butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Harrison PT et al. | Early changes in the forestomach of rats, mice and hamsters exposed to dietary propionic and butyric acid. | 1991 | Food Chem. Toxicol. | pmid:1874463 |
Nutting CW et al. | Vasorelaxant effects of short chain fatty acid salts in rat caudal artery. | 1991 | Am. J. Physiol. | pmid:1877681 |
Mascolo N et al. | Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon. | 1991 | Gastroenterology | pmid:2065907 |
Streutker C and Drucker DJ | Rapid induction of parathyroid hormone-like peptide gene expression by sodium butyrate in a rat islet cell line. | 1991 | Mol. Endocrinol. | pmid:2072929 |
Rezanka T et al. | Isobutyrate as a precursor of n-butyrate in the biosynthesis of tylosine and fatty acids. | 1991 | FEMS Microbiol. Lett. | pmid:1769552 |
Church DL et al. | Physiological effects of metronidazole on Clostridium pasteurianum. | 1991 | J. Antimicrob. Chemother. | pmid:1778853 |
Rephaeli A et al. | Derivatives of butyric acid as potential anti-neoplastic agents. | 1991 | Int. J. Cancer | pmid:1874573 |
Latella G and Caprilli R | Metabolism of large bowel mucosa in health and disease. | 1991 | Int J Colorectal Dis | pmid:1875122 |
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Lewandowski ED et al. | NMR studies of beta-oxidation and short-chain fatty acid metabolism during recovery of reperfused hearts. | 1991 | Am. J. Physiol. | pmid:1877663 |
Demigné C et al. | Interactions between propionate and amino acid metabolism in isolated sheep hepatocytes. | 1991 | Br. J. Nutr. | pmid:2043606 |
Kondoh N et al. | Effects of sodium butyrate on the rearranged c-myc expression in mouse plasmacytoma cells. | 1991 | Exp. Cell Res. | pmid:1879469 |
Deng MH et al. | Melatonin and its precursors in Y79 human retinoblastoma cells: effect of sodium butyrate. | 1991 | Brain Res. | pmid:1802344 |
Saito S et al. | Flow cytometric and biochemical analysis of dose-dependent effects of sodium butyrate on human endometrial adenocarcinoma cells. | 1991 | Cytometry | pmid:1794255 |
Ohtoshi T et al. | Human upper airway epithelial cell-derived granulocyte-macrophage colony-stimulating factor induces histamine-containing cell differentiation of human progenitor cells. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1959978 |
Awad AB et al. | Influence of butyrate on lipid metabolism, survival, and differentiation of colon cancer cells. | 1991 | Nutr Cancer | pmid:1796008 |
Kooistra T et al. | Stimulation of tissue-type plasminogen activator synthesis by retinoids in cultured human endothelial cells and rat tissues in vivo. | 1991 | Thromb. Haemost. | pmid:1908141 |
Lee MJ | Relationship between stool pH and butyrate levels. | 1991 | Nutr Cancer | pmid:1796010 |
Thakur MK and Prasad S | Analysis of age-associated alteration in the synthesis of HMG nonhistone proteins of the rat liver. | 1991 | Mol. Biol. Rep. | pmid:1908550 |
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Howard MA et al. | Effect of butyrate and corticosteroids on retinoblastoma in vitro and in vivo. | 1991 | Invest. Ophthalmol. Vis. Sci. | pmid:2032794 |
Bertrand-Mercat P and Pasqualini JR | Antagonistic effect of the antiestrogen 4-hydroxytamoxifen on estradiol-stimulated acetylation of nuclear high mobility group (HMG) proteins in the uterus of newborn guinea-pigs. | 1991 | Life Sci. | pmid:2034036 |
Parekh D et al. | Differential effects of sodium butyrate and hexamethylene bisacetamide on growth and secretion of cultured human endocrine tumor cells. | 1991 | Arch Surg | pmid:1706915 |
Walling JM et al. | Role of the extracellular matrix on the growth and differentiated phenotype of murine colonic adenocarcinoma cells in vitro. | 1991 | Int. J. Cancer | pmid:2004858 |
Saito H et al. | Differentiating effect of sodium butyrate on human hepatoma cell lines PLC/PRF/5, HCC-M and HCC-T. | 1991 | Int. J. Cancer | pmid:1708367 |
Pan CJ et al. | Transcriptional regulation and the effects of sodium butyrate and glycosylation on catalytic activity of human germ cell alkaline phosphatase. | 1991 | Cancer Res. | pmid:2009524 |
