butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Otto A et al. | The protein inventory of Clostridium difficile grown in complex and minimal medium. | 2016 | Proteomics Clin Appl | pmid:27511832 |
Yin F et al. | Transcriptome Analysis Reveals Regulation of Gene Expression for Lipid Catabolism in Young Broilers by Butyrate Glycerides. | 2016 | PLoS ONE | pmid:27508934 |
Moore JB et al. | The Epigenetic Regulator HDAC1 Modulates Transcription of a Core Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells Through a p53-Dependent Mechanism. | 2016 | Stem Cells | pmid:27501845 |
Lakhter AJ et al. | Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth. | 2016 | J. Biol. Chem. | pmid:27539851 |
Fialova B et al. | Epigenetic modulation of AR gene expression in prostate cancer DU145 cells with the combination of sodium butyrate and 5'-Aza-2'-deoxycytidine. | 2016 | Oncol. Rep. | pmid:27499010 |
Hou G et al. | Tetracycline removal and effect on the formation and degradation of extracellular polymeric substances and volatile fatty acids in the process of hydrogen fermentation. | 2016 | Bioresour. Technol. | pmid:27070285 |
Longpré J et al. | Impact of mash feeding versus pellets on propionic/butyric acid levels and on total load in the gastrointestinal tract of growing pigs. | 2016 | J. Anim. Sci. | pmid:27065267 |
Wu Y et al. | Influence of Butyrate Loaded Clinoptilolite Dietary Supplementation on Growth Performance, Development of Intestine and Antioxidant Capacity in Broiler Chickens. | 2016 | PLoS ONE | pmid:27104860 |
Rivera-Chávez F et al. | Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella. | 2016 | Cell Host Microbe | pmid:27078066 |
Lazarova DL and Bordonaro M | Vimentin, colon cancer progression and resistance to butyrate and other HDACis. | 2016 | J. Cell. Mol. Med. | pmid:27072512 |
Early JV et al. | Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis. | 2016 | Antimicrob. Agents Chemother. | pmid:27044545 |
Kaczmarek SA et al. | Effect of different doses of coated butyric acid on growth performance and energy utilization in broilers. | 2016 | Poult. Sci. | pmid:26740137 |
Jung JM et al. | Pseudo catalytic transformation of volatile fatty acids into fatty acid methyl esters. | 2016 | Bioresour. Technol. | pmid:26720136 |
Xin F et al. | Strategies for production of butanol and butyl-butyrate through lipase-catalyzed esterification. | 2016 | Bioresour. Technol. | pmid:26710347 |
Junicke H et al. | Kinetic and thermodynamic control of butyrate conversion in non-defined methanogenic communities. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26403924 |
Russo R et al. | Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice. | 2016 | Pharmacol. Res. | pmid:26675718 |
Polycarpo GV et al. | Effects of lipid sources, lysophospholipids and organic acids in maize-based broiler diets on nutrient balance, liver concentration of fat-soluble vitamins, jejunal microbiota and performance. | 2016 | Br. Poult. Sci. | pmid:27494540 |
Villain H et al. | HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice. | 2016 | Sci Rep | pmid:27270584 |
Zhang Q et al. | Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium. | 2016 | Sci Rep | pmid:27264309 |
Xiong H et al. | Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition. | 2016 | Sci Rep | pmid:27230284 |
Anderson NA et al. | Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis. | 2016 | Org. Biomol. Chem. | pmid:27226381 |
Subramanian U et al. | Retinoic acid and sodium butyrate suppress the cardiac expression of hypertrophic markers and proinflammatory mediators in Npr1 gene-disrupted haplotype mice. | 2016 | Physiol. Genomics | pmid:27199456 |
Bastiaansen JA et al. | Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate. | 2016 | Sci Rep | pmid:27150735 |
Seki K et al. | Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease progression. | 2016 | Apoptosis | pmid:26994613 |
Vazquez-DeRose J et al. | Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain. | 2016 | Brain Struct Funct | pmid:25431268 |
Popp D et al. | The alkaloid gramine in the anaerobic digestion process-inhibition and adaptation of the methanogenic community. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27138201 |
