butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nozawa S et al. | In vitro and in vivo induction of squamous cell carcinoma antigen (SCC) in a uterine cervical cancer cell line (SKG-IIIa) with peplomycin and sodium butyrate. | 1990 | Asia Oceania J Obstet Gynaecol | pmid:1696099 |
Cockett MI et al. | High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification. | 1990 | Biotechnology (N.Y.) | pmid:1369995 |
Li SY | [Expression of cellular oncogenes in human hepatocellular carcinoma cell line BEL 7402 and the effect of sodium butyrate on the expression of cellular oncogenes]. | 1990 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:1964112 |
Bartalena L et al. | The differentiation-inducing agent sodium butyrate produces divergent effects on albumin and thyroxine-binding globulin synthesis by human hepatoblastoma-derived (Hep G2) cells. | 1990 | J. Endocrinol. Invest. | pmid:1965315 |
Charollais RH et al. | Butyrate blocks the accumulation of CDC2 mRNA in late G1 phase but inhibits both the early and late G1 progression in chemically transformed mouse fibroblasts BP-A31. | 1990 | J. Cell. Physiol. | pmid:1976640 |
Yusta B et al. | Regulation of thyroid hormone receptor and c-erbA mRNA levels by butyrate in neuroblastoma (N2A) and glioma (C6) cells. | 1990 | J. Neurosci. Res. | pmid:1979350 |
Murphy LD et al. | Modulation of EGF receptor expression by differentiating agents in human colon carcinoma cell lines. | 1990 | Cancer Commun. | pmid:2206777 |
Staiano-Coico L et al. | Epidermal cell-shape regulation and subpopulation kinetics during butyrate-induced terminal maturation of normal and SV40-transformed human keratinocytes: epithelial models of differentiation therapy. | 1990 | Int. J. Cancer | pmid:2210888 |
Lazar MA | Sodium butyrate selectively alters thyroid hormone receptor gene expression in GH3 cells. | 1990 | J. Biol. Chem. | pmid:2211641 |
Guilbaud NF et al. | Effects of differentiation-inducing agents on maturation of human MCF-7 breast cancer cells. | 1990 | J. Cell. Physiol. | pmid:2211839 |
McDevitt J et al. | Urinary organic acid profiles in fatty Zucker rats: indications for impaired oxidation of butyrate and hexanoate. | 1990 | Metab. Clin. Exp. | pmid:2215249 |
Järvinen M | Vimentin in human erythroleukemia (HEL) cells is modulated with differentiation inducers. | 1990 | Cell Biol. Int. Rep. | pmid:2188740 |
Marchetti P et al. | Diurnal pattern of plasma metformin concentrations and its relation to metabolic effects in type 2 (non-insulin-dependent) diabetic patients. | 1990 | Diabete Metab | pmid:2086278 |
Trautmann ME et al. | Inverse relationship between glucose metabolism and glucose-induced insulin secretion in rat insulinoma cells. | 1990 | Horm. Res. | pmid:2097293 |
Cary JW et al. | Cloning and expression of Clostridium acetobutylicum ATCC 824 acetoacetyl-coenzyme A:acetate/butyrate:coenzyme A-transferase in Escherichia coli. | 1990 | Appl. Environ. Microbiol. | pmid:2383002 |
Breitman TR and He RY | Combinations of retinoic acid with either sodium butyrate, dimethyl sulfoxide, or hexamethylene bisacetamide synergistically induce differentiation of the human myeloid leukemia cell line HL60. | 1990 | Cancer Res. | pmid:2400989 |
Gálfi P and Bokori J | Feeding trial in pigs with a diet containing sodium n-butyrate. | 1990 | Acta Vet. Hung. | pmid:2100936 |
Waterborg JH et al. | Dynamic histone acetylation in alfalfa cells. Butyrate interference with acetate labeling. | 1990 | Biochim. Biophys. Acta | pmid:2383588 |
