Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Aortic Aneurysm D001014 8 associated lipids
Lupus Nephritis D008181 8 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Arthritis, Juvenile D001171 8 associated lipids
Diabetes, Gestational D016640 8 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Obesity, Morbid D009767 8 associated lipids
Fistula D005402 8 associated lipids
Arthus Reaction D001183 8 associated lipids
Mastitis, Bovine D008414 8 associated lipids
Renal Artery Obstruction D012078 8 associated lipids
Bacteremia D016470 9 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Hypertension, Renal D006977 9 associated lipids
Coronary Vasospasm D003329 9 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Leukopenia D007970 9 associated lipids
Tooth, Impacted D014095 9 associated lipids
Thrombocythemia, Essential D013920 9 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Mucocutaneous Lymph Node Syndrome D009080 9 associated lipids
Sleep Apnea, Obstructive D020181 9 associated lipids
Hypolipoproteinemias D007009 9 associated lipids
Cleft Palate D002972 9 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Pneumonia D011014 10 associated lipids
Hypertension, Renovascular D006978 10 associated lipids
Rhinitis D012220 10 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Ovarian Neoplasms D010051 10 associated lipids
Retinal Detachment D012163 10 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Migraine Disorders D008881 11 associated lipids
Influenza, Human D007251 11 associated lipids
Shock D012769 11 associated lipids
Shock, Septic D012772 11 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Sepsis D018805 11 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Venous Thrombosis D020246 11 associated lipids
Nephrotic Syndrome D009404 11 associated lipids
Radiation Injuries, Experimental D011833 11 associated lipids
Byssinosis D002095 11 associated lipids
Meningioma D008579 11 associated lipids
Death, Sudden D003645 12 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Authors Title Published Journal PubMed Link
Pestel S et al. Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. 2003 Biochem. Pharmacol. pmid:12906929
Basta M et al. F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins. 2003 Nat. Med. pmid:12612546
Fiorucci S et al. Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study. 2003 Gastroenterology pmid:12612897
Vigorita MG et al. Chiral 3,3'-(1,2-ethanediyl)-bis[2-(3,4-dimethoxyphenyl)-4-thiazolidinones] with anti-inflammatory activity. Part 11: evaluation of COX-2 selectivity and modelling. 2003 Bioorg. Med. Chem. pmid:12614885
Bosetti F et al. Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain. 2003 J. Neurochem. pmid:12694395
Gama de Abreu M et al. One-lung ventilation with high tidal volumes and zero positive end-expiratory pressure is injurious in the isolated rabbit lung model. 2003 Anesth. Analg. pmid:12505956
Szebeni J et al. Complement activation during hemorrhagic shock and resuscitation in swine. 2003 Shock pmid:14501949
Tanaka Y et al. Effects of exercise on platelet and aortic functions in aged rats. 2003 Acta Physiol. Scand. pmid:14510779
Chen Z et al. [Correlation between TXB2, 6-Keto-PGF1alpha and liver metastasis in rats model with blood stasis]. 2003 Zhong Xi Yi Jie He Xue Bao pmid:15339561
He LQ et al. [Effect and mechanism of Tangshenning Recipe on micro-albuminuria in rats with early diabetic nephropathy]. 2003 Zhong Xi Yi Jie He Xue Bao pmid:15339583
Al-Waili NS and Boni NS Natural honey lowers plasma prostaglandin concentrations in normal individuals. 2003 J Med Food pmid:12935324
Jones AE et al. Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12639842
Davì G et al. Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration. 2003 Circulation pmid:12810609
De La Cruz JP et al. Differences in the effects of extended-release aspirin and plain-formulated aspirin on prostanoids and nitric oxide in healthy volunteers. 2003 Fundam Clin Pharmacol pmid:12803576
Guyton K et al. Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. 2003 Shock pmid:12813370
