Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Myxosarcoma D009236 1 associated lipids
Darier Disease D007644 2 associated lipids
Leukemia, Biphenotypic, Acute D015456 2 associated lipids
Carcinoma, Mucoepidermoid D018277 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
Genital Neoplasms, Male D005834 3 associated lipids
Hematologic Neoplasms D019337 4 associated lipids
Protein Deficiency D011488 5 associated lipids
Infertility, Female D007247 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Saksena SK and Salmonsen RA Antifertility effects of gossypol in male hamsters. 1982 Fertil. Steril. pmid:7075801
Jensen DR et al. Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats. 1982 Toxicology pmid:7135404
Zhou LF et al. [Further observations on the effect of prolonged administration of gossypol acetic acid to rats]. 1982 Yao Xue Xue Bao pmid:7136708
Lee CY et al. Enzyme inactivation and inhibition by gossypol. 1982 Mol. Cell. Biochem. pmid:7144742
Montamat EE et al. Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. 1982 Science pmid:6750791
Kalla NR et al. Studies on the male antifertility agent--gossypol acetic acid. III. Effect of gossypol acetic acid on rat testis. 1981 May-Jun Andrologia pmid:6455943
Kalla NR and Vasudev M Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa. 1981 Mar-Apr Andrologia pmid:6454365
Liu GZ Clinical study of gossypol as a male contraceptive. 1981 Jul-Sep Reproduccion pmid:6793420
El'chits SV et al. [Glucoamylase immobilization on silochrome using gossypol]. 1981 Jan-Feb Ukr. Biokhim. Zh. pmid:6259793
Jacobs HS Contraception in the future. 1981 Proc Annu Symp Eugen Soc pmid:7050975
Ye YX et al. [The effect of gossypol on the incorporation of H3-thymidine in the liver, testis and small intestine of experimental animals (author's transl)]. 1981 Yao Xue Xue Bao pmid:7246187
Tso WW and Lee CS Effect of gossypol on boar spermatozoa in vitro. 1981 Arch. Androl. pmid:7271366
Bozek SA et al. Scanning electron microscopic study of spermatozoa from gossypol-treated rats. 1981 Cell Tissue Res. pmid:7273120
Hahn DW et al. Antifertility and endocrine activities of gossypol in rodents. 1981 Contraception pmid:7273769
Waller DP et al. Antifertility effects of gossypol and its impurities on male hamsters. 1981 Contraception pmid:7285581
Sakesena SK et al. Gossypol: its toxicological and endocrinological effects in male rabbits. 1981 Contraception pmid:7297071
Bi XF et al. The effect of gossypol on ATPase activity of the kidney. 1981 Sci. Sin. pmid:6266011
Ridley AJ and Blasco L Testosterone and gossypol effects on human sperm motility. 1981 Fertil. Steril. pmid:6273239
Wu YM et al. Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. 1981 Contraception pmid:6796329
Hei LS [Electron-microscopic observations on bioptic testicular tissue of cancerous patients after oral administration of gossypol (author's transl)]. 1981 Zhonghua Yi Xue Za Zhi pmid:6804060