Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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MacNab MW et al. | The effects of a new thromboxane synthetase inhibitor, CGS-13080, in man. | 1984 Feb-Mar | J Clin Pharmacol | pmid:6371062 |
Buchanan MR and Hirsh J | Effect of aspirin and salicylate on platelet-vessel wall interactions in rabbits. | 1984 Jul-Aug | Arteriosclerosis | pmid:6380468 |
Paajanen H et al. | Modification of platelet aggregation and thromboxane synthesis by intravascular contrast media. | 1984 Jul-Aug | Invest Radiol | pmid:6434489 |
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Egg D | Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis. | 1984 Mar-Apr | Z Rheumatol | pmid:6730731 |
Tanabe M et al. | Inhibition of coronary circulatory failure and thromboxane A2 release during coronary occlusion and reperfusion by 2-phenylaminoadenosine (CV-1808) in anesthetized dogs. | 1984 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6202970 |
Laustiola K et al. | Exercise-induced increase in plasma arachidonic acid and thromboxane B2 in healthy men: effect of beta-adrenergic blockade. | 1984 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6202971 |
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Menitove JE et al. | Use of prostacyclin to inhibit activation of platelets during preparation of platelet concentrates. | 1984 Nov-Dec | Transfusion | pmid:6390814 |
Fisher M et al. | Selective thromboxane inhibition: a new approach to antiplatelet therapy. | 1984 Sep-Oct | Stroke | pmid:6474531 |
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Papanicolaou N et al. | Selective inhibition of renal thromboxane biosynthesis increased sodium excretion rate in normal and saline-loaded rats. | 1985 | Clin. Sci. | pmid:3880524 |
Bakhle YS et al. | Differential release of eicosanoids by bradykinin, arachidonic acid and calcium ionophore A23187 in guinea-pig isolated perfused lung. | 1985 | Br. J. Pharmacol. | pmid:2996675 |
Bakhle YS and Grantham CJ | Selective effect of pulmonary oedema on prostaglandin E2 pharmacokinetics in rat lung. | 1985 | Biochem. Pharmacol. | pmid:3935117 |
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Hugli TE and Marceau F | Effects of the C5a anaphylatoxin and its relationship to cyclo-oxygenase metabolites in rabbit vascular strips. | 1985 | Br. J. Pharmacol. | pmid:3921089 |
Bowers GJ et al. | Prostanoid production by lipopolysaccharide-stimulated Kupffer cells. | 1985 | J. Surg. Res. | pmid:3887037 |
Kiyomiya K and Oh-ishi S | Involvement of arachidonic acid metabolites in acute inflammation: detection of 6-keto-PGF1 alpha, thromboxane B2 and PGD2 in rat pleurisy induced by phorbol myristate acetate. | 1985 | Jpn. J. Pharmacol. | pmid:3936958 |
Bottoms GD et al. | Endotoxin-induced eicosanoid production by equine vascular endothelial cells and neutrophils. | 1985 | Circ. Shock | pmid:3919961 |
McKechnie K et al. | Metabolic and cardiovascular effects of endotoxin infusion in conscious unrestrained rats: effects of methylprednisolone and BW755C. | 1985 | Circ. Shock | pmid:3919962 |
Panse M et al. | An improved malondialdehyde assay for estimation of thromboxane synthase activity in washed human blood platelets. | 1985 | Prostaglandins | pmid:3937179 |
Toivanen J et al. | Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphinpyrazone, acetylsalicylic acid and indomethacin by human tissues in vitro. | 1985 | Thromb. Res. | pmid:3920778 |
Heinz TR et al. | Radiation-induced alterations in cyclooxygenase product synthesis by isolated perfused rat lungs. | 1985 | Prog Biochem Pharmacol | pmid:3921980 |
Lauri D et al. | Amplification of primary response of human platelets to platelet-activating factor: aspirin-sensitive and aspirin-insensitive pathways. | 1985 | J. Lab. Clin. Med. | pmid:3923145 |
Yamaguchi M and Mori N | 6-Keto prostaglandin F1 alpha, thromboxane B2, and 13,14-dihydro-15-keto prostaglandin F concentrations of normotensive and preeclamptic patients during pregnancy, delivery, and the postpartum period. | 1985 | Am. J. Obstet. Gynecol. | pmid:3838119 |
Johnson A and Malik AB | Pulmonary transvascular fluid and protein exchange after thrombin-induced microembolism. Differential effects of cyclooxygenase inhibitors. | 1985 | Am. Rev. Respir. Dis. | pmid:3925828 |
Patrono C et al. | Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus. | 1985 | J. Clin. Invest. | pmid:3900132 |
O'Keefe EH et al. | Effects of a thromboxane synthetase inhibitor and a thromboxane antagonist on release and activity of thromboxane A2 and prostacyclin in vitro. | 1985 | Prostaglandins | pmid:3925501 |
Aitokallio-Tallberg A et al. | Prostacyclin and thromboxane in breast cancer: relationship between steroid receptor status and medroxyprogesterone acetate. | 1985 | Br. J. Cancer | pmid:2986666 |
Schmitz JM et al. | Vascular prostaglandin and thromboxane production in a canine model of myocardial ischemia. | 1985 | Circ. Res. | pmid:3926340 |
Conti P et al. | Enhanced thromboxane synthesis and vacuolization in human polymorphonuclear leucocytes induced by human lymphokine containing supernatants. | 1985 | Clin. Rheumatol. | pmid:3879473 |
