Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Abdel-Halim MS et al. | Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain. | 1977 | Prostaglandins | pmid:594367 |
Williams KI and Downing I | Prostaglandin and thromboxane production by rat decidual microsomes. | 1977 | Prostaglandins | pmid:594385 |
Ali M et al. | Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes. | 1977 | Prostaglandins | pmid:594386 |
Wasserman MA and Griffin RL | Thromboxane B2--comparative bronchoactivity in experimental systems. | 1977 | Eur. J. Pharmacol. | pmid:590340 |
Poyser NL | Identification of thromboxane B2 in guinea-pig uterine homogenates. | 1977 | Experientia | pmid:590434 |
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Murota SI et al. | The effects of thromboxane B2 and 6-ketoprostaglandin F1alpha on cultured fibroblasts. | 1977 | Biochim. Biophys. Acta | pmid:911847 |
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Mitchell MD et al. | Possible role for prostacyclin in human parturition. | 1978 | Prostaglandins | pmid:373020 |
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Murota S and Morita I | Effect of prostaglandin I2 and related compounds on vascular permeability response in granuloma tissues. | 1978 | Prostaglandins | pmid:635221 |
Powell WS and Solomon S | Biosynthesis of prostaglandins and thromboxane B2 by fetal lung homogenates. | 1978 | Prostaglandins | pmid:635224 |
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Murota SI et al. | Transformation of arachidonic acid into thromboxane B2 by the homogenates of activated macrophages. | 1978 | Biochim. Biophys. Acta | pmid:638172 |
Mallen DN et al. | Structural verification of 15-oxo-13,14-dihydrothromboxane B2. | 1978 | Biomed. Mass Spectrom. | pmid:678616 |
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Sors H et al. | Analytical methods for thromboxane B2 measurement and validation of radioimmunoassay by gas liquid chromatography-mass spectrometry. | 1978 | Prostaglandins | pmid:704933 |
Turk J et al. | Fluorescent derivatives of prostaglandins and thromboxanes for liquid chromatography. | 1978 | Prostaglandins | pmid:704934 |
Raz A and Aharony D | Prostaglandin biosynthesis in platelets: demonstration and role of prostaglandin H2 leads to E2 isomerase. | 1978 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:705027 |
Chang WC et al. | Inhibition of thromboxane B2 and 6-ketoprostaglandin F1 alpha formation by anti-inflammatory drugs in carrageenin-induced granuloma. | 1978 | Biochem. Pharmacol. | pmid:619892 |
Goetzl EJ and Gorman RR | Chemotactic and chemokinetic stimulation of human eosinophil and neutrophil polymorphonuclear leukocytes by 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). | 1978 | J. Immunol. | pmid:621391 |
Mitchell MD et al. | Thromboxane B2 and human parturition: concentrations in the plasma and production in vitro. | 1978 | J. Endocrinol. | pmid:712300 |
Yoshimoto T et al. | Selective inhibition of prostaglandin endoperoxide thromboxane isomerase by 1-carboxyalkylimidazoles. | 1978 | Prostaglandins | pmid:725083 |
Anderson MW et al. | Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase. | 1978 | Prostaglandins | pmid:725086 |
Mitchell MD et al. | Concentrations of thromboxane B2 in the maternal and foetal plasma of sheep during late pregnancy and induced parturition [proceedings]. | 1978 | J. Endocrinol. | pmid:731165 |
Anhut H et al. | Release of 15-keto-13, 14-dihydro-thromboxane B2 and prostaglandin D2 during anaphylaxis as measured by radioimmunoassay. | 1978 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:740052 |
McMillan RM et al. | Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase. | 1978 | Biochem. J. | pmid:743261 |