Chou JY et al. | Effects of sodium butyrate on the synthesis of human pregnancy-specific beta 1-glycoprotein. | 1990 | J. Biol. Chem. | pmid:2341406 |
Coscia CJ et al. | Effects of up-regulation by butyrate on delta opioid receptor GTP sensitivity and distribution in subcellular compartments. | 1990 | Prog. Clin. Biol. Res. | pmid:2154771 |
Hwang GY et al. | Chromatographic purification and characterization of EBV DNase from chemically induced lymphoid cells. | 1990 | Virology | pmid:2155513 |
Persky B and McGarvey T | A quantitative assessment of F-actin content and distribution in untreated and butyric acid treated murine melanoma B16a tumour cells: a fluorescence image analysis study. | 1990 | Histochem. J. | pmid:2074210 |
Fischkoff SA et al. | Characterization of sublines of HL-60 human leukemia cells resistant to induction of differentiation by butyric acid. | 1990 | Leukemia | pmid:2164121 |
Radom J et al. | Influence of chain length of pyrene fatty acids on their uptake and metabolism by Epstein-Barr-virus-transformed lymphoid cell lines from a patient with multisystemic lipid storage myopathy and from control subjects. | 1990 | Biochem. J. | pmid:2165389 |
Chiou JF et al. | Purification of Epstein-Barr virus associated DNase with affinity chromatography of nasopharyngeal carcinoma patient serum. | 1990 | Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi | pmid:2168313 |
Kadowaki K et al. | Adenosine 3',5'-cyclic monophosphate enhances dopamine accumulation in rat hypothalamic cell culture containing dopaminergic neurons. | 1990 | Neuroendocrinology | pmid:2170853 |
Gossen D et al. | Secretin receptors in the neuroglioma hybrid cell line NG108-15. Characterization and regulation of their expression. | 1990 | Eur. J. Biochem. | pmid:2171930 |
Weidner DA and Sommadossi JP | 3'-Azido-3'-deoxythymidine inhibits globin gene transcription in butyric acid-induced K-562 human leukemia cells. | 1990 | Mol. Pharmacol. | pmid:2174502 |
Naranjo JR et al. | Unusual c-fos induction upon chromaffin PC12 differentiation by sodium butyrate: loss of fos autoregulatory function. | 1990 | Nucleic Acids Res. | pmid:2114014 |
Roediger WE and Nance S | Selective reduction of fatty acid oxidation in colonocytes: correlation with ulcerative colitis. | 1990 | Lipids | pmid:2127822 |
Kalina M et al. | Modulation of alkaline phosphatase activity in alveolar type II like cells. | 1990 | Histochemistry | pmid:1962764 |
Fürll M and Dabbash MN | [Subacute butyric acid exposure in cattle. 6. Effects of a butyric acid or a sodium butyrate exposure up to 2.0 g. per kg. body weight per day]. | 1990 | Arch Exp Veterinarmed | pmid:2102649 |
Perrine SP | Pharmacologic modulation of fetal globin gene expression in the perinatal period. | 1990 | Semin. Perinatol. | pmid:1705052 |
Perrine SP et al. | Stopping the biologic clock for globin gene switching. | 1990 | Ann. N. Y. Acad. Sci. | pmid:1705405 |
Takahashi H and Parsons PG | In vitro phenotypic alteration of human melanoma cells induced by differentiating agents: heterogeneous effects on cellular growth and morphology, enzymatic activity, and antigenic expression. | 1990 | Pigment Cell Res. | pmid:1710361 |
Constantoulakis P et al. | A transgenic mouse model for studying the induction of fetal hemoglobin in the adult. | 1990 | Trans. Assoc. Am. Physicians | pmid:1721467 |
Tokiwa T et al. | Butyrate decreases AFP and increases albumin in combination with laminin in a human hepatoma cell line. | 1990 | In Vitro Cell. Dev. Biol. | pmid:1690701 |
Adinolfi M et al. | Alpha-fetoprotein levels in different strains of mice during development. | 1990 | Exp. Clin. Immunogenet. | pmid:1691009 |