Karlsen AE et al. | Effects of sodium butyrate on proliferation-dependent insulin gene expression and insulin release in glucose-sensitive RIN-5AH cells. | 1991 | J. Biol. Chem. | pmid:1708388 |
Tsukamoto A et al. | Novobiocin modulates cytokeratin assembly and differentiation of human hepatoma cells induced by butyrate and teleocidin. | 1991 | Cancer Lett. | pmid:1717136 |
Kalinich JF et al. | Radioprotective properties of DNA methylation-disrupting agents. | 1991 | Int. J. Radiat. Biol. | pmid:1710643 |
Brooks SE et al. | Effect of differentiation agents on expression of CA 125, alkaline phosphatase, and cytokeratins in human ovarian adenocarcinoma cells (OVCA 433). | 1991 | Gynecol. Oncol. | pmid:1720110 |
Tsukamoto A and Kaneko Y | Novobiocin and butyrate synergistically enhanced cytokeratin assembly and acetate uptake of human liver cells. | 1991 | Cell Biol. Int. Rep. | pmid:1723029 |
Tanaka J et al. | Sodium butyrate-inducible replication of human cytomegalovirus in a human epithelial cell line. | 1991 | Virology | pmid:1656587 |
Nuebling CM and Mueller-Lantzsch N | Identification of the gene product encoded by the PstI repeats (IR4) of the Epstein-Barr virus genome. | 1991 | Virology | pmid:1656605 |
Tonetti M et al. | Intracellular pH regulates the production of different oxygen metabolites in neutrophils: effects of organic acids produced by anaerobic bacteria. | 1991 | J. Leukoc. Biol. | pmid:1846905 |
McIntyre A et al. | Different fibers have different regional effects on luminal contents of rat colon. | 1991 | Gastroenterology | pmid:1657677 |
Donadel G et al. | Identification of a novel nuclear protein synthesized in growth-arrested human hepatoblastoma HepG2 cells. | 1991 | Eur. J. Biochem. | pmid:1847869 |
Klebe RJ et al. | Quantitative assay for morphogenesis indicates the role of extracellular matrix components and G proteins. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1658786 |
Richardson A et al. | Short chain fatty acids in the terminal ileum accelerate stomach to caecum transit time in the rat. | 1991 | Gut | pmid:2013421 |
Krajewski WA and Luchnik AN | High rotational mobility of DNA in animal cells and its modulation by histone acetylation. | 1991 | Mol. Gen. Genet. | pmid:1661371 |
Krajewski WA and Luchnik AN | Relationship of histone acetylation to DNA topology and transcription. | 1991 | Mol. Gen. Genet. | pmid:1662766 |
Hay FG et al. | Modulation of the cluster 1 and mucin antigens in human small cell lung cancer and other epithelial tumour cell lines after treatment with the differentiation inducing agent, sodium butyrate. | 1991 | Br. J. Cancer Suppl. | pmid:1645568 |
Nakai T et al. | Drug effects on CA125 antigen expression and antibody binding to cancer cells. | 1991 | Int. J. Cancer | pmid:1645702 |
Arao Y et al. | Reactivatable latency of three avirulent strains of herpes simplex virus type 1 after intranasal inoculation in mice. | 1991 | Acta Med. Okayama | pmid:1648298 |
Granitzer M and Steels P | Role of Na+/K+ exchange and organic acids in base induced hyperpolarization of renal proximal amphibian tubule. | 1991 | Biochim. Biophys. Acta | pmid:1648393 |
Mitsui K et al. | Multiple neurite formation in neuroblastoma cell lines by griseolic acid, a potent inhibitor of cyclic nucleotide phosphodiesterases. | 1991 | J. Neurochem. | pmid:1649254 |
Levine A et al. | Inhibition of promoter activity by methylation: possible involvement of protein mediators. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1650472 |
Uenoyama Y et al. | Dibutyryl cyclic AMP induces formyl peptide receptor expression and chemotactic responses in a human eosinophilic cell line, EoL-1. | 1991 | Exp. Hematol. | pmid:1651253 |
Asai S et al. | Quantitative analysis of the Epstein-Barr virus-inducing properties of short-chain fatty acids present in the culture fluids of oral bacteria. | 1991 | Arch. Virol. | pmid:1652240 |
Rius C et al. | Comparative effects of butyrate and N6, 2'-O-dibutyryladenosine-3':5'-cyclic monophosphate on growth, differentiation and gene expression in U937 human monoblastoid cells. | 1991 | Biochem. Int. | pmid:1652247 |