Stephenson AH et al. Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12609822
Beck-Speier I et al. Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. 2003 Prostaglandins Other Lipid Mediat. pmid:14518563
Cipollone F et al. Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina. 2003 Circulation pmid:12515743
Fike CD et al. Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12388340
Dionne RA et al. Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation. 2003 J. Oral Maxillofac. Surg. pmid:12966473
Tsipas G and Morphake P Beneficial effects of a diet rich in a mixture of n - 6/n - 3 essential fatty acids and of their metabolites on cyclosporine - nephrotoxicity. 2003 J. Nutr. Biochem. pmid:12948879
Cerletti C et al. Pharmacokinetic and pharmacodynamic differences between two low dosages of aspirin may affect therapeutic outcomes. 2003 Clin Pharmacokinet pmid:12959636
Dai H et al. Effects of diltiazem on platelet activation and cytosolic calcium during percutaneous transluminal coronary angioplasty. 2003 Postgrad Med J pmid:13679549
Liu H et al. Clinical implication of the changes of cAMP, TXA2 and PGI2 in CSF of asphyxiated newborns. 2003 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:12973949
Davì G et al. Platelet activation in obese women: role of inflammation and oxidant stress. 2002 Oct 23-30 JAMA pmid:12387653
Hayashi M et al. Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre-eclampsia. 2002 Nov-Dec Eur. J. Haematol. pmid:12460234
Wolfram RM et al. Effect of black tea on (iso-)prostaglandins and platelet aggregation in healthy volunteers. 2002 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:12144875
Alarayyed NA et al. Differential actions of naftopidil, doxazosin and nifedipine on platelet thromboxane generation and platelet-derived growth factor efflux in vitro. 2002 Aug-Sep Platelets pmid:12189011
Ersöz G et al. Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. 2002 Thromb. Res. pmid:12676189
Connolly E et al. Cyclooxygenase isozyme expression and intimal hyperplasia in a rat model of balloon angioplasty. 2002 J. Pharmacol. Exp. Ther. pmid:11805196
Pinheiro RM and Calixto JB Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. 2002 Inflamm. Res. pmid:12558194
Saldeen P et al. Signs of platelet activation, but not lipid peroxidation, in fetal blood associated with functional and structural umbilicoplacental lesions in pregnancies complicated by impaired glucose metabolism. 2002 J. Matern. Fetal. Neonatal. Med. pmid:12530613
Bermejo BP et al. Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. 2002 Biol. Pharm. Bull. pmid:11824534
Ersöz G et al. The effect of submaximal exercise on platelet aggregation during late follicular and midluteal phases in women. 2002 Thromb. Res. pmid:12590951
Küsters S et al. Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. 2002 Arzneimittelforschung pmid:11878205
Lees P and Landoni MF Pharmacodynamics and enantioselective pharmacokinetics of racemic carprofen in the horse. 2002 J. Vet. Pharmacol. Ther. pmid:12485349
Lassus P et al. Pulmonary prostacyclin is associated with less severe respiratory distress in preterm infants. 2002 Early Hum. Dev. pmid:11893431
Tang L et al. [Relationship between cyclooxygenase-2 protein expression, prostaglandins levels and biologic behavior in ovarian carcinoma tissue]. 2002 Zhonghua Fu Chan Ke Za Zhi pmid:12487927
Tuersun K and Huang Y [Changes of blood vessel active substances in acute pulmonary embolism induced by echinococus granulous cyst in rabbits]. 2002 Zhonghua Jie He He Hu Xi Za Zhi pmid:12490126
Zaitsu M et al. Induction of thromboxane A2 synthesizing enzymes in DMSO-induced granulocytic differentiation of HL-60 cells. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12468261
Thomson M et al. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12468270
Sheu JR et al. Mechanisms involved in the antiplatelet activity of magnesium in human platelets. 2002 Br. J. Haematol. pmid:12472585
Fiorucci S et al. NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide. 2002 Circulation pmid:12473561
