butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Cao QF et al. | TRPM2 mediates histone deacetylase inhibition-induced apoptosis in bladder cancer cells. | 2015 | Cancer Biother. Radiopharm. | pmid:25760728 |
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Jawed K et al. | Engineered Production of Short Chain Fatty Acid in Escherichia coli Using Fatty Acid Synthesis Pathway. | 2016 | PLoS ONE | pmid:27466817 |
Gargari G et al. | Consumption of a Bifidobacterium bifidum Strain for 4 Weeks Modulates Dominant Intestinal Bacterial Taxa and Fecal Butyrate in Healthy Adults. | 2016 | Appl. Environ. Microbiol. | pmid:27451450 |
Teixeira C et al. | Effects of variety and steeping conditions on some barley components associated with colonic health. | 2016 | J. Sci. Food Agric. | pmid:27450418 |
Zhou J et al. | Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats. | 2016 | Lipids Health Dis | pmid:27449927 |
Astakhova L et al. | Short Chain Fatty Acids (SCFA) Reprogram Gene Expression in Human Malignant Epithelial and Lymphoid Cells. | 2016 | PLoS ONE | pmid:27441625 |
Bai G et al. | Dietary Casein and Soy Protein Isolate Modulate the Effects of Raffinose and Fructooligosaccharides on the Composition and Fermentation of Gut Microbiota in Rats. | 2016 | J. Food Sci. | pmid:27434756 |
Reijnders D et al. | Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial. | 2016 | Cell Metab. | pmid:27411009 |
Longpré J et al. | Impact of mash feeding versus pellets on propionic/butyric acid levels and on total load in the gastrointestinal tract of growing pigs. | 2016 | J. Anim. Sci. | pmid:27065267 |
Venkataraman A et al. | Variable responses of human microbiomes to dietary supplementation with resistant starch. | 2016 | Microbiome | pmid:27357127 |
Liang B and Fang J | Postnatal Isoflurane Exposure Induces Cognitive Impairment and Abnormal Histone Acetylation of Glutamatergic Systems in the Hippocampus of Adolescent Rats. | 2016 | J. Mol. Neurosci. | pmid:27307148 |
Lee J et al. | Deciphering Clostridium tyrobutyricum Metabolism Based on the Whole-Genome Sequence and Proteome Analyses. | 2016 | MBio | pmid:27302759 |
Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
Rephaeli A et al. | Bi-functional prodrugs of 5-aminolevulinic acid and butyric acid increase erythropoiesis in anemic mice in an erythropoietin-independent manner. | 2016 | Eur J Pharm Sci | pmid:27283485 |
Moreno FS et al. | Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents. | 2016 | Nutr Cancer | pmid:27266713 |
Aguilar EC et al. | Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells. | 2016 | J. Nutr. Biochem. | pmid:27261536 |
Zeng J et al. | Autophagy regulates biliary differentiation of hepatic progenitor cells through Notch1 signaling pathway. | 2016 | Cell Cycle | pmid:27259983 |
Wang A et al. | Sodium butyrate mitigates in vitro ammonia generation in cecal content of laying hens. | 2016 | Environ Sci Pollut Res Int | pmid:27154844 |
Early JV et al. | Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis. | 2016 | Antimicrob. Agents Chemother. | pmid:27044545 |
He B et al. | Effects of sodium butyrate supplementation on reproductive performance and colostrum composition in gilts. | 2016 | Animal | pmid:27040131 |
Petry FS et al. | Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction. | 2016 | Behav. Brain Res. | pmid:27025446 |
Frycz BA et al. | Transcript level of AKR1C3 is down-regulated in gastric cancer. | 2016 | Biochem. Cell Biol. | pmid:27019068 |
Li H et al. | Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury mice. | 2016 | Brain Res. | pmid:27017959 |
Ortega JF et al. | Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein. | 2016 | Oncotarget | pmid:27013579 |
Sjöblom M et al. | Catalytic upgrading of butyric acid towards fine chemicals and biofuels. | 2016 | FEMS Microbiol. Lett. | pmid:26994015 |
Zhao Z et al. | Potential enhancement of direct interspecies electron transfer for syntrophic metabolism of propionate and butyrate with biochar in up-flow anaerobic sludge blanket reactors. | 2016 | Bioresour. Technol. | pmid:26967338 |
Sun J et al. | Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. | 2016 | Neurosci. Lett. | pmid:26957230 |
Su CL et al. | Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression. | 2016 | J Psychiatr Res | pmid:26921875 |
