butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Reijnders D et al. | Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial. | 2016 | Cell Metab. | pmid:27411009 |
Venkataraman A et al. | Variable responses of human microbiomes to dietary supplementation with resistant starch. | 2016 | Microbiome | pmid:27357127 |
Liang B and Fang J | Postnatal Isoflurane Exposure Induces Cognitive Impairment and Abnormal Histone Acetylation of Glutamatergic Systems in the Hippocampus of Adolescent Rats. | 2016 | J. Mol. Neurosci. | pmid:27307148 |
Lee J et al. | Deciphering Clostridium tyrobutyricum Metabolism Based on the Whole-Genome Sequence and Proteome Analyses. | 2016 | MBio | pmid:27302759 |
Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
Rephaeli A et al. | Bi-functional prodrugs of 5-aminolevulinic acid and butyric acid increase erythropoiesis in anemic mice in an erythropoietin-independent manner. | 2016 | Eur J Pharm Sci | pmid:27283485 |
Sun J et al. | Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. | 2016 | Neurosci. Lett. | pmid:26957230 |
Su CL et al. | Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression. | 2016 | J Psychiatr Res | pmid:26921875 |
Tanaka S et al. | Relationship of Enhanced Butyrate Production by Colonic Butyrate-Producing Bacteria to Immunomodulatory Effects in Normal Mice Fed an Insoluble Fraction of Brassica rapa L. | 2016 | Appl. Environ. Microbiol. | pmid:26921420 |
Donovan JD et al. | Volatile Retention and Morphological Properties of Microencapsulated Tributyrin Varied by Wall Material and Drying Method. | 2016 | J. Food Sci. | pmid:26878682 |
Wang ZT et al. | Histone deacetylase inhibitors suppress mutant p53 transcription via HDAC8/YY1 signals in triple negative breast cancer cells. | 2016 | Cell. Signal. | pmid:26876786 |
Zounr RA et al. | Improved Gas Chromatographic Determination of Guanidino Compounds Using Isovaleroylacetone and Ethyl Chloroformate as Derivatizing Reagents. | 2016 | Anal Sci | pmid:26860556 |
Wang J et al. | Therapeutic Effect of Histone Deacetylase Inhibitor, Sodium Butyrate, on Allergic Rhinitis In Vivo. | 2016 | DNA Cell Biol. | pmid:26859163 |
Ziegler K et al. | Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4). | 2016 | Arch. Biochem. Biophys. | pmid:26854723 |
Tao Y et al. | Production of Butyrate from Lactate by a Newly Isolated Clostridium sp. BPY5. | 2016 | Appl. Biochem. Biotechnol. | pmid:26842597 |
Heidor R et al. | The chemopreventive activity of butyrate-containing structured lipids in experimental rat hepatocarcinogenesis. | 2016 | Mol Nutr Food Res | pmid:26548572 |
Cueno ME et al. | Periodontal disease level-butyric acid amounts locally administered in the rat gingival mucosa induce ER stress in the systemic blood. | 2016 | Microb. Pathog. | pmid:26541671 |
Sergeev E et al. | Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands. | 2016 | J. Biol. Chem. | pmid:26518871 |
Curren J et al. | Identification and quantification of nuisance odors at a trash transfer station. | 2016 | Waste Manag | pmid:27692531 |
Han M et al. | Dietary grape seed proanthocyanidins (GSPs) improve weaned intestinal microbiota and mucosal barrier using a piglet model. | 2016 | Oncotarget | pmid:27880936 |
Karthikeyan OP et al. | Hydrolysis-acidogenesis of food waste in solid-liquid-separating continuous stirred tank reactor (SLS-CSTR) for volatile organic acid production. | 2016 | Bioresour. Technol. | pmid:26512860 |
Youn YS et al. | Molecular tuning of amino acids to form two-dimensional molecular networks driven by conformational preorganization. | 2016 | Chem. Commun. (Camb.) | pmid:27858018 |
MartÃn Juárez J et al. | Saccharification of microalgae biomass obtained from wastewater treatment by enzymatic hydrolysis. Effect of alkaline-peroxide pretreatment. | 2016 | Bioresour. Technol. | pmid:27372005 |
Khan S and Jena G | Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin. | 2016 | Chem. Biol. Interact. | pmid:27270450 |
Grimaldi R et al. | Fermentation properties and potential prebiotic activity of Bimuno® galacto-oligosaccharide (65 % galacto-oligosaccharide content) on in vitro gut microbiota parameters. | 2016 | Br. J. Nutr. | pmid:27267934 |
