(-)-Limonene

(-)-limonene is a lipid of Prenol Lipids (PR) class. (-)-limonene often locates in Kinetochores.

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Introduction

To understand associated biological information of (-)-Limonene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Limonene

MeSH term MeSH ID Detail
Acute Lung Injury D055371 33 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Stomach Ulcer D013276 75 associated lipids
Neuroblastoma D009447 66 associated lipids
Hypolipoproteinemias D007009 9 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cataract D002386 34 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 | Total 11

PubChem Associated disorders and diseases

What pathways are associated with (-)-Limonene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Limonene?

Related references are published most in these journals:

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What functions are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What lipids are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What genes are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (-)-Limonene

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Per page 10 20 50 100 | Total 1129
Authors Title Published Journal PubMed Link
Wang YY and Wang H [Analysis of chemical constituents of essential oil from dechengqi decoction]. 1994 Zhongguo Zhong Yao Za Zhi pmid:8011141
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Haag JD and Gould MN Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. 1994 Cancer Chemother. Pharmacol. pmid:7923558
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Karlberg AT et al. Influence of an anti-oxidant on the formation of allergenic compounds during auto-oxidation of d-limonene. 1994 Ann Occup Hyg pmid:8210084
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Jonker D et al. Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds. 1993 Food Chem. Toxicol. pmid:8095245
Reicks MM and Crankshaw D Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse. 1993 Xenobiotica pmid:8237062
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Jonker D et al. Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: comparison with the toxicity of the individual compounds. 1993 Food Chem. Toxicol. pmid:8449457
Elegbede JA et al. Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes. 1993 Carcinogenesis pmid:8508509
Duchamp-Viret P and Duchamp A GABAergic control of odour-induced activity in the frog olfactory bulb: possible GABAergic modulation of granule cell inhibitory action. 1993 Neuroscience pmid:8284042
Plaisier PW et al. Dissolution of gallstones. 1993 Dig Dis pmid:8370143
Crowell PL et al. Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene. 1992 Carcinogenesis pmid:1638695
Igimi H et al. A useful cholesterol solvent for medical dissolution of gallstones. 1992 Gastroenterol. Jpn. pmid:1526435
Frank AA et al. Toxic epidermal necrolysis associated with flea dips. 1992 Vet Hum Toxicol pmid:1621364
Saito K et al. Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin. 1992 Toxicology pmid:1281346
Crowell PL et al. Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growth. 1992 Cancer Chemother. Pharmacol. pmid:1464157
Sternal RS and Davis MA In vitro dissolution of cholesterol gallstones. 1992 Invest Radiol pmid:1473922
Kikuchi K et al. Effect of d-limonene on the amounts of ethanol and indomethacin penetrated from aqueous gel ointments to rat skin. 1992 Chem. Pharm. Bull. pmid:1477929
Okabe H et al. Percutaneous absorption of ketoprofen from acrylic gel patches containing d-limonene and ethanol as absorption enhancers. 1992 Chem. Pharm. Bull. pmid:1394713
Karlberg AT et al. Air oxidation of d-limonene (the citrus solvent) creates potent allergens. 1992 Contact Derm. pmid:1395597
Sauerbruch T Non-surgical management of bile duct stones refractory to routine endoscopic measures. 1992 Baillieres Clin. Gastroenterol. pmid:1362502
Zheng GQ et al. Anethofuran, carvone, and limonene: potential cancer chemopreventive agents from dill weed oil and caraway oil. 1992 Planta Med. pmid:1438594
Hansen AP and Heinis JJ Benzaldehyde, citral, and d-limonene flavor perception in the presence of casein and whey proteins. 1992 J. Dairy Sci. pmid:1597575
