| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myxosarcoma | D009236 | 1 associated lipids |
| Darier Disease | D007644 | 2 associated lipids |
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Genital Neoplasms, Male | D005834 | 3 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
| Protein Deficiency | D011488 | 5 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xiao B and Wang M | Birth control techniques in China. | 1983 | China Popul Newsl | pmid:12312957 |
| Huang GZ et al. | [Etiological study of the burning sensation disease]. | 1983 | Acta Acad Med Wuhan | pmid:6621973 |
| Xue SP et al. | Subcellular site of antispermatogenic effect of gossypol and its possible molecular mechanism of action. | 1983 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:6623054 |
| Ratsula K et al. | Vaginal contraception with gossypol: a clinical study. | 1983 | Contraception | pmid:6684533 |
| Wong SM et al. | 14C-gossypol: optimum conditions for synthesis by cotton seedlings. | 1983 | Yao Xue Xue Bao | pmid:6687973 |
| El-Nahry FI et al. | Detoxification and nutritional evaluation of solvent extracted Egyptian cottonseed meal. | 1983 | Nahrung | pmid:6688656 |
| Herrera J et al. | Cottonseed flour effects on androgen testicular content and serum levels in rats. | 1983 | Arch. Androl. | pmid:6688944 |
| Stephens DT et al. | Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro. | 1983 | J. Reprod. Fertil. | pmid:6631812 |
| Lei HP | [Prospect of gossypol as a contraceptive agents for men]. | 1983 | Yao Xue Xue Bao | pmid:6637482 |
| Shi QX and Friend DS | Gossypol-induced inhibition of guinea pig sperm capacitation in vitro. | 1983 | Biol. Reprod. | pmid:6640034 |
| Manmade A et al. | Gossypol. Synthesis and in vitro spermicidal activity of isomeric hemigossypol derivatives. | 1983 | Experientia | pmid:6641903 |
| Gu ZP et al. | Morphological changes in the testes and epididymides of rats after gossypol. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6223497 |
| Xu Y et al. | [Antagonism of antifertility effect of gossypol by aspirin]. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6225300 |
| Qian SZ et al. | Antispermatogenic activity of gossypol in rats on low-potassium diet. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6228118 |
| Fei RR et al. | [Effects of gossypol on rat testicular mitochondria]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228314 |
| Chen XM et al. | [Effects of gossypol on lactate dehydrogenase isoenzyme-X in human spermatozoa]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228315 |
| Cao J and Liu GZ | [Reversibility of azoospermia following gossypol withdrawal]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228316 |
| Wang MZ | [High performance liquid chromatographic analysis of gossypol]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228325 |
| Wichmann K et al. | Effect of gossypol on the motility and metabolism of human spermatozoa. | 1983 | J. Reprod. Fertil. | pmid:6411909 |
| Eliasson R and Virji N | Effects of gossypol acetic acid on the activity of LDH-C4 from human and rabbit spermatozoa. | 1983 | Int. J. Androl. | pmid:6840877 |
| Tsui YC et al. | The effect of the male contraceptive agent Gossypol on human lymphocytes in vitro: traditional chromosome breakage, micronuclei, sister chromatid exchange, and cell kinetics. | 1983 | J. Med. Genet. | pmid:6842561 |
| Wong PY et al. | Lack of an effect of gossypol on the epididymis of the rat. | 1983 | Contraception | pmid:6851567 |
| Floridi A et al. | The effect of the association of Gossypol and Lonidamine on the energy metabolism of Ehrlich ascites tumor cells. | 1983 | Exp. Mol. Pathol. | pmid:6852206 |
| Vander Jagt DL et al. | Regulation of the glutathione S-transferase activity of bilirubin transport protein (ligandin) from human liver. Enzymic memory involving protein-protein interactions. | 1983 | J. Biol. Chem. | pmid:6853539 |
