Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mäkilä UM et al. | Relation between umbilical prostacyclin production and blood-flow in the fetus. | 1983 | Lancet | pmid:6132081 |
Thorngren M et al. | Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid. | 1983 | Lancet | pmid:6133107 |
Stenson WF and Lobos E | Inhibition of platelet thromboxane synthetase by sulfasalazine. | 1983 | Biochem. Pharmacol. | pmid:6135423 |
Chang J et al. | Effects of thiazinamium chloride, promethazine and chlorpromazine on thromboxane B2 synthesis, phagocytosis and respiratory burst by rat alveolar macrophages. | 1983 | Biochem. Pharmacol. | pmid:6138040 |
Saldeen P et al. | Increased synthesis of thromboxane B2 and 6-keto-PGF1 alpha in hand veins from patients with deep venous thrombosis. | 1983 | Thromb. Res. | pmid:6658723 |
Ferraris VA and Swanson E | Aspirin usage and perioperative blood loss in patients undergoing unexpected operations. | 1983 | Surg Gynecol Obstet | pmid:6836459 |
Margotat A et al. | A rapid and simple assay for the study of thromboxane B2 synthesis by intact human platelets. | 1983 | J Pharmacol Methods | pmid:6843139 |
Rotmensch HH et al. | Plasma platelet products and exercise-induced myocardial ischemia. | 1983 | J. Lab. Clin. Med. | pmid:6854135 |
Hamelin SS and Chan AC | Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate. | 1983 | Lipids | pmid:6855486 |
De Clerck F et al. | Platelet activation by endogenous 5-hydroxytryptamine and histamine released by mast cell degranulation with compound 48/80 in the rat. | 1983 | Agents Actions | pmid:6858790 |
Preston FE | Aspirin, prostaglandins, and peripheral gangrene. | 1983 | Am. J. Med. | pmid:6859070 |
Winter M et al. | Synthesis of thromboxane B2 in uraemia and the effects of dialysis. | 1983 | Thromb. Res. | pmid:6868024 |
Hartung HP and Toyka KV | Activation of macrophages by substance P: induction of oxidative burst and thromboxane release. | 1983 | Eur. J. Pharmacol. | pmid:6191998 |
Tanganelli I et al. | [Thromboxane, beta-thromboglobulin and the degree of blood sugar control in type 1 diabetes mellitus]. | 1983 | Boll. Soc. Ital. Biol. Sper. | pmid:6194801 |
Capodicasa G et al. | Platelet thromboxane formation and BTG levels after intensive charcoal HP in uremics or regular hemodialytic treatment (RHT). | 1983 | Int J Artif Organs | pmid:6195116 |
Ditter H et al. | Effects of prostacyclin during cardiopulmonary bypass in men on plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1 alpha and heparin. | 1983 | Thromb. Res. | pmid:6197766 |
Lismonde M et al. | [The presence of 6-oxo-PGF1alpha and thromboxane B2 in peritoneal exudates released by iota-carrageenan in the rat]. | 1983 | Arch. Int. Physiol. Biochim. | pmid:6198994 |
Tolman EL and Fuller BL | Inhibition of thromboxane synthesis in guinea pig lung and human platelets by clotrimazole and other imidazole antifungals. | 1983 | Biochem. Pharmacol. | pmid:6316985 |
Wientroub S et al. | Changes in tissue concentration of prostaglandins during endochondral bone differentiation. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6582850 |
Salmon JA et al. | The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation. | 1983 | J. Pharm. Pharmacol. | pmid:6141244 |
Stimler NP and O'Flaherty JT | Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues. | 1983 | Am. J. Pathol. | pmid:6624879 |
Boughton-Smith NK et al. | Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa. | 1983 | Gut | pmid:6416934 |
Eldor A et al. | Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells. | 1983 | Thromb. Haemost. | pmid:6346571 |
Menys VC and Davies JA | Selective inhibition of thromboxane synthetase with dazoxiben - basis of its inhibitory effect on platelet adhesion. | 1983 | Thromb. Haemost. | pmid:6346575 |
Reeves WC et al. | The release of thromboxane A2 and prostacyclin following experimental acute pulmonary embolism. | 1983 | Prostaglandins Leukot Med | pmid:6348800 |
