Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Clark KE et al. | Effect of bisenoic prostaglandins and arachidonic acid on the uterine vasculature of pregnant sheep. | 1982 | Am. J. Obstet. Gynecol. | pmid:7065014 |
Schuette AH et al. | Effect of lung thromboxane generation on regional blood flow during sheep bypass. | 1982 | Am. J. Physiol. | pmid:7065206 |
Mäkilä UM et al. | Regulation of prostacyclin and thromboxane production by human umbilical vessels: the effect of estradiol and progesterone in a superfusion model. | 1982 | Prostaglandins Leukot Med | pmid:7043492 |
Han P et al. | Inhibition of platelet function of antiarrhythmic drugs, verapamil and disopyramide. | 1982 | Thromb. Haemost. | pmid:7101234 |
Krausz MM et al. | Adverse effects of prostacyclin used to perfuse isolated lung lobes. | 1982 | Am. J. Physiol. | pmid:7044149 |
Hirsh PD et al. | Influence of blood sampling site and technique on thromboxane concentrations in patients with ischemic heart disease. | 1982 | Am. Heart J. | pmid:7102506 |
Siess W et al. | Plasma catecholamines, platelet aggregation and associated thromboxane formation after physical exercise, smoking or norepinephrine infusion. | 1982 | Circulation | pmid:7044612 |
Chierchia S et al. | Failure of thromboxane A2 blockade to prevent attacks of vasospastic angina. | 1982 | Circulation | pmid:7116586 |
Sasagawa S et al. | Effects of thromboxane A2 injection on the rabbit coronary artery. I. Physiologic effects in healthy animals. | 1982 | Exp. Mol. Pathol. | pmid:7117494 |
Socini A et al. | Effects of the coumarin derivative AD6 on platelet aggregation, platelet vessel wall interactions and 6 keto PGF1 alpha production in perfused aortas, in experimentally hypercholesterolaemic rabbits. | 1982 | Pharmacol Res Commun | pmid:7048340 |
Fantone JC et al. | Inhibition of vascular permeability changes in rats by captopril. | 1982 | J. Clin. Invest. | pmid:6282931 |
Ylikorkala O and Viinikka L | Effect of amnioscopy on concentrations of prostaglandin F2 alpha, prostacyclin and thromboxane in maternal plasma. | 1982 | Gynecol. Obstet. Invest. | pmid:6954125 |
Simpson RM et al. | Generation of thromboxane A2 and aorta-contracting activity from platelets stimulated with modified C-reactive protein. | 1982 | Immunology | pmid:7118160 |
Leach CM and Thorburn GD | A comparative study of collagen induced thromboxane release from platelets of different species: implications for human atherosclerosis models. | 1982 | Prostaglandins | pmid:7122912 |
Bottoms GD et al. | Thromboxane, prostaglandin I2 (epoprostenol), and the hemodynamic changes in equine endotoxin shock. | 1982 | Am. J. Vet. Res. | pmid:7049018 |
Poubelle P et al. | [Mononucleated phagocytes from rheumatoid synovial fluid. Synthesis of prostanoids and first pharmacological applications]. | 1982 | Rev Rhum Mal Osteoartic | pmid:7123126 |
Homma T and Malik KU | Effect of prostaglandins on pancreatic circulation in anesthetized dogs. | 1982 | J. Pharmacol. Exp. Ther. | pmid:7050343 |
Bradlow BA and Chetty N | Dosage frequency for suppression of platelet function by low dose aspirin therapy. | 1982 | Thromb. Res. | pmid:7123514 |
Dorsch W et al. | Mediator studies in skin blister fluid from patients with dual skin reactions after intradermal allergen injection. | 1982 | J. Allergy Clin. Immunol. | pmid:6181112 |
Fletcher MS et al. | Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice. | 1982 | Br J Surg | pmid:6751458 |
Shaw JO and Lyons RM | Requirement for different Ca2+ pools in the activation of rabbit platelets II. Phospholipase activity. | 1982 | Biochim. Biophys. Acta | pmid:6800410 |
Dejana E et al. | Bleeding time in rats: a comparison of different experimental conditions. | 1982 | Thromb. Haemost. | pmid:6753230 |
Addonizio VP et al. | Inhibition of human platelet function by verapamil. | 1982 | Thromb. Res. | pmid:7164035 |