| Hoffer AP | Effects of gossypol on the seminiferous epithelium in the rat: a light and electron microscope study. | 1983 | Biol. Reprod. | pmid:6860736 |
| Royer RE and Vander Jagt DL | Gossypol binds to a high-affinity binding site on human serum albumin. | 1983 | FEBS Lett. | pmid:6862017 |
| Waller DP et al. | Effect of (+)-gossypol on fertility in male hamsters. | 1983 Jul-Aug | J. Androl. | pmid:6618998 |
| Weinbauer GF et al. | Toxicity of gossypol at antifertility dosages in male rats: statistical analysis of lethal rates and body weight responses. | 1983 May-Jun | Andrologia | pmid:6881556 |
| Kalla NR et al. | Effect of gossypol on testicular testosterone production in vitro. | 1983 Sep-Oct | J. Androl. | pmid:6630052 |
| Zhuang LZ et al. | Effects of gossypol on rat Sertoli and Leydig cells in primary culture and established cell lines. | 1983 Sep-Oct | J. Androl. | pmid:6685120 |
| Gerez de Burgos NM et al. | Inhibition by gossypol of oxidoreductases from Trypanosoma cruzi. | 1984 | Biochem. Pharmacol. | pmid:6370265 |
| Qian SZ and Wang ZG | Gossypol: a potential antifertility agent for males. | 1984 | Annu. Rev. Pharmacol. Toxicol. | pmid:6375548 |
| Wang NG et al. | [Antisteroidal and antigonadotrophic effects of gossypol acetic acid in rats]. | 1984 | Yao Xue Xue Bao | pmid:6464763 |
| Zu PD et al. | Electron microscopic observations of the effects of gossypol on the human endometrium. | 1984 | Am. J. Obstet. Gynecol. | pmid:6465231 |
| Whaley KJ et al. | Optically active gossypol as a circular dichroism probe of interactions with serum albumins. | 1984 | Biochim. Biophys. Acta | pmid:6466708 |
| Paz GF and Homonnai ZT | Effect of the antifertility agent, gossypol acetic acid, on the metabolism and testosterone secretion of isolated rat interstitial cells in vitro. | 1984 | Contraception | pmid:6467943 |
| Coutinho EM et al. | Antispermatogenic action of gossypol in men. | 1984 | Fertil. Steril. | pmid:6468676 |
| Reddy RM et al. | Pattern of ovarian and uterine carbohydrate metabolism during induced antiimplantation by (+)gossypol. | 1984 | Indian J. Exp. Biol. | pmid:6510968 |
| Gossypol prospects. | 1984 | Lancet | pmid:6144835 | |
| Soufir JC et al. | Epididymal effects of gossypol. | 1984 | Lancet | pmid:6145995 |
| Tvermyr SM et al. | Glucose metabolism in rat germ cells: mechanism of action of gossypol. | 1984 | Ann. N. Y. Acad. Sci. | pmid:6598341 |
| Tuszynski GP and Cossu G | Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines. | 1984 | Cancer Res. | pmid:6581864 |
| Haspel HC et al. | Cytocidal effect of gossypol on cultured murine erythroleukemia cells is prevented by serum protein. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6584595 |
| Kim IC et al. | Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone. | 1984 | Contraception | pmid:6509980 |
| Ali SF and El-Sewedy SM | Effect of gossypol on liver metabolic enzymes in male rats. | 1984 | Toxicol. Lett. | pmid:6084346 |
| Bi XF et al. | [Effects of potassium on the inhibitory effect of gossypol on Na,K-ATPase in vitro]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6087611 |
| Olgiati KL et al. | Gossypol inhibition of adenylate cyclase. | 1984 | Arch. Biochem. Biophys. | pmid:6732240 |
| Hoffer AP and Hinton BT | Morphological evidence for a blood-epididymis barrier and the effects of gossypol on its integrity. | 1984 | Biol. Reprod. | pmid:6733204 |
| Oko R and Hrudka F | Comparison of the effects of gossypol, estradiol-17 beta and testosterone compensation on male rat reproductive organs. | 1984 | Biol. Reprod. | pmid:6733210 |
| Whaley KJ et al. | A circular dichroism study of (+) gossypol binding to proteins. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743322 |