acacetin is a lipid of Polyketides (PK) class. Acacetin is associated with abnormalities such as Cardiovascular Diseases, Janiceps and Meralgia paresthetica. The involved functions are known as Cell Cycle Arrest, Cell Growth, Agent, Metabolic Inhibition and Cell Death. Acacetin often locates in Protoplasm, Membrane, Plasma membrane, Capillary blood and Endothelium. The associated genes with acacetin are CDKN1B gene, KCNH2 gene, MSMP gene, COX8A gene and PI3 gene. The related lipids are Lipopolysaccharides. The related experimental models are Xenograft Model.
To understand associated biological information of acacetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
acacetin is suspected in Cardiovascular Diseases, Janiceps, Meralgia paresthetica and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with acacetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Xenograft Model are used in the study 'The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer.' (Jung SK et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Šarić Mustapić D et al. | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 | Molecules | pmid:30301254 |
| Negi S et al. | Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. | 2018 | Toxicol In Vitro | pmid:29933105 |
| Liu L et al. | Acacetin regulated the reciprocal differentiation of Th17 cells and Treg cells and mitigated the symptoms of collagen-induced arthritis in mice. | 2018 | Scand. J. Immunol. | pmid:30176062 |
| Ren H et al. | Low Dose of Acacetin Promotes Breast Cancer MCF-7 Cells Proliferation Through the Activation of ERK/ PI3K /AKT and Cyclin Signaling Pathway. | 2018 | Recent Pat Anticancer Drug Discov | pmid:29676234 |
| Ruparelia KC et al. | The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells. | 2018 | Med Chem | pmid:29332599 |
| Liu HR et al. | Discovery of potent and selective acetylcholinesterase (AChE) inhibitors: acacetin 7-O-methyl ether Mannich base derivatives synthesised from easy access natural product naringin. | 2018 | Nat. Prod. Res. | pmid:28617100 |
| Feng X et al. | Characterization of the In Vivo and In Vitro Metabolites of Linarin in Rat Biosamples and Intestinal Flora Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. | 2018 | Molecules | pmid:30149616 |
| Kim SM et al. | Acacetin inhibits neuronal cell death induced by 6-hydroxydopamine in cellular Parkinson's disease model. | 2017 | Bioorg. Med. Chem. Lett. | pmid:29089232 |
| Zhang Q et al. | Sulfonation Disposition of Acacetin: In Vitro and in Vivo. | 2017 | J. Agric. Food Chem. | pmid:28540728 |
| Punia R et al. | Acacetin enhances the therapeutic efficacy of doxorubicin in non-small-cell lung carcinoma cells. | 2017 | PLoS ONE | pmid:28859099 |