butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Palmer DG et al. | Modulation of p53 expression in cultured colonic adenoma cell lines by the naturally occurring lumenal factors butyrate and deoxycholate. | 1997 | Int. J. Cancer | pmid:9398049 |
Vimard C et al. | Changes in the sedimentation properties of acetycholinesterase during neuroblastoma differentiation. | 1976 | Biochimie | pmid:938691 |
Hassig CA et al. | Fiber-derived butyrate and the prevention of colon cancer. | 1997 | Chem. Biol. | pmid:9384528 |
Onaga T et al. | Effect of pituitary adenylate cyclase-activating polypeptide on exocrine and endocrine secretion in the ovine pancreas. | 1996 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:9375356 |
Coradini D et al. | Effect of sodium butyrate on human breast cancer cell lines. | 1997 Mar-Apr | Cell Prolif. | pmid:9375027 |
Faller DV and Perrine SP | Butyrate in the treatment of sickle cell disease and beta-thalassemia. | 1995 | Curr. Opin. Hematol. | pmid:9371980 |
Kolesnitchenko V et al. | A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis. | 1997 | J. Virol. | pmid:9371641 |
Velázquez OC et al. | Butyrate inhibits deoxycholate-induced increase in colonic mucosal DNA and protein synthesis in vivo. | 1997 | Dis. Colon Rectum | pmid:9369115 |
Payne KL et al. | Modulation of T3-induced sex hormone-binding globulin secretion by human hepatoblastoma cells. | 1997 | Eur. J. Endocrinol. | pmid:9368511 |
Singh M | Calcium and cyclic nucleotide interaction in secretion of amylase from rat pancreas in vitro. | 1979 | J. Physiol. (Lond.) | pmid:93637 |
Velázquez OC and Rombeau JL | Butyrate. Potential role in colon cancer prevention and treatment. | 1997 | Adv. Exp. Med. Biol. | pmid:9361842 |
Velázquez OC et al. | Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications. | 1997 | Adv. Exp. Med. Biol. | pmid:9361838 |
Barnard JA et al. | Short chain fatty acid regulation of intestinal gene expression. | 1997 | Adv. Exp. Med. Biol. | pmid:9361821 |
O'Mara FP et al. | Rumen fermentation and nutrient flows for cows fed grass and grass supplemented with molassed beet pulp pellets. | 1997 | J. Dairy Sci. | pmid:9361218 |
Kavaliers M et al. | Opioid and non-opioid NMDA-mediated predator-induced analgesia in mice and the effects of parasitic infection. | 1997 | Brain Res. | pmid:9359582 |
Loukopoulos D | New therapies for the haemoglobinopathies. | 1997 | J Intern Med Suppl | pmid:9350181 |
Vecchia MG et al. | Acetate and propionate potentiate the antiproliferative effect of butyrate on RBL-2H3 growth. | 1997 | Gen. Pharmacol. | pmid:9347317 |
Garcia-Bermejo L et al. | Modulation of heat-shock protein 70 (HSP70) gene expression by sodium butyrate in U-937 promonocytic cells: relationships with differentiation and apoptosis. | 1997 | Exp. Cell Res. | pmid:9344607 |
Sovová V et al. | Differences of alkaline phosphatase and arginase activities in human colorectal carcinoma cell lines. | 1997 | Folia Biol. (Praha) | pmid:9338115 |
Janson W et al. | Butyrate modulates DNA-damage-induced p53 response by induction of p53-independent differentiation and apoptosis. | 1997 | Oncogene | pmid:9333015 |
Kaiser E and Weiss K | [Fermentation process during the ensiling of green forage low in nitrate. 2. Fermentation process after supplementation of nitrate, nitrite, lactic acid bacteria and formic acid]. | 1997 | Arch Tierernahr | pmid:9324922 |
Scannell JP et al. | Antimetabolites produced by microorganisms. XIII. The synthesis and microbiological production of a novel amino acid, L-2-amino-4-(2-aminoethoxy) butanoic acid. | 1976 | J. Antibiot. | pmid:931793 |
Engelhard HH et al. | Molecular characterization of glioblastoma cell differentiation. | 1997 | Neurosurgery | pmid:9316051 |
Dohi H et al. | Intake stimulants in perennial ryegrass (Lolium perenne L.) fed to sheep. | 1997 | J. Dairy Sci. | pmid:9313150 |
Hague A et al. | bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis. | 1997 | Int. J. Cancer | pmid:9311611 |
