MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Insipidus | D003919 | 5 associated lipids |
Carotid Artery Injuries | D020212 | 8 associated lipids |
Neointima | D058426 | 3 associated lipids |
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
To understand associated biological information of 20-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
20-HETE is suspected in Hypertensive disease, Renal tubular disorder, endothelial dysfunction, Renal glomerular disease, Ischemia, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 20-HETE
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 20-HETE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study '20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.' (Park F et al., 2008), Mouse Model are used in the study 'Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.' (Alexanian A et al., 2009) and Mouse Model are used in the study 'Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.' (Harder DR and Roman RJ, 2006).
Knock-out are used in the study 'Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.' (Yu M et al., 2007) and Knock-out are used in the study 'Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.' (Williams JM et al., 2007).
Streptozotocin Diabetes are used in the study 'Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.' (Chen YJ et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mapelli L et al. | Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System. | 2017 | J. Neurosci. | pmid:28039371 |
Yi M et al. | Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis. | 2017 | Arch. Biochem. Biophys. | pmid:28347661 |
Yi X et al. | Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke. | 2016 | J. Atheroscler. Thromb. | pmid:27087514 |
Ziegler N et al. | β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function. | 2016 | J. Neurosci. | pmid:27559173 |
Garbacz WG et al. | Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance. | 2016 | Mol. Cell. Biol. | pmid:27528620 |
Jackson WF | Arteriolar oxygen reactivity: where is the sensor and what is the mechanism of action? | 2016 | J. Physiol. (Lond.) | pmid:27324312 |
Dordea AC et al. | Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27199131 |
Dalmasso C et al. | 20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27194719 |
Gebremedhin D et al. | Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:27174801 |
Chen L et al. | 20-HETE contributes to ischemia-induced angiogenesis. | 2016 | Vascul. Pharmacol. | pmid:27084395 |