Priborský J et al. Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs. 1992 Arzneimittelforschung pmid:1610418
Wrba H et al. Carcinogenicity testing of some constituents of black pepper (Piper nigrum). 1992 Exp. Toxicol. Pathol. pmid:1617288
Haag JD et al. Limonene-induced regression of mammary carcinomas. 1992 Cancer Res. pmid:1617679
Wattenberg LW and Coccia JB Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils. 1991 Carcinogenesis pmid:1988170
Igimi H et al. Medical dissolution of gallstones. Clinical experience of d-limonene as a simple, safe, and effective solvent. 1991 Dig. Dis. Sci. pmid:1988264
Jensen OC and Petersen I [Occupational asthma caused by scented gravel in cat litter boxes]. 1991 Ugeskr. Laeg. pmid:2024303
Maltzman TH et al. Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes. 1991 Carcinogenesis pmid:1934293
Saito K et al. Behavior of alpha 2u-globulin accumulating in kidneys of male rats treated with d-limonene: kidney-type alpha 2u-globulin in the urine as a marker of d-limonene nephropathy. 1991 Toxicology pmid:1722357
Falk A et al. Purpuric rash caused by dermal exposure to d-limonene. 1991 Contact Derm. pmid:1782772
Flamm WG and Lehman-McKeeman LD The human relevance of the renal tumor-inducing potential of d-limonene in male rats: implications for risk assessment. 1991 Regul. Toxicol. Pharmacol. pmid:2024047
Vergunst H et al. In vitro comparison of different gall stone dissolution solvents. 1991 Gut pmid:1864544
Dietrich DR and Swenberg JA The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. 1991 Cancer Res. pmid:1711412
Rodriguez PA et al. Design of a gas chromatograph with parallel radioactivity and mass spectrometric detection. Application to the identification of the major metabolite of d-limonene associated with alpha 2u-globulin. 1991 J. Chromatogr. pmid:1711535
Karlberg AT et al. Animal experiments on the allergenicity of d-limonene--the citrus solvent. 1991 Ann Occup Hyg pmid:1836319
Crowell PL et al. Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites. 1991 J. Biol. Chem. pmid:1894647
Lehman-McKeeman LD et al. Comparative disposition of d-limonene in rats and mice: relevance to male-rat-specific nephrotoxicity. 1990 Toxicol. Lett. pmid:1699301
Karp F et al. Monoterpene biosynthesis: specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves. 1990 Arch. Biochem. Biophys. pmid:2297225
Huang Y and Pu F [Chemical components of the essential oil from Ligusticum brachylobum Franch]. 1990 Zhongguo Zhong Yao Za Zhi pmid:2261075
Webb DR et al. Assessment of the subchronic oral toxicity of d-limonene in dogs. 1990 Food Chem. Toxicol. pmid:2276695
Falk A et al. Liquid/air partition coefficients of four terpenes. 1990 Br J Ind Med pmid:2310709
Hooser SB Toxicology of selected pesticides, drugs, and chemicals. D-limonene, linalool, and crude citrus oil extracts. 1990 Vet. Clin. North Am. Small Anim. Pract. pmid:2180184
Yang S et al. [Effect of disintegrating method on quantity extracted and constituents of essential oil in fructus Aurantii]. 1990 Zhongguo Zhong Yao Za Zhi pmid:2206386
Gould MN et al. Chemoprevention and chemotherapy of mammary tumors by monoterpenoids. 1990 Prog. Clin. Biol. Res. pmid:2217395
Okabe H et al. Percutaneous absorption enhancing effect and skin irritation of monocyclic monoterpenes. 1990 Drug Des. Deliv. pmid:2076182
Matsuoka H et al. Evaluation of antifungal volatile compounds on the basis of the elongation rate of a single hypha. 1990 Appl. Environ. Microbiol. pmid:2082824
Gollnick K and Held S Merbromin (mercurochrome)--a photosensitizer for singlet oxygen reactions. 1990 J. Photochem. Photobiol. B, Biol. pmid:1692875
Lehman-McKeeman LD et al. d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and alpha 2u-globulin. 1989 Toxicol. Appl. Pharmacol. pmid:2472019
Webb DR et al. Acute and subchronic nephrotoxicity of d-limonene in Fischer 344 rats. 1989 Food Chem. Toxicol. pmid:2481635
Maltzman TH et al. The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil. 1989 Carcinogenesis pmid:2702727
Wattenberg LW et al. Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. 1989 Cancer Res. pmid:2713853
Cardullo AC et al. Allergic contact dermatitis resulting from sensitivity to citrus peel, geraniol, and citral. 1989 J. Am. Acad. Dermatol. pmid:2526827