Aznavoorian SA et al. | Prostacyclin inhibits 5-hydroxytryptamine release but stimulates thromboxane synthesis during cardiopulmonary bypass. | 1983 | Prostaglandins | pmid:6348886 |
Buchanan MR et al. | The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. | 1983 | Thromb. Res. | pmid:6221436 |
Kaar ML et al. | Prostacyclin and thromboxane in diabetic children. | 1983 | Prostaglandins Leukot Med | pmid:6351104 |
Yamamoto S et al. | Enzyme immunoassay of thromboxane B2 and 6-keto-prostaglandin F1 alpha as a substitute for radioimmunoassay. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221523 |
Fischer S et al. | The influence of selective thromboxane synthetase inhibition with a novel imidazole derivative, UK-38,485, on prostanoid formation in man. | 1983 | Circulation | pmid:6352080 |
Davi' G et al. | Platelet activation after adrenergic stimulation in hypertensive patients: effects of acebutolol. | 1983 | Eur. Heart J. | pmid:6352266 |
FitzGerald GA et al. | Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. | 1983 | J. Clin. Invest. | pmid:6355181 |
Jouve R et al. | [Plasma thromboxane B2 and capacity of the aorta to produce prostacyclin in arteriopathies of the lower extremities]. | 1983 | J Mal Vasc | pmid:6355348 |
Kiff PS et al. | Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing. | 1983 | Br J Clin Pharmacol | pmid:6681708 |
Hutton I et al. | Effects of dazoxiben on transcardiac thromboxane levels and haemodynamics in coronary heart disease. | 1983 | Br J Clin Pharmacol | pmid:6681709 |
Feddersen CO et al. | Leukotriene E4 causes pulmonary vasoconstriction, not inhibited by meclofenamate. | 1983 | Prostaglandins | pmid:6098932 |
Zijlstra FJ et al. | Thrombotic thrombocytopenic purpura and plasma thromboxane B2 levels. | 1983 | Thromb. Res. | pmid:6684333 |
Lianos EA et al. | Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics. | 1983 | J. Clin. Invest. | pmid:6685136 |
Wynalda MA et al. | Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A), a new, selective thromboxane synthase inhibitor: intravenous and oral pharmacokinetics in dogs and correlations with ex situ thromboxane B2 production. | 1983 | Prostaglandins | pmid:6685888 |
McDonald JW et al. | Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep. | 1983 | Circ. Res. | pmid:6687354 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01). | 1983 | Br J Clin Pharmacol | pmid:6687429 |
Bruckner G et al. | Dietary trilinoelaidate: effects on hematological parameters, serum eicosanoids and tissue fatty acid composition in rats. | 1983 | J. Nutr. | pmid:6687476 |
Bessin P et al. | Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs. | 1983 | Eur. J. Pharmacol. | pmid:6687572 |
Schumacher WA and Lucchesi BR | Effect of the thromboxane synthetase inhibitor UK-37,248 (dazoxiben) upon platelet aggregation, coronary artery thrombosis and vascular reactivity. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6418881 |
Morita I et al. | Stimulation of eicosapentaenoic acid metabolism in washed human platelets by 12-hydroperoxyeicosatetraenoic acid. | 1983 | J. Biol. Chem. | pmid:6309794 |
Zijlstra FJ and Vincent JE | Comparison of the determination of thromboxane A2 by bioassay on the rabbit mesenteric artery and in the form of TxB2 by radioimmunoassay. | 1983 | J Pharmacol Methods | pmid:6632924 |
Wilson L | Effects of estradiol and progesterone on uterine prostaglandin levels in the pregnant rat. | 1983 | Prostaglandins | pmid:6635211 |
Sanders TA and Hochland MC | A comparison of the influence on plasma lipids and platelet function of supplements of omega 3 and omega 6 polyunsaturated fatty acids. | 1983 | Br. J. Nutr. | pmid:6639916 |
Mehta JL | Prostaglandins: regulatory role in cardiovascular system and implications in ischemic heart disease. | 1983 | Int. J. Cardiol. | pmid:6642760 |
Mathieson MA et al. | Ischemia of the limb stimulates thromboxane production and myocardial depression. | 1983 | Surg Gynecol Obstet | pmid:6648769 |
