butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Aviram A et al. | Comparison between the effect of butyric acid and its prodrug pivaloyloxymethylbutyrate on histones hyperacetylation in an HL-60 leukemic cell line. | 1994 | Int. J. Cancer | pmid:8119779 |
Krief S et al. | Transcriptional modulation by n-butyric acid of beta 1-, beta 2-, and beta 3-adrenergic receptor balance in 3T3-F442A adipocytes. | 1994 | J. Biol. Chem. | pmid:8120022 |
Fedotov VP et al. | [The possible participation of gap junctions in the realization of the effects of stimulators of secretory processes in the hypophysis]. | 1993 | Biull Eksp Biol Med | pmid:8123822 |
Cann IK et al. | Effects of 3 chemical treatments on in vitro fermentation of rice straw by mixed rumen microbes in the presence or absence of anaerobic rumen fungi. | 1994 | Reprod. Nutr. Dev. | pmid:8129842 |
Morand C et al. | Importance of the modulation of glycolysis in the control of lactate metabolism by fatty acids in isolated hepatocytes from fed rats. | 1994 | Arch. Biochem. Biophys. | pmid:8135535 |
Lee S et al. | 1,25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion. | 1994 | Endocrinology | pmid:8137721 |
Honda J et al. | Spectroscopic observation of the intramolecular electron transfer in the photoactivation processes of nitrile hydratase. | 1994 | Biochemistry | pmid:8142355 |
Boffa LC et al. | Selective hypermethylation of transcribed nucleosomal DNA by sodium butyrate. | 1994 | Exp. Cell Res. | pmid:8143791 |
Higgins PJ and Lipkin M | Expression of plasminogen activator inhibitor type 1 (PAI-1) by HT-29di human large bowel carcinoma cells is modulated as a function of epithelial differentiation. | 1994 | Cancer Lett. | pmid:8149346 |
Schlake T et al. | Gene expression within a chromatin domain: the role of core histone hyperacetylation. | 1994 | Biochemistry | pmid:8155635 |
Duman RS et al. | Induction of beta 2-adrenergic receptor mRNA and ligand binding in HeLa cells. | 1994 | J. Recept. Res. | pmid:8158578 |
Ghibelli L et al. | A protein produced by a monocytic human cell line can induce apoptosis on tumor cells. | 1994 | FEBS Lett. | pmid:8181560 |
Goh SH et al. | Inhibition of tumour promotion by various palm-oil tocotrienols. | 1994 | Int. J. Cancer | pmid:8181855 |
Ogryzko VV et al. | Dissociation of retinoblastoma gene protein hyperphosphorylation and commitment to enter S phase. | 1994 | J. Virol. | pmid:8189510 |
Barratt MJ et al. | Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8197135 |
Sheikh MS et al. | Expression of estrogen receptors in estrogen receptor-negative human breast carcinoma cells: modulation of epidermal growth factor-receptor (EGF-R) and transforming growth factor alpha (TGF alpha) gene expression. | 1994 | J. Cell. Biochem. | pmid:8200909 |
Cairns SP and Dulhunty AF | Beta-adrenoceptor activation shows high-frequency fatigue in skeletal muscle fibers of the rat. | 1994 | Am. J. Physiol. | pmid:8203484 |
Gürtler H et al. | Acute metabolic and hormonal effects of intravenously administered sodium n-butyrate in untreated and alloxan-diabetic sheep. | 1993 | Zentralbl Veterinarmed A | pmid:8212952 |
Nakai T et al. | Changes in CA125 release and surface expression caused by drugs in uterine cervix adenocarcinoma cells. | 1993 | Ann Nucl Med | pmid:8217487 |
Gope R and Gope ML | Effect of sodium butyrate on the expression of retinoblastoma (RB1) and P53 gene and phosphorylation of retinoblastoma protein in human colon tumor cell line HT29. | 1993 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:8220069 |
Musk SR and Johnson IT | Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29. | 1993 | Carcinogenesis | pmid:8222057 |
Dimitrov S et al. | Chromatin transitions during early Xenopus embryogenesis: changes in histone H4 acetylation and in linker histone type. | 1993 | Dev. Biol. | pmid:8224538 |
Piñeiro M et al. | Transcription of mononucleosomal particles acetylated in the presence of n-butyrate. | 1993 | Mol. Biol. Rep. | pmid:8232292 |
Finnie IA et al. | Ileal and colonic epithelial metabolism in quiescent ulcerative colitis: increased glutamine metabolism in distal colon but no defect in butyrate metabolism. | 1993 | Gut | pmid:8244143 |
Roediger WE | Colonic epithelial metabolism in ulcerative colitis. | 1993 | Gut | pmid:8244158 |
