Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang WH et al. | [Antifertility actions of gossypol derivatives and analogues]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2088004 |
Morgan SE | Gossypol residues in organ meats vs thresholds of toxicity. | 1990 | Vet Hum Toxicol | pmid:2092408 |
Lu Q | [Comparative studies on antifertility mechanism and toxicology of Tripterygium wilfordii monomer T4 and gossypol]. | 1990 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2151263 |
Gu Y et al. | Inhibitory effect of gossypol on human chorionic gonadotropin (hCG)-induced progesterone secretion in cultured bovine luteal cells. | 1990 | Life Sci. | pmid:2168511 |
Hill MA et al. | Cyclooxygenase inhibition potentiates myogenic activity in skeletal muscle arterioles. | 1990 | Am. J. Physiol. | pmid:2105665 |
Zhong CQ et al. | Study on sperm function in men long after cessation of gossypol treatment. | 1990 | Contraception | pmid:2113849 |
Lei HQ and Xu YX | [Effects of gossypol acetic acid on transport and development of fertilized eggs in rats]. | 1990 | Yao Xue Xue Bao | pmid:2082677 |
Kunesch N et al. | [Preparation of derivatives of the aldehydic functions of gossypol]. | 1990 | Ann Pharm Fr | pmid:2082795 |
Johansen RL and Misra HP | Effects of gossypol on the hepatic drug metabolizing system in rats. | 1990 | Contraception | pmid:2083490 |
Huang T et al. | Gossypol-induced alterations of aminophospholipid composition in human sperm. | 1990 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2371261 |
Rikihisa Y et al. | Taenia taeniaeformis: inactivation of metacestodes by gossypol in vitro. | 1990 | Exp. Parasitol. | pmid:2373186 |
Zheng DK et al. | [Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. | 1990 | Yao Xue Xue Bao | pmid:2284966 |
Si YK et al. | [Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. | 1990 | Yao Xue Xue Bao | pmid:2284967 |
Zheng DK et al. | [Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent]. | 1990 | Yao Xue Xue Bao | pmid:2284968 |
Nair IN and Bhiwgade DA | Effect of gossypol on pituitary reproductive axis: ultrastructural and biochemical studies. | 1990 | Indian J. Exp. Biol. | pmid:2253964 |
Wiest E et al. | Removal of endothelial function in coronary resistance vessels by saponin. | 1989 Sep-Oct | Basic Res. Cardiol. | pmid:2818447 |
Agarwal A | Antifertility and ultrastructural effects of optical isomers of gossypol administered intratesticularly in rats. | 1989 Nov-Dec | Acta Eur. Fertil. | pmid:2488986 |
Achilova GSh et al. | [Antiviral activity of derivatives of aldehydophenols, aldehydo- naphthols and sugar derivatives]. | 1989 May-Jun | Vopr. Virusol. | pmid:2552684 |
Tanphaichitr N and Fitzgerald LM | Incorporation of gossypol and formation of its protein conjugates in mouse transformed Sertoli (TM4) cells. | 1989 May-Jun | J. Androl. | pmid:2745232 |
Gonzalez-Garza MT et al. | High susceptibility of five axenic Entamoeba histolytica strains to gossypol. | 1989 Jul-Aug | Trans. R. Soc. Trop. Med. Hyg. | pmid:2559507 |
Srivastava A et al. | Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. | 1989 | Contraception | pmid:2469550 |
Rillema JA et al. | Studies on the possible role of protein kinase C in the prolactin regulation of cell replication in Nb2 node lymphoma cells. | 1989 | Proc. Soc. Exp. Biol. Med. | pmid:2813443 |
Panigrahi S et al. | Effects of dietary cottonseed meal, with and without iron treatment, on laying hens. | 1989 | Br. Poult. Sci. | pmid:2819506 |
Tanphaichitr N and Fitzgerald LM | Adverse effects of gossypol analogs on TM4 cell mitochondrial function. | 1989 | Contraception | pmid:2752754 |
Laughton MJ et al. | Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. | 1989 | Biochem. Pharmacol. | pmid:2476132 |