Chignard M et al. | Synthesis of thromboxane B2 in incubates of dog platelet-rich plasma with arachidonic acid and its inhibition by different drugs. | 1978 | Biochem. Biophys. Res. Commun. | pmid:743319 |
Mitchell MD and Robinson JS | Concentrations of 6-oxo-prostaglandin F1 alpha and thromboxane B2 in the tracheal fluid of foetal sheep. | 1978 | J. Endocrinol. | pmid:744937 |
Agradi E et al. | Influence of short term dietary supplementation of different lipids on aggregation and arachidonic acid metabolism in rabbit platelets. | 1978 | Prostaglandins | pmid:748984 |
Fitzpatrick FA and Gorman RR | A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. | 1978 | Biochim. Biophys. Acta | pmid:629996 |
Malik KU | Prostaglandin-mediated inhibition of the vasoconstrictor responses of the isolated perfused art splenic vasculature to adrenergic stimuli. | 1978 | Circ. Res. | pmid:27321 |
Hamberg M et al. | A method for measurement of platelet regeneration in man. | 1978 | Prostaglandins Med | pmid:104315 |
Roberts LJ et al. | Metabolism of thromboxane B2 in the monkey. | 1978 | J. Biol. Chem. | pmid:97291 |
Mitchell MD et al. | Production of thromboxane B2 by the intra-uterine tissues from late pregnant Rhesus monkeys (Macaca mulatta) in vitro. | 1978 | J. Endocrinol. | pmid:101641 |
Barac G | [Does thromboxane B2 influence renal blood flow? (proceedings)]. | 1978 | Arch. Int. Physiol. Biochim. | pmid:80176 |
Engineer DM et al. | Modulation of slow-reacting substance of anaphylaxis and histamine release by prostacyclin and thromboxanes [proceedings]. | 1978 | J. Physiol. (Lond.) | pmid:81301 |
Best LC et al. | Dipyridamole and platelet function. | 1978 | Lancet | pmid:81402 |
Adcock JJ et al. | The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator release. | 1978 | Prostaglandins | pmid:81495 |
Lagarde M et al. | Impairment of platelet thromboxane A2 generation and of the platelet release reaction in two patients with congenital deficiency of platelet cyclo-oxygenase. | 1978 | Br. J. Haematol. | pmid:205238 |
Crawford A et al. | Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity. | 1978 | Biochem. Biophys. Res. Commun. | pmid:212039 |
Hyman AL et al. | Prostaglandins and the lung. | 1978 | Am. Rev. Respir. Dis. | pmid:339796 |
Boura AL and Murphy RD | Thromboxane B2 inhibits prostaglandin E2 inactivation by the rat isolated perfused lung. | 1978 Jul-Aug | Clin. Exp. Pharmacol. Physiol. | pmid:699382 |
Svensson J | Structure and quantitative determination of the major urinary metabolite of thromboxane B2 in the guinea pig. | 1979 | Prostaglandins | pmid:472333 |
Langs DA et al. | Thromboxane molecules do not adopt the prostaglandin hairpin conformation. | 1979 | Nature | pmid:481594 |
Jonsson CE et al. | Prostaglandins and thromboxanes in burn injury in man. | 1979 | Scand J Plast Reconstr Surg | pmid:451477 |
Bailey JM et al. | Anti-inflammatory drugs in experimental atherosclerosis. Part 4. Inhibition of atherosclerosis in vivo and thromboxane synthesis and platelet aggregation in vitro. | 1979 | Atherosclerosis | pmid:454516 |
Taylor L et al. | Prostaglandin production by type II alveolar epithelial cells. | 1979 | Biochim. Biophys. Acta | pmid:435506 |
Folkert VW and Schlondorff D | Prostaglandin synthesis in isolated glomeruli. | 1979 | Prostaglandins | pmid:441427 |
Parker CW et al. | Formation of thromboxane B2 and hydroxyarachidonic acids in purified human lymphocytes in the presence and absence of PHA. | 1979 | J. Immunol. | pmid:448099 |
Needleman P et al. | Platelet and blood vessel arachidonate metabolism and interactions. | 1979 | J. Clin. Invest. | pmid:372240 |
Morley J et al. | Prostaglandin and thromboxane production by human and guinea-pig macrophages and leucocytes. | 1979 | Prostaglandins | pmid:493559 |
