butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Gargari G et al. | Consumption of a Bifidobacterium bifidum Strain for 4 Weeks Modulates Dominant Intestinal Bacterial Taxa and Fecal Butyrate in Healthy Adults. | 2016 | Appl. Environ. Microbiol. | pmid:27451450 |
Teixeira C et al. | Effects of variety and steeping conditions on some barley components associated with colonic health. | 2016 | J. Sci. Food Agric. | pmid:27450418 |
Zhou J et al. | Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats. | 2016 | Lipids Health Dis | pmid:27449927 |
Astakhova L et al. | Short Chain Fatty Acids (SCFA) Reprogram Gene Expression in Human Malignant Epithelial and Lymphoid Cells. | 2016 | PLoS ONE | pmid:27441625 |
Frycz BA et al. | Transcript level of AKR1C3 is down-regulated in gastric cancer. | 2016 | Biochem. Cell Biol. | pmid:27019068 |
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Zhao Z et al. | Potential enhancement of direct interspecies electron transfer for syntrophic metabolism of propionate and butyrate with biochar in up-flow anaerobic sludge blanket reactors. | 2016 | Bioresour. Technol. | pmid:26967338 |
Han A et al. | Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells. | 2016 | J. Cell. Physiol. | pmid:26661480 |
Tiwari P et al. | Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs. | 2016 | Biochimie | pmid:26655363 |
Valvassori SS et al. | Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain. | 2016 | Psychiatry Res | pmid:26654753 |
Mátis G et al. | Feed-drug interaction of orally applied butyrate and phenobarbital on hepatic cytochrome P450 activity in chickens. | 2016 | J Anim Physiol Anim Nutr (Berl) | pmid:26614344 |
Luceri C et al. | Effect of butyrate enemas on gene expression profiles and endoscopic/histopathological scores of diverted colorectal mucosa: A randomized trial. | 2016 | Dig Liver Dis | pmid:26607831 |
Huang H et al. | Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. | 2016 | Cell. Mol. Immunol. | pmid:25683610 |
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Cui Y et al. | Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast. | 2015 | PLoS ONE | pmid:26710276 |
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Deng Y et al. | Driving carbon flux through exogenous butyryl-CoA: Acetate CoA-transferase to produce butyric acid at high titer in Thermobifida fusca. | 2015 | J. Biotechnol. | pmid:26535965 |
Durlak M et al. | A Novel High-Content Immunofluorescence Assay as a Tool to Identify at the Single Cell Level γ-Globin Inducing Compounds. | 2015 | PLoS ONE | pmid:26509275 |
Sasajima H et al. | Intranasal administration of rotenone in mice attenuated olfactory functions through the lesion of dopaminergic neurons in the olfactory bulb. | 2015 | Neurotoxicology | pmid:26493152 |
Huang C et al. | Dietary Sodium Butyrate Decreases Postweaning Diarrhea by Modulating Intestinal Permeability and Changing the Bacterial Communities in Weaned Piglets. | 2015 | J. Nutr. | pmid:26491121 |
Luo H et al. | Enhancing Butanol Production under the Stress Environments of Co-Culturing Clostridium acetobutylicum/Saccharomyces cerevisiae Integrated with Exogenous Butyrate Addition. | 2015 | PLoS ONE | pmid:26489085 |
Alva-Murillo N et al. | The activation of the TLR2/p38 pathway by sodium butyrate in bovine mammary epithelial cells is involved in the reduction of Staphylococcus aureus internalization. | 2015 | Mol. Immunol. | pmid:26471700 |
Turon V et al. | Growth of Chlorella sorokiniana on a mixture of volatile fatty acids: The effects of light and temperature. | 2015 | Bioresour. Technol. | pmid:26461792 |
Muñoz-Rugeles L and Alvarez-Idaboy JR | A proton-electron sequential transfer mechanism: theoretical evidence about its biological relevance. | 2015 | Phys Chem Chem Phys | pmid:26456543 |
