butyric acid

butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.

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Introduction

To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with butyric acid?

butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with butyric acid

MeSH term MeSH ID Detail
Trophoblastic Neoplasms D014328 1 associated lipids
Diverticulitis, Colonic D004239 1 associated lipids
Aphakia, Postcataract D001036 1 associated lipids
Diverticulosis, Colonic D043963 1 associated lipids
Facial Injuries D005151 1 associated lipids
Gastrinoma D015408 1 associated lipids
Proctitis D011349 1 associated lipids
Myoepithelioma D009208 1 associated lipids
Astigmatism D001251 1 associated lipids
Diverticulitis D004238 1 associated lipids
Salivary Gland Neoplasms D012468 1 associated lipids
Anaplasia D000708 1 associated lipids
Dentin, Secondary D003809 2 associated lipids
Colorectal Neoplasms, Hereditary Nonpolyposis D003123 2 associated lipids
Lymphoma, AIDS-Related D016483 2 associated lipids
Sarcoma, Avian D001357 2 associated lipids
Nevus D009506 2 associated lipids
Granuloma, Lethal Midline D006103 2 associated lipids
Urea Cycle Disorders, Inborn D056806 2 associated lipids
Glycogen Storage Disease Type II D006009 2 associated lipids
Intestinal Neoplasms D007414 2 associated lipids
Hemorrhoids D006484 2 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Epstein-Barr Virus Infections D020031 3 associated lipids
Hydatidiform Mole D006828 3 associated lipids
Pregnancy in Diabetics D011254 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Nose Neoplasms D009669 3 associated lipids
Pouchitis D019449 3 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Psychophysiologic Disorders D011602 3 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Disease Models, Animal D004195 4 associated lipids
Pituitary Neoplasms D010911 4 associated lipids
Marek Disease D008380 4 associated lipids
Herpesviridae Infections D006566 4 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Retroviridae Infections D012192 4 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Multiple Chemical Sensitivity D018777 4 associated lipids
Dysentery D004403 4 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Strongylida Infections D017206 5 associated lipids
Infectious Mononucleosis D007244 5 associated lipids
Dental Leakage D003763 5 associated lipids
Ataxia Telangiectasia D001260 6 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Pleural Effusion, Malignant D016066 6 associated lipids
Lymphoproliferative Disorders D008232 7 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Laryngeal Neoplasms D007822 7 associated lipids
Leukemia, Megakaryoblastic, Acute D007947 7 associated lipids
Teratocarcinoma D018243 7 associated lipids
Dementia, Vascular D015140 7 associated lipids
Genomic Instability D042822 7 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Phenylketonurias D010661 7 associated lipids
Constipation D003248 8 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Thalassemia D013789 8 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Hepatoblastoma D018197 10 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Ovarian Neoplasms D010051 10 associated lipids
Hyperkinesis D006948 11 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Retinoblastoma D012175 12 associated lipids
Acidosis D000138 13 associated lipids
Ketosis D007662 13 associated lipids
Corneal Diseases D003316 13 associated lipids
Radiation Injuries D011832 14 associated lipids
Burkitt Lymphoma D002051 15 associated lipids
Periodontal Diseases D010510 15 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Lymphoma D008223 18 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
HIV Infections D015658 20 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Sarcoma 180 D012510 21 associated lipids
Poultry Diseases D011201 21 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Periodontitis D010518 22 associated lipids
Medulloblastoma D008527 22 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cattle Diseases D002418 24 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Brain Diseases D001927 27 associated lipids
Angina Pectoris D000787 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with butyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with butyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with butyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with butyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with butyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with butyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with butyric acid