Ishiguro K and Sartorelli AC | Clonal variability in beta-globin mRNA content in an interleukin-3-dependent bone marrow cell line transfected with the erythropoietin receptor before and after stimulation with erythropoietin. | 1997 | Blood | pmid:9310478 |
Birkett AM et al. | Dietary intake and faecal excretion of carbohydrate by Australians: importance of achieving stool weights greater than 150 g to improve faecal markers relevant to colon cancer risk. | 1997 | Eur J Clin Nutr | pmid:9306090 |
Cuisset L et al. | The effects of sodium butyrate on transcription are mediated through activation of a protein phosphatase. | 1997 | J. Biol. Chem. | pmid:9305863 |
Chénais B et al. | Time-course of butyric acid-induced differentiation in human K562 leukemic cell line: rapid increase in gamma-globin, porphobilinogen deaminase and NF-E2 mRNA levels. | 1997 | Leukemia | pmid:9305615 |
Lewis SJ and Heaton KW | Increasing butyrate concentration in the distal colon by accelerating intestinal transit. | 1997 | Gut | pmid:9301506 |
Ohno Y et al. | Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9294201 |
Talley NA et al. | Short-chain fatty acids in the treatment of radiation proctitis: a randomized, double-blind, placebo-controlled, cross-over pilot trial. | 1997 | Dis. Colon Rectum | pmid:9293933 |
Medina V et al. | Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. | 1997 | Cancer Res. | pmid:9288776 |
Chen ZJ and Pikaard CS | Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance. | 1997 | Genes Dev. | pmid:9284051 |
Kenyon E et al. | Apical and basolateral membrane mechanisms that regulate pHi in bovine retinal pigment epithelium. | 1997 | Am. J. Physiol. | pmid:9277343 |
De Visser H et al. | Nutrient fluxes in splanchnic tissue of dairy cows: influence of grass quality. | 1997 | J. Dairy Sci. | pmid:9276806 |
Humbert G et al. | Method for the measurement of lipase activity in milk. | 1997 | J. Dairy Res. | pmid:9275261 |
Simon B et al. | Transient transcriptional activation of gastrin during sodium butyrate-induced differentiation of islet cells. | 1997 | Regul. Pept. | pmid:9272626 |
Xiao H et al. | Sodium butyrate induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1 in p53-independent manner. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9268733 |
Nakano K et al. | Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. | 1997 | J. Biol. Chem. | pmid:9268365 |
Tai G et al. | Different effects of cyclic AMP and butyrate on eosinophilic differentiation, apoptosis and bcl-2 expression of a human eosinophilic leukemia cell line, EoL-1. | 1996 | Hematol Oncol | pmid:9267464 |
Navarro JM et al. | Differentiation of BCS-TC2 human colon adenocarcinoma cells by sodium butyrate: increase in 5'-nucleotidase activity. | 1997 | Eur. J. Clin. Invest. | pmid:9263751 |
Qin S and Yamamura H | Up-regulation of Syk activity during HL60 cell differentiation into granulocyte but not into monocyte/macrophage-lineage. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9245716 |
Jacobasch G and Jacobasch KH | [Molecular etiology of colorectal carcinogenesis, clinical manifestations and therapy]. | 1997 | Z Arztl Fortbild Qualitatssich | pmid:9244653 |
Kaeffer B et al. | Treatment of rat proximal and distal colonic cells with sodium orthovanadate enhances their adhesion and survival in primary culture. | 1997 | Cell Biol. Int. | pmid:9243806 |
Siavoshian S et al. | Comparison of the effect of different short chain fatty acids on the growth and differentiation of human colonic carcinoma cell lines in vitro. | 1997 | Cell Biol. Int. | pmid:9243803 |
Ferry AE et al. | Globin gene silencing in primary erythroid cultures. An inhibitory role for interleukin-6. | 1997 | J. Biol. Chem. | pmid:9242673 |
Millais AJ et al. | The biotransformation of t-butylacetonitrile and its boron-containing analogue trimethylamine-cyanoborane by Brevibacterium R312. | 1997 | Arch. Microbiol. | pmid:9238109 |
Erickson KD and Martin JM | Early detection of the lytic LMP-1 protein in EBV-infected B-cells suggests its presence in the virion. | 1997 | Virology | pmid:9234942 |
