butyric acid
butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with butyric acid?
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with butyric acid
PubChem Associated disorders and diseases
What pathways are associated with butyric acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with butyric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with butyric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with butyric acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with butyric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with butyric acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with butyric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Harada E and Kato S | Effect of short-chain fatty acids on the secretory response of the ovine exocrine pancreas. | 1983 | Am. J. Physiol. | pmid:6187225 |
| Mannon PJ et al. | Characterization of a Y1-preferring NPY/PYY receptor in HT-29 cells. | 1994 | Am. J. Physiol. | pmid:7977753 |
| Charney AN et al. | Nonionic diffusion of short-chain fatty acids across rat colon. | 1998 | Am. J. Physiol. | pmid:9530153 |
| Gullans SR et al. | Interactions between gluconeogenesis and sodium transport in rabbit proximal tubule. | 1984 | Am. J. Physiol. | pmid:6331176 |
| Brubaker PL et al. | Synthesis and secretion of somatostatin-28 and -14 by fetal rat intestinal cells in culture. | 1990 | Am. J. Physiol. | pmid:1694403 |
| Mailman D et al. | Villous motility and unstirred water layers in canine intestine. | 1990 | Am. J. Physiol. | pmid:2305890 |
| Sussman NL et al. | Intestinal alkaline phosphatase is secreted bidirectionally from villous enterocytes. | 1989 | Am. J. Physiol. | pmid:2546440 |
| Nichols KV et al. | Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung. | 1990 | Am. J. Physiol. | pmid:2175559 |
| Dagher PC et al. | Dissociation of colonic apical Na/H exchange activity from bulk cytoplasmic pH. | 1996 | Am. J. Physiol. | pmid:8764164 |
| Snow TR and Caspar T | Substrate dependence of myocardial response to hypoxia in the presence of theophylline. | 1983 | Am. J. Physiol. | pmid:6881369 |
| Vinolo MA et al. | Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22621868 |
| Arvans DL et al. | Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15528251 |
| Musch MW et al. | SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11254495 |
| Kiela PR et al. | Regulation of the rat NHE3 gene promoter by sodium butyrate. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557515 |
| Jørgensen J and Mortensen PB | Substrate utilization by intestinal mucosal tissue strips from patients with inflammatory bowel disease. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11447021 |
| Shie JL et al. | Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11005769 |
| Suply E et al. | Butyrate enemas enhance both cholinergic and nitrergic phenotype of myenteric neurons and neuromuscular transmission in newborn rat colon. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22492692 |
| Lal S et al. | Vagal afferent responses to fatty acids of different chain length in the rat. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557510 |
| Tyagi S et al. | Mechanism of n-butyrate uptake in the human proximal colonic basolateral membranes. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11897627 |
| Alrefai WA et al. | Molecular cloning and promoter analysis of downregulated in adenoma (DRA). | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17761837 |
| Saksena S et al. | PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19033536 |
| Subramanya SB et al. | Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17690171 |
| Fukushima K and Fiocchi C | Paradoxical decrease of mitochondrial DNA deletions in epithelial cells of active ulcerative colitis patients. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15068964 |
| Cremin JD et al. | Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12637251 |
| Kumar A et al. | Lactobacillus acidophilus counteracts enteropathogenic E. coli-induced inhibition of butyrate uptake in intestinal epithelial cells. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26272259 |
| Amin MR et al. | Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma/TNF-alpha. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17540780 |
| Xu H et al. | Sodium butyrate stimulates NHE8 expression via its role on activating NHE8 basal promoter activity. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26159698 |
| Parhar K et al. | Short-chain fatty acid mediated phosphorylation of heat shock protein 25: effects on camptothecin-induced apoptosis. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16469826 |
| Marcil V et al. | Modulation of lipid synthesis, apolipoprotein biogenesis, and lipoprotein assembly by butyrate. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12121881 |
| Schweigel M et al. | Mechanisms of Mg(2+) transport in cultured ruminal epithelial cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10712259 |
| Archer SY et al. | The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21/WAF-1-dependent mechanism in human colon cancer cells. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16160080 |
| Borthakur A et al. | Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16150873 |
| Borthakur A et al. | The probiotic Lactobacillus plantarum counteracts TNF-{alpha}-induced downregulation of SMCT1 expression and function. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20671196 |
| Srinivas SR et al. | Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17855766 |
| Cuche G et al. | Desensitization of ileal vagal receptors by short-chain fatty acids in pigs. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11292611 |
| Kolar SS et al. | Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17717041 |
| Cao Y et al. | Dietary fiber enhances TGF-β signaling and growth inhibition in the gut. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21454444 |
| Saksena S et al. | Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20501436 |
| Alrefai WA et al. | Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14525727 |
| Perry MD and Sandle GI | Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19407217 |
| Gaudier E et al. | Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15308471 |
| Venkatraman A et al. | Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappaB. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12637250 |
| Grider JR and Piland BE | The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16973914 |
| Schweigel M and Martens H | Anion-dependent Mg2+ influx and a role for a vacuolar H+-ATPase in sheep ruminal epithelial cells. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12606303 |
| Vidyasagar S et al. | Role of short-chain fatty acids in colonic HCO(3) secretion. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15677553 |
| Pawelka AJ and Huizinga JD | Induction of rhythmic transient depolarizations associated with waxing and waning of slow wave activity in intestinal smooth muscle. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25540235 |
| Hadjiagapiou C et al. | Role of USF1 and USF2 as potential repressor proteins for human intestinal monocarboxylate transporter 1 promoter. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15691871 |
| Yuan L et al. | Schlafen 3 induction by cyclic strain regulates intestinal epithelial differentiation. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299602 |
| Pender SL et al. | Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11052988 |
| Sonoyama K et al. | Upregulation of activin A gene by butyrate in human colon cancer cell lines. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12540370 |