Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
De Candia E et al. | Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. | 2007 | J. Thromb. Haemost. | pmid:17137471 |
Miyamoto A et al. | Ibuprofen or ozagrel increases NO release and l-nitro arginine induces TXA(2) release from cultured porcine basilar arterial endothelial cells. | 2007 | Vascul. Pharmacol. | pmid:17113355 |
Graff J et al. | Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. | 2007 | Clin Ther | pmid:17577465 |
Crescente M et al. | Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings. | 2007 | Thromb. Haemost. | pmid:17549313 |
Undas A et al. | Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin. | 2007 | Thromb. Haemost. | pmid:17549314 |
Chakroun T et al. | Screening for aspirin resistance in stable coronary artery patients by three different tests. | 2007 | Thromb. Res. | pmid:17553552 |
Pucsok JM et al. | Effect of exercise on levels of cyclo-oxygenase mediators in exhaled breath condensate in elite athletes. | 2007 | J Sports Med Phys Fitness | pmid:17557063 |
Guthikonda S et al. | Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin. | 2007 | J. Thromb. Haemost. | pmid:17319904 |
Rohatagi S et al. | Predictive population pharmacokinetic/pharmacodynamic model for a novel COX-2 inhibitor. | 2007 | J Clin Pharmacol | pmid:17322148 |
González-Correa JA et al. | Differences in the influence of the interaction between acetylsalicylic acid and salicylic acid on platelet function in whole blood and isolated platelets: influence of neutrophils. | 2007 | Pharmacol. Res. | pmid:17644353 |
Gendron ME and Thorin E | A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17644574 |
Weber AA et al. | Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers. | 2007 | Platelets | pmid:17654308 |
Capone ML et al. | Human pharmacology of naproxen sodium. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17473175 |
Vidal C et al. | Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17015640 |
Shemesh E et al. | Symptoms of posttraumatic stress disorder in patients who have had a myocardial infarction. | 2006 May-Jun | Psychosomatics | pmid:16684940 |
Tuominen OM et al. | Effects of bisphosphonates on prostaglandin E2 and thromboxane B2 production in human whole blood and monocytes stimulated by lipopolysaccharide and A23187. | 2006 Jul-Aug | Methods Find Exp Clin Pharmacol | pmid:16894405 |
Wang LH et al. | Effect of heparin on activation of platelet function in patients during radiofrequency catheter ablation. | 2006 Jan-Feb | Clin. Exp. Pharmacol. Physiol. | pmid:16445701 |
Wynn RL and Cook J | Does ibuprofen block the cardioprotective effects of aspirin in dental patients? | 2006 Jan-Feb | Gen Dent | pmid:16494111 |
Sciulli MG et al. | Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease. | 2006 | Clin. Pharmacol. Ther. | pmid:16890573 |
Shi T et al. | Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V. | 2006 | Arthritis Rheum. | pmid:16868978 |
Ramamurthy S et al. | Characterization of thromboxane A2 receptor signaling in developing rat oligodendrocytes: nuclear receptor localization and stimulation of myelin basic protein expression. | 2006 | J. Neurosci. Res. | pmid:16998891 |
Zhou Y et al. | Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice. | 2006 | Circ. Res. | pmid:16645140 |
Karkabounas S et al. | Anticarcinogenic and antiplatelet effects of carvacrol. | 2006 | Exp. Oncol. | pmid:16837902 |
Wilder-Smith CH et al. | Dose-effect comparisons of the CINOD AZD3582 and naproxen on upper gastrointestinal tract mucosal injury in healthy subjects. | 2006 | Scand. J. Gastroenterol. | pmid:16497612 |
Brenneis C et al. | Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. | 2006 | FASEB J. | pmid:16816110 |
Baltzer WI et al. | Measurement of urinary 11-dehydro-thromboxane B2 excretion in dogs with gastric dilatation-volvulus. | 2006 | Am. J. Vet. Res. | pmid:16426215 |
Chiu HF et al. | Mechanisms involved in the antiplatelet effect of C-phycocyanin. | 2006 | Br. J. Nutr. | pmid:16469164 |
Ibrahim S et al. | Transfer of very low density lipoprotein-associated phospholipids to activated human platelets. | 2006 | J. Lipid Res. | pmid:16293890 |
Friton GM et al. | Clinical and anti-inflammatory effects of treating endotoxin-challenged pigs with meloxicam. | 2006 | Vet. Rec. | pmid:17056651 |
Ma K et al. | [Study on comparative pharmacology of series of Muskone]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17061560 |
Myers SI et al. | Oxygen-radical regulation of renal blood flow following suprarenal aortic clamping. | 2006 | J. Vasc. Surg. | pmid:16520177 |
Fu JH et al. | [Protective effects of saponines of stem and leaf of Panax notoginseng on acute myocardial ischemia in anaesthetic dogs]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16548173 |
Kanazawa S et al. | Aspirin reduces adverse effects of gefitinib. | 2006 | Anticancer Drugs | pmid:16550000 |
Lee KS et al. | Anti-platelet activity of KR-32560, a novel sodium/hydrogen exchanger-1 inhibitor. | 2006 | Pharmacol. Res. | pmid:16420980 |
Yin M et al. | [Experimental study of effects of cyclooxygenase-2 inhibitor on apoptosis of hypoxic myocardial cells in vitro]. | 2006 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:16647015 |
Ahmad S et al. | Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. | 2006 | Eur. J. Pharmacol. | pmid:16650843 |
Fontana P et al. | Biological effects of aspirin and clopidogrel in a randomized cross-over study in 96 healthy volunteers. | 2006 | J. Thromb. Haemost. | pmid:16634751 |
Markuszewski L et al. | Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin? | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16635110 |
Cheung PY et al. | Platelet dysfunction in asphyxiated newborn piglets resuscitated with 21% and 100% oxygen. | 2006 | Pediatr. Res. | pmid:16627873 |
Laleman W et al. | A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited. | 2006 | Eur. J. Clin. Invest. | pmid:16620286 |
Zhao Y et al. | Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis. | 2006 | Ann. Allergy Asthma Immunol. | pmid:16802773 |
Lee KS et al. | Antiplatelet activity of [5-(2-methoxy-5-chlorophenyl)furan-2-ylcarbonyl]guanidine (KR-32570), a novel sodium/hydrogen exchanger-1 and its mechanism of action. | 2006 | Arch. Pharm. Res. | pmid:16756082 |
Eligini S et al. | Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism. | 2006 | Cardiovasc. Res. | pmid:16154551 |
Nobutoki T et al. | Fluctuating hearing loss, episodic headache, and stroke with platelet hyperaggregability: coexistence of auditory neuropathy and cochlear hearing loss. | 2006 | Brain Dev. | pmid:16168600 |
Zhang JY et al. | [Study on therapeutic effects of series of muskone on myocardial infarction canines]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17225541 |
Basili S et al. | Insulin resistance as a determinant of platelet activation in obese women. | 2006 | J. Am. Coll. Cardiol. | pmid:17174194 |
Hrushka NH et al. | [Effect of thromboxane B2 on morphological features of apoptosis in cultured rat hepatocytes exposed to hepatotropic substances]. | 2006 | Fiziol Zh | pmid:17176837 |
Chiang N and Serhan CN | New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications. | 2006 | Compr Ther | pmid:17435267 |
Michel F et al. | Thromboxane A2/prostaglandin H2 receptor activation mediates angiotensin II-induced postischemic neovascularization. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16385086 |
Chiang N et al. | Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16293793 |