Halvorsen YD et al. | Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes. | 1993 | J. Clin. Invest. | pmid:8254042 |
Planchon P et al. | Differential elimination of synthetic butyric triglycerides in vivo: a pharmacokinetic study. | 1993 | J Pharm Sci | pmid:8254490 |
Perry CA et al. | Parental nucleosomes segregated to newly replicated chromatin are underacetylated relative to those assembled de novo. | 1993 | Biochemistry | pmid:8257695 |
Karuri AR et al. | Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. | 1993 | Br. J. Cancer | pmid:8260358 |
Stark AH and Madar Z | In vitro production of short-chain fatty acids by bacterial fermentation of dietary fiber compared with effects of those fibers on hepatic sterol synthesis in rats. | 1993 | J. Nutr. | pmid:8263612 |
Fürll M et al. | [Hormonal reactions in fattening bulls and cows during a three-week butyric acid exposure]. | 1993 | Berl. Munch. Tierarztl. Wochenschr. | pmid:8267563 |
Fürll M et al. | [Effect of a three-week butyric acid exposure on the mineral metabolism and the skeletal system in cattle]. | 1993 | Berl. Munch. Tierarztl. Wochenschr. | pmid:8267564 |
Haag MM et al. | Reverse transformation and genome exposure in the C6 glial tumor cell line. | 1994 | Cancer Invest. | pmid:8281464 |
Hague A et al. | Escape from negative regulation of growth by transforming growth factor beta and from the induction of apoptosis by the dietary agent sodium butyrate may be important in colorectal carcinogenesis. | 1993 | Cancer Metastasis Rev. | pmid:8281610 |
Sperker B et al. | The expression of human plasma cholesteryl-ester-transfer protein in HepG2 cells is induced by sodium butyrate. Quantification of low mRNA levels by polymerase chain reaction. | 1993 | Eur. J. Biochem. | pmid:8281947 |
Roediger WE et al. | Sulphide impairment of substrate oxidation in rat colonocytes: a biochemical basis for ulcerative colitis? | 1993 | Clin. Sci. | pmid:8287651 |
Iwami K and Moriyama T | Effects of short chain fatty acid, sodium butyrate, on osteoblastic cells and osteoclastic cells. | 1993 | Int. J. Biochem. | pmid:8288032 |
Carraro S et al. | [Influence of sodium butyrate intake on murine colonic carcinogenesis]. | 1993 | Medicina (B Aires) | pmid:8295530 |
Dong QG et al. | Isolation of a mitomycin-resistant human lung adenocarcinoma cell subline to investigate the modulation by sodium butyrate of cell growth and drug resistance. | 1993 | Anticancer Drugs | pmid:8298162 |
Fernandez-Mejia C and Davidson MB | Effect of sodium butyrate on glucose transport and glucose-phosphorylating enzymes in RIN-m5F cells. | 1993 | Pancreas | pmid:8302795 |
Steinhart AH et al. | Treatment of refractory ulcerative proctosigmoiditis with butyrate enemas. | 1994 | Am. J. Gastroenterol. | pmid:8304299 |
Yabushita H and Sartorelli AC | Effects of sodium butyrate, dimethylsulfoxide and dibutyryl cAMP on the poorly differentiated ovarian adenocarcinoma cell line AMOC-2. | 1993 | Oncol. Res. | pmid:8305743 |
Chapman MA et al. | Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis. | 1994 | Gut | pmid:8307454 |
Bartram HP et al. | Proliferation of human colonic mucosa as an intermediate biomarker of carcinogenesis: effects of butyrate, deoxycholate, calcium, ammonia, and pH. | 1993 | Cancer Res. | pmid:8324739 |
Souleimani A and Asselin C | Regulation of c-myc expression by sodium butyrate in the colon carcinoma cell line Caco-2. | 1993 | FEBS Lett. | pmid:8325387 |
Komatsu N et al. | Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7. | 1993 | Blood | pmid:8329702 |
Cremer JE et al. | The influence of portocaval anastomosis on the metabolism of labelled octanoate, butyrate and leucine in rat brain. | 1977 | J. Neurochem. | pmid:833594 |
Murray NR et al. | Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that beta II protein kinase C is required for proliferation. | 1993 | J. Biol. Chem. | pmid:8340409 |
Taggart M and Wray S | Simultaneous measurement of intracellular pH and contraction in uterine smooth muscle. | 1993 | Pflugers Arch. | pmid:8351202 |
Mollinedo F et al. | Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes. | 1993 | Biochem. J. | pmid:8363564 |
Calabresse C et al. | Butyric acid and its monosaccharide ester induce apoptosis in the HL-60 cell line. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8363611 |
