Flavokawain b is a lipid of Polyketides (PK) class. Flavokawain b is associated with abnormalities such as Helminthiasis. The involved functions are known as Cell Death and MAPK Signaling Pathway. Flavokawain b often locates in Blood, Entire bony skeleton and Integumentary system.
To understand associated biological information of Flavokawain b, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Flavokawain b is suspected in Helminthiasis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Flavokawain b
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Eskander RN et al. | Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. | 2012 | J. Obstet. Gynaecol. Res. | pmid:22540374 |
| Teschke R et al. | Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. | 2011 | Dig Liver Dis | pmid:21377431 |
| Mohamad AS et al. | Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K(+) channels pathway in the systemic antinociception of flavokawin B. | 2011 | Basic Clin. Pharmacol. Toxicol. | pmid:21214864 |
| Zhao X et al. | Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression. | 2011 | Can. J. Physiol. Pharmacol. | pmid:22115332 |
| Zhou P et al. | Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. | 2010 | FASEB J. | pmid:20696856 |
| Mohamad AS et al. | Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice. | 2010 | Eur. J. Pharmacol. | pmid:20826146 |
| Kuo YF et al. | Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. | 2010 | Free Radic. Biol. Med. | pmid:20398749 |
| Tang Y et al. | Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. | 2010 | Int. J. Cancer | pmid:20112340 |
| Burns AR et al. | A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans. | 2010 | Nat. Chem. Biol. | pmid:20512140 |
| Shaik AA et al. | Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19716299 |