Järvinen M et al. | K562 erythroleukemia cells express cytokeratins 8, 18, and 19 and epithelial membrane antigen that disappear after induced differentiation. | 1990 | J. Cell. Physiol. | pmid:1692028 |
Watanabe M et al. | Effect of liposomes containing sodium butyrate conjugated with anti-CD19 monoclonal antibody on in vitro and in vivo growth of malignant lymphoma. | 1990 | Cancer Res. | pmid:1692257 |
Tamura RN and Cox GS | Enhancement by theophylline of the butyrate-mediated induction of choriogonadotropin alpha-subunit in HeLa cells. I. Lack of correlation with cAMP. | 1990 | Arch. Biochem. Biophys. | pmid:1693836 |
Cosgrove DE and Cox GS | Enhancement by theophylline of the butyrate-mediated induction of choriogonadotropin alpha-subunit in HeLa cells. II. Effect of both agents on mRNA turnover. | 1990 | Arch. Biochem. Biophys. | pmid:1693837 |
Brubaker PL et al. | Synthesis and secretion of somatostatin-28 and -14 by fetal rat intestinal cells in culture. | 1990 | Am. J. Physiol. | pmid:1694403 |
Matsumine H et al. | Sebright and Campine chickens express aromatase P-450 messenger RNA inappropriately in extraglandular tissues and in skin fibroblasts. | 1990 | Mol. Endocrinol. | pmid:1700281 |
Orlow SJ et al. | Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers. | 1990 | Exp. Cell Res. | pmid:1701721 |
Williams AC et al. | Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence. | 1990 | Cancer Res. | pmid:2369746 |
Zhang JW et al. | Butyrate induces expression of transfected human fetal and endogenous mouse embryonic globin genes in GM 979 erythroleukemia cells. | 1990 | Dev. Genet. | pmid:2379328 |
Martin RL et al. | Characterisation of putrescine uptake by cultured adult mouse hepatocytes. | 1990 | Biochim. Biophys. Acta | pmid:2297540 |
Staiano-Coico L et al. | TGF-alpha and TGF-beta expression during sodium-N-butyrate-induced differentiation of human keratinocytes: evidence for subpopulation-specific up-regulation of TGF-beta mRNA in suprabasal cells. | 1990 | Exp. Cell Res. | pmid:2257881 |
Davidson AM and Halestrap AP | Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms. | 1990 | Biochem. J. | pmid:2344354 |
Kim RY and Stern WH | Retinoids and butyrate modulate fibroblast growth and contraction of collagen matrices. | 1990 | Invest. Ophthalmol. Vis. Sci. | pmid:2354920 |
Natke E | Cell volume regulation of rabbit cortical collecting tubule in anisotonic media. | 1990 | Am. J. Physiol. | pmid:2360659 |
Thakur MK and Prasad S | ADP-ribosylation of HMG proteins and its modulation by different effectors in the liver of aging rats. | 1990 | Mech. Ageing Dev. | pmid:2325444 |
Rius C et al. | The induction of vimentin gene expression by sodium butyrate in human promonocytic leukemia U937 cells. | 1990 | Exp. Cell Res. | pmid:2328771 |
Herz F and Halwer M | Differential effects of sodium butyrate and hyperosmolality on the modulation of alkaline phosphatases of LoVo cells. | 1990 | Exp. Cell Res. | pmid:2328777 |
Doi Y et al. | Cyclic nature of poly(3-hydroxyalkanoate) metabolism in Alcaligenes eutrophus. | 1990 | FEMS Microbiol. Lett. | pmid:2328906 |
Saito S et al. | [Quenching effect and analysis of cell proliferation in dual-laser flow cytometry with human endometrial adenocarcinoma cells in vitro]. | 1990 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:2332670 |
Chou JY and Zilberstein M | Expression of the pregnancy-specific beta 1-glycoprotein gene in cultured human trophoblasts. | 1990 | Endocrinology | pmid:2226305 |