Mahiout A et al. | Ex vivo model for pre-clinical evaluation of dialyzers containing new membranes. | 1985 | Life Support Syst | pmid:3879954 |
Wong C et al. | Effect of a body burn on the lung response to endotoxin. | 1985 | J Trauma | pmid:3880823 |
Khirabadi BS et al. | Urine immunoreactive thromboxane B2 in rat cardiac allograft rejection. | 1985 | Transplantation | pmid:3880966 |
Mehta J and Mehta P | Prostacyclin and thromboxane A2 production by human cardiac atrial tissues. | 1985 | Am. Heart J. | pmid:3880988 |
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Shephard EG et al. | Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin F1 alpha and beta-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. | 1985 | Br J Clin Pharmacol | pmid:2581599 |
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McGowan HM et al. | The effect of dietary alteration of prostaglandin synthesis on blood pressure and the reversal of hypertension in the one-kidney, one-clip rat. | 1985 | Prostaglandins | pmid:3859891 |
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FitzGerald GA et al. | Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936207 |
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Kuzuya T et al. | Determination of plasma thromboxane B2 by radioimmunoassay: methodological problems and accuracy. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936210 |
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Hsu CY et al. | Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury. | 1985 | Neurology | pmid:3892363 |
Morita I et al. | Effect of dietary protein level on platelet aggregation in rat. | 1985 | Prostaglandins Leukot Med | pmid:3892545 |
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Kelton JG et al. | A platelet function defect in preeclampsia. | 1985 | Obstet Gynecol | pmid:3966011 |
Mundie TG et al. | Byssinosis: Release of prostaglandins, thromboxane, and 5-hydroxytryptamine in bronchopulmonary lavage fluid after inhalation of cotton dust extracts. | 1985 | Am. J. Pathol. | pmid:3966532 |
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Nawroth PP et al. | Thromboxane production by perturbed bovine aortic endothelial cells in culture. | 1985 | Blut | pmid:3967102 |
Westenfelder C et al. | Renal function in calves with total artificial hearts. | 1985 | Trans Am Soc Artif Intern Organs | pmid:3837477 |
Morris HG et al. | Effects of salsalate (nonacetylated salicylate) and aspirin on serum prostaglandins in humans. | 1985 | Ther Drug Monit | pmid:3866409 |
Codde JP et al. | Study of diet and drug interactions on prostanoid metabolism. | 1985 | Prostaglandins | pmid:4034991 |
Brace LD and Fareed J | An objective assessment of the interaction of heparin and its fractions with human platelets. | 1985 | Semin. Thromb. Hemost. | pmid:4035366 |
Demling RH et al. | Role of subcutaneous tissue endotoxin in the production of prostanoid-induced lung injury: comparison with intravenous endotoxin response. | 1985 | Circ. Shock | pmid:3840417 |
Lorenz RR and Vanhoutte PM | Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels. | 1985 | Am. J. Physiol. | pmid:4037113 |
Takeda H et al. | [Early changes of vasoactive prostanoids in patients with mitral valve replacement]. | 1985 | Nihon Kyobu Geka Gakkai Zasshi | pmid:3840511 |
Remuzzi G et al. | Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. | 1985 | J. Clin. Invest. | pmid:4038407 |
Vinge E et al. | Single intravenous and oral doses of fenflumizole: pharmacokinetics and effects on prostanoid formation. | 1985 | Acta Pharmacol Toxicol (Copenh) | pmid:3840639 |
Mogensen F et al. | Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. | 1985 | Thromb. Res. | pmid:4038824 |
Bennett A et al. | Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo. | 1985 | Br. J. Pharmacol. | pmid:3840708 |
Tada M et al. | Augmented thromboxane A2 generation and efficacy of its blockade in acute myocardial infarction. | 1985 | Int. J. Cardiol. | pmid:4040500 |
Lorenzana RM et al. | Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1 alpha, thromboxane B2, and acid-base parameters. | 1985 | Fundam Appl Toxicol | pmid:3840756 |
Palmer RM and Salmon JA | Comparison of the effects of some compounds on human neutrophil degranulation and leukotriene B4 and thromboxane B2 synthesis. | 1985 | Biochem. Pharmacol. | pmid:2986647 |
Lynch TJ et al. | Carbon tetrachloride-induced eicosanoid synthesis and enzyme release from rat peritoneal leucocytes. | 1985 | Biochem. Pharmacol. | pmid:2986650 |
Armstrong RA et al. | Effect of the thromboxane receptor antagonist EP 092 on endotoxin shock in the sheep. | 1985 | Prostaglandins | pmid:2989977 |
Gay SW and Kosher RA | Prostaglandin synthesis during the course of limb cartilage differentiation in vitro. | 1985 | J Embryol Exp Morphol | pmid:3867724 |
Elliott GR et al. | Changes in resident rat peritoneal macrophage eicosanoid release, induced by altering the buffer K+/Na+ ratio, are Ca2+ dependent. | 1985 | Biochim. Biophys. Acta | pmid:3933563 |