Wiekowski M et al. | Requirements for promoter activity in mouse oocytes and embryos distinguish paternal pronuclei from maternal and zygotic nuclei. | 1993 | Dev. Biol. | pmid:8365573 |
Schmidt JE and Ahring BK | Effects of hydrogen and formate on the degradation of propionate and butyrate in thermophilic granules from an upflow anaerobic sludge blanket reactor. | 1993 | Appl. Environ. Microbiol. | pmid:8368842 |
Laughlin MA et al. | Sodium butyrate treatment of cells latently infected with HIV-1 results in the expression of unspliced viral RNA. | 1993 | Virology | pmid:8372431 |
Barnard JA and Warwick G | Butyrate rapidly induces growth inhibition and differentiation in HT-29 cells. | 1993 | Cell Growth Differ. | pmid:8373733 |
Nishina Y et al. | The induction of jun genes during the reversible changes induced with sodium butyrate on the differentiation of F9 cells. | 1993 | Exp. Cell Res. | pmid:8375477 |
Griner RD et al. | The role of short chain fatty acid substrates in aerobic and glycolytic metabolism in primary cultures of renal proximal tubule cells. | 1993 | In Vitro Cell. Dev. Biol. Anim. | pmid:8376317 |
Heruth DP et al. | Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells. | 1993 | J. Biol. Chem. | pmid:8376401 |
Darcy-Vrillon B et al. | Metabolic characteristics of pig colonocytes after adaptation to a high fiber diet. | 1993 | J. Nutr. | pmid:8381478 |
Gaudet SJ et al. | Differential regulation of arylamine and arylalkylamine N-acetyltransferases in human retinoblastoma (Y-79) cells. | 1993 | Neurochem. Int. | pmid:8382984 |
Datti A and Dennis JW | Regulation of UDP-GlcNAc:Gal beta 1-3GalNAc-R beta 1-6-N-acetylglucosaminyltransferase (GlcNAc to GalNAc) in Chinese hamster ovary cells. | 1993 | J. Biol. Chem. | pmid:8383671 |
Wind JC et al. | Stimulation of calcitonin/CGRP-I and CGRP-II gene expression by dibutyryl cAMP in a human medullary thyroid carcinoma (TT) cell line. | 1993 | Mol. Cell. Endocrinol. | pmid:8386116 |
Sakamoto K et al. | Relative mitogenic activities of wild-type and retinoblastoma binding-defective SV40 T antigens in serum-deprived and senescent human diploid fibroblasts. | 1993 | Oncogene | pmid:8390037 |
Khan MZ et al. | Induction of phenotypic changes in SCLC cell lines in vitro by hexamethylene bisacetamide, sodium butyrate, and cyclic AMP. | 1993 | Ann. Oncol. | pmid:8394737 |
Rius C et al. | Differential modulation of the expression of the intermediate filament proteins vimentin and nuclear lamins A and C by differentiation inducers in human myeloid leukemia (U-937, HL-60) cells. | 1993 | Exp. Cell Res. | pmid:8395394 |
Telfer JF and Green CD | Placental alkaline phosphatase activity is inversely related to cell growth rate in HeLaS3 cervical cancer cells. | 1993 | FEBS Lett. | pmid:8396040 |
Hague A et al. | Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. | 1993 | Int. J. Cancer | pmid:8397167 |
Salvador V et al. | Sugar composition of dietary fibre and short-chain fatty acid production during in vitro fermentation by human bacteria. | 1993 | Br. J. Nutr. | pmid:8399101 |
Polack A et al. | Regulatory elements in the immunoglobulin kappa locus induce c-myc activation and the promoter shift in Burkitt's lymphoma cells. | 1993 | EMBO J. | pmid:8404859 |
Wischmeyer P et al. | Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study. | 1993 | Mayo Clin. Proc. | pmid:8412364 |
Diener M et al. | Effect of short-chain fatty acids on cell volume and intracellular pH in rat distal colon. | 1993 | Pflugers Arch. | pmid:8414909 |
Dohi T et al. | Induction of the fundic mucosa-specific glycolipid with dimethylformamide in gastric-cancer cell lines. | 1993 | Int. J. Cancer | pmid:8416198 |
Sommerville J et al. | Histone H4 acetylation and transcription in amphibian chromatin. | 1993 | J. Cell Biol. | pmid:8421048 |
Herz F | Divergent effects of butyrate on the alkaline phosphatases of SW-620 cells. | 1993 | Biochim. Biophys. Acta | pmid:8422435 |
Blau CA et al. | Fetal hemoglobin induction with butyric acid: efficacy and toxicity. | 1993 | Blood | pmid:8422469 |
Gerharz CD et al. | Modulation of invasive potential in different clonal subpopulations of a rat rhabdomyosarcoma cell line (BA-HAN-1) by differentiation induction. | 1993 | Clin. Exp. Metastasis | pmid:8422707 |