Oliva R et al. | Histone hyperacetylation can induce unfolding of the nucleosome core particle. | 1990 | Nucleic Acids Res. | pmid:2339060 |
Tang DC and Taylor MW | Transcriptional activation of the adenine phosphoribosyltransferase promoter by an upstream butyrate-induced Moloney murine sarcoma virus enhancer-promoter element. | 1990 | J. Virol. | pmid:2159551 |
Boulikas T | Poly(ADP-ribosylated) histones in chromatin replication. | 1990 | J. Biol. Chem. | pmid:2387872 |
Kocache MM and Pearson GR | Protein kinase activity associated with a cell cycle regulated, membrane-bound Epstein-Barr virus induced early antigen. | 1990 | Intervirology | pmid:2159954 |
Plaetinck G et al. | Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells. | 1990 | J. Exp. Med. | pmid:2388031 |
Bresnick EH et al. | Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2160080 |
Wiechmann AF et al. | Cyclic AMP and butyrate modulate melatonin synthesis in Y79 human retinoblastoma cells. | 1990 | J. Neurochem. | pmid:2162375 |
Saini K et al. | Induction of carcinoembryonic-antigen-gene expression in human colorectal carcinoma by sodium butyrate. | 1990 | Biochem. J. | pmid:2268282 |
Prasad KN et al. | Decreased expressions of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture. | 1990 | Biochem. Cell Biol. | pmid:2177340 |
Mailman D et al. | Villous motility and unstirred water layers in canine intestine. | 1990 | Am. J. Physiol. | pmid:2305890 |
Fischkoff SA and Rossi RM | Lineage directed HL-60 cell sublines as a model system for the study of early events in lineage determination of myeloid cells. | 1990 | Leuk. Res. | pmid:2177814 |
Tanaka Y et al. | Effects of 1,25-dihydroxyvitamin D3 and its analogs on butyrate-induced differentiation of HT-29 human colonic carcinoma cells and on the reversal of the differentiated phenotype. | 1990 | Arch. Biochem. Biophys. | pmid:2306105 |
Toscani A et al. | Sodium butyrate in combination with insulin or dexamethasone can terminally differentiate actively proliferating Swiss 3T3 cells into adipocytes. | 1990 | J. Biol. Chem. | pmid:2180933 |
Gorisse MC et al. | Alterations of growth fraction and DNA content in K562 cells by differentiating agents. | 1990 | Cytometry | pmid:1980242 |
Buscail L et al. | Divergent regulation of beta 2-adrenoceptors and adenylate cyclase in the Cyc- mouse T lymphoma cell line TL2-9. | 1990 | Immunobiology | pmid:1980264 |
Shibata H et al. | Increase in the level of P-glycoprotein mRNA expression in multidrug-resistant K562 cell lines treated with sodium butyrate is not accompanied with erythroid differentiation. | 1990 | Jpn. J. Cancer Res. | pmid:1980493 |
Ramp U et al. | Uniform response of c-raf expression to differentiation induction and inhibition of proliferation in a rat rhabdomyosarcoma cell line. | 1990 | Virchows Arch., B, Cell Pathol. | pmid:1980557 |
Nichols KV et al. | Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung. | 1990 | Am. J. Physiol. | pmid:2175559 |
Tichonicky L et al. | Sodium butyrate inhibits c-myc and stimulates c-fos expression in all the steps of the cell-cycle in hepatoma tissue cultured cells. | 1990 | Biol. Cell | pmid:2261575 |
Murphy LD et al. | Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression. | 1990 | Biochemistry | pmid:1979752 |
Gabius S et al. | Regulation of distribution, amount and ligand affinity of sugar receptors in human colon carcinoma cells by treatment with sodium butyrate, retinoic acid and phorbol ester. | 1990 Jul-Aug | Anticancer Res. | pmid:2382971 |
Sankaranarayanan K et al. | Effects of sodium butyrate on X-ray and bleomycin-induced chromosome aberrations in human peripheral blood lymphocytes. | 1990 Oct-Dec | Genet. Res. | pmid:1703101 |