Endesfelder D et al. | Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production. | 2016 | Microbiome | pmid:27114075 |
Gallo A et al. | Relationships among ensiling, nutritional, fermentative, microbiological traits and contamination in corn silages addressed with partial least squares regression. | 2016 | J. Anim. Sci. | pmid:27898868 |
Estensoro I et al. | Dietary Butyrate Helps to Restore the Intestinal Status of a Marine Teleost (Sparus aurata) Fed Extreme Diets Low in Fish Meal and Fish Oil. | 2016 | PLoS ONE | pmid:27898676 |
Chang MC et al. | Effect of Butyrate on Collagen Expression, Cell Viability, Cell Cycle Progression and Related Proteins Expression of MG-63 Osteoblastic Cells. | 2016 | PLoS ONE | pmid:27893752 |
Zhang T et al. | Sodium Butyrate Reduces Colitogenic Immunoglobulin A-Coated Bacteria and Modifies the Composition of Microbiota in IL-10 Deficient Mice. | 2016 | Nutrients | pmid:27886121 |
Zhu J et al. | Sodium butyrate modulates a methamphetamine-induced conditioned place preference. | 2017 | J. Neurosci. Res. | pmid:27426635 |
Liangzhan S et al. | Effect of substitution of oat hulls for traditional fiber source on digestion and performance of fattening rabbits. | 2017 | Animal | pmid:27821223 |
Tayebi B et al. | Modulation of microRNAs expression in hematopoietic stem cells treated with sodium butyrate in inducing fetal hemoglobin expression. | 2017 | Artif Cells Nanomed Biotechnol | pmid:26837891 |
Kamphayae S et al. | Effects of graded levels of liquid brewer's yeast on chemical composition and fermentation quality in cassava pulp and rice straw-based total mixed ration silage. | 2017 | Anim. Sci. J. | pmid:27611881 |
Sasajima H et al. | Intranasal Administration of Rotenone to Mice Induces Dopaminergic Neurite Degeneration of Dopaminergic Neurons in the Substantia Nigra. | 2017 | Biol. Pharm. Bull. | pmid:28049942 |
Kurano M et al. | Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. | 2017 | PLoS ONE | pmid:28494002 |
Machado CF et al. | Conditional Deletion of in Olfactory Sensory Neurons Leads to Olfactory Impairment. | 2017 | J. Neurosci. | pmid:29118104 |
Kobayashi H et al. | Clostridium pabulibutyricum sp. nov., a butyric-acid-producing organism isolated from high-moisture grass silage. | 2017 | Int. J. Syst. Evol. Microbiol. | pmid:29034861 |
Du H et al. | Exploring the microbial origins of p-cresol and its co-occurrence pattern in the Chinese liquor-making process. | 2017 | Int. J. Food Microbiol. | pmid:28843121 |
Wu T et al. | Anthocyanins in black rice, soybean and purple corn increase fecal butyric acid and prevent liver inflammation in high fat diet-induced obese mice. | 2017 | Food Funct | pmid:28792056 |
Berni Canani R et al. | Specific Signatures of the Gut Microbiota and Increased Levels of Butyrate in Children Treated with Fermented Cow's Milk Containing Heat-Killed Lactobacillus paracasei CBA L74. | 2017 | Appl. Environ. Microbiol. | pmid:28733284 |
Pelgrim CE et al. | Butyrate Reduces HFD-Induced Adipocyte Hypertrophy and Metabolic Risk Factors in Obese LDLr-/-.Leiden Mice. | 2017 | Nutrients | pmid:28686216 |
Tsung AJ et al. | Methylation regulates HEY1 expression in glioblastoma. | 2017 | Oncotarget | pmid:28574840 |
Wang L et al. | Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin-angiotensin system. | 2017 | J. Hypertens. | pmid:28509726 |
Dou X et al. | Sodium butyrate improves porcine host defense peptide expression and relieves the inflammatory response upon Toll-like receptor 2 activation and histone deacetylase inhibition in porcine kidney cells. | 2017 | Oncotarget | pmid:28460447 |
Pant K et al. | Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells. | 2017 | Redox Biol | pmid:28288414 |
Niwińska B et al. | Review: Exogenous butyrate: implications for the functional development of ruminal epithelium and calf performance. | 2017 | Animal | pmid:28193308 |
Jaworska J et al. | The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. | 2017 | J Neuroinflammation | pmid:28187734 |
Qiu Y et al. | Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. | 2017 | In Vitro Cell. Dev. Biol. Anim. | pmid:28127702 |
