(-)-Limonene

(-)-limonene is a lipid of Prenol Lipids (PR) class. (-)-limonene often locates in Kinetochores.

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Introduction

To understand associated biological information of (-)-Limonene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Limonene

MeSH term MeSH ID Detail
Acute Lung Injury D055371 33 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Stomach Ulcer D013276 75 associated lipids
Neuroblastoma D009447 66 associated lipids
Hypolipoproteinemias D007009 9 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cataract D002386 34 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 | Total 11

PubChem Associated disorders and diseases

What pathways are associated with (-)-Limonene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Limonene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What lipids are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What genes are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (-)-Limonene

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Authors Title Published Journal PubMed Link
Bardon S et al. Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines. 1998 Nutr Cancer pmid:9824849
Huang J et al. [GC-MS analysis of essential oils from the pericarps of Illicium majus Hook.f.et. Thoms. and I. micranthum Dunn]. 1996 Zhongguo Zhong Yao Za Zhi pmid:9812698
Zhao K and Singh J Mechanisms of percutaneous absorption of tamoxifen by terpenes: eugenol, D-limonene and menthone. 1998 J Control Release pmid:9795076
Huang J et al. [GC-MS analysis of essential oils from pericarps of Illicium brevistylum A. C. Smith and I. jiadifengpi B.N. Chang]. 1996 Zhongguo Zhong Yao Za Zhi pmid:9772632
Príborský J et al. Percutaneous absorption of disopyramide, lidocaine and trimecaine. 1998 Acta Univ Palacki Olomuc Fac Med pmid:9684478
Chen H et al. Pharmacokinetics of d-limonene in the rat by GC-MS assay. 1998 J Pharm Biomed Anal pmid:9682146
Morse MA Inhibition of NNK-induced lung tumorigenesis by modulators of NNK activation. 1998 Jul-Aug Exp. Lung Res. pmid:9659585
Vigushin DM et al. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. 1998 Cancer Chemother. Pharmacol. pmid:9654110
Diez I et al. Influence of d-limonene on the transdermal penetration of felodipine. 1998 Jan-Mar Eur J Drug Metab Pharmacokinet pmid:9625266
Oshiro Y et al. Exploration of the transformation potential of a unique male rat protein alpha2u-globulin using hamster embryonic cells. 1998 May-Jun Toxicol Pathol pmid:9608644
Kaur M et al. Receptor-Ck-dependent regulation of genes involved in the cell cycle. 1998 Mol. Cell. Biochem. pmid:9562250
Miller AC and Samid D Tumor radiosensitization based on the use of inhibitors of the mevalonate pathway of cholesterol synthesis. 1997 Adv. Exp. Med. Biol. pmid:9547635
van Lieshout EM et al. Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive tract. 1998 Biochim. Biophys. Acta pmid:9545594
Wakelin SH et al. Allergic contact dermatitis from d-limonene in a laboratory technician. 1998 Contact Derm. pmid:9536411
Lehman-McKeeman LD et al. 2-sec-butyl-4,5-dihydrothiazole is a ligand for mouse urinary protein and rat alpha 2u-globulin: physiological and toxicological relevance. 1998 Toxicol. Appl. Pharmacol. pmid:9512724
Crowell PL Monoterpenes in breast cancer chemoprevention. 1997 Nov-Dec Breast Cancer Res. Treat. pmid:9478274
Estell RE et al. Effects of volatile compounds on consumption of alfalfa pellets by sheep. 1998 J. Anim. Sci. pmid:9464903
Chang YC et al. Allergic contact dermatitis from oxidized d-limonene. 1997 Contact Derm. pmid:9455646
Kunta JR et al. Effect of menthol and related terpenes on the percutaneous absorption of propranolol across excised hairless mouse skin. 1997 J Pharm Sci pmid:9423148