Rikihisa Y and Lin YC | Effect of gossypol on the thyroid in young rats. | 1989 | J. Comp. Pathol. | pmid:2760274 |
Soufir JC et al. | Gossypol-induced modifications in the microenvironment of rat epididymal spermatozoa. | 1989 | J. Reprod. Fertil. | pmid:2760873 |
Keniry MA et al. | The effect of gossypol and 6-aminonicotinamide on tumor cell metabolism: a 31P-magnetic resonance spectroscopic study. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2530981 |
Band V et al. | Antiproliferative effect of gossypol and its optical isomers on human reproductive cancer cell lines. | 1989 | Gynecol. Oncol. | pmid:2920946 |
Mohan J et al. | Studies on antifertility effects of gossypol acetic acid in domestic cocks. | 1989 | J. Reprod. Fertil. | pmid:2536813 |
Alheid U et al. | Human endothelial cells inhibit platelet aggregation by separately stimulating platelet cyclic AMP and cyclic GMP. | 1989 | Eur. J. Pharmacol. | pmid:2546782 |
Aletor VA | Effect of varying levels of oyster shell on serum constituents and erythrocyte indices in growing chicken fed gossypol-containing Nigerian cottonseed cake. | 1989 | Nahrung | pmid:2628756 |
Medeiros YS et al. | Gossypol affects the responsiveness of isolated rat myometrium and vas deferens. | 1989 | Braz. J. Med. Biol. Res. | pmid:2638200 |
Sipkema P et al. | Does the endothelium play a role in flow-dependent constriction? A study in the isolated rabbit femoral artery. | 1989 | Blood Vessels | pmid:2641926 |
Adlakha RC et al. | Modulation of 4'-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol. | 1989 | Cancer Res. | pmid:2539251 |
Kanwar U et al. | Gossypol inhibition of Ca++ uptake and Ca++-ATPase in human ejaculated spermatozoal plasma membrane vesicles. | 1989 | Contraception | pmid:2541968 |
Morgan SE | Gossypol as a toxicant in livestock. | 1989 | Vet. Clin. North Am. Food Anim. Pract. | pmid:2667706 |
Wu D | An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. | 1989 | Drugs | pmid:2680434 |
Strøm-Hansen T et al. | Interaction of gossypol with amino acids and peptides as a model of enzyme inhibition. | 1989 | Int. J. Pept. Protein Res. | pmid:2599770 |
D'Orleans-Juste P et al. | Pharmacology of endothelin-1 in isolated vessels: effect of nicardipine, methylene blue, hemoglobin, and gossypol. | 1989 | J. Cardiovasc. Pharmacol. | pmid:2473306 |
Polsky B et al. | Inactivation of human immunodeficiency virus in vitro by gossypol. | 1989 | Contraception | pmid:2473865 |
Tareeva IE et al. | [Treatment of chronic glomerulonephritis with cytostatics]. | 1989 | Ter. Arkh. | pmid:2799726 |
Zhang SF et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: I. The activity for DNA synthesis. | 1989 | Contraception | pmid:2758843 |
Ye BK et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: II. The activity for the synthesis of cellular and nuclear basic proteins. | 1989 | Contraception | pmid:2758844 |
Grankvist K | Gossypol-induced free radical toxicity to isolated islet cells. | 1989 | Int. J. Biochem. | pmid:2684701 |
Wu YW et al. | An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma. | 1989 | Cancer Res. | pmid:2736516 |
Wang JM et al. | The entry of gossypol across the blood-testis barrier in rats. | 1989 | Contraception | pmid:2721201 |
Amanov N et al. | [Intestinal microbial ecology and its modulation under the influence of immunodepressants]. | 1989 | Antibiot. Khimioter. | pmid:2802878 |
Uchijima Y et al. | [Effects of gossypol on human specific lactate dehydrogenase-C4 (LDH-C4)]. | 1989 | Nihon Funin Gakkai Zasshi | pmid:12158558 |
Katoh N and Kimura K | Inhibition by gossypol of cyclic nucleotide-independent phosvitin kinase from pig testis. | 1989 | Nippon Juigaku Zasshi | pmid:2927017 |