Shubhada S and Tsai YH | Differential effects of FSH on the activities of S-adenosyl-L-methionine decarboxylase and ornithine decarboxylase in Rat sertoli cells. | 1990 Sep-Oct | J. Androl. | pmid:2174845 |
McGarvey TW et al. | The effect of butyric acid and retinoic acid on invasion and experimental metastasis of murine melanoma cells. | 1990 Sep-Oct | Clin. Exp. Metastasis | pmid:2390813 |
Belcheva MM et al. | Up-regulation of delta opioid receptors in neuroblastoma hybrid cells: evidence for differences in the mechanisms of action of sodium butyrate and naltrexone. | 1991 | J. Pharmacol. Exp. Ther. | pmid:1656025 |
Palermo DP et al. | Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression. | 1991 | J. Biotechnol. | pmid:1369310 |
Breuer RI et al. | Rectal irrigation with short-chain fatty acids for distal ulcerative colitis. Preliminary report. | 1991 | Dig. Dis. Sci. | pmid:1988261 |
He RY and Breitman TR | Retinoic acid inhibits sodium butyrate-induced monocytic differentiation of HL60 cells while synergistically inducing granulocytoid differentiation. | 1991 | Eur. J. Haematol. | pmid:1995327 |
Thomas DJ et al. | Effect of sodium butyrate on metallothionein induction and cadmium cytotoxicity in ROS 17/2.8 cells. | 1991 | Toxicology | pmid:1996466 |
Glauber JG et al. | 5'-flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells. | 1991 | Mol. Cell. Biol. | pmid:1875947 |
Hendzel MJ and Davie JR | Dynamically acetylated histones of chicken erythrocytes are selectively methylated. | 1991 | Biochem. J. | pmid:1996971 |
Lewandowski ED et al. | NMR studies of beta-oxidation and short-chain fatty acid metabolism during recovery of reperfused hearts. | 1991 | Am. J. Physiol. | pmid:1877663 |
Kondoh N et al. | Effects of sodium butyrate on the rearranged c-myc expression in mouse plasmacytoma cells. | 1991 | Exp. Cell Res. | pmid:1879469 |
Saito S et al. | Flow cytometric and biochemical analysis of dose-dependent effects of sodium butyrate on human endometrial adenocarcinoma cells. | 1991 | Cytometry | pmid:1794255 |
Munks RJ et al. | Histone H4 acetylation in Drosophila. Frequency of acetylation at different sites defined by immunolabelling with site-specific antibodies. | 1991 | FEBS Lett. | pmid:2060643 |
Awad AB et al. | Influence of butyrate on lipid metabolism, survival, and differentiation of colon cancer cells. | 1991 | Nutr Cancer | pmid:1796008 |
Granitzer M and Steels P | Role of Na+/K+ exchange and organic acids in base induced hyperpolarization of renal proximal amphibian tubule. | 1991 | Biochim. Biophys. Acta | pmid:1648393 |
Mitsui K et al. | Multiple neurite formation in neuroblastoma cell lines by griseolic acid, a potent inhibitor of cyclic nucleotide phosphodiesterases. | 1991 | J. Neurochem. | pmid:1649254 |
Levine A et al. | Inhibition of promoter activity by methylation: possible involvement of protein mediators. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1650472 |
Uenoyama Y et al. | Dibutyryl cyclic AMP induces formyl peptide receptor expression and chemotactic responses in a human eosinophilic cell line, EoL-1. | 1991 | Exp. Hematol. | pmid:1651253 |
Asai S et al. | Quantitative analysis of the Epstein-Barr virus-inducing properties of short-chain fatty acids present in the culture fluids of oral bacteria. | 1991 | Arch. Virol. | pmid:1652240 |
Golub EI et al. | Induction of dormant HIV-1 by sodium butyrate: involvement of the TATA box in the activation of the HIV-1 promoter. | 1991 | AIDS | pmid:1883541 |