Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ershov FI et al. | [A new interferon inducer active via peroral administration]. | 1986 May-Jun | Vopr. Virusol. | pmid:2429451 |
Karpovich LG et al. | [Indices of lymphocyte functional activity in patients with recurrent cutaneous-genital herpes during treatment with a herpes vaccine]. | 1986 Mar-Apr | Vopr. Virusol. | pmid:3014750 |
Ahluwalia B et al. | Morphologic and endocrine changes in the reproductive organs in rats implanted with gossypol acetate pellet in the testis. | 1986 Jul-Aug | J. Androl. | pmid:3745012 |
Kalla NR et al. | Studies on the male antifertility agent gossypol acetic acid. VII. Effect of motility stimulated factors on the revival of human spermatozoal motility after gossypol treatment in vitro. | 1986 Jul-Aug | Andrologia | pmid:3019180 |
Wang JM et al. | Electrolyte composition of rete testis fluid and cauda epididymal plasma and spermatozoa from rats following gossypol treatment. | 1986 Jan-Feb | Andrologia | pmid:3954086 |
Heywood R et al. | The toxicity of gossypol to the male rat. | 1986 | Toxicology | pmid:3750328 |
Pearce S et al. | Site of gossypol inhibition of steroidogenesis in purified mouse Leydig cells. | 1986 | J. Steroid Biochem. | pmid:3025516 |
Radloff RJ et al. | Antiviral activities of gossypol and its derivatives against herpes simplex virus type II. | 1986 | Pharmacol Res Commun | pmid:3025895 |
Robinson JM et al. | Gossypol-induced damage to mitochondria of transformed Sertoli cells. | 1986 | Am. J. Pathol. | pmid:3026188 |
Krassnigg F et al. | Investigations on the functional role of angiotensin converting enzyme (ACE) in human seminal plasma. | 1986 | Adv. Exp. Med. Biol. | pmid:3028067 |
Pearce S et al. | Inhibition by gossypol of cyclic AMP production in mouse Leydig cells. | 1986 | Contraception | pmid:3030630 |
Ye YX et al. | [Mode of inhibitory action of gossypol on Na+, K+-ATPase in vitro]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:3035869 |
Cheng CC | A common structural pattern among many biologically active compounds of natural and synthetic origin. | 1986 | Med. Hypotheses | pmid:3090407 |
Vongsorasak L and Svasti J | Gossypol prevents activation of purified proenzyme of human seminal plasma acidic proteinase. | 1986 | Biochim. Biophys. Acta | pmid:3091079 |
Sun TS | [Long-term follow-up studies on patients poisoned by cottonseed oil]. | 1986 | Zhonghua Yi Xue Za Zhi | pmid:3091216 |
Waites GM | Male fertility regulation: recent advances. | 1986 | Bull. World Health Organ. | pmid:3091279 |
Caulfield JJ and Bolander FF | Involvement of protein kinase C in mouse mammary gland development. | 1986 | J. Endocrinol. | pmid:3084697 |
Huang JX et al. | [Studies on the synthesis of gossypol derivatives and their antifertility action]. | 1986 | Shengzhi Yu Biyun | pmid:12267916 |
Tan FQ | [Gossypol acetate users]. | 1986 | Shengzhi Yu Biyun | pmid:12267917 |
Han S | New progress in research on contraceptive technology. | 1986 | China Popul Newsl | pmid:12268508 |
Nayak BN and Buttar HS | Induction of sister chromatid exchanges and chromosome damage by gossypol in bone marrow cells of mice. | 1986 | Teratog., Carcinog. Mutagen. | pmid:2874644 |
Tam SC | Acute hypokalemic effect of gossypol. | 1986 | Can. J. Physiol. Pharmacol. | pmid:3768796 |
Whaley KJ et al. | Monkey lactate dehydrogenase-C4 as a model for the interaction of enzymes with gossypol. | 1986 | Contraception | pmid:3769483 |
Hu F et al. | Gossypol effects on cultured normal and malignant melanocytes. | 1986 | In Vitro Cell. Dev. Biol. | pmid:3771439 |
