acacetin is a lipid of Polyketides (PK) class. Acacetin is associated with abnormalities such as Cardiovascular Diseases, Janiceps and Meralgia paresthetica. The involved functions are known as Cell Cycle Arrest, Cell Growth, Agent, Metabolic Inhibition and Cell Death. Acacetin often locates in Protoplasm, Membrane, Plasma membrane, Capillary blood and Endothelium. The associated genes with acacetin are CDKN1B gene, KCNH2 gene, MSMP gene, COX8A gene and PI3 gene. The related lipids are Lipopolysaccharides. The related experimental models are Xenograft Model.
To understand associated biological information of acacetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
acacetin is suspected in Cardiovascular Diseases, Janiceps, Meralgia paresthetica and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with acacetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer.' (Jung SK et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fesen MR et al. | Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. | 1994 | Biochem. Pharmacol. | pmid:7520698 |
| Hiremath SP and Rao SH | Antifertility efficacy of the plant Striga lutea (Scrophulariacae) on rats. | 1990 | Contraception | pmid:2257743 |
| Pettit GR et al. | Antineoplastic agents, 122. Constituents of Combretum caffrum. | 1987 May-Jun | J. Nat. Prod. | pmid:3668557 |
| Briançon-Scheid F et al. | HPLC Separation and Quantitative Determination of Biflavones in Leaves from Ginkgo biloba. | 1983 | Planta Med. | pmid:17405053 |
| Sinha NK et al. | Flavonoids from the flowers of Clerodendron infortunatum. | 1981 | Planta Med. | pmid:17401979 |
| Khafagy SM et al. | Isolation of sesamin-like compound and acacetin 7-o neohesperidoside from Otanthus maritimus. | 1979 | Planta Med. | pmid:419187 |
| Rendiuk TD et al. | [Spectrophotometric method of determining acacetin in the leaves of the thistle, Cirsium setosum (Willd.)]. | 1978 Mar-Apr | Farmatsiia | pmid:640040 |
| Salimi A et al. | Selective Anticancer Activity of Acacetin Against Chronic Lymphocytic Leukemia Using Both In Vivo and In Vitro Methods: Key Role of Oxidative Stress and Cancerous Mitochondria. | Nutr Cancer | pmid:27779444 | |
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