Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhang JB et al. | [Comparison of the action of racemic (+/-) and optically active (-and+) gossypols on HeLa cells]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2938762 |
Kim SH et al. | Gossypol, a hyperthermic sensitizer of HeLa cells. | 1985 | Cancer Res. | pmid:4063984 |
Haspel HC et al. | Effect of gossypol on erythrocyte membrane function: specific inhibition of inorganic anion exchange and interaction with band 3. | 1985 | J. Pharmacol. Exp. Ther. | pmid:4032282 |
Kimura K et al. | Inhibition by gossypol of phospholipid-sensitive Ca2+-dependent protein kinase from pig testis. | 1985 | Biochim. Biophys. Acta | pmid:3157405 |
Berry CN et al. | Gossypol is a potent inhibitor of the NAD+-dependent dehydrogenase responsible for the inactivation of prostaglandins. | 1985 | Zhongguo Yao Li Xue Bao | pmid:3158161 |
Li FY et al. | [The antiandrogen effect of gossypol and its influence on androgen receptor]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:3158419 |
Wang YF | [Late effect of gossypol treatment in gynecological diseases--a clinical study of 72 cases]. | 1985 | Zhong Xi Yi Jie He Za Zhi | pmid:3158438 |
[The clinical study of gossypol in 8,806 men]. | 1985 | Shengzhi Yu Biyun | pmid:12267797 | |
Wang MZ et al. | [Determination of gossypol with high performance liquid chromatography]. | 1985 | Yao Xue Xue Bao | pmid:3834747 |
Vongsorasak L and Svasti J | Inhibition of liquefaction and protein degradation in human semen by gossypol. | 1985 | Int. J. Androl. | pmid:3835162 |
Kainz P et al. | Effect of gossypol on macromolecular synthesis in rat testis. An in vitro study. | 1985 | Contraception | pmid:2580663 |
Haider SG et al. | Reversible changes in rat spermatogenesis induced by an antifertility substance (Gossypol). A histochemical report. | 1985 | Acta Histochem. | pmid:2420139 |
Tone JN and Jensen DR | Radioiron utilization and gossypol acetic acid in male rats. | 1985 | Drug Chem Toxicol | pmid:4017900 |
Rikihisa Y et al. | Histopathologic changes of uterus following gossypol treatment during early pregnancy in rats. | 1985 | Anat. Rec. | pmid:4073564 |
Krasil'nikov OV et al. | [Dependence of the protonophore and channel-forming capacity of gossypol on the pH]. | 1985 | Dokl. Akad. Nauk SSSR | pmid:2408838 |
Kainz P et al. | The in vivo effect of gossypol on macromolecular synthesis in rat testis. | 1985 | Contraception | pmid:2419026 |
McClarty GA et al. | Ribonucleotide reductase: an intracellular target for the male antifertility agent, gossypol. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3907637 |
Qian SZ | Gossypol-hypokalaemia interrelationships. | 1985 | Int. J. Androl. | pmid:3908325 |
Wang C and Yeung RT | Gossypol and hypokalaemia. | 1985 | Contraception | pmid:3910352 |
Liu GZ | [Clinical trial of gossypol as a male contraceptive: a randomized controlled study]. | 1985 | Zhonghua Yi Xue Za Zhi | pmid:3921206 |
Zhang LS | [Effect of gossypol on serum gonadotropin and testosterone levels: long-term follow-up study]. | 1985 | Zhonghua Yi Xue Za Zhi | pmid:3931874 |
Zhang GY et al. | Dynamic study of serum gonadotrophin and testosterone levels in gossypol-treated men. Long term follow-up study of 60 cases. | 1985 | Int. J. Androl. | pmid:3932223 |
Hawkins GE et al. | Physiological effects of whole cottonseed in the diet of lactating dairy cows. | 1985 | J. Dairy Sci. | pmid:3934243 |
Wang WC et al. | [Changes of serum concentrations of testosterone, LH and FSH in men taking gossypol]. | 1985 | Yao Xue Xue Bao | pmid:3938917 |
Hamasaki Y and Tai HH | Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases. | 1985 | Biochim. Biophys. Acta | pmid:3919771 |
