LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Authors Title Published Journal PubMed Link
Ibe BO et al. Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process. 1994 Eur. J. Clin. Invest. pmid:8187808
Fauler J et al. Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. 1994 Arthritis Rheum. pmid:8129769
Inamura T et al. Differential tissue expression of immunoreactive dehydropeptidase I, a peptidyl leukotriene metabolizing enzyme. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:8171072
Nathan RA et al. Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma. 1994 Chest pmid:8306751
Ramis I et al. Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. 1993 Nov-Dec J Pharm Biomed Anal pmid:8123725
Weide I et al. Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. 1993 Thromb. Res. pmid:8122190
Shikada K and Tanaka S Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121. 1993 Br. J. Pharmacol. pmid:8401920
Metters KM and Zamboni RJ Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung. 1993 J. Biol. Chem. pmid:8384212
Diener M and Scharrer E The leukotriene D4 receptor blocker, SK&F 104353, inhibits volume regulation in isolated crypts from the rat distal colon. 1993 Eur. J. Pharmacol. pmid:8405093
Nagahisa A et al. Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist. 1993 Regul. Pept. pmid:7692561