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de Deckere EA et al. | Influence of type of dietary fat on the prostaglandin release from isolated rabbit and rat hearts and from rat aortas. | 1979 | Prostaglandins | pmid:504696 |
Powell WS | Metabolism of prostaglandins, prostaglandin analogs and thromboxane B2 by lung and liver microsomes from pregnant rabbits. | 1979 | Biochim. Biophys. Acta | pmid:518891 |
Spagnuolo C et al. | Differential effects of probenecid on the levels of endogenous PGF2 alpha and TXB2 in brain cortex. | 1979 | Prostaglandins | pmid:523683 |
Bennett A and Sanger GJ | Trimethoquinol selectively antagonises longitudinal muscle contractions of rat isolated gastric fundus to thromboxane B2 and epoxymethano analogues of PGH2 [proceedings]. | 1979 | Br. J. Pharmacol. | pmid:526738 |
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Makheja AN et al. | Effects of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis. | 1979 | Prostaglandins Med | pmid:552092 |
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Lewy RI et al. | Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina. | 1979 | Prostaglandins Med | pmid:575861 |
Ohuchi K et al. | Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. | 1979 | Prostaglandins Med | pmid:583576 |
Daniel EE et al. | Prostaglandins and myogenic control of tension in lower esophageal sphincter in vitro. | 1979 | Prostaglandins | pmid:379920 |
Kanzaki Y et al. | Thromboxane as possible trigger of liver regeneration. | 1979 | Cell Mol Biol Incl Cyto Enzymol | pmid:535003 |
Lewy RI et al. | Comparison of plasma concentrations of thromboxane B2 in Prinzmetal's variant angina and classical angina pectoris. | 1979 | Clin Cardiol | pmid:544110 |
Russell FA and Deykin D | The use of high pressure liquid chromatography (HPLC) for the separation of radiolabeled arachidonic acid and its metabolities produced by thrombin-treated human platelets. I. The validation of the technique. | 1979 | Prostaglandins | pmid:523671 |
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Robinson JS et al. | Prostaglandin E, thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid and maternal plasma of rhesus monkeys (Macaca mulatta) during the latter third of gestation. | 1979 | J. Endocrinol. | pmid:112214 |
Burch RM et al. | Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of imidazole. | 1979 | J. Pharmacol. Exp. Ther. | pmid:113526 |
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Ford-Hutchinson AW et al. | The aggregation of rat neutrophils by arachidonic acid: a possible bioassay for lipoxygenase activity. | 1979 | J. Pharm. Pharmacol. | pmid:43380 |
Gorman RR et al. | Independence of the cyclic AMP-lowering activity of thromboxane A2 from the platelet release reaction. | 1979 | Biochim. Biophys. Acta | pmid:216409 |
Dembińska-Kièć A et al. | Prostacyclin-dependent differences in TXA2 formation by platelets from normal and atherosclerotic rabbits. | 1979 | Atherosclerosis | pmid:224890 |
Fitzpatrick FA and Gorman RR | Regulatory role of cyclic adenosine 3',5'-monophosphate on the platelet cyclooxygenase and platelet function. | 1979 | Biochim. Biophys. Acta | pmid:216415 |
Chignard M et al. | Arachidonate-mediated bronchoconstriction and platelet activation are inhibited by microgram doses of compound L8027 which are not selective for thromboxane synthetase. | 1979 | Agents Actions Suppl. | pmid:291306 |
Peskar BA and Holland A | Plasma levels of immunoreactive 15-keto-13,14-dihydro-thromboxane B2 in guinea pigs during anaphylaxis and after histamine injection. | 1979 | Agents Actions Suppl. | pmid:294148 |
Kass MA and Holmberg NJ | Prostaglandin and thromboxane synthesis by microsomes of rabbit ocular tissues. | 1979 | Invest. Ophthalmol. Vis. Sci. | pmid:761971 |