Sari O et al. | Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase. | 2015 | Eur J Med Chem | pmid:26451771 |
Jin CJ et al. | Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH). | 2015 | Br. J. Nutr. | pmid:26450277 |
Nasser Al-Shorgani NK et al. | Improvement of the butanol production selectivity and butanol to acetone ratio (B:A) by addition of electron carriers in the batch culture of a new local isolate of Clostridium acetobutylicum YM1. | 2015 | Anaerobe | pmid:26439644 |
Fomina-Yadlin D et al. | Transcriptome analysis of a CHO cell line expressing a recombinant therapeutic protein treated with inducers of protein expression. | 2015 | J. Biotechnol. | pmid:26325199 |
Patman G | Gut microbiota: Lactobacillus acidophilus opens the door to butyrate. | 2015 | Nat Rev Gastroenterol Hepatol | pmid:26323876 |
Desai VH et al. | Receptor-Guided De Novo Design of Dengue Envelope Protein Inhibitors. | 2015 | Appl. Biochem. Biotechnol. | pmid:26299376 |
Kumar A et al. | Lactobacillus acidophilus counteracts enteropathogenic E. coli-induced inhibition of butyrate uptake in intestinal epithelial cells. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26272259 |
Kumar P et al. | Differential Effects of Sodium Butyrate and Lithium Chloride on Rhesus Monkey Trophoblast Differentiation. | 2015 | PLoS ONE | pmid:26266541 |
Li L et al. | Increased Butyrate Production During Long-Term Fermentation of In Vitro-Digested High Amylose Cornstarch Residues with Human Feces. | 2015 | J. Food Sci. | pmid:26256258 |
Shang HM et al. | Effects of dietary polysaccharides from the submerged fermentation concentrate of Hericium caput-medusae (Bull.:Fr.) Pers. on fat deposition in broilers. | 2015 | J. Sci. Food Agric. | pmid:24771556 |
Bucki R et al. | Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection. | 2015 | Antimicrob. Agents Chemother. | pmid:26248361 |
Chen Y et al. | Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice. | 2015 | Cardiovasc Diabetol | pmid:26245924 |
Wang X et al. | Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway. | 2015 | Sci Rep | pmid:26234821 |
Regestein L et al. | Impact of butyric acid on butanol formation by Clostridium pasteurianum. | 2015 | Bioresour. Technol. | pmid:26233327 |
Baroi GN et al. | Butyric acid fermentation from pretreated and hydrolysed wheat straw by an adapted Clostridium tyrobutyricum strain. | 2015 | Microb Biotechnol | pmid:26230610 |
Zhong Y et al. | Barley malt increases hindgut and portal butyric acid, modulates gene expression of gut tight junction proteins and Toll-like receptors in rats fed high-fat diets, but high advanced glycation end-products partially attenuate the effects. | 2015 | Food Funct | pmid:26227569 |
Sandoval PY et al. | Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena. | 2015 | PLoS Genet. | pmid:26218270 |
Valvassori SS et al. | Sodium Butyrate, a Histone Deacetylase Inhibitor, Reverses Behavioral and Mitochondrial Alterations in Animal Models of Depression Induced by Early- or Late-life Stress. | 2015 | Curr Neurovasc Res | pmid:26216027 |
Qaisrani SN et al. | Diet structure, butyric acid, and fermentable carbohydrates influence growth performance, gut morphology, and cecal fermentation characteristics in broilers. | 2015 | Poult. Sci. | pmid:26175052 |
Xu H et al. | Sodium butyrate stimulates NHE8 expression via its role on activating NHE8 basal promoter activity. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26159698 |
Guglielmetti S and Riso P | Reply to Conlon et al. | 2015 | J. Nutr. | pmid:26125075 |
Fukushima A et al. | Ketogenic diet does not impair spatial ability controlled by the hippocampus in male rats. | 2015 | Brain Res. | pmid:26111645 |