Bencsik R et al. | Improved transgene expression in doxycycline-inducible embryonic stem cells by repeated chemical selection or cell sorting. | 2016 | Stem Cell Res | pmid:27591479 |
Han R et al. | Sodium Butyrate Upregulates miR-203 Expression to Exert Anti-Proliferation Effect on Colorectal Cancer Cells. | 2016 | Cell. Physiol. Biochem. | pmid:27771718 |
Polak U et al. | Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming. | 2016 | Stem Cells Dev. | pmid:27615158 |
Chen WS et al. | Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats. | 2016 | Brain Res. | pmid:27742468 |
Miao W et al. | Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCβ2. | 2016 | Int J Mol Sci | pmid:27735862 |
Ain QU et al. | Analysis of Differential Efficacy and Affinity of GABA (α1/α2) Selective Modulators. | 2016 | Mol. Pharm. | pmid:27704838 |
Sun H et al. | Effects of addition of Aspergillus oryzae culture and 2-hydroxyl-4-(methylthio) butanoic acid on milk performance and rumen fermentation of dairy cows. | 2017 | Anim. Sci. J. | pmid:27506446 |
Wang Y et al. | A Co-Drug of Butyric Acid Derived from Fermentation Metabolites of the Human Skin Microbiome Stimulates Adipogenic Differentiation of Adipose-Derived Stem Cells: Implications in Tissue Augmentation. | 2017 | J. Invest. Dermatol. | pmid:27498050 |
Zhu J et al. | Sodium butyrate modulates a methamphetamine-induced conditioned place preference. | 2017 | J. Neurosci. Res. | pmid:27426635 |
Liangzhan S et al. | Effect of substitution of oat hulls for traditional fiber source on digestion and performance of fattening rabbits. | 2017 | Animal | pmid:27821223 |
Zhang Q et al. | Histone acetylation and reactive oxygen species are involved in the preprophase arrest induced by sodium butyrate in maize roots. | 2017 | Protoplasma | pmid:26781092 |
Kamphayae S et al. | Effects of graded levels of liquid brewer's yeast on chemical composition and fermentation quality in cassava pulp and rice straw-based total mixed ration silage. | 2017 | Anim. Sci. J. | pmid:27611881 |
Gulfam A et al. | Characteristics of lactic acid bacteria isolates and their effect on the fermentation quality of Napier grass silage at three high temperatures. | 2017 | J. Sci. Food Agric. | pmid:27539868 |
Machado CF et al. | Conditional Deletion of in Olfactory Sensory Neurons Leads to Olfactory Impairment. | 2017 | J. Neurosci. | pmid:29118104 |
Kobayashi H et al. | Clostridium pabulibutyricum sp. nov., a butyric-acid-producing organism isolated from high-moisture grass silage. | 2017 | Int. J. Syst. Evol. Microbiol. | pmid:29034861 |
Du H et al. | Exploring the microbial origins of p-cresol and its co-occurrence pattern in the Chinese liquor-making process. | 2017 | Int. J. Food Microbiol. | pmid:28843121 |
Wu T et al. | Anthocyanins in black rice, soybean and purple corn increase fecal butyric acid and prevent liver inflammation in high fat diet-induced obese mice. | 2017 | Food Funct | pmid:28792056 |
Berni Canani R et al. | Specific Signatures of the Gut Microbiota and Increased Levels of Butyrate in Children Treated with Fermented Cow's Milk Containing Heat-Killed Lactobacillus paracasei CBA L74. | 2017 | Appl. Environ. Microbiol. | pmid:28733284 |
Pelgrim CE et al. | Butyrate Reduces HFD-Induced Adipocyte Hypertrophy and Metabolic Risk Factors in Obese LDLr-/-.Leiden Mice. | 2017 | Nutrients | pmid:28686216 |
Tsung AJ et al. | Methylation regulates HEY1 expression in glioblastoma. | 2017 | Oncotarget | pmid:28574840 |
Tylichová Z et al. | Activation of autophagy and PPARγ protect colon cancer cells against apoptosis induced by interactive effects of butyrate and DHA in a cell type-dependent manner: The role of cell differentiation. | 2017 | J. Nutr. Biochem. | pmid:27840291 |
Owusu BY and Klampfer L | Modulation of STAT1-Driven Transcriptional Activity by Histone Deacetylases. | 2017 | Methods Mol. Biol. | pmid:27761828 |
Andersen AD et al. | Supplementation with Lactobacillus paracasei or Pediococcus pentosaceus does not prevent diarrhoea in neonatal pigs infected with Escherichia coli F18. | 2017 | Br. J. Nutr. | pmid:28720151 |
Hrgovic I et al. | Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism. | 2017 | Exp. Dermatol. | pmid:27487811 |