Axelrod L and Levine L | Plasma prostaglandin levels in rats with diabetes mellitus and diabetic ketoacidosis. | 1982 | Diabetes | pmid:6816644 |
DiMinno G et al. | Stored human platelets retain full aggregation potential in response to pairs of aggregating agents. | 1982 | Blood | pmid:6800418 |
Strano A et al. | Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. | 1982 | Thromb. Haemost. | pmid:6753232 |
Vargaftig BB et al. | Adrenaline and PAF-acether synergize to trigger cyclooxygenase-independent activation of plasma-free human platelets. | 1982 | Thromb. Res. | pmid:7164036 |
Flynn JT and Demling RH | Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. | 1982 | Adv Shock Res | pmid:6753534 |
Vlodavsky I et al. | Platelet interaction with the extracellular matrix produced by cultured endothelial cells: a model to study the thrombogenicity of isolated subendothelial basal lamina. | 1982 | Thromb. Res. | pmid:7179215 |
Smith MC et al. | Prostacyclin substitution for heparin in long-term hemodialysis. | 1982 | Am. J. Med. | pmid:6753575 |
Deby-Dupont G et al. | Release of thromboxane B2 during adult respiratory distress syndrome and its inhibition by non steroidal anti-inflammatory substances in man. | 1982 | Arch Int Pharmacodyn Ther | pmid:7181589 |
Zipser RD and Martin K | Urinary excretion of arterial blood prostaglandins and thromboxanes in man. | 1982 | Am. J. Physiol. | pmid:6950668 |
Ylikorkala O et al. | Prostacyclin and thromboxane in chronic uremia: effect of hemodialysis. | 1982 | Clin. Nephrol. | pmid:6754193 |
Shohami E et al. | [Thromboxane in rat brain following incomplete ischemia]. | 1982 | Harefuah | pmid:7182317 |
Ylikorkala O et al. | Production of prostacyclin and thromboxane during cesarean section. | 1982 | Obstet Gynecol | pmid:6755324 |
Hamasaki Y et al. | Hypoxia stimulates prostacyclin generation by dog lung in vitro. | 1982 | Prostaglandins Leukot Med | pmid:7051045 |
Panganamala RV and Cornwell DG | The effects of vitamin E on arachidonic acid metabolism. | 1982 | Ann. N. Y. Acad. Sci. | pmid:6816121 |
Mitrovic D et al. | The in vitro production of prostanoids by cultured bovine articular chondrocytes. | 1982 | Prostaglandins | pmid:6801735 |
Watanabe T et al. | Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. | 1982 | J. Biol. Chem. | pmid:6816798 |
Numano F et al. | Changes in the plasma levels of thromboxane B2 and cyclic nucleotides in patients with Takayasu disease. | 1982 | Jpn. Circ. J. | pmid:6119373 |
Foegh ML et al. | Aspirin inhibition of thromboxane release in thrombosis and renal transplant rejection. | 1982 | Lancet | pmid:6119441 |
Graham RM et al. | Effects of short-term beta blockade on blood pressure, plasma thromboxane B2, and plasma and urinary prostaglandins E2 and F2 alpha in normal subjects. | 1982 | Clin. Pharmacol. Ther. | pmid:6120775 |
Rachmilewitz D et al. | Prostanoid synthesis by cultured peripheral blood mononuclear cells in inflammatory diseases of the bowel. | 1982 | Gastroenterology | pmid:6949849 |
Krishnamurthi S et al. | Effect of pyridoxal 5'-phosphate (PALP) on human platelet aggregation, dense granule release and thromboxane B2 generation--role of Schiff base formation. | 1982 | Thromb. Haemost. | pmid:6891107 |
Reines HD et al. | Plasma thromboxane concentrations are raised in patients dying with septic shock. | 1982 | Lancet | pmid:6123885 |
Capitanio A et al. | Detection of circulating released platelets after renal transplantation. | 1982 | Transplantation | pmid:6461116 |
Hall ER et al. | The reduction of platelet thrombi on damaged vessel wall by a thromboxane synthetase inhibitor in rabbits. | 1982 | Thromb. Res. | pmid:6891109 |
White JG and Rao GH | Effects of a microtubule stabilizing agent on the response of platelets to vincristine. | 1982 | Blood | pmid:6124288 |
Davì G et al. | [Effects of flurbiprofen on the platelet function in patients with ischemic cardiopathy]. | 1982 | Cardiologia | pmid:6892383 |