Levy AW et al. | Effect of feeding an encapsulated source of butyric acid (ButiPEARL) on the performance of male Cobb broilers reared to 42 d of age. | 2015 | Poult. Sci. | pmid:26015588 |
Liu H et al. | Post-occlusion administration of sodium butyrate attenuates cognitive impairment in a rat model of chronic cerebral hypoperfusion. | 2015 | Pharmacol. Biochem. Behav. | pmid:26013850 |
Chaturvedi K et al. | Oral insulin delivery using deoxycholic acid conjugated PEGylated polyhydroxybutyrate co-polymeric nanoparticles. | 2015 | Nanomedicine (Lond) | pmid:26008194 |
Theparambil SM et al. | Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes. | 2015 | J. Physiol. (Lond.) | pmid:25990710 |
Chou YC et al. | Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells. | 2015 | Mol. Cell. Biol. | pmid:25986606 |
Gurav A et al. | Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. | 2015 | Biochem. J. | pmid:25984582 |
Chen JH and Chou CC | Acrylamide inhibits cellular differentiation of human neuroblastoma and glioblastoma cells. | 2015 | Food Chem. Toxicol. | pmid:25959841 |
Conlon MA et al. | Lowering of large bowel butyrate levels in healthy populations is unlikely to be beneficial. | 2015 | J. Nutr. | pmid:25934666 |
Steckert AV et al. | Effects of sodium butyrate on aversive memory in rats submitted to sepsis. | 2015 | Neurosci. Lett. | pmid:25888815 |
Castino MR et al. | Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats. | 2015 | PLoS ONE | pmid:25880762 |
Ulfina GG et al. | Modulation of post-partum reproductive performance in dairy cows through supplementation of long- or short-chain fatty acids during transition period. | 2015 | J Anim Physiol Anim Nutr (Berl) | pmid:25879374 |
Blank M et al. | Enhancement of memory consolidation by the histone deacetylase inhibitor sodium butyrate in aged rats. | 2015 | Neurosci. Lett. | pmid:25837444 |
Gonnella R et al. | PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction. | 2015 | Biochim. Biophys. Acta | pmid:25827954 |
Shimoyama T et al. | Study of the mechanisms of a Japanese traditional fermented medicine in the improvement of constipation. | 2015 | J. Gastroenterol. Hepatol. | pmid:25827805 |
Huang YW et al. | Brain isoform glycogen phosphorylase as a novel hepatic progenitor cell marker. | 2015 | PLoS ONE | pmid:25826279 |
Chen L et al. | Free and bound volatile chemicals in mulberry (Morus atropurpurea Roxb.). | 2015 | J. Food Sci. | pmid:25817411 |
Cueno ME et al. | High butyric acid amounts induce oxidative stress, alter calcium homeostasis, and cause neurite retraction in nerve growth factor-treated PC12 cells. | 2015 | Cell Stress Chaperones | pmid:25808460 |
Kanika G et al. | Sodium Butyrate Ameliorates L-Arginine-Induced Pancreatitis and Associated Fibrosis in Wistar Rat: Role of Inflammation and Nitrosative Stress. | 2015 | J. Biochem. Mol. Toxicol. | pmid:25774002 |
Cao QF et al. | TRPM2 mediates histone deacetylase inhibition-induced apoptosis in bladder cancer cells. | 2015 | Cancer Biother. Radiopharm. | pmid:25760728 |
Mackmull MT et al. | Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). | 2015 | Mol. Cell Proteomics | pmid:25755299 |
Li L et al. | Histone deacetylase inhibitor sodium butyrate suppresses DNA double strand break repair induced by etoposide more effectively in MCF-7 cells than in HEK293 cells. | 2015 | BMC Biochem. | pmid:25592494 |
Henagan TM et al. | Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning. | 2015 | Br. J. Pharmacol. | pmid:25559882 |
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Arai T et al. | Actinomyces naeslundii GroEL-dependent initial attachment and biofilm formation in a flow cell system. | 2015 | J. Microbiol. Methods | pmid:25555820 |