Wellis DP et al. Discrimination among odorants by single neurons of the rat olfactory bulb. 1989 J. Neurophysiol. pmid:2746317
Laing DG et al. Odor masking in the rat. 1989 Physiol. Behav. pmid:2780835
d-limonene, an anticarcinogenic terpene. 1988 Nutr. Rev. pmid:3067145
Powers KA et al. An evaluation of the acute toxicity of an insecticidal spray containing linalool, d-limonene, and piperonyl butoxide applied topically to domestic cats. 1988 Vet Hum Toxicol pmid:3388747
Stel'makh VA [Toxicologic properties and the nature of the combined effect of a orthomenthane hydrocarbon mixture]. 1988 Gig Tr Prof Zabol pmid:3234846
Elson CE et al. Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis. 1988 Carcinogenesis pmid:3123086
Laing DG and Willcox ME An investigation of the mechanisms of odor suppression using physical and dichorhinic mixtures. 1987 Nov-Dec Behav. Brain Res. pmid:3426790
Sugata F [New therapeutic methods--technics, application, efficacy and problems. Litholysis. c) Present status of direct litholytic agents]. 1987 Nippon Rinsho pmid:3118078
Evans DL et al. Modulation of immune responses in mice by d-limonene. 1987 J Toxicol Environ Health pmid:3492608
Lacy MJ et al. d-Limonene: an effective vasodilator for use in collecting rabbit blood. 1987 Lab. Anim. Sci. pmid:3669603
Kanerva RL et al. Comparison of short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats. 1987 Food Chem. Toxicol. pmid:3609973
Kanerva RL and Alden CL Review of kidney sections from a subchronic d-limonene oral dosing study conducted by the National Cancer Institute. 1987 Food Chem. Toxicol. pmid:3609974
Bell GA et al. Odour mixture suppression: evidence for a peripheral mechanism in human and rat. 1987 Brain Res. pmid:3690320
O'Neill HJ et al. Identification of isoprenoid-type components in human expired air: a possible shunt pathway in sterol metabolism. 1987 Biomed. Chromatogr. pmid:3147729
Neoptolemos JP et al. Chemical treatment of stones in the biliary tree. 1986 Br J Surg pmid:3089354
Elegbede JA et al. Mouse skin tumor promoting activity of orange peel oil and d-limonene: a re-evaluation. 1986 Carcinogenesis pmid:3096589
Elegbede JA et al. Regression of rat primary mammary tumors following dietary d-limonene. 1986 J. Natl. Cancer Inst. pmid:3080636
Hooser SB et al. Effects of an insecticidal dip containing d-limonene in the cat. 1986 J. Am. Vet. Med. Assoc. pmid:3771360
Hink WF and Fee BJ Toxicity of D-limonene, the major component of citrus peel oil, to all life stages of the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). 1986 J. Med. Entomol. pmid:3735346
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Abraham WR et al. Microbial transformations of some monoterpenoids and sesquiterpenoids. 1985 Ciba Found. Symp. pmid:3848377
Elegbede JA et al. Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. 1984 Carcinogenesis pmid:6426810
Ighimi H [Gallstone solubilizers]. 1984 Nihon Geka Gakkai Zasshi pmid:6503981
Guin JD et al. The effect of quenching agents on contact urticaria caused by cinnamic aldehyde. 1984 J. Am. Acad. Dermatol. pmid:6693599
Bell GD Cholelitholytic agents. 1983 Pharmacol. Ther. pmid:6419241
Kjonaas R and Croteau R Demonstration that limonene is the first cyclic intermediate in the biosynthesis of oxygenated p-menthane monoterpenes in Mentha piperita and other Mentha species. 1983 Arch. Biochem. Biophys. pmid:6830247
Fahrig R Effects of food additives in the mammalian spot test. 1982 Prog. Clin. Biol. Res. pmid:7167550
Watabe T et al. A comparative study on the metabolism of d-limonene and 4-vinylcyclohex-1-ene by hepatic microsomes. 1981 Xenobiotica pmid:7293224
Köppel C et al. Acute poisoning with pine oil - metabolism of monoterpenes. 1981 Arch. Toxicol. pmid:7325802
Schenk J et al. [Studies on tissue compatibility of d-limonene as a dissolving agent of cholesterol gallstones (author's transl)]. 1980 Z Gastroenterol pmid:7424079
Rycroft RJ Allergic contact dermatitis from dipentene in honing oil. 1980 Contact Derm. pmid:6448119
Watabe T et al. Metabolism of d-limonene by hepatic microsomes to non-mutagenic epoxides toward Salmonella typhimurium. 1980 Biochem. Pharmacol. pmid:6992785
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ROSSI A [Not Available]. 1947 Mar-Apr Farmaco Sci Tec pmid:20261998
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