Tanaka S et al. | Relationship of Enhanced Butyrate Production by Colonic Butyrate-Producing Bacteria to Immunomodulatory Effects in Normal Mice Fed an Insoluble Fraction of Brassica rapa L. | 2016 | Appl. Environ. Microbiol. | pmid:26921420 |
Donovan JD et al. | Volatile Retention and Morphological Properties of Microencapsulated Tributyrin Varied by Wall Material and Drying Method. | 2016 | J. Food Sci. | pmid:26878682 |
Wang ZT et al. | Histone deacetylase inhibitors suppress mutant p53 transcription via HDAC8/YY1 signals in triple negative breast cancer cells. | 2016 | Cell. Signal. | pmid:26876786 |
Zounr RA et al. | Improved Gas Chromatographic Determination of Guanidino Compounds Using Isovaleroylacetone and Ethyl Chloroformate as Derivatizing Reagents. | 2016 | Anal Sci | pmid:26860556 |
Wang J et al. | Therapeutic Effect of Histone Deacetylase Inhibitor, Sodium Butyrate, on Allergic Rhinitis In Vivo. | 2016 | DNA Cell Biol. | pmid:26859163 |
Ziegler K et al. | Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4). | 2016 | Arch. Biochem. Biophys. | pmid:26854723 |
Tao Y et al. | Production of Butyrate from Lactate by a Newly Isolated Clostridium sp. BPY5. | 2016 | Appl. Biochem. Biotechnol. | pmid:26842597 |
Zhu P et al. | [Effect and mechanism of inhibition of lipopolysaccharide-induced pulmonary fibrosis by butyric acid]. | 2016 | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | pmid:26805528 |
Sayed M et al. | Selective oxidation of trimethylolpropane to 2,2-bis(hydroxymethyl)butyric acid using growing cells of Corynebacterium sp. ATCC 21245. | 2016 | J. Biotechnol. | pmid:26804932 |
Zhang J et al. | Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis. | 2016 | PLoS ONE | pmid:26784903 |
Ng CH and Yang KL | Lipase in biphasic alginate beads as a biocatalyst for esterification of butyric acid and butanol in aqueous media. | 2016 | Enzyme Microb. Technol. | pmid:26672465 |
Han A et al. | Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells. | 2016 | J. Cell. Physiol. | pmid:26661480 |
Tiwari P et al. | Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs. | 2016 | Biochimie | pmid:26655363 |
Valvassori SS et al. | Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain. | 2016 | Psychiatry Res | pmid:26654753 |
Mátis G et al. | Feed-drug interaction of orally applied butyrate and phenobarbital on hepatic cytochrome P450 activity in chickens. | 2016 | J Anim Physiol Anim Nutr (Berl) | pmid:26614344 |
Luceri C et al. | Effect of butyrate enemas on gene expression profiles and endoscopic/histopathological scores of diverted colorectal mucosa: A randomized trial. | 2016 | Dig Liver Dis | pmid:26607831 |
Kratsman N et al. | Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory/excitatory genes in the frontal cortex of an autism model. | 2016 | Neuropharmacology | pmid:26577018 |
Heidor R et al. | The chemopreventive activity of butyrate-containing structured lipids in experimental rat hepatocarcinogenesis. | 2016 | Mol Nutr Food Res | pmid:26548572 |
Cueno ME et al. | Periodontal disease level-butyric acid amounts locally administered in the rat gingival mucosa induce ER stress in the systemic blood. | 2016 | Microb. Pathog. | pmid:26541671 |
Sergeev E et al. | Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands. | 2016 | J. Biol. Chem. | pmid:26518871 |
Curren J et al. | Identification and quantification of nuisance odors at a trash transfer station. | 2016 | Waste Manag | pmid:27692531 |
Silva FT et al. | Replacement of sugars to hydrogen production by Rhodobacter capsulatus using dark fermentation effluent as substrate. | 2016 | Bioresour. Technol. | pmid:26476167 |
Cueno ME and Ochiai K | Re-discovering periodontal butyric acid: New insights on an old metabolite. | 2016 | Microb. Pathog. | pmid:26466516 |
Junicke H et al. | Kinetic and thermodynamic control of butyrate conversion in non-defined methanogenic communities. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26403924 |
Ayers LW et al. | Changes in dam and pup behavior following repeated postnatal exposure to a predator odor (TMT): A preliminary investigation in Long-Evans rats. | 2016 | Dev Psychobiol | pmid:26394891 |
Contreras-Leal E et al. | Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. | 2016 | Mol. Carcinog. | pmid:26331238 |
Russo R et al. | Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice. | 2016 | Pharmacol. Res. | pmid:26675718 |
Reddy YS et al. | Study on Synthesis, Characterization and Antiproliferative Activity of Novel Diisopropylphenyl Esters of Selected Fatty Acids. | 2016 | J Oleo Sci | pmid:26666272 |