Rouvier J et al. Aspirin resistance. 2002 Circulation pmid:12473569
Celik I et al. Effects of ibuprofen on the physiology and outcome of rabbit endotoxic shock. 2002 BMC Infect. Dis. pmid:12445332
Dai CF et al. [Clinical and experimental study of treatment of nanmiqing capsule for chronic prostatitis]. 2002 Zhonghua Nan Ke Xue pmid:12479132
Khan I et al. Cyclooxygenase-2 inhibition and experimental colitis: beneficial effects of phosphorothioated antisense oligonucleotide and meloxicam. 2002 Scand. J. Gastroenterol. pmid:12523593
Miyataka M et al. Nitric oxide, anti-inflammatory drugs on renal prostaglandins and cyclooxygenase-2. 2002 Hypertension pmid:11897764
Minuz P et al. Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease. 2002 Circulation pmid:12451006
Ozaki N et al. Differential regulation of prostacyclin and thromboxane by dexamethasone and celecoxib during oxidative stress in newborn rabbits. 2002 Prostaglandins Other Lipid Mediat. pmid:12428679
De La Cruz JP et al. Effects of the selective inhibition of platelet thromboxane synthesis on the platelet-subendothelium interaction. 2002 Br. J. Pharmacol. pmid:12429581
Bruno A et al. Aspirin and urinary 11-dehydrothromboxane B(2) in African American stroke patients. 2002 Stroke pmid:11779889
Canbaz M et al. Effects of tibolone on thromboxane B(2) levels in postmenopausal women. 2002 Gynecol. Obstet. Invest. pmid:11803222
Huang F et al. Anti-platelet and anti-thrombotic effects of triacetylshikimic acid in rats. 2002 J. Cardiovasc. Pharmacol. pmid:11791012
Bayorh MA et al. 1A-779 attenuates angiotensin-(1-7) depressor response in salt-induced hypertensive rats. 2002 Peptides pmid:11814618
Jeng JH et al. Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. 2002 Free Radic. Biol. Med. pmid:11978487
Streppa HK et al. Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. 2002 Am. J. Vet. Res. pmid:16206787
Jiang Z et al. [The changes of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha(6-keto-PGF1 alpha) in the lungs of rats drowned in hypothermic-sea-water]. 2002 Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi pmid:14694611
Saareks V et al. Opposite effects of nicotinic acid and pyridoxine on systemic prostacyclin, thromboxane and leukotriene production in man. 2002 Pharmacol. Toxicol. pmid:12403056
Kudolo GB et al. Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. 2002 Thromb. Res. pmid:12590952
Sinzinger H Comments on "Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications". 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12445490
Obase Y et al. Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. 2002 Chest pmid:11796443
Vecino AM et al. Phospholipase A2 activity in platelets of patients with uremia. 2002 Platelets pmid:12487789
Tzanakakis GN et al. The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis. 2002 Int J Gastrointest Cancer pmid:12630766
Park CH et al. Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors. 2002 Eur J Med Chem pmid:12204472
Cipollone F et al. Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy. 2002 Circulation pmid:12135935
Association between ibuprofen, aspirin therapy found. 2002 J Am Dent Assoc pmid:12136787
Rinder HM et al. Effects of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled trial. 2002 J Clin Pharmacol pmid:12162470
Wong DA et al. Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2). 2002 J. Exp. Med. pmid:12163563
Kiemer AK et al. Inhibition of cyclooxygenase-2 by natriuretic peptides. 2002 Endocrinology pmid:11861506
Huang K et al. Role of selenium in cytoprotection against cholesterol oxide-induced vascular damage in rats. 2002 Atherosclerosis pmid:11947907
Hu X et al. [The influence of nasal continual positive airway pressure on some vasoactive substances in patients with obstructive sleep apnea syndrome]. 2002 Zhonghua Jie He He Hu Xi Za Zhi pmid:11953098
Burleigh ME et al. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. 2002 Circulation pmid:11956125
Jankov RP et al. Thromboxane A(2) receptors mediate pulmonary hypertension in 60% oxygen-exposed newborn rats by a cyclooxygenase-independent mechanism. 2002 Am. J. Respir. Crit. Care Med. pmid:12119234