Gálfi P et al. | Influences of extracellular matrix components on the growth and differentiation of ruminal epithelial cells in primary culture. | 1993 | Res. Vet. Sci. | pmid:8434137 |
Saito H et al. | Effect of butyric acid on induction of differentiation into eosinophil-like cells in human eosinophilic leukemia cells, EoL-1 cell line: possible role of granulocyte-macrophage colony-stimulating factor as an autocrine differentiating factor. | 1993 | Int. Arch. Allergy Immunol. | pmid:8453311 |
Utesch D et al. | Effects of sodium butyrate on DNA content, glutathione S-transferase activities, cell morphology and growth characteristics of rat liver nonparenchymal epithelial cells in vitro. | 1993 | Carcinogenesis | pmid:8453722 |
Iwai SA et al. | Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction. | 1993 | Exp. Cell Res. | pmid:8453995 |
Gill RK and Christakos S | Identification of sequence elements in mouse calbindin-D28k gene that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible responses. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8464915 |
Lea MA et al. | Butyramide and monobutyrin: growth inhibitory and differentiating agents. | 1993 Jan-Feb | Anticancer Res. | pmid:8476205 |
Van Lier JB et al. | Effects of acetate, propionate, and butyrate on the thermophilic anaerobic degradation of propionate by methanogenic sludge and defined cultures. | 1993 | Appl. Environ. Microbiol. | pmid:8476278 |
Hume ID et al. | Acetate, butyrate and proline uptake in the caecum and colon of prairie voles (Microtus ochrogaster). | 1993 | J. Exp. Biol. | pmid:8478602 |
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Huhtanen P et al. | Effect of increasing ruminal butyrate on milk yield and blood constituents in dairy cows fed a grass silage-based diet. | 1993 | J. Dairy Sci. | pmid:8486840 |
Kight CE and Fleming SE | Nutrient oxidation by rat intestinal epithelial cells is concentration dependent. | 1993 | J. Nutr. | pmid:8487099 |
Sjöholm A | Sodium butyrate inhibits rat insulinoma cell proliferation without affecting the cellular insulin content or insulin release. | 1993 | Anticancer Drugs | pmid:8490204 |
Yanagi S et al. | Sodium butyrate inhibits the enhancing effect of high fat diet on mammary tumorigenesis. | 1993 Jul-Aug | Oncology | pmid:8497370 |
Ford R et al. | Modulation of SPARC expression during butyrate-induced terminal differentiation of cultured human keratinocytes: regulation via a TGF-beta-dependent pathway. | 1993 | Exp. Cell Res. | pmid:8500547 |
Souleimani A and Asselin C | Regulation of C-fos expression by sodium butyrate in the human colon carcinoma cell line Caco-2. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8503924 |
Zon LI et al. | Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. | 1993 | Blood | pmid:8507862 |
Desai TK et al. | Potentiation of butyrate-induced differentiation in human colon tumor cells by deoxycholate. | 1993 | Cancer Lett. | pmid:8513444 |
Khochbin S and Wolffe AP | Developmental regulation and butyrate-inducible transcription of the Xenopus histone H1(0) promoter. | 1993 | Gene | pmid:8514185 |
Petit JM et al. | mdr 1 gene-expression and villin synthesis in a colon cancer cell line differentiated by sodium butyrate. | 1993 Mar-Apr | Anticancer Res. | pmid:8517666 |
Afonso RodrÃguez JJ et al. | [Cytometric study of colonic tumors in a model of experimental colonic cancer. Impact of the diet]. | 1995 Sep-Oct | Nutr Hosp | pmid:8519854 |
Oda S et al. | Insulin and glucagon secretion in goats (Capra hircus Linnaeus) exposed to cold. | 1995 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:8521249 |
Brill S et al. | Maturation-dependent changes in the regulation of liver-specific gene expression in embryonal versus adult primary liver cultures. | 1995 | Differentiation | pmid:8522072 |
Kvale D and Brandtzaeg P | Butyrate differentially affects constitutive and cytokine-induced expression of HLA molecules, secretory component (SC), and ICAM-1 in a colonic epithelial cell line (HT-29, clone m3). | 1995 | Adv. Exp. Med. Biol. | pmid:8525902 |
Olsen JC and Sechelski J | Use of sodium butyrate to enhance production of retroviral vectors expressing CFTR cDNA. | 1995 | Hum. Gene Ther. | pmid:8527478 |