Shimizu T et al. | Volume-sensitive outwardly rectifying Cl(-) channels contribute to butyrate-triggered apoptosis of murine colonic epithelial MCE301 cells. | 2015 | J Physiol Sci | pmid:25544596 |
Rodrigues MF et al. | Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin A on the energy metabolism of breast cancer cells. | 2015 | J. Cell. Biochem. | pmid:25510910 |
Huang C et al. | Evaluating the possibility of using acetone-butanol-ethanol (ABE) fermentation wastewater for bacterial cellulose production by Gluconacetobacter xylinus. | 2015 | Lett. Appl. Microbiol. | pmid:25615895 |
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Tiwari P et al. | Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events. | 2015 | Chem. Biol. Interact. | pmid:25478867 |
Varela RB et al. | Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats. | 2015 | J Psychiatr Res | pmid:25467060 |
Turon V et al. | Use of fermentative metabolites for heterotrophic microalgae growth: Yields and kinetics. | 2015 | Bioresour. Technol. | pmid:25459841 |
Zgorzynska E et al. | Docosahexaenoic acid attenuates oxidative stress and protects human gingival fibroblasts against cytotoxicity induced by hydrogen peroxide and butyric acid. | 2015 | Arch. Oral Biol. | pmid:25455128 |
Lee C et al. | Effect of 2-hydroxy-4-methylthio-butanoic acid on ruminal fermentation, bacterial distribution, digestibility, and performance of lactating dairy cows. | 2015 | J. Dairy Sci. | pmid:25434334 |
Lopes-Borges J et al. | Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain. | 2015 | Pharmacol. Biochem. Behav. | pmid:25433326 |
Barichello T et al. | Sodium Butyrate Prevents Memory Impairment by Re-establishing BDNF and GDNF Expression in Experimental Pneumococcal Meningitis. | 2015 | Mol. Neurobiol. | pmid:25284351 |
Mátis G et al. | Effects of oral butyrate application on insulin signaling in various tissues of chickens. | 2015 | Domest. Anim. Endocrinol. | pmid:25240231 |
Esteras N et al. | G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients. | 2015 | Mol. Neurobiol. | pmid:25182869 |
Ray A et al. | Absorption spectrophotometric, fluorescence and quantum chemical investigations on non-covalent interaction between PC₇₀BM and designed diporphyrin in solution. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25138385 |
Simon-O'Brien E et al. | The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals. | 2015 | Addict Biol | pmid:25041570 |
Szymanowska-Powałowska D and Kubiak P | Effect of 1,3-propanediol, organic acids, and ethanol on growth and metabolism of Clostridium butyricum DSP1. | 2015 | Appl. Microbiol. Biotechnol. | pmid:25524700 |
Cottier F et al. | MIG1 Regulates Resistance of Candida albicans against the Fungistatic Effect of Weak Organic Acids. | 2015 | Eukaryotic Cell | pmid:26297702 |
Dengler F et al. | Both butyrate incubation and hypoxia upregulate genes involved in the ruminal transport of SCFA and their metabolites. | 2015 | J Anim Physiol Anim Nutr (Berl) | pmid:24804847 |
Chen F et al. | Unusual effects of monocarboxylic acids on the structure and on the transport and mechanical properties of chitosan films. | 2015 | Carbohydr Polym | pmid:26256366 |
Katsou E et al. | Coupling the treatment of low strength anaerobic effluent with fermented biowaste for nutrient removal via nitrite. | 2015 | J. Environ. Manage. | pmid:25463576 |
Pawelka AJ and Huizinga JD | Induction of rhythmic transient depolarizations associated with waxing and waning of slow wave activity in intestinal smooth muscle. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25540235 |
Xiong XR et al. | Sodium butyrate improves the cloned yak embryo viability and corrects gene expression patterns. | 2015 | Zygote | pmid:23759515 |