Tylichová Z et al. | Activation of autophagy and PPARγ protect colon cancer cells against apoptosis induced by interactive effects of butyrate and DHA in a cell type-dependent manner: The role of cell differentiation. | 2017 | J. Nutr. Biochem. | pmid:27840291 |
Owusu BY and Klampfer L | Modulation of STAT1-Driven Transcriptional Activity by Histone Deacetylases. | 2017 | Methods Mol. Biol. | pmid:27761828 |
Yokoyama Y et al. | Profile of preoperative fecal organic acids closely predicts the incidence of postoperative infectious complications after major hepatectomy with extrahepatic bile duct resection: Importance of fecal acetic acid plus butyric acid minus lactic acid gap. | 2017 | Surgery | pmid:28684159 |
Green AL et al. | Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. | 2017 | Neuropharmacology | pmid:28743636 |
Pant K et al. | Oxidative stress plays a key role in butyrate-mediated autophagy via Akt/mTOR pathway in hepatoma cells. | 2017 | Chem. Biol. Interact. | pmid:28600122 |
Yang S et al. | Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. | 2017 | Chem. Res. Toxicol. | pmid:28595002 |
Zapletal O et al. | Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. | 2017 | Arch. Toxicol. | pmid:27830268 |
Li P et al. | Effect of grape pomace on fermentation quality and aerobic stability of sweet sorghum silage. | 2017 | Anim. Sci. J. | pmid:28485116 |
Chang PJ et al. | Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. | 2017 | J. Virol. | pmid:28701396 |
Ito T et al. | Occurrence of the (2R,3S)-Isomer of 2-Amino-3,4-dihydroxybutanoic Acid in the Mushroom Hypsizygus marmoreus. | 2017 | J. Agric. Food Chem. | pmid:28686838 |
Chen X et al. | Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway. | 2017 | Biochem. Pharmacol. | pmid:28684304 |
Yan H and Ajuwon KM | Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. | 2017 | PLoS ONE | pmid:28654658 |
Batlle-Vilanova P et al. | Microbial electrosynthesis of butyrate from carbon dioxide: Production and extraction. | 2017 | Bioelectrochemistry | pmid:28633067 |
Asquith M et al. | Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis. | 2017 | pmid:28622455 | |
Lucchetti D et al. | Differentiation Affects the Release of Exosomes from Colon Cancer Cells and Their Ability to Modulate the Behavior of Recipient Cells. | 2017 | Am. J. Pathol. | pmid:28619275 |
Lu N et al. | Butyric acid regulates progesterone and estradiol secretion via cAMP signaling pathway in porcine granulosa cells. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28602959 |
Kumar P et al. | Inhibition of HDAC enhances STAT acetylation, blocks NF-κB, and suppresses the renal inflammation and fibrosis in haplotype male mice. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28566502 |
Tian L et al. | Sodium butyrate improved intestinal immune function associated with NF-κB and p38MAPK signalling pathways in young grass carp (Ctenopharyngodon idella). | 2017 | Fish Shellfish Immunol. | pmid:28546021 |
Wu Q et al. | Insights from the complete genome sequence of Clostridium tyrobutyricum provide a platform for biotechnological and industrial applications. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:28536840 |
Kihara T et al. | Bacillus cereus-type polyhydroxyalkanoate biosynthetic gene cluster contains R-specific enoyl-CoA hydratase gene. | 2017 | Biosci. Biotechnol. Biochem. | pmid:28532241 |
Payandeh S et al. | Probiotic supplementation effects on milk fatty acid profile in ewes. | 2017 | J. Dairy Res. | pmid:28524013 |
Donovan JD et al. | In Vitro Digestion and Fermentation of Microencapsulated Tributyrin for the Delivery of Butyrate. | 2017 | J. Food Sci. | pmid:28485486 |
Zhou Z et al. | Changes of cecal microflora in chickens following Eimeria tenella challenge and regulating effect of coated sodium butyrate. | 2017 | Exp. Parasitol. | pmid:28455119 |
Suo Y et al. | Enhanced butyric acid tolerance and production by Class I heat shock protein-overproducing Clostridium tyrobutyricum ATCC 25755. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:28439766 |
Arriaga JM et al. | Metallothionein 1G promotes the differentiation of HT-29 human colorectal cancer cells. | 2017 | Oncol. Rep. | pmid:28393194 |