Giardiello FM et al. Primary chemoprevention of familial adenomatous polyposis with sulindac. 2002 N. Engl. J. Med. pmid:11932472
Signorello MG et al. Effect of homocysteine on arachidonic acid release in human platelets. 2002 Eur. J. Clin. Invest. pmid:11952814
Yamasaki M et al. No involvement of interleukin-5 or eosinophils in experimental allergic rhinitis in guinea pigs. 2002 Eur. J. Pharmacol. pmid:11937106
Eikelboom JW et al. Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. 2002 Circulation pmid:11940542
Knijff-Dutmer EA et al. Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclo-oxygenase-2-selective inhibitors in patients with rheumatoid arthritis. 2002 Rheumatology (Oxford) pmid:11961179
Hayashi M et al. The levels of five markers of hemostasis and endothelial status at different stages of normotensive pregnancy. 2002 Acta Obstet Gynecol Scand pmid:11966476
Leese PT et al. Valdecoxib does not impair platelet function. 2002 Am J Emerg Med pmid:12098171
Tsukamoto H et al. Simultaneous quantification of prostaglandins, isoprostane and thromboxane in cell-cultured medium using gas chromatography-mass spectrometry. 2002 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:12076690
Sakai H et al. E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. 2002 Br. J. Pharmacol. pmid:12023941
Zhang H et al. [Perioperative lung injury in ventricular septal defect with severe pulmonary hypertension, a clinical study of 31 cases]. 2002 Zhonghua Yi Xue Za Zhi pmid:12425808
Jones CJ et al. In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs. 2002 Am. J. Vet. Res. pmid:12428662
Buluç M et al. Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats. 2002 Prostaglandins Other Lipid Mediat. pmid:12428691
Gray PA et al. Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors. 2002 Br. J. Pharmacol. pmid:12429575
Valeri CR et al. Circulation and hemostatic function of autologous fresh, liquid-preserved, and cryopreserved baboon platelets transfused to correct an aspirin-induced thrombocytopathy. 2002 Transfusion pmid:12430680
Wilner KD et al. Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteers. 2002 J Clin Pharmacol pmid:12211219
Molina V et al. D-003, a potential antithrombotic compound isolated from sugar cane wax with effects on arachidonic acid metabolites. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12213431
Koizumi T et al. Inhibition of endogenous nitric oxide during endotoxemia in awake sheep - effects of Nomega-nitro-l-arginine on the distribution of pulmonary vascular resistance and prostanoid products. 2002 Exp. Lung Res. pmid:12217213
Khan I et al. Altered expression of Na(+)/H(+) exchanger isoforms 1 and 3 in clipped and unclipped kidneys of a 2-kidney-1-clip Goldblatt model of hypertension. 2002 Nephron pmid:12218313
Yokoyama C et al. Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction. 2002 Circulation pmid:12403673
Evgenov OV et al. Methylene blue reduces pulmonary oedema and cyclo-oxygenase products in endotoxaemic sheep. 2002 Eur. Respir. J. pmid:12412689
Bergh K et al. Production of prostaglandin e(2) by iridial melanocytes exposed to latanoprost acid, a prostaglandin F(2 alpha) analogue. 2002 J Ocul Pharmacol Ther pmid:12419090
Chen TL et al. [Effects of fast decompression on prostaglandins content in cerebral tissue of guinea pigs]. 2002 Space Med Med Eng (Beijing) pmid:12222577
Kim H et al. Effect of mannitol on Helicobacter pylori-induced cyclooxygenase-2 expression in gastric epithelial AGS cells. 2002 Pharmacology pmid:12393940
Shashikant MP et al. Physicochemical properties of perfluorochemical liquids influence ventilatory requirements, pulmonary mechanics, and microvascular permeability during partial liquid ventilation following intestinal ischemia/reperfusion injury. 2002 Crit. Care Med. pmid:12394959
Vaughan JE and Walsh SW Oxidative stress reproduces placental abnormalities of preeclampsia. 2002 Hypertens Pregnancy pmid:12517328
Ferlito M et al. Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production. 2002 J. Endotoxin Res. pmid:12701623