Pöhle H and Kliche R [Emission of odors from composting of biological waste]. 1996 Zentralbl Hyg Umweltmed pmid:9409908
Youngentob SL et al. Odorant threshold following methyl bromide-induced lesions of the olfactory epithelium. 1997 Physiol. Behav. pmid:9383109
Devlieghere F et al. Evaluation, modelling and optimization of the cleaning process of contaminated plastic food refillables. 1997 Aug-Oct Food Addit Contam pmid:9373531
Lewis KA and Hohl RJ Modulation of RAS expression in human malignant cells by dietary supplements. 1997 Nutrition pmid:9357036
Galli I et al. DNA replication and order of cell cycle events: a role for protein isoprenylation? 1997 Biol. Chem. pmid:9348105
Poet TS and Borghoff SJ In vitro uptake of methyl tert-butyl ether in male rat kidney: use of a two-compartment model to describe protein interactions. 1997 Toxicol. Appl. Pharmacol. pmid:9266807
Chen X et al. Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin. 1997 Jul-Aug Anticancer Res. pmid:9252680
Kreuzer J et al. Protein kinase C activation after cellular adhesion on fibronectin: partial suppression after inhibition of protein isoprenylation. 1997 Eur. J. Med. Res. pmid:9233906
Nakaizumi A et al. d-Limonene inhibits N-nitrosobis(2-oxopropyl)amine induced hamster pancreatic carcinogenesis. 1997 Cancer Lett. pmid:9233838
Savithiry N et al. Production of alpha-terpineol from Escherichia coli cells expressing thermostable limonene hydratase. 1997 Appl. Biochem. Biotechnol. pmid:9170246
Karlberg AT and Dooms-Goossens A Contact allergy to oxidized d-limonene among dermatitis patients. 1997 Contact Derm. pmid:9165203
Gilbert ES and Crowley DE Plant compounds that induce polychlorinated biphenyl biodegradation by Arthrobacter sp. strain B1B. 1997 Appl. Environ. Microbiol. pmid:9143124
Jonker D et al. Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action. 1996 Nov-Dec Food Chem. Toxicol. pmid:9119318
Misra G et al. Aerobic biodegradation of selected monoterpenes. 1996 Appl. Microbiol. Biotechnol. pmid:8987470
Yamane MA et al. Terpene penetration enhancers in propylene glycol/water co-solvent systems: effectiveness and mechanism of action. 1995 J. Pharm. Pharmacol. pmid:8932680
el-Bayoumy K et al. Effects of 1,4-phenylenebis(methylene)selenocyanate, phenethyl isothiocyanate, indole-3-carbinol, and d-limonene individually and in combination on the tumorigenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. 1996 Sep-Oct Anticancer Res. pmid:8917375
Whysner J and Williams GM d-limonene mechanistic data and risk assessment: absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion. 1996 Pharmacol. Ther. pmid:8910952
Ariazi EA and Gould MN Identifying differential gene expression in monoterpene-treated mammary carcinomas using subtractive display. 1996 J. Biol. Chem. pmid:8910589
Crowell PL et al. Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer. 1996 Adv. Exp. Med. Biol. pmid:8886131
Broitman SA et al. Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo. 1996 Adv. Exp. Med. Biol. pmid:8886130
Karlson J et al. Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action. 1996 Anticancer Drugs pmid:8826611
Adam KP et al. Partial purification and characterization of a monoterpene cyclase, limonene synthase, from the liverwort Ricciocarpos natans. 1996 Arch. Biochem. Biophys. pmid:8806745
Kimura J et al. Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model. 1996 Jpn. J. Cancer Res. pmid:8766522
Poon GK et al. Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry. 1996 Drug Metab. Dispos. pmid:8723738
Williams GM and Whysner J Epigenetic carcinogens: evaluation and risk assessment. 1996 Exp. Toxicol. Pathol. pmid:8672874
