(-)-Limonene

(-)-limonene is a lipid of Prenol Lipids (PR) class. (-)-limonene often locates in Kinetochores.

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Introduction

To understand associated biological information of (-)-Limonene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Limonene

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Asthma D001249 52 associated lipids
Neuroblastoma D009447 66 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypolipoproteinemias D007009 9 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Per page 10 20 | Total 11

PubChem Associated disorders and diseases

What pathways are associated with (-)-Limonene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Limonene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What lipids are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What genes are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (-)-Limonene

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Authors Title Published Journal PubMed Link
Chen X et al. Inhibition of farnesyl protein transferase and P21ras memebrane association by d-limonene in human pancreas tumor cells in vitro. 1999 Chin. Med. Sci. J. pmid:12903812
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Roy A Chemoenzymatic synthesis of homochiral (R)- and (S)-karahanaenol from (R)-limonene. 1999 J. Agric. Food Chem. pmid:10606597
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Safety assessment and potential health benefits of food components based on selected scientific criteria. ILSI North America Technical Committee on Food Components for Health Promotion. 1999 Crit Rev Food Sci Nutr pmid:10367185
Bhatia KS and Singh J Effect of linolenic acid/ethanol or limonene/ethanol and iontophoresis on the in vitro percutaneous absorption of LHRH and ultrastructure of human epidermis. 1999 Int J Pharm pmid:10370194
Greene-McDowelle DM et al. The effects of selected cotton-leaf volatiles on growth, development and aflatoxin production of Aspergillus parasiticus. 1999 Toxicon pmid:10340828
Uedo N et al. Inhibition by D-limonene of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. 1999 Cancer Lett. pmid:10374833
Duchamp-Viret P et al. Odor response properties of rat olfactory receptor neurons. 1999 Science pmid:10381881
van der Werf MJ et al. Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene. 1999 Appl. Environ. Microbiol. pmid:10224006
Karlberg AT et al. Regulatory classification of substances oxidized to skin sensitizers on exposure to air. 1999 Contact Derm. pmid:10208503
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Hardcastle IR et al. Inhibition of protein prenylation by metabolites of limonene. 1999 Biochem. Pharmacol. pmid:10075086
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Crowell PL Prevention and therapy of cancer by dietary monoterpenes. 1999 J. Nutr. pmid:10082788
Donaldson MJ et al. XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase. 1999 Eur. J. Cancer pmid:10533487
Oshiro Y et al. Exploration of the transformation potential of a unique male rat protein alpha2u-globulin using hamster embryonic cells. 1998 May-Jun Toxicol Pathol pmid:9608644
Morse MA Inhibition of NNK-induced lung tumorigenesis by modulators of NNK activation. 1998 Jul-Aug Exp. Lung Res. pmid:9659585
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Zhao K and Singh J Mechanisms of percutaneous absorption of tamoxifen by terpenes: eugenol, D-limonene and menthone. 1998 J Control Release pmid:9795076
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van Lieshout EM et al. Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive tract. 1998 Biochim. Biophys. Acta pmid:9545594
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Vigushin DM et al. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. 1998 Cancer Chemother. Pharmacol. pmid:9654110
Savithiry N et al. Degradation of pinene by Bacillus pallidus BR425. 1998 Biodegradation pmid:10192895
Bardon S et al. Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines. 1998 Nutr Cancer pmid:9824849
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Chen X et al. [Effect of d-limonene, Salvia miltiorrhiza and turmeric derivatives on membrane association of Ras gene product and gap junction intercellular communication]. 1998 Yao Xue Xue Bao pmid:12016941
Crowell PL Monoterpenes in breast cancer chemoprevention. 1997 Nov-Dec Breast Cancer Res. Treat. pmid:9478274
Chen X et al. Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin. 1997 Jul-Aug Anticancer Res. pmid:9252680
