Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fulda S | Modulation of apoptosis by natural products for cancer therapy. | 2010 | Planta Med. | pmid:20486070 |
Williams JL et al. | Fitness cost of resistance to Bt cotton linked with increased gossypol content in pink bollworm larvae. | 2011 | PLoS ONE | pmid:21738799 |
Varadarajan S et al. | Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. | 2013 | PLoS ONE | pmid:23457590 |
Zhang P et al. | Suppression of jasmonic acid-dependent defense in cotton plant by the mealybug Phenacoccus solenopsis. | 2011 | PLoS ONE | pmid:21818315 |
Mishra PJ et al. | Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. | 2016 | PLoS ONE | pmid:27846237 |
Zhang J et al. | Breeding Potential of Introgression Lines Developed from Interspecific Crossing between Upland Cotton (Gossypium hirsutum) and Gossypium barbadense: Heterosis, Combining Ability and Genetic Effects. | 2016 | PLoS ONE | pmid:26730964 |
Wong FY et al. | Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. | 2012 | PLoS ONE | pmid:23226540 |
Câmara AC et al. | Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. | 2015 | PLoS ONE | pmid:26600470 |
He Z et al. | Chemical Composition of Defatted Cottonseed and Soy Meal Products. | 2015 | PLoS ONE | pmid:26079931 |
Wang Q et al. | Salt Stress Effects on Secondary Metabolites of Cotton in Relation to Gene Expression Responsible for Aphid Development. | 2015 | PLoS ONE | pmid:26061875 |
Tang H et al. | Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones. | 2013 | PLoS ONE | pmid:23555724 |
Thakur A et al. | Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. | 2012 | PLoS ONE | pmid:23185240 |
Kaza N et al. | BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells. | 2014 | PLoS ONE | pmid:24824755 |
Cho H et al. | Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance. | 2014 | PLoS ONE | pmid:24587157 |
Jiao X et al. | Comparative transcriptomic analysis of developing cotton cotyledons and embryo axis. | 2013 | PLoS ONE | pmid:23977137 |
Lordelo MM et al. | Relative toxicity of gossypol enantiomers in laying and broiler breeder hens. | 2007 | Poult. Sci. | pmid:17297172 |
Berg LR and Lawrence WW | Cottonseed meal, dehydrated grass and ascorbic acid as dietary factors preventing toxicity of vanadium for the chick. | 1971 | Poult. Sci. | pmid:5109894 |
Lordelo MM et al. | Relative toxicity of gossypol enantiomers in broilers. | 2005 | Poult. Sci. | pmid:16206558 |
Blevins S et al. | Effects of silymarin on gossypol toxicosis in divergent lines of chickens. | 2010 | Poult. Sci. | pmid:20709972 |
Rikihisa Y and Lin YC | Ultrastructure of the testis and epididymis of Japanese quail (Coturnix coturnix japonica) administered gossypol. | 1988 | Poult. Sci. | pmid:3413024 |
Zeng QF et al. | The response of meat ducks from 15 to 35 d of age to gossypol from cottonseed meal. | 2015 | Poult. Sci. | pmid:25834247 |
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Zeng QF et al. | Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks. | 2014 | Poult. Sci. | pmid:24902707 |
Henry MH et al. | The performance of broiler chicks fed diets containing extruded cottonseed meal supplemented with lysine. | 2001 | Poult. Sci. | pmid:11441843 |
Gamboa DA et al. | Use of expander cottonseed meal in broiler diets formulated on a digestible amino acid basis. | 2001 | Poult. Sci. | pmid:11441847 |
Aitken RJ | New techniques in contraception: gossypol, vaccines and GnRH analogues. | 1983 | Proc Annu Symp Eugen Soc | pmid:6366784 |
Jacobs HS | Contraception in the future. | 1981 | Proc Annu Symp Eugen Soc | pmid:7050975 |
Wu DF and Yu YW | Superoxide free radical formation stimulated by (+/-), (+), (-) gossypol in rat liver and kidney microsomes. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2827151 |
Su SY and Liu Y | Electron microscopic observation of gossypol effects on gastrocnemius muscles in laboratory animals. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2827153 |
Zhao Y et al. | Studies on frequencies of sister chromatid exchange in peripheral blood lymphocytes before and after gossypol treatment. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3422992 |
Liu GZ et al. | Effect of K salt and K sparing agent in preventing gossypol-induced hypokalemia. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423005 |
Cheng JX et al. | Effect of gossypol(+/-, +, -) on Leydig cells of rat in vitro. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423013 |
Huang T et al. | Gossypol-induced alterations of aminophospholipid composition in human sperm. | 1990 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2371261 |
Zhang JB et al. | Effect of gossypol on fertilization capacity and chromosome formation of human sperm in vitro. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432238 |
Ye WS et al. | Cytological toxicity of gossypol on rat gametogenesis and spermatozoa. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432239 |
Lei HP | Future research priorities of gossypol in the field of fertility regulation. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3321051 |
Damaty S and Hudson BJ | A secondary interaction between gossypol and cottonseed protein. | 1975 | Proc Nutr Soc | pmid:1187618 |
Heiser V et al. | Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10829068 |
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Dash R et al. | Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21555592 |
Le A et al. | Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20133848 |
Rillema JA et al. | Studies on the possible role of protein kinase C in the prolactin regulation of cell replication in Nb2 node lymphoma cells. | 1989 | Proc. Soc. Exp. Biol. Med. | pmid:2813443 |
HARMS WS and HOLLEY KT | Hypoprothrombinemia induced by gossypol. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14854026 |
Othman MA and Abou-Donia MB | Pharmacokinetic profile of (+/-)-gossypol in male Sprague-Dawley rats following single intravenous and oral and subchronic oral administration. | 1988 | Proc. Soc. Exp. Biol. Med. | pmid:3368474 |
CASTILLON LE and ALTSCHUL AM | Preparation of water-soluble combination products of gossypol and their toxicity to aquarium fish. | 1950 | Proc. Soc. Exp. Biol. Med. | pmid:15440911 |
Jennings MB and Reidenberg MM | Adaptation to nephrotoxic chemicals. | 1988 | Proc. Soc. Exp. Biol. Med. | pmid:3205883 |
Gonzalez-Garza T et al. | In vitro evaluation of gossypol as potential antiamoebic drug. | 1991 | Proc. West. Pharmacol. Soc. | pmid:1788315 |
Fu YF et al. | Effects of gossypol on the activity of rabbit kidney Na,K-ATPase and the functions of human erythrocyte membrane. | 1988 | Prog. Clin. Biol. Res. | pmid:2975784 |
Sessions RB et al. | A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia. | 1997 | Protein Eng. | pmid:9194154 |
Zerp SF et al. | Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. | 2015 | Radiat Oncol | pmid:26223311 |