Barrett PA and Butler KD | Shortening of platelet survival by induced hypercholesterolaemia in rabbits and its prolongation by anagrelide. | 1983 | Thromb. Haemost. | pmid:6648889 |
Robinson C and Hoult JR | Thromboxane A2 analogues inhibit the metabolism of thromboxane B2 in perfused guinea-pig lung. | 1983 | Biochim. Biophys. Acta | pmid:6652102 |
Higgs GA et al. | The source of thromboxane and prostaglandins in experimental inflammation. | 1983 | Br. J. Pharmacol. | pmid:6652359 |
Anton RF et al. | In vivo regional levels of PGE and thromboxane in mouse brain: effect of decapitation, focused microwave fixation, and indomethacin. | 1983 | Prostaglandins | pmid:6658001 |
Mahoney D et al. | Influence of dietary polyunsaturated fatty acids on renal & aortic prostaglandin synthesis in 1 kidney 1 clip Goldblatt hypertensive rats. | 1983 | Prostaglandins | pmid:6658002 |
Socini A et al. | Fish oil administration as a supplement to a corn oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat. | 1983 | Prostaglandins | pmid:6310702 |
Karmali RA et al. | Prostaglandins in breast cancer: relationship to disease stage and hormone status. | 1983 | Br. J. Cancer | pmid:6416285 |
Gethmann U et al. | Effect of catecholestrogens on prostaglandin release by rat pituitaries superfused in vitro. | 1983 | Arch. Gynecol. | pmid:6320749 |
Flynn JT et al. | Effects of anesthesia and surgery on prostanoid concentrations in plasma and pulmonary lymph. | 1983 | Prostaglandins Leukot Med | pmid:6573688 |
Patel K and Bakhle YS | Thromboxane B2 (TxB2) metabolism in rat isolated lung and its inhibition by drugs. | 1983 | Prostaglandins Leukot Med | pmid:6573689 |
Davì G et al. | Plasmatic TXB2 and 6-keto-PGF1 alpha levels during charcoal hemoperfusion in chronic renal failure patients. | 1983 | Prostaglandins Leukot Med | pmid:6573692 |
Lieb J et al. | Elevated levels of prostaglandin E2 and thromboxane B2 in depression. | 1983 | Prostaglandins Leukot Med | pmid:6574523 |
Coceani F et al. | Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat. | 1983 | Am. J. Physiol. | pmid:6574712 |
Viinikka L et al. | Effect of prolonged treatment with acetylsalicylic acid and dipyridamole on platelet thromboxane A2 production in atherosclerotic subjects. | 1983 | Prostaglandins Leukot Med | pmid:6576385 |
Fukumoto S and Tanaka K | Protective effects of thromboxane A2 synthetase inhibitors on endotoxin shock. | 1983 | Prostaglandins Leukot Med | pmid:6576388 |
Kinney EL et al. | Mechanism of action of amrinone: role of thromboxane synthetase inhibition. | 1983 | Prostaglandins Leukot Med | pmid:6576389 |
Hawkey CJ et al. | Imbalance of prostacyclin and thromboxane synthesis in Crohn's disease. | 1983 | Gut | pmid:6578172 |
Carr BR et al. | Prostaglandin secretion by the neocortex and fetal zones of the human fetal adrenal gland. | 1983 | J. Clin. Endocrinol. Metab. | pmid:6313732 |
Rao GH et al. | Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin. | 1983 Jul-Aug | Arteriosclerosis | pmid:6411052 |
Konieczkowski M et al. | Glomerular synthesis of prostaglandins and thromboxane in spontaneously hypertensive rats. | 1983 Jul-Aug | Hypertension | pmid:6407990 |
Stuart MJ | The effect of irradiation on platelet arachidonic acid metabolism. | 1983 Mar-Apr | Transfusion | pmid:6404019 |
Newman WH et al. | Increased myocardial release of prostacyclin in dogs with heart failure. | 1983 Mar-Apr | J. Cardiovasc. Pharmacol. | pmid:6188889 |
Coker SJ and Parratt JR | Nifedipine reduces arrhythmias but does not alter prostanoid release during coronary artery occlusion and reperfusion in anaesthetised greyhounds. | 1983 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6191139 |
Peskar BM | Effects of carbenoxolone on the gastric mucosal prostaglandin and thromboxane system. | 1983 Sep-Oct | Acta Gastroenterol. Belg. | pmid:6324520 |
Burke SE et al. | Protection of ischemic cat myocardium by CGS-13080, a selective potent thromboxane A2 synthesis inhibitor. | 1983 Sep-Oct | J. Cardiovasc. Pharmacol. | pmid:6195474 |
