Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Vesterqvist O and Gréen K | Urinary excretion of 2,3-dinor-thromboxane B2 in man under normal conditions, following drugs and during some pathological conditions. | 1984 | Prostaglandins | pmid:6539491 |
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Cooper C et al. | Production of prostaglandins and thromboxane by isolated cells from intracranial tumours. | 1984 | J. Neurol. Neurosurg. Psychiatr. | pmid:6330309 |
Du JT et al. | Sex differences in arachidonate cyclo-oxygenase products in elicited rat peritoneal macrophages. | 1984 | Biochim. Biophys. Acta | pmid:6428458 |
Gross S and Worthington-White DA | The effects of PGF2 alpha, PGI2, and TxB2 on human CFU-C in healthy and leukemic patients. | 1984 | Am. J. Hematol. | pmid:6372442 |
Carter AJ et al. | A comparison of human pulmonary arterial and venous prostacyclin and thromboxane synthesis--effect of a thromboxane synthase inhibitor. | 1984 | Thromb. Haemost. | pmid:6377567 |
Salvetti A et al. | The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients. | 1984 | Br J Clin Pharmacol | pmid:6378233 |
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Roy AC et al. | Thromboxane A2 and prostacyclin levels in molar pregnancy. | 1984 | Br J Obstet Gynaecol | pmid:6383461 |
Mackey WC et al. | Aspirin decreases platelet uptake on Dacron vascular grafts in baboons. | 1984 | Ann. Surg. | pmid:6233945 |
Brown C et al. | Effects of age and steroid treatment on prostaglandin production by the rat uterus in relation to implantation. | 1984 | J. Reprod. Fertil. | pmid:6583409 |
Luderer JR et al. | Dazoxiben, a thromboxane synthetase inhibitor, in Raynaud's phenomenon. | 1984 | Clin. Pharmacol. Ther. | pmid:6428793 |
Runkle B et al. | Cardiovascular changes in group B streptococcal sepsis in the piglet: response to indomethacin and relationship to prostacyclin and thromboxane A2. | 1984 | Pediatr. Res. | pmid:6384909 |
Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
Stegmeier K et al. | The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug. | 1984 | Thromb. Res. | pmid:6385334 |
Ritter JM | Prostanoid synthesis by aortic rings in human blood: selective increase of prostacyclin mediated by a serum factor. | 1984 | Br. J. Pharmacol. | pmid:6386089 |
Schneidkraut MJ et al. | Thromboxane and prostacyclin synthesis following whole body irradiation in rats. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6386769 |
Puustinen T et al. | Glucocorticoids do not decrease thromboxane and prostacyclin levels in human blood. | 1984 | Prostaglandins Leukot Med | pmid:6387721 |
Del Maschio A et al. | Inhibition of human platelet cyclo-oxygenase activity by sulfinpyrazone and three of its metabolites. | 1984 | Eur. J. Pharmacol. | pmid:6432556 |
Essien EM et al. | Blood changes and enhanced thromboxane and 6-keto prostaglandin F1 alpha production in experimental acute Plasmodium bergei infection in hamsters. | 1984 | Thromb. Haemost. | pmid:6388013 |
Mäkäräinen L and Ylikorkala O | Amniotic fluid 6-keto-prostaglandin F1 alpha and thromboxane B2 during labor. | 1984 | Am. J. Obstet. Gynecol. | pmid:6388335 |
Baughman RP et al. | Prostaglandins and thromboxanes in the bronchoalveolar lavage fluid: possible immunoregulation in sarcoidosis. | 1984 | Am. Rev. Respir. Dis. | pmid:6388445 |
Watanabe J et al. | Effect of prostaglandin synthetase inhibitors on platelet aggregation and thromboxane production in diabetes mellitus. | 1984 | Tohoku J. Exp. Med. | pmid:6515648 |
Ditter H and Matthias FR | Changes in thromboxane formation by platelets during and after a continuous endotoxin infusion into rabbits. | 1984 | VASA | pmid:6516562 |
Fitscha P et al. | Follow-up of in-vivo platelet function (platelet half-life, thromboxane B2) in patients with coronary heart disease. | 1984 | VASA | pmid:6516563 |