Devlieghere F et al. Evaluation, modelling and optimization of the cleaning process of contaminated plastic food refillables. 1997 Aug-Oct Food Addit Contam pmid:9373531
Chang YC et al. Allergic contact dermatitis from oxidized d-limonene. 1997 Contact Derm. pmid:9455646
Galli I et al. DNA replication and order of cell cycle events: a role for protein isoprenylation? 1997 Biol. Chem. pmid:9348105
Savithiry N et al. Production of alpha-terpineol from Escherichia coli cells expressing thermostable limonene hydratase. 1997 Appl. Biochem. Biotechnol. pmid:9170246
Nakaizumi A et al. d-Limonene inhibits N-nitrosobis(2-oxopropyl)amine induced hamster pancreatic carcinogenesis. 1997 Cancer Lett. pmid:9233838
Kreuzer J et al. Protein kinase C activation after cellular adhesion on fibronectin: partial suppression after inhibition of protein isoprenylation. 1997 Eur. J. Med. Res. pmid:9233906
Gilbert ES and Crowley DE Plant compounds that induce polychlorinated biphenyl biodegradation by Arthrobacter sp. strain B1B. 1997 Appl. Environ. Microbiol. pmid:9143124
Miller AC and Samid D Tumor radiosensitization based on the use of inhibitors of the mevalonate pathway of cholesterol synthesis. 1997 Adv. Exp. Med. Biol. pmid:9547635
Lewis KA and Hohl RJ Modulation of RAS expression in human malignant cells by dietary supplements. 1997 Nutrition pmid:9357036
Poet TS and Borghoff SJ In vitro uptake of methyl tert-butyl ether in male rat kidney: use of a two-compartment model to describe protein interactions. 1997 Toxicol. Appl. Pharmacol. pmid:9266807
Karlberg AT and Dooms-Goossens A Contact allergy to oxidized d-limonene among dermatitis patients. 1997 Contact Derm. pmid:9165203
Youngentob SL et al. Odorant threshold following methyl bromide-induced lesions of the olfactory epithelium. 1997 Physiol. Behav. pmid:9383109
Kunta JR et al. Effect of menthol and related terpenes on the percutaneous absorption of propranolol across excised hairless mouse skin. 1997 J Pharm Sci pmid:9423148
el-Bayoumy K et al. Effects of 1,4-phenylenebis(methylene)selenocyanate, phenethyl isothiocyanate, indole-3-carbinol, and d-limonene individually and in combination on the tumorigenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. 1996 Sep-Oct Anticancer Res. pmid:8917375
Jonker D et al. Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action. 1996 Nov-Dec Food Chem. Toxicol. pmid:9119318
Adam KP et al. Partial purification and characterization of a monoterpene cyclase, limonene synthase, from the liverwort Ricciocarpos natans. 1996 Arch. Biochem. Biophys. pmid:8806745
Karlson J et al. Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action. 1996 Anticancer Drugs pmid:8826611
O'Shaughnessy JA Chemoprevention of breast cancer. 1996 JAMA pmid:8614122
Alvares K et al. Ciprofibrate represses alpha 2u-globulin expression in liver and inhibits d-limonene nephrotoxicity. 1996 Carcinogenesis pmid:8625456
Jansen LA and Jongen WM The use of initiated cells as a test system for the detection of inhibitors of gap junctional intercellular communication. 1996 Carcinogenesis pmid:8625460
Kawamori T et al. Inhibitory effects of d-limonene on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. 1996 Carcinogenesis pmid:8625465
Kimura J et al. Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model. 1996 Jpn. J. Cancer Res. pmid:8766522
Poon GK et al. Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry. 1996 Drug Metab. Dispos. pmid:8723738
Williams GM and Whysner J Epigenetic carcinogens: evaluation and risk assessment. 1996 Exp. Toxicol. Pathol. pmid:8672874
Morse MA and Toburen AL Inhibition of metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by limonene. 1996 Cancer Lett. pmid:8665490
Saito K et al. Alpha 2u-globulins in the urine of male rats: a reliable indicator for alpha 2u-globulin accumulation in the kidney. 1996 Toxicology pmid:8571386
Pöhle H and Kliche R [Emission of odors from composting of biological waste]. 1996 Zentralbl Hyg Umweltmed pmid:9409908
Broitman SA et al. Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo. 1996 Adv. Exp. Med. Biol. pmid:8886130
Crowell PL et al. Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer. 1996 Adv. Exp. Med. Biol. pmid:8886131
Misra G et al. Aerobic biodegradation of selected monoterpenes. 1996 Appl. Microbiol. Biotechnol. pmid:8987470
Ariazi EA and Gould MN Identifying differential gene expression in monoterpene-treated mammary carcinomas using subtractive display. 1996 J. Biol. Chem. pmid:8910589
