, Oxidants, Metabolic Process, Cellular and Drug Interactions. Glabridin often locates in Hepatic, membrane fraction, Microsomes, Microsomes, Liver and Extracellular. The associated genes with Glabridin are P4HTM gene, SPEN gene, SLC33A1 gene, ABCB1 gene and CD9 gene. The related lipids are Nonesterified Fatty Acids, Total cholesterol, Lipopolysaccharides, Hydroxycholesterols and 7-ketocholesterol. The related experimental models are Mouse Model.
To understand associated biological information of Glabridin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glabridin is suspected in Obesity, Fatty Liver, Metabolic Diseases, Hyperlipidemia, Septicemia, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Glabridin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Nephritis | D009393 | 19 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Hyperpigmentation | D017495 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Macrophage enrichment with the isoflavan glabridin inhibits NADPH oxidase-induced cell-mediated oxidation of low density lipoprotein. A possible role for protein kinase C.' (Rosenblat M et al., 1999) and Mouse Model are used in the study 'Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock.' (Kang JS et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yokota T et al. | The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. | 1998 | Pigment Cell Res. | pmid:9870547 |
| Belinky PA et al. | Structural aspects of the inhibitory effect of glabridin on LDL oxidation. | 1998 | Free Radic. Biol. Med. | pmid:9641259 |
| Fuhrman B et al. | Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice. | 1997 | Am. J. Clin. Nutr. | pmid:9250104 |
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| Viswanathan V and Mukne AP | Development and Validation of HPLC and HPTLC Methods for Estimation of Glabridin in Extracts of Glycyrrhiza glabra. | J AOAC Int | pmid:27103104 |