Chong BH et al. | Heparin-induced thrombocytopenia: association of thrombotic complications with heparin-dependent IgG antibody that induces thromboxane synthesis in platelet aggregation. | 1982 | Lancet | pmid:6128550 |
De Caterina R et al. | [Effects of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. | 1982 | Cardiologia | pmid:6892461 |
Di Minno G et al. | Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides. | 1982 | Thromb. Res. | pmid:6803385 |
Suehiro A et al. | The role of platelet hyperfunction in thrombus formation in hyperlipidemia. | 1982 | Thromb. Res. | pmid:6803387 |
Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
Goldyne ME and Stobo JD | Human monocytes synthesize eicosanoids from T lymphocyte-derived arachidonic acid. | 1982 | Prostaglandins | pmid:6819603 |
Rock JA et al. | Cul-de-sac fluid in women with endometriosis: fluid volume and prostanoid concentration during the proliferative phase of the cycle--days 8 to 12. | 1982 | Fertil. Steril. | pmid:6953017 |
Mehta P et al. | Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production. | 1982 | Prostaglandins | pmid:6820165 |
Stuart MJ and Allen JB | Arachidonic acid metabolism in the neonatal platelet. | 1982 | Pediatrics | pmid:6804924 |
Evans CA et al. | Gestational changes in prostanoid concentrations in intrauterine tissues and fetal fluids from pregnant sheep, and the relation to prostanoid output in vitro. | 1982 | Biol. Reprod. | pmid:6896829 |
Nolan RD et al. | The pericardium as a source of prostacyclin in the dog, ox and rat. | 1982 | Prostaglandins | pmid:6820168 |
Koyama I et al. | Release of 6-keto-prostaglandin F1 alpha and thromboxane B2 from mouse peritoneal macrophages during their adhesion and spreading on a glass surface. | 1982 | Prostaglandins | pmid:6896924 |
Uderman HD et al. | Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone. | 1982 | Prostaglandins | pmid:6897296 |
Katsumata M et al. | Diphenylhydantoin: an alternative ligand of a glucocorticoid receptor affecting prostaglandin generation in A/J mice. | 1982 | Science | pmid:6897299 |
Koyama I et al. | [Production of 6-keto-prostaglandin F1 alpha and thromboxane B2 in mouse peritoneal macrophages during preparation of the cells]. | 1982 | Yakugaku Zasshi | pmid:6897423 |
Wilson L et al. | Alterations in reproductive tissue prostaglandins E and F, 6-keto-prostaglandin F1 alpha and thromboxane B2 with gestational age in the rat. | 1982 | Biol. Reprod. | pmid:6897617 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). | 1982 | Thromb. Res. | pmid:6897751 |
De Caterina R et al. | [Effect of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. | 1982 | Cardiologia | pmid:6927441 |
Davì G et al. | [Effects of flurbiprofen on platelet function in patients with ischemic cardiomyopathy]. | 1982 | Cardiologia | pmid:6927457 |
Whinnery MA et al. | Thromboxane B2 and prostaglandin E2 in the rat kidney with unilateral ureteral obstruction. | 1982 | Am. J. Physiol. | pmid:6950670 |
Hwang DH and Donovan J | In vitro and in vivo effects of vitamin E on arachidonic acid metabolism in rat platelets. | 1982 | J. Nutr. | pmid:6806455 |
McNamara DB et al. | Prostaglandin endoperoxide metabolism by microsomes of whole kidneys from normal, congenital unilateral hydronephrotic and unilateral ureteral obstructed rats. | 1982 | Prostaglandins | pmid:6962465 |
Hornych A et al. | [Urinary thromboxane B2 in hypertensive patients]. | 1982 | Arch Mal Coeur Vaiss | pmid:6810812 |
Worthington RE and Nakeff A | Aspirin inhibits rat megakaryocyte thromboxane synthesis. | 1982 | Prostaglandins | pmid:6812167 |
Lecompte T et al. | Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6809005 |
Patrignani P et al. | Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. | 1982 | J. Clin. Invest. | pmid:7045161 |