Morse MA and Toburen AL Inhibition of metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by limonene. 1996 Cancer Lett. pmid:8665490
Kawamori T et al. Inhibitory effects of d-limonene on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. 1996 Carcinogenesis pmid:8625465
Jansen LA and Jongen WM The use of initiated cells as a test system for the detection of inhibitors of gap junctional intercellular communication. 1996 Carcinogenesis pmid:8625460
Alvares K et al. Ciprofibrate represses alpha 2u-globulin expression in liver and inhibits d-limonene nephrotoxicity. 1996 Carcinogenesis pmid:8625456
O'Shaughnessy JA Chemoprevention of breast cancer. 1996 JAMA pmid:8614122
Von Burg R Limonene. 1995 Nov-Dec J Appl Toxicol pmid:8603937
York M et al. Skin irritation testing in man for hazard assessment--evaluation of four patch systems. 1995 Hum Exp Toxicol pmid:8579884
Saito K et al. Alpha 2u-globulins in the urine of male rats: a reliable indicator for alpha 2u-globulin accumulation in the kidney. 1996 Toxicology pmid:8571386
Martins C et al. Allergic contact dermatitis from dipentene in wax polish. 1995 Contact Derm. pmid:8549131
Luján HD et al. Isoprenylation of proteins in the protozoan Giardia lamblia. 1995 Mol. Biochem. Parasitol. pmid:8538683
Gould MN Prevention and therapy of mammary cancer by monoterpenes. 1995 J. Cell. Biochem. Suppl. pmid:8538191
Williams GM and Whysner J Mechanistic considerations in risk assessment for epigenetic tumor-promoting carcinogens. 1995 Prog. Clin. Biol. Res. pmid:8532729
Scheuplein RJ The use of biological data in addition to the carcinogen bioassay in quantitative risk assessment. 1995 Prog. Clin. Biol. Res. pmid:8532727
Elegbede JA et al. Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes. 1993 Carcinogenesis pmid:8508509
Jonker D et al. Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: comparison with the toxicity of the individual compounds. 1993 Food Chem. Toxicol. pmid:8449457
Falk-Filipsson A et al. d-limonene exposure to humans by inhalation: uptake, distribution, elimination, and effects on the pulmonary function. 1993 J Toxicol Environ Health pmid:8421324
d-Limonene. 1993 IARC Monogr Eval Carcinog Risks Hum pmid:8411619
Plaisier PW et al. Dissolution of gallstones. 1993 Dig Dis pmid:8370143
Jirtle RL et al. Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors. 1993 Cancer Res. pmid:8358708
Schulz S et al. Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene related monoterpenes. 1994 Eur. J. Immunol. pmid:8299679
Duchamp-Viret P and Duchamp A GABAergic control of odour-induced activity in the frog olfactory bulb: possible GABAergic modulation of granule cell inhibitory action. 1993 Neuroscience pmid:8284042
Reicks MM and Crankshaw D Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse. 1993 Xenobiotica pmid:8237062
Karlberg AT et al. Influence of an anti-oxidant on the formation of allergenic compounds during auto-oxidation of d-limonene. 1994 Ann Occup Hyg pmid:8210084
Sybilska D et al. Chromatographic studies of the enantiomeric composition of some therapeutic compositions applied in the treatment of liver and kidney diseases. 1994 J Chromatogr A pmid:8205230
Kawata S et al. Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2). 1994 Br. J. Cancer pmid:8198962
Meding B et al. Hand eczema in car mechanics. 1994 Contact Derm. pmid:8187510
Crowell PL et al. Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. 1994 Biochem. Pharmacol. pmid:8185648
Chander SK et al. Effectiveness of combined limonene and 4-hydroxyandrostenedione in the treatment of NMU-induced rat mammary tumours. 1994 Br. J. Cancer pmid:8180018