Zhang J et al. | Metabolic engineering of Clostridium tyrobutyricum for n-butanol production from sugarcane juice. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28238080 |
Mathew MP et al. | Glycoengineering of Esterase Activity through Metabolic Flux-Based Modulation of Sialic Acid. | 2017 | Chembiochem | pmid:28218815 |
Maeshige N et al. | Low-Intensity Ultrasound Enhances Histone Acetylation and Inhibition of Interleukin 6 Messenger RNA Expression by the Histone Deacetylase Inhibitor Sodium Butyrate in Fibroblasts. | 2017 | J Ultrasound Med | pmid:28195362 |
Yoo M et al. | Metabolic flexibility of a butyrate pathway mutant of Clostridium acetobutylicum. | 2017 | Metab. Eng. | pmid:28159643 |
Chen C et al. | Use of Acetate, Propionate, and Butyrate for Reduction of Nitrate and Sulfate and Methanogenesis in Microcosms and Bioreactors Simulating an Oil Reservoir. | 2017 | Appl. Environ. Microbiol. | pmid:28130297 |
Zhang L et al. | Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice. | 2017 | J. Cell. Biochem. | pmid:28109123 |
Cueno ME et al. | Periodontal disease level-butyric acid putatively contributes to the ageing blood: A proposed link between periodontal diseases and the ageing process. | 2017 | Mech. Ageing Dev. | pmid:28108180 |
Zhou D et al. | Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier. | 2017 | World J. Gastroenterol. | pmid:28104981 |
Huang JC et al. | [Protective effect of histone acetylation against cortical injury in neonatal rats]. | 2017 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:28100329 |
Albuquerque Filho MO et al. | Dual influences of early-life maternal deprivation on histone deacetylase activity and recognition memory in rats. | 2017 | Neuroscience | pmid:28089578 |
Kataoka N et al. | Butyrate production under aerobic growth conditions by engineered Escherichia coli. | 2017 | J. Biosci. Bioeng. | pmid:28089378 |
Hichino A et al. | Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. | 2017 | J. Biol. Chem. | pmid:28057758 |
Millat T and Winzer K | Mathematical modelling of clostridial acetone-butanol-ethanol fermentation. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28210797 |
Fu H et al. | Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose. | 2017 | Metab. Eng. | pmid:28040464 |
Jin X et al. | TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment. | 2017 | Cancer Med | pmid:28033672 |
Dai H et al. | Sodium Butyrate Ameliorates High-Concentrate Diet-Induced Inflammation in the Rumen Epithelium of Dairy Goats. | 2017 | J. Agric. Food Chem. | pmid:28032994 |
Bosmans JW et al. | Comparison of three different application routes of butyrate to improve colonic anastomotic strength in rats. | 2017 | Int J Colorectal Dis | pmid:27942836 |
Johnstone M et al. | Characterization of the Pro-Inflammatory Cytokine IL-1β on Butyrate Oxidation in Colorectal Cancer Cells. | 2017 | J. Cell. Biochem. | pmid:27922186 |
Herrick KJ et al. | Single-dose infusion of sodium butyrate, but not lactose, increases plasma β-hydroxybutyrate and insulin in lactating dairy cows. | 2017 | J. Dairy Sci. | pmid:27837980 |
Moens F et al. | Lactate- and acetate-based cross-feeding interactions between selected strains of lactobacilli, bifidobacteria and colon bacteria in the presence of inulin-type fructans. | 2017 | Int. J. Food Microbiol. | pmid:27810444 |
Dong W et al. | Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC. | 2017 | J. Endocrinol. | pmid:27799462 |
Zhang K et al. | Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1. | 2017 | Appl. Biochem. Biotechnol. | pmid:27832512 |
Wang YQ et al. | Enhancement of acetate productivity in a thermophilic (55 °C) hollow-fiber membrane biofilm reactor with mixed culture syngas (H/CO) fermentation. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28110397 |
Chriett S et al. | The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1. | 2017 | Mol. Cell. Endocrinol. | pmid:27619406 |
Kumar G et al. | Microbial responses to various process disturbances in a continuous hydrogen reactor fed with galactose. | 2017 | J. Biosci. Bioeng. | pmid:27614820 |