butyric acid

butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with butyric acid?

butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with butyric acid

MeSH term MeSH ID Detail
Anaplasia D000708 1 associated lipids
Trophoblastic Neoplasms D014328 1 associated lipids
Diverticulitis, Colonic D004239 1 associated lipids
Aphakia, Postcataract D001036 1 associated lipids
Diverticulosis, Colonic D043963 1 associated lipids
Facial Injuries D005151 1 associated lipids
Gastrinoma D015408 1 associated lipids
Myoepithelioma D009208 1 associated lipids
Proctitis D011349 1 associated lipids
Diverticulitis D004238 1 associated lipids
Salivary Gland Neoplasms D012468 1 associated lipids
Astigmatism D001251 1 associated lipids
Intestinal Neoplasms D007414 2 associated lipids
Hemorrhoids D006484 2 associated lipids
Sarcoma, Avian D001357 2 associated lipids
Dentin, Secondary D003809 2 associated lipids
Colorectal Neoplasms, Hereditary Nonpolyposis D003123 2 associated lipids
Lymphoma, AIDS-Related D016483 2 associated lipids
Nevus D009506 2 associated lipids
Granuloma, Lethal Midline D006103 2 associated lipids
Per page 10 20 50 100 | Total 149

PubChem Associated disorders and diseases

What pathways are associated with butyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with butyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with butyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with butyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with butyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with butyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with butyric acid

Download all related citations
Per page 10 20 50 100 | Total 7933
Authors Title Published Journal PubMed Link
George CH et al. Rapid determination of gap junction formation using HeLa cells microinjected with cDNAs encoding wild-type and chimeric connexins. 1998 Biochem. Biophys. Res. Commun. pmid:9647771
Dangond F and Gullans SR Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. 1998 Biochem. Biophys. Res. Commun. pmid:9647779
Filippovich I et al. Butyrate induced apoptosis in lymphoid cells preceded by transient over-expression of HSP70 mRNA. 1994 Biochem. Biophys. Res. Commun. pmid:7904816
Rivero JA and Adunyah SE Sodium butyrate stimulates PKC activation and induces differential expression of certain PKC isoforms during erythroid differentiation. 1998 Biochem. Biophys. Res. Commun. pmid:9703983
Kitzis A et al. Effect of sodium butyrate on chromatin structure. 1980 Biochem. Biophys. Res. Commun. pmid:7387680
Gaudier E et al. Butyrate regulation of glycosylation-related gene expression: evidence for galectin-1 upregulation in human intestinal epithelial goblet cells. 2004 Biochem. Biophys. Res. Commun. pmid:15541394
Tong X et al. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. 2004 Biochem. Biophys. Res. Commun. pmid:15063780
Bai L and Merchant JL ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. 2007 Biochem. Biophys. Res. Commun. pmid:17560543
Daniel C et al. p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression. 2004 Biochem. Biophys. Res. Commun. pmid:15504345
Nagelberg SB et al. Pretranslational regulation of ectopic hCG alpha production in ChaGo lung cancer cells by sodium butyrate. 1985 Biochem. Biophys. Res. Commun. pmid:2417603
Seki J et al. Dimethyl sulfoxide and related polar compounds enhance infection of human T cells with HIV-1 in vitro. 1996 Biochem. Biophys. Res. Commun. pmid:8886001
BektaÅŸoÄŸlu B et al. Novel hydroxyl radical scavenging antioxidant activity assay for water-soluble antioxidants using a modified CUPRAC method. 2006 Biochem. Biophys. Res. Commun. pmid:16716257
Otaka M et al. Antibody-mediated targeting of differentiation inducers to tumor cells: inhibition of colonic cancer cell growth in vitro and in vivo. A preliminary note. 1989 Biochem. Biophys. Res. Commun. pmid:2912449
Reppe S et al. Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells. 2004 Biochem. Biophys. Res. Commun. pmid:15465005
Bohan C et al. Sodium butyrate activates human immunodeficiency virus long terminal repeat--directed expression. 1987 Biochem. Biophys. Res. Commun. pmid:2825693
Fishman PH et al. Induction of glycolipid biosynthesis by sodium butyrate in HeLa cells. 1974 Biochem. Biophys. Res. Commun. pmid:4858378