Atkins KB et al. | Stimulation of osteopontin mRNA expression in HL-60 cells is independent of differentiation. | 1997 | Arch. Biochem. Biophys. | pmid:9224725 |
Ebert SN et al. | Adrenergic differentiation potential in PC12 cells: influence of sodium butyrate and dexamethasone. | 1997 | Brain Res. Mol. Brain Res. | pmid:9221898 |
Alaoui-Ismaïli O et al. | Odor hedonics: connection with emotional response estimated by autonomic parameters. | 1997 | Chem. Senses | pmid:9218136 |
McBain JA et al. | Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors. | 1997 | Biochem. Pharmacol. | pmid:9214697 |
Singh B et al. | Butyrate can act as a stimulator of growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources. | 1997 | Carcinogenesis | pmid:9214612 |
Nakajima T et al. | The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency. | 1997 | Pediatr. Res. | pmid:9212045 |
Gossett RE et al. | Expression of fatty acyl-CoA binding proteins in colon cells: response to butyrate and transformation. | 1997 | Lipids | pmid:9208385 |
Marchetti MC et al. | Possible mechanisms involved in apoptosis of colon tumor cell lines induced by deoxycholic acid, short-chain fatty acids, and their mixtures. | 1997 | Nutr Cancer | pmid:9200153 |
Edward M et al. | Effect of retinoic acid on melanoma cell-derived factor stimulation of fibroblast glycosaminoglycan synthesis. | 1997 | Melanoma Res. | pmid:9195557 |
Otonkoski T et al. | Nicotinamide and sodium butyrate for the induction of fetal porcine beta-cell differentiation prior to transplantation. | 1997 | Transplant. Proc. | pmid:9193518 |
Wallace KK et al. | In vivo and in vitro effects of thiolactomycin on fatty acid biosynthesis in Streptomyces collinus. | 1997 | J. Bacteriol. | pmid:9190803 |
Graham ME et al. | Modification of annexin II expression in PC12 cell lines does not affect Ca(2+)-dependent exocytosis. | 1997 | Mol. Biol. Cell | pmid:9188096 |
Kashanchi F et al. | Rapid and sensitive detection of cell-associated HIV-1 in latently infected cell lines and in patient cells using sodium-n-butyrate induction and RT-PCR. | 1997 | J. Med. Virol. | pmid:9179766 |
Ou HC et al. | Sodium butyrate decreases histamine-stimulated calcium mobilization in C6 glioma cells. | 1997 | Neuroreport | pmid:9172138 |
Dimitrov SI and Wolffe AP | Fine resolution of histones by two-dimensional polyacrylamide gel electrophoresis: developmental implications. | 1997 | Methods | pmid:9169195 |
Russo GL et al. | Down-regulation of protein kinase CKII activity by sodium butyrate. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9168912 |
Napolitano LM | Dose-response effect of butyrate. | 1997 May-Jun | JPEN J Parenter Enteral Nutr | pmid:9168372 |
Kim J et al. | Studies on the effects of selenium on rumen microbial fermentation in vitro. | 1997 | Biol Trace Elem Res | pmid:9164665 |
Chen WY et al. | Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9159154 |
Garcia-Villalba P et al. | Histone acetylation influences thyroid hormone and retinoic acid-mediated gene expression. | 1997 | DNA Cell Biol. | pmid:9150429 |
Scheppach W et al. | Effects of short-chain fatty acids on the inflamed colonic mucosa. | 1997 | Scand. J. Gastroenterol. Suppl. | pmid:9145448 |
Benard O and Balasubramanian KA | Modulation of glutathione level during butyrate-induced differentiation in human colon derived HT-29 cells. | 1997 | Mol. Cell. Biochem. | pmid:9144324 |
Mariadason JM et al. | Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model. | 1997 | Am. J. Physiol. | pmid:9142899 |
Pöllänen MT et al. | Bacterial metabolites sodium butyrate and propionate inhibit epithelial cell growth in vitro. | 1997 | J. Periodont. Res. | pmid:9138199 |
Autrup H et al. | Effect of various chemicals on the metabolism of benzo(a)pyrene by cultured rat colon. | 1977 | Chem. Biol. Interact. | pmid:912816 |
Siavoshian S et al. | Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9125124 |
Zimra Y et al. | Butyric acid and pivaloyloxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells. | 1997 | J. Cancer Res. Clin. Oncol. | pmid:9119880 |