Karlberg AT et al. Hydroperoxides in oxidized d-limonene identified as potent contact allergens. 1994 Arch. Dermatol. Res. pmid:8154930
Jonker D et al. Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds. 1993 Food Chem. Toxicol. pmid:8095245
Friedman MI et al. Limonene in expired lung air of patients with liver disease. 1994 Dig. Dis. Sci. pmid:8050315
Kurahashi T et al. Suppression of odorant responses by odorants in olfactory receptor cells. 1994 Science pmid:8016645
Gould MN et al. Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras. 1994 Cancer Res. pmid:8012978
Wang YY and Wang H [Analysis of chemical constituents of essential oil from dechengqi decoction]. 1994 Zhongguo Zhong Yao Za Zhi pmid:8011141
Koyama Y et al. Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model. 1994 Pharm. Res. pmid:8008702
Crowell PL et al. Human metabolism of the experimental cancer therapeutic agent d-limonene. 1994 Cancer Chemother. Pharmacol. pmid:7987974
Yoshii H et al. Minimum number of water molecules required for inclusion of d-limonene in the cyclodextrin cavity. 1994 J. Biochem. pmid:7982877
Larsen MC et al. The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific. 1994 Arch. Biochem. Biophys. pmid:7979401
Crowell PL and Gould MN Chemoprevention and therapy of cancer by d-limonene. 1994 Crit Rev Oncog pmid:7948106
Hard GC and Whysner J Risk assessment of d-limonene: an example of male rat-specific renal tumorigens. 1994 Crit. Rev. Toxicol. pmid:7945892
Haag JD and Gould MN Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. 1994 Cancer Chemother. Pharmacol. pmid:7923558
Gelb MH et al. The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. 1995 Cancer Lett. pmid:7767906
Whalen JD et al. Xylene substitutes in frozen sections. 1995 Dermatol Surg pmid:7712095
Kurahashi T and Yau KW Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells. 1993 Nature pmid:7683113
Miyazaki S et al. Percutaneous absorption of indomethacin from pluronic F127 gels in rats. 1995 J. Pharm. Pharmacol. pmid:7674126
Hursting SD et al. Chemoprevention of spontaneous tumorigenesis in p53-knockout mice. 1995 Cancer Res. pmid:7664260
Hohl RJ and Lewis K Differential effects of monoterpenes and lovastatin on RAS processing. 1995 J. Biol. Chem. pmid:7615555
Rosenbaum MR and Kerlin RL Erythema multiforme major and disseminated intravascular coagulation in a dog following application of a d-limonene-based insecticidal dip. 1995 J. Am. Vet. Med. Assoc. pmid:7591926
Ohara N et al. Combined effect of d-limonene pretreatment and temperature on the rat skin permeation of lipophilic and hydrophilic drugs. 1995 Biol. Pharm. Bull. pmid:7550099
Touvay C et al. Effect of limonene and sobrerol on monocrotaline-induced lung alterations and pulmonary hypertension. 1995 May-Jun Int. Arch. Allergy Immunol. pmid:7542078
Cornwell PA et al. Wide-angle X-ray diffraction of human stratum corneum: effects of hydration and terpene enhancer treatment. 1994 J. Pharm. Pharmacol. pmid:7536240
Lehman-McKeeman LD and Caudill D d-Limonene induced hyaline droplet nephropathy in alpha 2u-globulin transgenic mice. 1994 Fundam Appl Toxicol pmid:7532604
Kristiansen E and Madsen C Induction of protein droplet (alpha 2 mu-globulin) nephropathy in male rats after short-term dosage with 1,8-cineole and l-limonene. 1995 Toxicol. Lett. pmid:7482582
Schenk J et al. [Studies on tissue compatibility of d-limonene as a dissolving agent of cholesterol gallstones (author's transl)]. 1980 Z Gastroenterol pmid:7424079
Köppel C et al. Acute poisoning with pine oil - metabolism of monoterpenes. 1981 Arch. Toxicol. pmid:7325802
Watabe T et al. A comparative study on the metabolism of d-limonene and 4-vinylcyclohex-1-ene by hepatic microsomes. 1981 Xenobiotica pmid:7293224