Sheehan DV et al. | Some biochemical correlates of panic attacks with agoraphobia and their response to a new treatment. | 1984 | J Clin Psychopharmacol | pmid:6142907 |
Barnett AH et al. | Specific thromboxane synthetase inhibition and albumin excretion rate in insulin-dependent diabetes. | 1984 | Lancet | pmid:6145027 |
Schenkelaars EJ and Bonta IL | Beta 2-adrenoceptor agonists reverse the leukotriene C4-induced release response of macrophages. | 1984 | Eur. J. Pharmacol. | pmid:6151905 |
Patrignani P et al. | Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6537977 |
Vesterqvist O and Gréen K | Urinary excretion of 2,3-dinor-thromboxane B2 in man under normal conditions, following drugs and during some pathological conditions. | 1984 | Prostaglandins | pmid:6539491 |
McCluskey ER et al. | In vivo inhibition of thromboxane synthetase in infarcted canine myocardium. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6539597 |
Brown CG and Poyser NL | Studies on the control of prostaglandin production by the hypothalamus in relation to LH release in the rat. | 1984 | J. Endocrinol. | pmid:6593408 |
Okazaki K et al. | [Measurement of prostaglandins in human bile juice]. | 1984 | Nihon Shokakibyo Gakkai Zasshi | pmid:6549033 |
Garcia-Szabo RR et al. | Comparison of alpha- and gamma-thrombin on lung fluid balance in anesthetized sheep. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6549181 |
Takeda H et al. | [Comparison of centrifugal pump (bio pump) with roller pump: clinical study]. | 1984 | Kyobu Geka | pmid:6549344 |
Gross S and Worthington-White DA | The effects of PGF2 alpha, PGI2, and TxB2 on human CFU-C in healthy and leukemic patients. | 1984 | Am. J. Hematol. | pmid:6372442 |
Essien EM et al. | Blood changes and enhanced thromboxane and 6-keto prostaglandin F1 alpha production in experimental acute Plasmodium bergei infection in hamsters. | 1984 | Thromb. Haemost. | pmid:6388013 |
Mäkäräinen L and Ylikorkala O | Amniotic fluid 6-keto-prostaglandin F1 alpha and thromboxane B2 during labor. | 1984 | Am. J. Obstet. Gynecol. | pmid:6388335 |
McGoon MD and Vanhoutte PM | Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. | 1984 | J. Clin. Invest. | pmid:6470141 |
Jackson CA et al. | Near-normal glycaemic control does not correct abnormal platelet reactivity in diabetes mellitus. | 1984 | Clin. Sci. | pmid:6434224 |
Higashihara M et al. | Interaction of Solanum tuberosum agglutinin with human platelets. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732807 |
Ylikorkala O et al. | Peritoneal fluid prostaglandins in endometriosis, tubal disorders, and unexplained infertility. | 1984 | Obstet Gynecol | pmid:6232475 |
Foegh ML et al. | Monitoring of rat heart allograft rejection by urinary thromboxane. | 1984 | Transplant. Proc. | pmid:6390873 |
Willerson JT et al. | Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms. | 1984 | Am. J. Cardiol. | pmid:6391133 |
Fareed J et al. | Molecular markers of contrast media-induced adverse reactions. | 1984 | Semin. Thromb. Hemost. | pmid:6393351 |
Fuller RW et al. | Dexamethasone inhibits the production of thromboxane B2 and leukotriene B4 by human alveolar and peritoneal macrophages in culture. | 1984 | Clin. Sci. | pmid:6091982 |
Gal D et al. | Effect of radiation on prostaglandin production by human bowel in vitro. | 1984 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:6588048 |
Eldor A et al. | The effect of oral administration of dipyrone on the capacity of blood platelets to synthesize thromboxane A2 in man. | 1984 | Eur. J. Clin. Pharmacol. | pmid:6723755 |
Cerletti C et al. | Plasma levels of salicylate and aspirin in healthy volunteers: relevance to drug interaction on platelet function. | 1984 | J. Lab. Clin. Med. | pmid:6726057 |
Anderson CB et al. | Renal thromboxane synthesis in excised kidney distal to renovascular lesions. | 1984 | JAMA | pmid:6726983 |