Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sharma S et al. | Reversible antispermatogenic effect of gossypol in langur monkeys (Presbytis entellus entellus). | 1999 | Adv Contracept | pmid:10794043 |
Thomas KD et al. | Effects of an aqueous extract of cotton seed (Gossypium barbadense Linn.) on adult male rats. | 1991 | Adv Contracept | pmid:1776560 |
Achudume AC and Eno TL | Characterization of ion interference in gossypol consumption. | 1996 | Adv Contracept | pmid:8910664 |
Yu ZH and Chan HC | Gossypol and hypokalemia: a critical review. | 1994 | Adv Contracept Deliv Syst | pmid:12289957 |
Tung DS et al. | Effect of long term gossypol treatment on human testicular structure. | 1987 | Adv Contracept Deliv Syst | pmid:12314752 |
Xian SC et al. | Antifertility treating with long term gossypol. | 1987 | Adv Contracept Deliv Syst | pmid:12268655 |
Krassnigg F et al. | Investigations on the functional role of angiotensin converting enzyme (ACE) in human seminal plasma. | 1986 | Adv. Exp. Med. Biol. | pmid:3028067 |
Cherry JP et al. | Potential for improving cottonseed quality by genetic and agronomic practices. | 1978 | Adv. Exp. Med. Biol. | pmid:581532 |
Broderick GA | Effect of processing on protein utilization by ruminants. | 1977 | Adv. Exp. Med. Biol. | pmid:906927 |
Rekha GK and Sladek NE | Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol. | 1997 | Adv. Exp. Med. Biol. | pmid:9059615 |
Deck LM et al. | Inhibition of aldose reductase by gossypol and gossypol-related compounds. | 1999 | Adv. Exp. Med. Biol. | pmid:10352723 |
Wang X et al. | Gossypol--a polyphenolic compound from cotton plant. | 2009 | Adv. Food Nutr. Res. | pmid:19878861 |
Fedeli E and Jacini G | Lipid composition of vegetable oils. | 1971 | Adv. Lipid Res. | pmid:4942102 |
Schmidt K et al. | EDRF-formation increases cGMP-levels in cultured endothelial cells. | 1990 | Adv. Second Messenger Phosphoprotein Res. | pmid:1976336 |
Adekunle AO et al. | Seminal plasma zinc level in users of gossypol. | 1999 Mar-Jun | Afr J Med Med Sci | pmid:12953977 |
Baram N et al. | Inactivation of intestinal brush-border enzymes by gossypol. | 1987 | Agric. Biol. Chem. | pmid:12283503 |
Knych ET | Endothelium-dependent tolerance to ethanol-induced contraction of rat aorta: effect of inhibition of EDRF action and nitric oxide synthesis. | 1992 | Alcohol. Clin. Exp. Res. | pmid:1558303 |
Lawrence SV | Gossypol: a potential male contraceptive? | 1981 | Am Pharm | pmid:7304423 |
Wen W | China invents male birth control pill. | 1980 Spring-Summer | Am. J. Chin. Med. | pmid:7395797 |
Sein GM | The embryotoxic and immunodepressive effects of gossypol. | 1986 | Am. J. Chin. Med. | pmid:3799526 |
Graham GG et al. | Dietary protein quality in infants and children. II. Metabolic studies with cottonseed flour. | 1969 | Am. J. Clin. Nutr. | pmid:5819114 |
Tosukhowong P et al. | Environmental distal renal tubular acidosis in Thailand: an enigma. | 1999 | Am. J. Kidney Dis. | pmid:10352213 |
Cheng KF et al. | Endometrial changes after administration of gossypol for menorrhagia. | 1980 | Am. J. Obstet. Gynecol. | pmid:7446637 |
Sheriff DS et al. | Gossypol and lipid peroxidation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3740171 |
Zu PD et al. | Electron microscopic observations of the effects of gossypol on the human endometrium. | 1984 | Am. J. Obstet. Gynecol. | pmid:6465231 |
Wichmann K et al. | Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agent. | 1982 | Am. J. Obstet. Gynecol. | pmid:6277198 |
Liu GZ et al. | Experiences with gossypol as a male pill. | 1987 | Am. J. Obstet. Gynecol. | pmid:3314523 |
SMITH HA | The pathology of gossypol poisoning. | 1957 Mar-Apr | Am. J. Pathol. | pmid:13402891 |
Robinson JM et al. | Gossypol-induced damage to mitochondria of transformed Sertoli cells. | 1986 | Am. J. Pathol. | pmid:3026188 |
Busse R et al. | Vasomotor activity of diadenosine triphosphate and diadenosine tetraphosphate in isolated arteries. | 1988 | Am. J. Physiol. | pmid:3364587 |
Hill MA et al. | Cyclooxygenase inhibition potentiates myogenic activity in skeletal muscle arterioles. | 1990 | Am. J. Physiol. | pmid:2105665 |
Reyes J et al. | A bioenergetic model of gossypol action: effects of gossypol on adult rat spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354654 |
Hasegawa K et al. | Angiotensin II-induced endothelium-dependent relaxation of fowl aorta. | 1993 | Am. J. Physiol. | pmid:8498599 |
Radermacher J et al. | Endothelium-derived relaxing factor influences renal vascular resistance. | 1990 | Am. J. Physiol. | pmid:2115741 |
Reyes J and Benos DJ | Specificity of gossypol uncoupling: a comparative study of liver and spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354655 |
Pohl U et al. | Selective inhibition of endothelium-dependent dilation in resistance-sized vessels in vivo. | 1987 | Am. J. Physiol. | pmid:2887120 |
Kottmann RM et al. | Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26408551 |
Judge JL et al. | Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26254422 |
Pérez A et al. | Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19386788 |
Gupta GS and Syal N | Newly exposed immunochemically cross-reactive epitopes in sperm-specific LDH after glucosylation and gossypol interaction. | 2000 | Am. J. Reprod. Immunol. | pmid:11125794 |
Jones LA | Gossypol toxicosis. | 1988 | Am. J. Vet. Res. | pmid:3178038 |
Morgan S et al. | Clinical, clinicopathologic, pathologic, and toxicologic alterations associated with gossypol toxicosis in feeder lambs. | 1988 | Am. J. Vet. Res. | pmid:3377308 |
Meyer R et al. | Identification and quantification of gossypol in cotton by using packed micro-tips columns in combination with HPLC. | 2004 | Anal Bioanal Chem | pmid:15372136 |
Schmidt JH and Wells R | Recovery of soluble proteins from glanded cotton tissues with amines. | 1986 | Anal. Biochem. | pmid:3706729 |
Admasu A and Chandravanshi BS | Spectrophotometric determination of total gossypol in cottonseeds and cottonseed meals. | 1984 | Anal. Chem. | pmid:6546479 |
Rikihisa Y et al. | Histopathologic changes of uterus following gossypol treatment during early pregnancy in rats. | 1985 | Anat. Rec. | pmid:4073564 |
Weinbauer GF et al. | Antifertility efficacy of gossypol acetic acid in male rats. | 1982 May-Jun | Andrologia | pmid:7114507 |
Kalla NR and Vasudev M | Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa. | 1981 Mar-Apr | Andrologia | pmid:6454365 |
Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. III. Effect of gossypol acetic acid on rat testis. | 1981 May-Jun | Andrologia | pmid:6455943 |
Ikeda M | Inhibition kinetics of NAD-linked enzymes by gossypol acetic acid. | 1990 Sep-Oct | Andrologia | pmid:2073051 |