Matlin SA et al. | (-)-Gossypol: an active male antifertility agent. | 1985 | Contraception | pmid:3987276 |
Sufi SB et al. | Inhibition by (+) and (-) isomers of gossypol of testosterone release from mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987277 |
Lin YC et al. | Gossypol in female fertility control: ovum implantation and early pregnancy inhibited in rats. | 1985 | Life Sci. | pmid:4010468 |
Wang Y et al. | Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. | 1985 | Contraception | pmid:4092462 |
Wu YW et al. | Effect of gossypol on the potential difference of rat seminiferous tubules. | 1985 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:4012264 |
Lagerlöf RK and Tone JN | The effect of gossypol acetic acid on female reproduction. | 1985 | Drug Chem Toxicol | pmid:4092619 |
Maliwal BP et al. | Spectroscopic study of the interaction of gossypol with bovine serum albumin. | 1985 | Int. J. Pept. Protein Res. | pmid:4019021 |
Liang JC and Ye WS | Clastogenicity of a male contraceptive, gossypol, in mammalian cell cultures with and without the metabolic activation by S9 mix. | 1985 | Environ. Res. | pmid:3967635 |
Vainio P et al. | Hydrolysis of phospholipid monolayers by human spermatozoa. Inhibition by male contraceptive gossypol. | 1985 | Biochim. Biophys. Acta | pmid:3978108 |
Beaudoin AR | The embryotoxicity of gossypol. | 1985 | Teratology | pmid:4049283 |
Gao H et al. | [Primary observations on distal renal tubule acidosis in 177 cases caused by gossypol intoxication]. | 1985 | Zhonghua Nei Ke Za Zhi | pmid:4053804 |
Wang MZ et al. | High-performance liquid chromatography with electrochemical detection of gossypol in human plasma. | 1985 | J. Chromatogr. | pmid:4066879 |
Wang WH et al. | [Influence of salicylaldehyde and its analogs on the antispermatogenic effect of gossypol]. | 1985 | Yao Xue Xue Bao | pmid:4083027 |
Pearce S et al. | The viability of mouse Leydig cells in vitro following incubation with gossypol. | 1985 | Contraception | pmid:4085245 |
Gu Y and Anderson NO | Effects of gossypol on the estrous cycle and ovarian weight in the rat. | 1985 | Contraception | pmid:4085249 |
Patton CS et al. | Heart failure caused by gossypol poisoning in two dogs. | 1985 | J. Am. Vet. Med. Assoc. | pmid:4086371 |
Ding LA et al. | [Hepatoma initiating and promoting effects of gossypol]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2986867 |
Shi QX and Friend DS | Effect of gossypol acetate on guinea pig epididymal spermatozoa in vivo and their susceptibility to capacitation in vitro. | 1985 Jan-Feb | J. Androl. | pmid:3972719 |
Sadykov AS et al. | [Effect of gossypol on spermatogenesis and fertility in man and mammals]. | 1985 Jul-Aug | Ontogenez | pmid:3900844 |
Fody EP and Walker EM | Effects of drugs on the male and female reproductive systems. | 1985 Nov-Dec | Ann. Clin. Lab. Sci. | pmid:4062226 |
Kim IC et al. | Inhibition of LDH-X by gossypol optical isomers. | 1985 Nov-Dec | J. Androl. | pmid:4077725 |
Krassnigg F et al. | Investigations on the functional role of angiotensin converting enzyme (ACE) in human seminal plasma. | 1986 | Adv. Exp. Med. Biol. | pmid:3028067 |
Wong YK and Li JH | [Quantum pharmacological investigations of gossypol and some simple aromatic compounds]. | 1986 | Yao Xue Xue Bao | pmid:3728037 |
Medrano FJ and Andreu JM | Binding of gossypol to purified tubulin and inhibition of its assembly into microtubules. | 1986 | Eur. J. Biochem. | pmid:3732269 |
Kanje M et al. | The effect of gossypol on fast axonal transport and microtubule assembly. | 1986 | Biochim. Biophys. Acta | pmid:2421770 |