Kinoshita M et al. Butyrate reduces colonic paracellular permeability by enhancing PPARgamma activation. 2002 Biochem. Biophys. Res. Commun. pmid:12054544
Tabuchi Y et al. Identification of genes responsive to sodium butyrate in colonic epithelial cells. 2002 Biochem. Biophys. Res. Commun. pmid:12054516
Lallemand F et al. Direct inhibition of the expression of cyclin D1 gene by sodium butyrate. 1996 Biochem. Biophys. Res. Commun. pmid:8954100
Kitzis A et al. Localization of phosphoproteins and of protein kinases in chromatin from butyrate treated HTC cells. 1980 Biochem. Biophys. Res. Commun. pmid:7470113
Oster T et al. Induction of recombinant human gamma-glutamyl transferase by sodium butyrate in transfected V79 and CHO Chinese hamster cells. 1993 Biochem. Biophys. Res. Commun. pmid:8099285
Kitajima M et al. Characterization of baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mammalian cells. 2006 Biochem. Biophys. Res. Commun. pmid:16545777
Steiner E et al. SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. 2004 Biochem. Biophys. Res. Commun. pmid:15047174
Weingarten D and de Vellis J Selective inhibition by sodium butyrate of the glucocorticoid induction of glycerol phosphate dehydrogenase in glial cultures. 1980 Biochem. Biophys. Res. Commun. pmid:6772178
TaÅŸtan Bishop AO and Sewell T A new approach to possible substrate binding mechanisms for nitrile hydratase. 2006 Biochem. Biophys. Res. Commun. pmid:16540090
Akiba Y et al. Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream. 2010 Biochem. Biophys. Res. Commun. pmid:20170631
Wiegandt H et al. Retinoic acid alters the metabolic 3H-labelling of glycosphingolipids. 1987 Biochem. Biophys. Res. Commun. pmid:3032172
Mori Y et al. Differential effect of sodium butyrate on cyclic AMP phosphodiesterase activities in butyrate sensitive and resistant mastocytoma cells. 1986 Biochem. Biophys. Res. Commun. pmid:3019329
Siavoshian S et al. Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells. 1997 Biochem. Biophys. Res. Commun. pmid:9125124
Ide Y et al. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. 2006 Biochem. Biophys. Res. Commun. pmid:16434023
Ogawa H et al. Butyrate modulates gene and protein expression in human intestinal endothelial cells. 2003 Biochem. Biophys. Res. Commun. pmid:12963019
Abramova MV et al. e2f1 Gene is a new member of Wnt/beta-catenin/Tcf-regulated genes. 2010 Biochem. Biophys. Res. Commun. pmid:19900401
McMillan L et al. Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis. 2000 Biochem. Biophys. Res. Commun. pmid:10873561
Lee IH et al. Involvement of CCAAT/enhancer-binding protein alpha in haptoglobin gene expression by all-trans-retinoic acid. 2002 Biochem. Biophys. Res. Commun. pmid:12074569
Gaschott T et al. Butyrate-induced differentiation of Caco-2 cells is mediated by vitamin D receptor. 2001 Biochem. Biophys. Res. Commun. pmid:11676498
Ormandy CJ et al. Coordinate regulation of oestrogen and prolactin receptor expression by sodium butyrate in human breast cancer cells. 1992 Biochem. Biophys. Res. Commun. pmid:1734881
Radhakrishnan P et al. Butyrate induces sLex synthesis by stimulation of selective glycosyltransferase genes. 2007 Biochem. Biophys. Res. Commun. pmid:17553459
Staecker JL et al. Stimulation of DNA synthesis in primary cultures of adult rat hepatocytes by sodium butyrate. 1987 Biochem. Biophys. Res. Commun. pmid:3632683
Tang DC and Taylor MW Memory of butyrate induction by the Moloney murine sarcoma virus enhancer-promoter element. 1992 Biochem. Biophys. Res. Commun. pmid:1449468
Garbutt GJ and Abraham EC Stimulation of minor fetal hemoglobin synthesis in cord blood reticulocytes by butyrate. 1981 Biochem. Biophys. Res. Commun. pmid:6164369
Leibovitch MP et al. Effect of sodium butyrate on gene expression in a rat myogenic cell line. 1984 Biochem. Biophys. Res. Commun. pmid:6517941
Wei P et al. Reversible immortalization of Nestin-positive precursor cells from pancreas and differentiation into insulin-secreting cells. 2012 Biochem. Biophys. Res. Commun. pmid:22266322
Wächtershäuser A et al. Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation. 2000 Biochem. Biophys. Res. Commun. pmid:10679282
Newman JD et al. Induction of the insulin receptor and other differentiation markers by sodium butyrate in the Burkitt lymphoma cell, Raji. 1989 Biochem. Biophys. Res. Commun. pmid:2786417