Yokoyama Y et al. | Profile of preoperative fecal organic acids closely predicts the incidence of postoperative infectious complications after major hepatectomy with extrahepatic bile duct resection: Importance of fecal acetic acid plus butyric acid minus lactic acid gap. | 2017 | Surgery | pmid:28684159 |
Hofmanová J et al. | Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities. | 2017 | Eur J Nutr | pmid:26983609 |
Anantharaju PG et al. | Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC). | 2017 | PLoS ONE | pmid:29190639 |
Seifrtová M et al. | Haemanthamine alters sodium butyrate-induced histone acetylation, p21 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. | 2017 | Phytomedicine | pmid:28991639 |
Sałkowska A et al. | Differentiation stage-specific effect of histone deacetylase inhibitors on the expression of RORγT in human lymphocytes. | 2017 | J. Leukoc. Biol. | pmid:28951421 |
Wu Q et al. | Tailoring the Oxidative Stress Tolerance of Clostridium tyrobutyricum CCTCC W428 by Introducing Trehalose Biosynthetic Capability. | 2017 | J. Agric. Food Chem. | pmid:28925260 |
Sanz M et al. | Namalides B and C and Spumigins K-N from the Cultured Freshwater Cyanobacterium Sphaerospermopsis torques-reginae. | 2017 | J. Nat. Prod. | pmid:28876933 |
Górka P et al. | Effect of butyrate infusion into the rumen on butyrate flow to the duodenum, selected gene expression in the duodenum epithelium, and nutrient digestion in sheep. | 2017 | J. Anim. Sci. | pmid:28726987 |
Chang PJ et al. | Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. | 2017 | J. Virol. | pmid:28701396 |
Ito T et al. | Occurrence of the (2R,3S)-Isomer of 2-Amino-3,4-dihydroxybutanoic Acid in the Mushroom Hypsizygus marmoreus. | 2017 | J. Agric. Food Chem. | pmid:28686838 |
Chen X et al. | Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway. | 2017 | Biochem. Pharmacol. | pmid:28684304 |
Yan H and Ajuwon KM | Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. | 2017 | PLoS ONE | pmid:28654658 |
Batlle-Vilanova P et al. | Microbial electrosynthesis of butyrate from carbon dioxide: Production and extraction. | 2017 | Bioelectrochemistry | pmid:28633067 |
Asquith M et al. | Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis. | 2017 | pmid:28622455 | |
Lucchetti D et al. | Differentiation Affects the Release of Exosomes from Colon Cancer Cells and Their Ability to Modulate the Behavior of Recipient Cells. | 2017 | Am. J. Pathol. | pmid:28619275 |
Meenongyai W et al. | Effects of forage ensiling and ration fermentation on total mixed ration pH, ruminal fermentation and performance of growing Holstein-Zebu cross steers. | 2017 | Anim. Sci. J. | pmid:28370998 |
Lu N et al. | Butyric acid regulates progesterone and estradiol secretion via cAMP signaling pathway in porcine granulosa cells. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28602959 |
Zheng ML et al. | Dynamics of microbial community during ensiling direct-cut alfalfa with and without LAB inoculant and sugar. | 2017 | J. Appl. Microbiol. | pmid:28370869 |
Kumar P et al. | Inhibition of HDAC enhances STAT acetylation, blocks NF-κB, and suppresses the renal inflammation and fibrosis in haplotype male mice. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28566502 |
Suo Y et al. | Enhanced butyric acid tolerance and production by Class I heat shock protein-overproducing Clostridium tyrobutyricum ATCC 25755. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:28439766 |
Arriaga JM et al. | Metallothionein 1G promotes the differentiation of HT-29 human colorectal cancer cells. | 2017 | Oncol. Rep. | pmid:28393194 |
Foote AP et al. | Effect of abomasal butyrate infusion on gene expression in the duodenum of lambs. | 2017 | J. Anim. Sci. | pmid:28380531 |
Paiva I et al. | Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage. | 2017 | Hum. Mol. Genet. | pmid:28369321 |
Lynch H et al. | Investigation of in-feed organic acids as a low cost strategy to combat Salmonella in grower pigs. | 2017 | Prev. Vet. Med. | pmid:28364832 |
Fu H et al. | Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing xylose catabolism genes for glucose and xylose co-utilization. | 2017 | Bioresour. Technol. | pmid:28343058 |
Kim YH and Lee JK | Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression. | 2017 | Cell. Immunol. | pmid:28341057 |
Egawa G et al. | SCFAs Control Skin Immune Responses via Increasing Tregs. | 2017 | J. Invest. Dermatol. | pmid:28340682 |