Reyes J et al. | Membrane actions of male contraceptive gossypol tautomers. | 1986 | Biochim. Biophys. Acta | pmid:3778905 |
Rosenberg LJ et al. | Inhibition of DNA polymerase alpha by gossypol. | 1986 | Biochim. Biophys. Acta | pmid:3697356 |
Wong YK and Li JH | [Quantum pharmacological investigations of gossypol and some simple aromatic compounds]. | 1986 | Yao Xue Xue Bao | pmid:3728037 |
Medrano FJ and Andreu JM | Binding of gossypol to purified tubulin and inhibition of its assembly into microtubules. | 1986 | Eur. J. Biochem. | pmid:3732269 |
Walia V et al. | Effect of gossypol on peripheral blood cells. | 1986 | Indian J. Med. Res. | pmid:3733198 |
Sheriff DS et al. | Gossypol and lipid peroxidation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3740171 |
Sein GM | The embryotoxic and immunodepressive effects of gossypol. | 1986 | Am. J. Chin. Med. | pmid:3799526 |
Burgos C et al. | In vitro inhibition by gossypol of oxidoreductases from human tissues. | 1986 | Biochem. Pharmacol. | pmid:3754138 |
Joseph AE et al. | Cytotoxicity of enantiomers of gossypol. | 1986 | Br. J. Cancer | pmid:3756086 |
Wichmann K et al. | Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism. | 1986 | Contraception | pmid:3757514 |
Jiang DH et al. | [The comparison of some properties of gossypol recrystallized from different solvents]. | 1986 | Yao Xue Xue Bao | pmid:3811948 |
Eisele GR | A perspective on gossypol ingestion in swine. | 1986 | Vet Hum Toxicol | pmid:3705437 |
Sampath DS and Balaram P | Resolution of racemic gossypol and interaction of individual enantiomers with serum albumins and model peptides. | 1986 | Biochim. Biophys. Acta | pmid:3085727 |
Zhao Y et al. | Studies on frequencies of sister chromatid exchange in peripheral blood lymphocytes before and after gossypol treatment. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3422992 |
Förstermann U et al. | Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3487639 |
Schmidt JH and Wells R | Recovery of soluble proteins from glanded cotton tissues with amines. | 1986 | Anal. Biochem. | pmid:3706729 |
Zhang JB et al. | Effect of gossypol on fertilization capacity and chromosome formation of human sperm in vitro. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432238 |
Kalla NR et al. | Involvement of prostaglandin in the antifertility effects of gossypol. | 1986 | Contraception | pmid:3465506 |
Hadley MA and Burgos MH | Gossypol injected in the rat epididymal fat pad inhibits epididymal sperm motility. | 1986 | Microsc Electron Biol Celular | pmid:3587061 |
Chongthammakun S et al. | Effects of gossypol on human and monkey sperm motility in vitro. | 1986 | Contraception | pmid:3791997 |
Chen Y et al. | The effect of gossypol on the frequency of DNA-strand breaks in human leukocytes in vitro. | 1986 | Mutat. Res. | pmid:3951461 |
Rikihisa Y and Lin YC | Taenia taeniaeformis: inhibition of metacestode development in the rat by gossypol. | 1986 | Exp. Parasitol. | pmid:3956677 |
Ye WS et al. | [Clastogenicity of a male contraceptive, gossypol, in mammalian cell cultures with and without metabolic activation by S9 mix]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2944636 |
Ye YX et al. | [Studies on the action mechanism of gossypol with fixed concentration radioactive-ligand receptor assay]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2944651 |
Zhao DP et al. | [Effect of gossypol formic acid on the fluidity of the spermatocyte plasma membrane of the rat]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2945391 |
Xu Y et al. | [Analysis of the effect of gossypol on the activity of purified LDH-X]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2952308 |