Ahmed N et al. | The human promyelocytic HL60 cell line: a model of myeloid cell differentiation using dimethylsulphoxide, phorbol ester and butyrate. | 1991 | Biochem. Int. | pmid:1652248 |
Goto H et al. | Effects of parathyroid hormone on ornithine decarboxylase activity in human osteosarcoma cells. | 1991 | Arch. Biochem. Biophys. | pmid:1654784 |
Thomsen B et al. | Histone hyperacetylation is accompanied by changes in DNA topology in vivo. | 1991 | Eur. J. Biochem. | pmid:1655426 |
O'Shea JJ et al. | Expression of v-src in a murine T-cell hybridoma results in constitutive T-cell receptor phosphorylation and interleukin 2 production. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2000381 |
Kosaka M et al. | Reversible effects of sodium butyrate on the differentiation of F9 embryonal carcinoma cells. | 1991 | Exp. Cell Res. | pmid:1898593 |
Sandvig K et al. | Endocytosis and intracellular transport of the glycolipid-binding ligand Shiga toxin in polarized MDCK cells. | 1991 | J. Cell Biol. | pmid:1901867 |
Fleming SE et al. | Nutrient utilization by cells isolated from rat jejunum, cecum and colon. | 1991 | J. Nutr. | pmid:1903440 |
Goya L and Timiras PS | Characterization of nuclear T3 receptors in human neuroblastoma cells SH-SY5Y: effect of differentiation with sodium butyrate and nerve growth factor. | 1991 | Neurochem. Res. | pmid:1679204 |
Tisdale EJ et al. | Sodium butyrate causes reexpression of three membrane proteins on glycolipid-anchoring mutants. | 1991 | Somat. Cell Mol. Genet. | pmid:1679568 |
Levine GM and Rosenthal J | Effects of fiber-containing liquid diets on colonic structure and function in the rat. | 1991 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:1658409 |
Wilson JR and Weiser MM | Colonic cancer cell (HT29) adhesion to laminin is altered by differentiation: adhesion may involve galactosyltransferase. | 1992 | Exp. Cell Res. | pmid:1639132 |
Hertzberg S et al. | Alginate as immobilization matrix and stabilizing agent in a two-phase liquid system: application in lipase-catalysed reactions. | 1992 | Enzyme Microb. Technol. | pmid:1367810 |
Yamada K et al. | Effects of butyrate on cell cycle progression and polyploidization of various types of mammalian cells. | 1992 | Biosci. Biotechnol. Biochem. | pmid:1368839 |
Witte MM et al. | Repression of SV40 T oncoprotein expression by DMSO. | 1992 | J. Cell. Physiol. | pmid:1373148 |
Tsukamoto A et al. | Increased assembly of cytoskeletal proteins associated with the transformation of human liver cells into fibroblast-like cells. | 1992 | Experientia | pmid:1376281 |
Dyson JE et al. | The effect of sodium butyrate on the growth characteristics of human cervix tumour cells. | 1992 | Br. J. Cancer | pmid:1377482 |
Rius C and Aller P | Vimentin expression as a late event in the in vitro differentiation of human promonocytic cells. | 1992 | J. Cell. Sci. | pmid:1352781 |
Bates SE et al. | Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate. | 1992 | Biochemistry | pmid:1352990 |
Gentile V et al. | Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: effects on cellular morphology and adhesion. | 1992 | J. Cell Biol. | pmid:1356992 |
Johnston LA et al. | Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogenin. | 1992 | Mol. Cell. Biol. | pmid:1328872 |
Le Ruyet P et al. | Influence of dietary fiber and buffer value index on the ruminal milieu of lactating dairy cows. | 1992 | J. Dairy Sci. | pmid:1333496 |
Tucker WB et al. | Sodium bicarbonate or multielement buffer via diet or rumen: effects on performance and acid-base status of lactating cows. | 1992 | J. Dairy Sci. | pmid:1333497 |
Watanabe T et al. | Alteration of phosphotyrosine-containing proteins at the early stage of erythroid differentiation of mouse erythroleukemia (MEL) cells. | 1992 | J. Biol. Chem. | pmid:1380959 |
Bruce JH et al. | Effects of cyclic AMP and butyrate on cell cycle, DNA, RNA, and purine synthesis of cultured astrocytes. | 1992 | Neurochem. Res. | pmid:1381055 |