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Per page 10 20 50 100 | Total 7933
Authors Title Published Journal PubMed Link
Stoilov L et al. Inhibition of repair of X-ray-induced DNA double-strand breaks in human lymphocytes exposed to sodium butyrate. 2000 Int. J. Radiat. Biol. pmid:11098851
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Sadar MD and Gleave ME Ligand-independent activation of the androgen receptor by the differentiation agent butyrate in human prostate cancer cells. 2000 Cancer Res. pmid:11059779
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Cox GS Cellular responses to sodium butyrate exhibit the dominance of one parental phenotype in somatic cell hybrids. 2000 Mol. Cell Biol. Res. Commun. pmid:11032754
Hezayen FF et al. Polymer production by two newly isolated extremely halophilic archaea: application of a novel corrosion-resistant bioreactor. 2000 Appl. Microbiol. Biotechnol. pmid:11030566
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Schröder O et al. Substrate and inhibitor specificity of butyrate uptake in apical membrane vesicles of the rat distal colon. 2000 Digestion pmid:11025362
Säemann MD et al. Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production. 2000 FASEB J. pmid:11024006
Murphy JP et al. Histone deacetylase inhibitors and cell proliferation in pea root meristems. 2000 Phytochemistry pmid:11021638
Hirayama F et al. Release characteristics of a short-chain fatty acid, n-butyric acid, from its beta-cyclodextrin ester conjugate in rat biological media. 2000 J Pharm Sci pmid:11015693
Evdokiou A et al. Identification of a novel calcitonin-response element in the promoter of the human p21WAF1/CIP1 gene. 2000 J. Mol. Endocrinol. pmid:11013346
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Lauricella M et al. Synergistic cytotoxic interactions between sodium butyrate, MG132 and camptothecin in human retinoblastoma Y79 cells. 2000 Nov-Dec Tumour Biol. pmid:11006574
Shie JL et al. Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation. 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11005769
Maier S et al. Tributyrin induces differentiation, growth arrest and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines. 2000 Int. J. Cancer pmid:11004676
Karlsson S et al. Toxins, butyric acid, and other short-chain fatty acids are coordinately expressed and down-regulated by cysteine in Clostridium difficile. 2000 Infect. Immun. pmid:10992498
Kano K et al. Complexation of polyvalent cyclodextrin ions with oppositely charged guests: entropically favorable complexation due to dehydration. 2000 Chemistry pmid:10985719
Xie P et al. Nerve growth factor potentiated the sodium butyrate- and PMA-induced megakaryocytic differentiation of K562 leukemia cells. 2000 Leuk. Res. pmid:10978779
Weinmann W et al. Simultaneous determination of THC-COOH and THC-COOH-glucuronide in urine samples by LC/MS/MS. 2000 Forensic Sci. Int. pmid:10978652
Pedersen G et al. Cytokine-induced impairment of short-chain fatty acid oxidation and viability in human colonic epithelial cells. 2000 Cytokine pmid:10976002
Kovaríková M et al. TNF-alpha modulates the differentiation induced by butyrate in the HT-29 human colon adenocarcinoma cell line. 2000 Eur. J. Cancer pmid:10974633
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Hsu CP et al. Suppression of proline-directed protein kinase F(A) expression potentiates erythroid differentiation of human myeloid leukemia cells. 2000 Cancer pmid:10964330
Birkett AM et al. Changes to the quantity and processing of starchy foods in a western diet can increase polysaccharides escaping digestion and improve in vitro fermentation variables. 2000 Br. J. Nutr. pmid:10961162
Wolever TM and Chiasson JL Acarbose raises serum butyrate in human subjects with impaired glucose tolerance. 2000 Br. J. Nutr. pmid:10961161
Wisker E et al. Short-chain fatty acids produced in vitro from fibre residues obtained from mixed diets containing different breads and in human faeces during the ingestion of the diets. 2000 Br. J. Nutr. pmid:10961158
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Nudelman A and Rephaeli A Novel mutual prodrug of retinoic and butyric acids with enhanced anticancer activity. 2000 J. Med. Chem. pmid:10956204
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Masuda T et al. Up-regulation of E-cadherin and I-catenin in human hepatocellular carcinoma cell lines by sodium butyrate and interferon-alpha. 2000 In Vitro Cell. Dev. Biol. Anim. pmid:10949998
Shadan FF and Villarreal LP n-Butyrate mediated inhibition of papovavirus DNA replication in vivo and in cell culture: a mechanistic approach. 2000 Virus Genes pmid:10949947
Jensen UB et al. Transgene expression in human epidermal keratinocytes: cell cycle arrest of productively transfected cells. 2000 Exp. Dermatol. pmid:10949553
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Gilbert KM et al. Potential clinical use of butyric acid derivatives to induce antigen-specific T cell inactivation. 2000 J. Pharmacol. Exp. Ther. pmid:10945871
Marilley D and Schwaller B Association between the calcium-binding protein calretinin and cytoskeletal components in the human colon adenocarcinoma cell line WiDr. 2000 Exp. Cell Res. pmid:10942575
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Segain JP et al. Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease. 2000 Gut pmid:10940278
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Magee RM et al. Synthesis of osteonectin by human retinal pigment epithelial cells is modulated by cell density. 2000 Invest. Ophthalmol. Vis. Sci. pmid:10937587
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Lee CH et al. NMR studies on novel antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxoartemisinin. 2000 Biochem. Biophys. Res. Commun. pmid:10913344
Jørgensen J and Mortensen PB Utilization of short-chain fatty acids by colonic mucosal tissue strips. A new method of assessing colonic mucosal metabolism. 2000 Scand. J. Gastroenterol. pmid:10912669
Witt O et al. Tributyrin plus all-trans-retinoic acid efficiently induces fetal hemoglobin expression in human erythroleukemia cells. 2000 Am. J. Hematol. pmid:10911389
Krig SR and Rice RH TCDD suppression of tissue transglutaminase stimulation by retinoids in malignant human keratinocytes. 2000 Toxicol. Sci. pmid:10910994
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Lupton JR Is fiber protective against colon cancer? Where the research is leading us. 2000 Jul-Aug Nutrition pmid:10906555
Bai L and Merchant JL Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells. 2000 J. Biol. Chem. pmid:10899165
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Wu YD and Song JD The expression of glucose regulated protein-94 in colorectal carcinoma cells treated by sodium butyrate. 2000 Cell Res. pmid:10896173
Ferguson LR et al. Comparative effects of three resistant starch preparations on transit time and short-chain fatty acid production in rats. 2000 Nutr Cancer pmid:10890035
Belobrajdic DP and McIntosh GH Dietary butyrate inhibits NMU-induced mammary cancer in rats. 2000 Nutr Cancer pmid:10890033
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Takahashi M et al. Studies of the effect of Clostridium butyricum on Helicobacter pylori in several test models including gnotobiotic mice. 2000 J. Med. Microbiol. pmid:10882089
McMillan L et al. Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis. 2000 Biochem. Biophys. Res. Commun. pmid:10873561
Wilson AJ and Gibson PR Role of urokinase and its receptor in basal and stimulated colonic epithelial cell migration in vitro. 2000 Gut pmid:10861271
Bonge H et al. Cytostar-T scintillating microplate assay for measurement of sodium-dependent bile acid uptake in transfected HEK-293 cells. 2000 Anal. Biochem. pmid:10860504
Segouffin-Cariou C et al. Characterization of the epstein-barr virus BRRF1 gene, located between early genes BZLF1 and BRLF1. 2000 J. Gen. Virol. pmid:10859385
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Andoh A et al. Modulation of complement component (C3 and factor B) biosynthesis by a histone deacetylase inhibitor in human intestinal epithelial cells. 2000 Int. J. Mol. Med. pmid:10851266