Kaneko Y et al. Fibroblast-like transformation and c-myc gene alteration of human hepatocytes induced by novobiocin and butyrate. 1988 Biochem. Biophys. Res. Commun. pmid:2843181
Leibovitch MP and Kruh J Effect of sodium butyrate on myoblast growth and differentiation. 1979 Biochem. Biophys. Res. Commun. pmid:454435
Xiao H et al. Sodium butyrate induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1 in p53-independent manner. 1997 Biochem. Biophys. Res. Commun. pmid:9268733
Hatayama H et al. The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T. 2007 Biochem. Biophys. Res. Commun. pmid:17374366
Lee SK et al. Cellular differentiation-induced attenuation of LPS response in HT-29 cells is related to the down-regulation of TLR4 expression. 2005 Biochem. Biophys. Res. Commun. pmid:16202385
Qin S and Yamamura H Up-regulation of Syk activity during HL60 cell differentiation into granulocyte but not into monocyte/macrophage-lineage. 1997 Biochem. Biophys. Res. Commun. pmid:9245716
Adolf GR and Swetly P Effects of butyrate on induction and action of interferon. 1981 Biochem. Biophys. Res. Commun. pmid:6174120
Bell PA and Jones CN Cytotoxic effects of butyrate and other 'differentiation inducers' on immature lymphoid cells. 1982 Biochem. Biophys. Res. Commun. pmid:6176240
Stevens MS et al. Associated effects of sodium butyrate on histone acetylation and estrogen receptor in the human breast cancer cell line MCF-7. 1984 Biochem. Biophys. Res. Commun. pmid:6704117
Hammill D et al. The D-domain of Sp3 modulates its protein levels and activation of the p21(CIP1/WAF1) promoter. 2005 Biochem. Biophys. Res. Commun. pmid:16081043
Russo GL et al. Down-regulation of protein kinase CKII activity by sodium butyrate. 1997 Biochem. Biophys. Res. Commun. pmid:9168912
Gaschott T et al. 1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression. 2001 Biochem. Biophys. Res. Commun. pmid:11322770
Aung CS et al. Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation. 2007 Biochem. Biophys. Res. Commun. pmid:17321497
Jahangeer S et al. beta-Adrenergic receptor induction in HeLa cells: synergistic effect of 5-azacytidine and butyrate. 1982 Biochem. Biophys. Res. Commun. pmid:6185119
Laubach VE et al. High-level expression of human inducible nitric oxide synthase in Chinese hamster ovary cells and characterization of the purified enzyme. 1996 Biochem. Biophys. Res. Commun. pmid:8579595
Ho LH et al. Involvement of intracellular labile zinc in suppression of DEVD-caspase activity in human neuroblastoma cells. 2000 Biochem. Biophys. Res. Commun. pmid:10652229
Kim HS et al. Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors. 2003 Biochem. Biophys. Res. Commun. pmid:14651963
Prasad MR et al. Kinetic evidence for two separate trans-2-enoyl CoA reductases in rat hepatic microsomes: NADPH-specific short chain- and NAD(P)H-dependent long chain-reductase. 1983 Biochem. Biophys. Res. Commun. pmid:6870879
Ramirez ML et al. Chlorambucil-induced changes in chromatin methylation and their modulation by sodium butyrate. 1982 Biochem. Biophys. Res. Commun. pmid:7181918
Belakavadi M et al. Butyrate-induced proapoptotic and antiangiogenic pathways in EAT cells require activation of CAD and downregulation of VEGF. 2005 Biochem. Biophys. Res. Commun. pmid:16105646
Mandal M et al. Redistribution of activated caspase-3 to the nucleus during butyric acid-induced apoptosis. 1999 Biochem. Biophys. Res. Commun. pmid:10403841
Vider BZ et al. Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. 2000 Biochem. Biophys. Res. Commun. pmid:10833444
Nilsson NE et al. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. 2003 Biochem. Biophys. Res. Commun. pmid:12684041
Rabelo FL et al. Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell line. 2003 Biochem. Biophys. Res. Commun. pmid:12589807
Yan JK et al. Sodium butyrate attenuates soybean oil-based lipid emulsion-induced increase in intestinal permeability of lipopolysaccharide by modulation of P-glycoprotein in Caco-2 cells. 2017 Biochem. Biophys. Res. Commun. pmid:27888107
Terakawa M et al. Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway. 2005 Biochem. Biophys. Res. Commun. pmid:15919053