Polycarpo GV et al. | Effects of lipid sources, lysophospholipids and organic acids in maize-based broiler diets on nutrient balance, liver concentration of fat-soluble vitamins, jejunal microbiota and performance. | 2016 | Br. Poult. Sci. | pmid:27494540 |
Kim M et al. | Butyric acid production from softwood hydrolysate by acetate-consuming Clostridium sp. S1 with high butyric acid yield and selectivity. | 2016 | Bioresour. Technol. | pmid:27474955 |
Han M et al. | Dietary grape seed proanthocyanidins (GSPs) improve weaned intestinal microbiota and mucosal barrier using a piglet model. | 2016 | Oncotarget | pmid:27880936 |
Rumpagaporn P et al. | Elevated propionate and butyrate in fecal ferments of hydrolysates generated by oxalic acid treatment of corn bran arabinoxylan. | 2016 | Food Funct | pmid:27841429 |
Karthikeyan OP et al. | Hydrolysis-acidogenesis of food waste in solid-liquid-separating continuous stirred tank reactor (SLS-CSTR) for volatile organic acid production. | 2016 | Bioresour. Technol. | pmid:26512860 |
Xing X et al. | Sodium butyrate protects against oxidative stress in HepG2 cells through modulating Nrf2 pathway and mitochondrial function. | 2016 | J. Physiol. Biochem. | pmid:28600747 |
Youn YS et al. | Molecular tuning of amino acids to form two-dimensional molecular networks driven by conformational preorganization. | 2016 | Chem. Commun. (Camb.) | pmid:27858018 |
Huang H et al. | Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. | 2016 | Cell. Mol. Immunol. | pmid:25683610 |
Liu Y et al. | Dietary resistant starch type 4-derived butyrate attenuates nuclear factor-kappa-B1 through modulation of histone H3 trimethylation at lysine 27. | 2016 | Food Funct | pmid:27713965 |
MartÃn Juárez J et al. | Saccharification of microalgae biomass obtained from wastewater treatment by enzymatic hydrolysis. Effect of alkaline-peroxide pretreatment. | 2016 | Bioresour. Technol. | pmid:27372005 |
Seki K et al. | Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease progression. | 2016 | Apoptosis | pmid:26994613 |
Khan S and Jena G | Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin. | 2016 | Chem. Biol. Interact. | pmid:27270450 |
Zhang Z et al. | O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter. | 2016 | J. Biol. Chem. | pmid:27231347 |
Grimaldi R et al. | Fermentation properties and potential prebiotic activity of Bimuno® galacto-oligosaccharide (65 % galacto-oligosaccharide content) on in vitro gut microbiota parameters. | 2016 | Br. J. Nutr. | pmid:27267934 |
Kulcsár A et al. | Effects of butyrate on the insulin homeostasis of chickens kept on maize- or wheat-based diets. | 2016 | Acta Vet. Hung. | pmid:27993103 |
Tochio T et al. | An Alteration in the Cecal Microbiota Composition by Feeding of 1-Kestose Results in a Marked Increase in the Cecal Butyrate Content in Rats. | 2016 | PLoS ONE | pmid:27861621 |
Tian H et al. | Discovery of a Flexible Triazolylbutanoic Acid as a Highly Potent Uric Acid Transporter 1 (URAT1) Inhibitor. | 2016 | Molecules | pmid:27854343 |
Neis EP et al. | Effects of Liver Resection on Hepatic Short-Chain Fatty Acid Metabolism in Humans. | 2016 | PLoS ONE | pmid:27835668 |
Khairy H et al. | The NADH:flavin oxidoreductase Nox from Rhodococcus erythropolis MI2 is the key enzyme of 4,4'-dithiodibutyric acid degradation. | 2016 | Lett. Appl. Microbiol. | pmid:27564089 |
Kong X et al. | Inhibiting excessive acidification using zero-valent iron in anaerobic digestion of food waste at high organic load rates. | 2016 | Bioresour. Technol. | pmid:26998799 |
Bencsik R et al. | Improved transgene expression in doxycycline-inducible embryonic stem cells by repeated chemical selection or cell sorting. | 2016 | Stem Cell Res | pmid:27591479 |
Han R et al. | Sodium Butyrate Upregulates miR-203 Expression to Exert Anti-Proliferation Effect on Colorectal Cancer Cells. | 2016 | Cell. Physiol. Biochem. | pmid:27771718 |
Polak U et al. | Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming. | 2016 | Stem Cells Dev. | pmid:27615158 |
Chen WS et al. | Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats. | 2016 | Brain Res. | pmid:27742468 |
Miao W et al. | Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCβ2. | 2016 | Int J Mol Sci | pmid:27735862 |
Ain QU et al. | Analysis of Differential Efficacy and Affinity of GABA (α1/α2) Selective Modulators. | 2016 | Mol. Pharm. | pmid:27704838 |