Whysner J and Williams GM d-limonene mechanistic data and risk assessment: absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion. 1996 Pharmacol. Ther. pmid:8910952
Huang J et al. [GC-MS analysis of essential oils from the pericarps of Illicium majus Hook.f.et. Thoms. and I. micranthum Dunn]. 1996 Zhongguo Zhong Yao Za Zhi pmid:9812698
Huang J et al. [GC-MS analysis of essential oils from pericarps of Illicium brevistylum A. C. Smith and I. jiadifengpi B.N. Chang]. 1996 Zhongguo Zhong Yao Za Zhi pmid:9772632
Von Burg R Limonene. 1995 Nov-Dec J Appl Toxicol pmid:8603937
Touvay C et al. Effect of limonene and sobrerol on monocrotaline-induced lung alterations and pulmonary hypertension. 1995 May-Jun Int. Arch. Allergy Immunol. pmid:7542078
Whalen JD et al. Xylene substitutes in frozen sections. 1995 Dermatol Surg pmid:7712095
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Scheuplein RJ The use of biological data in addition to the carcinogen bioassay in quantitative risk assessment. 1995 Prog. Clin. Biol. Res. pmid:8532727
Williams GM and Whysner J Mechanistic considerations in risk assessment for epigenetic tumor-promoting carcinogens. 1995 Prog. Clin. Biol. Res. pmid:8532729
Gould MN Prevention and therapy of mammary cancer by monoterpenes. 1995 J. Cell. Biochem. Suppl. pmid:8538191
Luján HD et al. Isoprenylation of proteins in the protozoan Giardia lamblia. 1995 Mol. Biochem. Parasitol. pmid:8538683
Martins C et al. Allergic contact dermatitis from dipentene in wax polish. 1995 Contact Derm. pmid:8549131
Hursting SD et al. Chemoprevention of spontaneous tumorigenesis in p53-knockout mice. 1995 Cancer Res. pmid:7664260
Hohl RJ and Lewis K Differential effects of monoterpenes and lovastatin on RAS processing. 1995 J. Biol. Chem. pmid:7615555
Rosenbaum MR and Kerlin RL Erythema multiforme major and disseminated intravascular coagulation in a dog following application of a d-limonene-based insecticidal dip. 1995 J. Am. Vet. Med. Assoc. pmid:7591926
Ohara N et al. Combined effect of d-limonene pretreatment and temperature on the rat skin permeation of lipophilic and hydrophilic drugs. 1995 Biol. Pharm. Bull. pmid:7550099
Yamane MA et al. Terpene penetration enhancers in propylene glycol/water co-solvent systems: effectiveness and mechanism of action. 1995 J. Pharm. Pharmacol. pmid:8932680
Gelb MH et al. The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. 1995 Cancer Lett. pmid:7767906
Miyazaki S et al. Percutaneous absorption of indomethacin from pluronic F127 gels in rats. 1995 J. Pharm. Pharmacol. pmid:7674126
Kristiansen E and Madsen C Induction of protein droplet (alpha 2 mu-globulin) nephropathy in male rats after short-term dosage with 1,8-cineole and l-limonene. 1995 Toxicol. Lett. pmid:7482582
Kurahashi T et al. Suppression of odorant responses by odorants in olfactory receptor cells. 1994 Science pmid:8016645
Wang YY and Wang H [Analysis of chemical constituents of essential oil from dechengqi decoction]. 1994 Zhongguo Zhong Yao Za Zhi pmid:8011141
Gould MN et al. Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras. 1994 Cancer Res. pmid:8012978
Larsen MC et al. The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific. 1994 Arch. Biochem. Biophys. pmid:7979401
Haag JD and Gould MN Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. 1994 Cancer Chemother. Pharmacol. pmid:7923558
Friedman MI et al. Limonene in expired lung air of patients with liver disease. 1994 Dig. Dis. Sci. pmid:8050315
Hard GC and Whysner J Risk assessment of d-limonene: an example of male rat-specific renal tumorigens. 1994 Crit. Rev. Toxicol. pmid:7945892
Crowell PL and Gould MN Chemoprevention and therapy of cancer by d-limonene. 1994 Crit Rev Oncog pmid:7948106
Lehman-McKeeman LD and Caudill D d-Limonene induced hyaline droplet nephropathy in alpha 2u-globulin transgenic mice. 1994 Fundam Appl Toxicol pmid:7532604
Cornwell PA et al. Wide-angle X-ray diffraction of human stratum corneum: effects of hydration and terpene enhancer treatment. 1994 J. Pharm. Pharmacol. pmid:7536240
Crowell PL et al. Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. 1994 Biochem. Pharmacol. pmid:8185648
Meding B et al. Hand eczema in car mechanics. 1994 Contact Derm. pmid:8187510
Sybilska D et al. Chromatographic studies of the enantiomeric composition of some therapeutic compositions applied in the treatment of liver and kidney diseases. 1994 J Chromatogr A pmid:8205230
Karlberg AT et al. Influence of an anti-oxidant on the formation of allergenic compounds during auto-oxidation of d-limonene. 1994 Ann Occup Hyg pmid:8210084