Biard DS et al. | Flow cytometric detection of drugs altering the DNA methylation pattern. | 1992 | Cancer Res. | pmid:1382840 |
Sklan D et al. | Fatty acids, calcium soaps of fatty acids, and cottonseeds fed to high yielding cows. | 1992 | J. Dairy Sci. | pmid:1452851 |
Tung RS et al. | In vitro effects of the thiopeptide A10255 on ruminal fermentation and microbial populations. | 1992 | J. Dairy Sci. | pmid:1452854 |
Kato M et al. | Effect of hyperosmolality on alkaline phosphatase and stress-response protein 27 of MCF-7 breast cancer cells. | 1992 | Breast Cancer Res. Treat. | pmid:1463864 |
Grünberg J et al. | Proteolytic processing of human intestinal lactase-phlorizin hydrolase precursor is not a prerequisite for correct sorting in Madin Darby canine kidney (MDCK) cells. | 1992 | FEBS Lett. | pmid:1468552 |
Helliger W et al. | Alteration in proportions of histone H1 variants during the differentiation of murine erythroleukaemic cells. | 1992 | Biochem. J. | pmid:1471988 |
Garsetti D et al. | Butyric acid-induced differentiation of HL-60 cells increases the expression of a single lysophospholipase. | 1992 | Biochem. J. | pmid:1471998 |
Lutter LC et al. | Effects of histone acetylation on chromatin topology in vivo. | 1992 | Mol. Cell. Biol. | pmid:1406675 |
Chiofalo V et al. | Influence of the method of forage conservation on feeding behaviour, intake and characteristics of reticulo-rumen content, in sheep fed ad libitum. | 1992 | Reprod. Nutr. Dev. | pmid:1418399 |
Suzuki M et al. | [Production of CA125 in cell lines derived from human ovarian carcinoma: in relation to the cell cycle]. | 1992 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:1506733 |
deFazio A et al. | Effect of sodium butyrate on estrogen receptor and epidermal growth factor receptor gene expression in human breast cancer cell lines. | 1992 | J. Biol. Chem. | pmid:1517234 |
Seagrave JC et al. | Intracellular pH changes induced by exposure to weak acids and bases in submandibular cells of early postnatal rats. | 1992 | Arch. Oral Biol. | pmid:1384459 |
Jesse BW et al. | Palmitate metabolism by isolated sheep rumen epithelial cells. | 1992 | J. Anim. Sci. | pmid:1644697 |
Perey L et al. | Effects of differentiating agents on cell surface expression of the breast carcinoma-associated DF3-P epitope. | 1992 | Cancer Res. | pmid:1384960 |
Reynolds CK et al. | Effects of mesenteric vein n-butyrate infusion on liver metabolism by beef steers. | 1992 | J. Anim. Sci. | pmid:1644699 |
McDonagh KT et al. | Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate. | 1992 | Exp. Hematol. | pmid:1385194 |
Takeda M et al. | Teratocarcinoma F9 cells induced to differentiate with sodium butyrate produce both tissue-type and urokinase-type plasminogen activators. | 1992 | J. Cell. Biochem. | pmid:1644865 |
Johnson JA | L-carnitine for treatment of distal ulcerative colitis. | 1992 | Gastroenterology | pmid:1426898 |
Rowley PT et al. | Single K562 human leukemia cells express and are inducible for both erythroid and megakaryocytic antigens. | 1992 | Int. J. Cell Cloning | pmid:1645031 |
Nudelman A et al. | Novel anticancer prodrugs of butyric acid. 2. | 1992 | J. Med. Chem. | pmid:1542095 |
Chow JC and Jesse BW | Interactions between gluconeogenesis and fatty acid oxidation in isolated sheep hepatocytes. | 1992 | J. Dairy Sci. | pmid:1401366 |
Yeivin A et al. | Sodium butyrate selectively induces transcription of promoters adjacent to the MoMSV viral enhancer. | 1992 | Gene | pmid:1634113 |
Morimoto T et al. | Conversion of mitochondrial redox state toward oxidation by prostacyclin in 70%-hepatectomized rats. | 1992 | Res Exp Med (Berl) | pmid:1636060 |
Roediger WE | Oxidative and synthetic functions of n-Butyrate in colonocytes. | 1992 | Dis. Colon Rectum | pmid:1568404 |
Collins JF et al. | c-myc antisense oligonucleotides inhibit the colony-forming capacity of Colo 320 colonic carcinoma cells. | 1992 | J. Clin. Invest. | pmid:1569190 |
Gamet L et al. | Effects of short-chain fatty acids on growth and differentiation of the human colon-cancer cell line HT29. | 1992 | Int. J. Cancer | pmid:1521915 |