Bakhle YS and Zakrzewski JT | Effects of the oestrous cycle on the metabolism of arachidonic acid in rat isolated lung. | 1982 | J. Physiol. (Lond.) | pmid:6809935 |
Meydani SN and Dupont J | Effect of zinc deficiency on prostaglandin synthesis in different organs of the rat. | 1982 | J. Nutr. | pmid:7045297 |
Neri Serheri GG et al. | Platelet aggregation and thromboxane A2 production after adrenergic stimulation in young healthy humans. | 1982 | Haemostasis | pmid:6279476 |
Watkins WD et al. | Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: effect of an imidazole derivative. | 1982 | Prostaglandins | pmid:7048422 |
Dore-Duffy P | Differential effect of prostaglandins and other products of arachidonic acid metabolism on measles virus replication in Vero cells. | 1982 | Prostaglandins Leukot Med | pmid:6281810 |
Miller OV et al. | Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. | 1982 | Biochim. Biophys. Acta | pmid:6285985 |
Hüttemeier PC et al. | Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep. | 1982 | Circ. Res. | pmid:7042108 |
Cerletti C et al. | Non-steroidal anti-inflammatory drugs react with two sites on platelet cyclo-oxygenase. Evidence from "in vivo" drug interaction studies in rats. | 1982 | Biochim. Biophys. Acta | pmid:6799004 |
Kunkel SL et al. | Production of cyclooxygenase products and superoxide anion by macrophages in response to chemotactic factors. | 1982 | Prostaglandins | pmid:6300969 |
Levy-Toledano S et al. | Human platelet activation in the absence of aggregation: a calcium-dependent phenomenon independent of thromboxane formation. | 1982 | Blood | pmid:6803854 |
Rettkowski W et al. | Studies of the influence of nitroglycerin on the synthesis of prostaglandins and thromboxane A2 and on platelet aggregation. | 1982 | Arzneimittelforschung | pmid:6805480 |
Panossian A et al. | On the mechanism of biosynthesis of leukotrienes and related compounds. | 1982 | FEBS Lett. | pmid:6297982 |
Michelassi F et al. | Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. | 1982 | Science | pmid:6808665 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane formation by platelets and vascular prostacyclin production from BB rats. An animal model for type I diabetes. | 1982 | Prostaglandins | pmid:6812171 |
Pawlowski NA et al. | Uptake and metabolism of monohydroxy-eicosatetraenoic acids by macrophages. | 1982 | J. Exp. Med. | pmid:6951919 |
Nugent WC et al. | Prostaglandin response to intravenous nitroglycerin. | 1982 | J. Surg. Res. | pmid:6810023 |
Harada Y et al. | Changes in the levels of prostaglandins and thromboxane and their roles in the accumulation of exudate in rat carrageenin-induced pleurisy--a profile analysis using gas chromatography-mass spectrometry. | 1982 | Prostaglandins | pmid:6889754 |
Yoshimoto T and Yamamoto S | Partial purification and assay of thromboxane A synthase from bovine platelets. | 1982 | Meth. Enzymol. | pmid:6890138 |
Tai HH | Assay of thromboxane A synthase inhibitors. | 1982 | Meth. Enzymol. | pmid:6890139 |
Scherhag R et al. | Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. | 1982 | Prostaglandins | pmid:6285420 |
Watkins WD et al. | Thromboxane and prostacyclin changes during cardiopulmonary bypass with and without pulsatile flow. | 1982 | J. Thorac. Cardiovasc. Surg. | pmid:6980332 |
Malemud CJ et al. | Correlation of the biosynthesis of prostaglandin and cyclic AMP in monolayer cultures of rabbit articular chondrocytes. | 1982 | Biochim. Biophys. Acta | pmid:6280776 |
Xiu RJ et al. | Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock. | 1982 | JAMA | pmid:7057538 |
Kelton JG et al. | Sex related differences in platelet function: the effect of aspirin. | 1982 | Blood | pmid:7059670 |
Ylikorkala O et al. | The effect of oral contraceptives on antiaggregatory prostacyclin and proaggregatory thromboxane A2 in humans. | 1982 | Am. J. Obstet. Gynecol. | pmid:7036746 |