Block HU et al. | Estimation of thromboxane B2 in the clotting human whole blood by gas chromatography. | 1984 | Biomed. Biochim. Acta | pmid:6517904 |
Beitz A et al. | Thromboxane B2 (TXB2) formation in clotting whole blood of healthy and diabetic humans in vitro. | 1984 | Biomed. Biochim. Acta | pmid:6517908 |
Keinänen-Kiukaanniemi S et al. | Decreased thromboxane production in migraine patients during headache-free period. | 1984 | Headache | pmid:6519984 |
Uehara Y et al. | [A solid phase direct radioimmunoassay for urinary thromboxane B2 and its clinical application]. | 1984 | Nihon Jinzo Gakkai Shi | pmid:6527429 |
Wang JP et al. | Antiplatelet effect of capsaicin. | 1984 | Thromb. Res. | pmid:6528310 |
Sedor JR et al. | Effects of sulindac and indomethacin on renal prostaglandin synthesis. | 1984 | Clin. Pharmacol. Ther. | pmid:6428794 |
Hornych A et al. | [Changes in plasma prostaglandins in normal subjects in an orthostatic position. Comparison with the response of the renin-aldosterone system]. | 1984 | Presse Med | pmid:6242503 |
McGoon MD and Vanhoutte PM | Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. | 1984 | J. Clin. Invest. | pmid:6470141 |
De Caterina R et al. | Inhibition of platelet function by injectable isosorbide dinitrate. | 1984 | Am. J. Cardiol. | pmid:6428211 |
Maddox Y et al. | A routine source of human peritoneal macrophages. | 1984 | Scand. J. Immunol. | pmid:6701470 |
Schieppati A et al. | The metabolism of arachidonic acid by platelets in nephrotic syndrome. | 1984 | Kidney Int. | pmid:6434788 |
Ditter H et al. | Comparison of sympathomimetic amines with collagen, calcium ionophor and adenosine diphosphate in their effects on thromboxane formation of human platelet rich plasma. | 1984 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:6083951 |
Tanganelli I et al. | Effects of somatostatin on the behavior of thromboxane B2 and B-thromboglobulin in type 1 diabetes. | 1984 | Boll. Soc. Ital. Biol. Sper. | pmid:6084513 |
Lewis GP and Smith JR | Prostaglandin endoperoxides and thromboxane A2 in thrombus formation in the hamster cheek pouch in vivo. | 1984 | Prostaglandins | pmid:6435186 |
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Ylikorkala O et al. | Peritoneal fluid prostaglandins in endometriosis, tubal disorders, and unexplained infertility. | 1984 | Obstet Gynecol | pmid:6232475 |
Simberg N | Maternal aspirin administration inhibits pulmonary arachidonic acid metabolism in fetal rabbits. | 1984 | Prostaglandins Leukot Med | pmid:6425868 |
Rao GH et al. | Enteric-coated aspirin, platelet cyclooxygenase activity and function. | 1984 | Prostaglandins Leukot Med | pmid:6425869 |
Burghuber O et al. | Lung edema due to hydrogen peroxide is independent of cyclooxygenase products. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6427146 |
Iacopino VJ et al. | Responses to leukotriene C4 in the perfused rat lung. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6427447 |
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Worthington RE and Fuller GC | Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. | 1984 | Thromb. Res. | pmid:6322377 |
Foegh ML et al. | Urine thromboxane as an immunologic monitor in kidney transplant patients. | 1984 | Transplant. Proc. | pmid:6390872 |
Foegh ML et al. | Monitoring of rat heart allograft rejection by urinary thromboxane. | 1984 | Transplant. Proc. | pmid:6390873 |
Willerson JT et al. | Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms. | 1984 | Am. J. Cardiol. | pmid:6391133 |
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Stimler NP | Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6440564 |
