FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
LeJeune TM et al. Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status. 2015 PLoS ONE pmid:26606169
Lin CH et al. Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. 2015 BMC Cancer pmid:26675309
Aslan E and Adem S In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. 2015 J. Biochem. Mol. Toxicol. pmid:25388478
Zhao W et al. Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process. 2015 J. Org. Chem. pmid:26291122
Yan J et al. The soybean R2R3 MYB transcription factor GmMYB100 negatively regulates plant flavonoid biosynthesis. 2015 Plant Mol. Biol. pmid:26231207
Yao X et al. Biochemical traits and proteomic changes in postharvest flowers of medicinal chrysanthemum exposed to enhanced UV-B radiation. 2015 J. Photochem. Photobiol. B, Biol. pmid:26114222
Untergehrer M et al. Structure-Dependent Deconjugation of Flavonoid Glucuronides by Human β-Glucuronidase - In Vitro and In Silico Analyses. 2015 Planta Med. pmid:26018917
Ting Y et al. Viscoelastic Emulsion Improved the Bioaccessibility and Oral Bioavailability of Crystalline Compound: A Mechanistic Study Using in Vitro and in Vivo Models. 2015 Mol. Pharm. pmid:25984595
Almeida JR et al. 3,6-Dimethoxy-6″,6″-Dimethyl-(7,8,2″,3″)-Chromeneflavone, a Flavonoid Isolated from Lonchocarpus Araripensis Benth. (Fabaceae), Reduces Nociceptive Behaviour in Mice. 2015 Phytother Res pmid:26172339
Hong H et al. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. 2015 Toxicol. Sci. pmid:25349334