Diakos C et al. n-Butyrate inhibits Jun NH(2)-terminal kinase activation and cytokine transcription in mast cells. 2006 Biochem. Biophys. Res. Commun. pmid:16949031
Souleimani A and Asselin C Regulation of C-fos expression by sodium butyrate in the human colon carcinoma cell line Caco-2. 1993 Biochem. Biophys. Res. Commun. pmid:8503924
Bergann T et al. A colonic mineralocorticoid receptor cell model expressing epithelial Na+ channels. 2009 Biochem. Biophys. Res. Commun. pmid:19275887
Han L et al. Histone acetyltransferase p300 regulates the transcription of human erythroid-specific 5-aminolevulinate synthase gene. 2006 Biochem. Biophys. Res. Commun. pmid:16904069
Yano S and Tierney DF Butyrate increases catalase activity and protects rat pulmonary artery smooth muscle cells against hyperoxia. 1989 Biochem. Biophys. Res. Commun. pmid:2590195
Moore-Hoon ML and Turner RJ Increased expression of the secretory Na+-K+-2Cl- cotransporter with differentiation of a human intestinal cell line. 1998 Biochem. Biophys. Res. Commun. pmid:9514875
Coats SR et al. Ligand-specific control of src-suppressed C kinase substrate gene expression. 2002 Biochem. Biophys. Res. Commun. pmid:12372401
Frycz BA et al. Transcript level of AKR1C3 is down-regulated in gastric cancer. 2016 Biochem. Cell Biol. pmid:27019068
Vamecq J et al. Studies on the metabolism of glycolyl-CoA. 1990 Biochem. Cell Biol. pmid:1976013
Sekhavat A et al. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. 2007 Biochem. Cell Biol. pmid:18059533
Ji XJ et al. Effect of fetal hemoglobin-stimulating medicines on the interaction of DNA and protein of important erythroid regulatory elements. 2003 Biochem. Cell Biol. pmid:14569302
Vargas JE et al. Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells. 2014 Biochem. Cell Biol. pmid:25070040
Prasad KN et al. Decreased expressions of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture. 1990 Biochem. Cell Biol. pmid:2177340
Hatayama T et al. Effects of sodium butyrate and dibutyryl cyclic AMP on thermosensitivity of HeLa cells and their production of heat shock proteins. 1986 Biochem. Int. pmid:3028421
Palmer TN et al. Can isolated spans of the tricarboxylic acid cycle operate independently? L-proline, oleate and butyrate metabolism in rat hepatocytes. 1983 Biochem. Int. pmid:6435625
Rius C et al. Comparative effects of butyrate and N6, 2'-O-dibutyryladenosine-3':5'-cyclic monophosphate on growth, differentiation and gene expression in U937 human monoblastoid cells. 1991 Biochem. Int. pmid:1652247
Ahmed N et al. The human promyelocytic HL60 cell line: a model of myeloid cell differentiation using dimethylsulphoxide, phorbol ester and butyrate. 1991 Biochem. Int. pmid:1652248
Aller P et al. Modification of cell growth-dependent gene transcript levels by sodium butyrate in serum stimulated fibroblasts. 1989 Biochem. Int. pmid:2719709
Yu BS et al. Dynamic properties of interaction between nucleic acid bases and models of amino acids. 1989 Biochem. Int. pmid:2719711
Schofield PS et al. Hormonal regulation of ketogenesis in hepatocytes from fed rats before and after glycogen depletion. 1984 Biochem. Int. pmid:6098276
Prasad S and Thakur MK Age-dependent effects of sodium butyrate and hydrocortisone on acetylation of high mobility group proteins of rat liver. 1988 Biochem. Int. pmid:3365268
Park SH et al. Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b. 2006 Biochem. J. pmid:16584384
Newsholme P et al. Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages. 1987 Biochem. J. pmid:3593269
Malakooti J et al. Transcriptional regulation of the intestinal luminal Na⁺ and Cl⁻ transporters. 2011 Biochem. J. pmid:21726200
Yarlett N et al. Respiration of the rumen ciliate Dasytricha ruminantium Schuberg. 1982 Biochem. J. pmid:6293462
Izumi T et al. Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation. 1995 Biochem. J. pmid:7848283
Hodny Z et al. Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. 2000 Biochem. J. pmid:10657244
Burger-van Paassen N et al. The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection. 2009 Biochem. J. pmid:19228118
Lee HJ et al. KLF4 positively regulates human ghrelin expression. 2009 Biochem. J. pmid:19327128
Zhang DE and Nelson DA Histone acetylation in chicken erythrocytes. Rates of deacetylation in immature and mature red blood cells. 1988 Biochem. J. pmid:3355515