Mallarkey G and Smith GM | In vivo platelet aggregation in the rat: dependence on extracellular divalent cation and inhibition by nonsteroidal anti-inflammatory drugs. | 1984 | Br. J. Pharmacol. | pmid:6423018 |
Schafer AI et al. | Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells. | 1984 | J. Clin. Invest. | pmid:6423665 |
Driss F et al. | Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid. | 1984 | Thromb. Res. | pmid:6098051 |
Fuller RW et al. | Dexamethasone inhibits the production of thromboxane B2 and leukotriene B4 by human alveolar and peritoneal macrophages in culture. | 1984 | Clin. Sci. | pmid:6091982 |
Henke DC et al. | Analysis of leukotrienes, prostaglandins, and other oxygenated metabolites of arachidonic acid by high-performance liquid chromatography. | 1984 | Anal. Biochem. | pmid:6091494 |
Coker SJ | Further evidence that thromboxane exacerbates arrhythmias: effects of UK38485 during coronary artery occlusion and reperfusion in anaesthetized greyhounds. | 1984 | J. Mol. Cell. Cardiol. | pmid:6433026 |
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Jouve R et al. | Thromboxane B2, 6-keto-PGF1 alpha, PGE2, PGF2 alpha, and PGA1 plasma levels in arteriosclerosis obliterans: relationship to clinical manifestations, risk factors, and arterial pathoanatomy. | 1984 | Am. Heart J. | pmid:6581715 |
Ylikorkala O and Tenhunen A | Follicular fluid prostaglandins in endometriosis and ovarian hyperstimulation. | 1984 | Fertil. Steril. | pmid:6363141 |
Yarom R et al. | The effect of T-2 toxin on human platelets. | 1984 | Toxicol. Appl. Pharmacol. | pmid:6710522 |
Walenga RW et al. | Recovery of megakaryocyte thromboxane production in vitro after aspirin inhibition. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6712680 |
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Turk J et al. | Arachidonic acid metabolism in isolated pancreatic islets. I. Identification and quantitation of lipoxygenase and cyclooxygenase products. | 1984 | Biochim. Biophys. Acta | pmid:6329307 |
Zipser RD and Smorlesi C | Regulation of urinary thromboxane B2 in man: influence of urinary flow rate and tubular transport. | 1984 | Prostaglandins | pmid:6718753 |
Cremer KF et al. | Effects of diltiazem, dipyridamole, and their combination on hemostasis. | 1984 | Clin. Pharmacol. Ther. | pmid:6435926 |
Gal D et al. | Effect of radiation on prostaglandin production by human bowel in vitro. | 1984 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:6588048 |
Kutti J et al. | The effect of acetylsalicylic acid in 3 different formulations on in vitro and in vivo platelet function tests. An experimental study on healthy male volunteers. | 1984 | Scand J Haematol | pmid:6719042 |
Holme S et al. | The effect of albumin bound polyunsaturated fatty acids on human platelets. | 1984 | Thromb. Haemost. | pmid:6719386 |
Pedersen AK and FitzGerald GA | Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. | 1984 | N. Engl. J. Med. | pmid:6436696 |
Eldor A et al. | The effect of oral administration of dipyrone on the capacity of blood platelets to synthesize thromboxane A2 in man. | 1984 | Eur. J. Clin. Pharmacol. | pmid:6723755 |
Cerletti C et al. | Plasma levels of salicylate and aspirin in healthy volunteers: relevance to drug interaction on platelet function. | 1984 | J. Lab. Clin. Med. | pmid:6726057 |
Anderson CB et al. | Renal thromboxane synthesis in excised kidney distal to renovascular lesions. | 1984 | JAMA | pmid:6726983 |
Rehr RB et al. | Mechanism of nitroglycerin-induced coronary dilatation: lack of relation to intracoronary thromboxane concentrations. | 1984 | Am. J. Cardiol. | pmid:6437206 |
Tremoli E et al. | Increased platelet sensitivity and thromboxane B2 formation in type-II hyperlipoproteinaemic patients. | 1984 | Eur. J. Clin. Invest. | pmid:6437830 |