Olsen S | Effects of ultra-high dilutions of sodium butyrate on viability and gene expression in HEK 293 cells. | 2017 | Homeopathy | pmid:28325222 |
Zhang J et al. | Metabolic engineering of Clostridium tyrobutyricum for n-butanol production from sugarcane juice. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28238080 |
Mathew MP et al. | Glycoengineering of Esterase Activity through Metabolic Flux-Based Modulation of Sialic Acid. | 2017 | Chembiochem | pmid:28218815 |
Maeshige N et al. | Low-Intensity Ultrasound Enhances Histone Acetylation and Inhibition of Interleukin 6 Messenger RNA Expression by the Histone Deacetylase Inhibitor Sodium Butyrate in Fibroblasts. | 2017 | J Ultrasound Med | pmid:28195362 |
Yoo M et al. | Metabolic flexibility of a butyrate pathway mutant of Clostridium acetobutylicum. | 2017 | Metab. Eng. | pmid:28159643 |
Chen C et al. | Use of Acetate, Propionate, and Butyrate for Reduction of Nitrate and Sulfate and Methanogenesis in Microcosms and Bioreactors Simulating an Oil Reservoir. | 2017 | Appl. Environ. Microbiol. | pmid:28130297 |
Nakazawa A et al. | Evaluation of Adsorption Characteristics of a Fibrous Adsorbent Containing Zwitter-Ionic Functional Group, Targeting Organic Acids. | 2017 | J. UOEH | pmid:28331124 |
Zhang L et al. | Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice. | 2017 | J. Cell. Biochem. | pmid:28109123 |
Cueno ME et al. | Periodontal disease level-butyric acid putatively contributes to the ageing blood: A proposed link between periodontal diseases and the ageing process. | 2017 | Mech. Ageing Dev. | pmid:28108180 |
Zhou D et al. | Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier. | 2017 | World J. Gastroenterol. | pmid:28104981 |
Millat T and Winzer K | Mathematical modelling of clostridial acetone-butanol-ethanol fermentation. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28210797 |
Bosmans JW et al. | Comparison of three different application routes of butyrate to improve colonic anastomotic strength in rats. | 2017 | Int J Colorectal Dis | pmid:27942836 |
Johnstone M et al. | Characterization of the Pro-Inflammatory Cytokine IL-1β on Butyrate Oxidation in Colorectal Cancer Cells. | 2017 | J. Cell. Biochem. | pmid:27922186 |
Shirasugi M et al. | Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27914813 |
Yan JK et al. | Sodium butyrate attenuates soybean oil-based lipid emulsion-induced increase in intestinal permeability of lipopolysaccharide by modulation of P-glycoprotein in Caco-2 cells. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27888107 |
Schwarz A et al. | The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System. | 2017 | J. Invest. Dermatol. | pmid:27887954 |
Ra CH et al. | Hyper-thermal acid hydrolysis and adsorption treatment of red seaweed, Gelidium amansii for butyric acid production with pH control. | 2017 | Bioprocess Biosyst Eng | pmid:27878375 |
Herrick KJ et al. | Single-dose infusion of sodium butyrate, but not lactose, increases plasma β-hydroxybutyrate and insulin in lactating dairy cows. | 2017 | J. Dairy Sci. | pmid:27837980 |
Moens F et al. | Lactate- and acetate-based cross-feeding interactions between selected strains of lactobacilli, bifidobacteria and colon bacteria in the presence of inulin-type fructans. | 2017 | Int. J. Food Microbiol. | pmid:27810444 |
Zhang C et al. | Differential effect of early antibiotic intervention on bacterial fermentation patterns and mucosal gene expression in the colon of pigs under diets with different protein levels. | 2017 | Appl. Microbiol. Biotechnol. | pmid:27913852 |
Dong W et al. | Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC. | 2017 | J. Endocrinol. | pmid:27799462 |
Meneses-Reyes JC et al. | Biochemical methane potential of oil-extracted microalgae and glycerol in co-digestion with chicken litter. | 2017 | Bioresour. Technol. | pmid:27864134 |
Zhang K et al. | Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1. | 2017 | Appl. Biochem. Biotechnol. | pmid:27832512 |
Wang YQ et al. | Enhancement of acetate productivity in a thermophilic (55 °C) hollow-fiber membrane biofilm reactor with mixed culture syngas (H/CO) fermentation. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28110397 |