Jasinskas A et al. | Turnover of histone acetyl groups during sea urchin early development is not required for histone, heat shock and actin gene transcription. | 1997 | Biochim. Biophys. Acta | pmid:9116030 |
Wang MC et al. | Protein tyrosine phosphatase-dependent activation of beta-globin and delta-aminolevulinic acid synthase genes in the camptothecin-induced IW32 erythroleukemia cell differentiation. | 1997 | Mol. Pharmacol. | pmid:9106619 |
Marchetti C et al. | Deoxycholic acid and SCFA-induced apoptosis in the human tumor cell-line HT-29 and possible mechanisms. | 1997 | Cancer Lett. | pmid:9103263 |
Bingham S | Meat, starch and non-starch polysaccharides, are epidemiological and experimental findings consistent with acquired genetic alterations in sporadic colorectal cancer? | 1997 | Cancer Lett. | pmid:9103247 |
Rolandelli RH et al. | Intravenous butyrate and healing of colonic anastomoses in the rat. | 1997 | Dis. Colon Rectum | pmid:9102264 |
Böhm L et al. | Influence of histone acetylation on the modification of cytoplasmic and nuclear proteins by ADP-ribosylation in response to free radicals. | 1997 | Biochim. Biophys. Acta | pmid:9101708 |
Zoran DL et al. | Diet and carcinogen alter luminal butyrate concentration and intracellular pH in isolated rat colonocytes. | 1997 | Nutr Cancer | pmid:9101550 |
Niki S et al. | [A case of hepatocellular carcinoma associated with autoimmune hepatitis and increased scintigraphy of liver accumulation]. | 1997 | Nihon Shokakibyo Gakkai Zasshi | pmid:9095644 |
Moulding D et al. | Regulation of neutrophil apoptosis by sodium butyrate. | 1996 | Biologicals | pmid:9088543 |
Litchfield TM and Sauer GR | Metallothionein induction in calcifying growth plate cartilage chondrocytes. | 1996 | Connect. Tissue Res. | pmid:9084657 |
Sun SH et al. | Altered phospholipid metabolism in sodium butyrate-induced differentiation of C6 glioma cells. | 1997 | Lipids | pmid:9076664 |
Skretting G et al. | Sodium butyrate inhibits the expression of the human lecithin: cholesterol acyltransferase gene in HepG2 cells by a post-transcriptional mechanism. | 1997 | FEBS Lett. | pmid:9074647 |
Stein TP et al. | Weight loss, the gut and the inflammatory response in aids patients. | 1997 | Cytokine | pmid:9071566 |
Huang N et al. | Inhibition of IL-8 gene expression in Caco-2 cells by compounds which induce histone hyperacetylation. | 1997 | Cytokine | pmid:9067093 |
Scheppach W et al. | Histological changes in the colonic mucosa following irrigation with short-chain fatty acids. | 1997 | Eur J Gastroenterol Hepatol | pmid:9058627 |
Bordonaro M and Augenlicht L | The 3' untranslated region of the carcinoembryonic antigen gene plays a minimal role in the regulation of gene expression. | 1997 | Cell Growth Differ. | pmid:9056678 |
Niitsu N et al. | AML1a but not AML1b inhibits erythroid differentiation induced by sodium butyrate and enhances the megakaryocytic differentiation of K562 leukemia cells. | 1997 | Cell Growth Differ. | pmid:9056674 |
Mandal M et al. | Bcl-2 deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells. | 1997 | Carcinogenesis | pmid:9054611 |
Chapman MA et al. | Metabolic adaptation of terminal ileal mucosa after construction of an ileoanal pouch. | 1997 | Br J Surg | pmid:9043459 |
Niederman R et al. | Short-chain carboxylic acid concentration in human gingival crevicular fluid. | 1997 | J. Dent. Res. | pmid:9042080 |
Hague A et al. | Butyrate acts as a survival factor for colonic epithelial cells: further fuel for the in vivo versus in vitro debate. | 1997 | Gastroenterology | pmid:9041270 |
Hass R et al. | Lack of butyrate is associated with induction of Bax and subsequent apoptosis in the proximal colon of guinea pig. | 1997 | Gastroenterology | pmid:9041249 |
Aukema HM et al. | Butyrate alters activity of specific cAMP-receptor proteins in a transgenic mouse colonic cell line. | 1997 | J. Nutr. | pmid:9040538 |
Rogler LE | Selective bipotential differentiation of mouse embryonic hepatoblasts in vitro. | 1997 | Am. J. Pathol. | pmid:9033273 |