Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mishra PJ et al. | Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. | 2016 | PLoS ONE | pmid:27846237 |
Zhao R et al. | AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations. | 2016 | BMC Cancer | pmid:27431492 |
Zubair H et al. | Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism. | 2016 | Int J Mol Sci | pmid:27331811 |
Ma D et al. | Genetic basis for glandular trichome formation in cotton. | 2016 | Nat Commun | pmid:26795254 |
Zhang J et al. | Breeding Potential of Introgression Lines Developed from Interspecific Crossing between Upland Cotton (Gossypium hirsutum) and Gossypium barbadense: Heterosis, Combining Ability and Genetic Effects. | 2016 | PLoS ONE | pmid:26730964 |
Antonietti P et al. | AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells. | 2016 | Biochim. Biophys. Acta | pmid:26721623 |
Stein MN et al. | A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. | 2016 | Clin Genitourin Cancer | pmid:26476589 |
Baoleri X et al. | Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. | 2015 | Mol Med Rep | pmid:26238307 |
Li K et al. | Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. | 2015 | Biomaterials | pmid:25477180 |
Quinn BA et al. | Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. | 2015 | Cancer Res. | pmid:26032425 |
Zhang SD et al. | Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. | 2015 | Chin J Nat Med | pmid:26412425 |
Bhatia C et al. | Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. | 2015 | Chem. Biol. Interact. | pmid:25526675 |
Câmara AC et al. | Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. | 2015 | PLoS ONE | pmid:26600470 |
Gong Y et al. | Valproic Acid Enhances the Anti-tumor Effect of (-)-gossypol to Burkitt Lymphoma Namalwa Cells. | 2015 | Biomed. Environ. Sci. | pmid:26582100 |
Wu Y et al. | Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1. | 2015 | Genet. Mol. Res. | pmid:26535659 |
Zhao GX et al. | The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. | 2015 | Oncotarget | pmid:26517515 |
Kottmann RM et al. | Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26408551 |
Judge JL et al. | Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26254422 |
Tomoda K et al. | Examination of Gossypol-Pluronic Micelles as Potential Radiosensitizers. | 2015 | AAPS J | pmid:26246329 |
Santana AT et al. | Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E. | 2015 | Biol. Res. | pmid:26227499 |
Zerp SF et al. | Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. | 2015 | Radiat Oncol | pmid:26223311 |
Ren T et al. | Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer. | 2015 | Drug Des Devel Ther | pmid:26089640 |
He Z et al. | Chemical Composition of Defatted Cottonseed and Soy Meal Products. | 2015 | PLoS ONE | pmid:26079931 |
Wang Q et al. | Salt Stress Effects on Secondary Metabolites of Cotton in Relation to Gene Expression Responsible for Aphid Development. | 2015 | PLoS ONE | pmid:26061875 |
Pan R et al. | Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia. | 2015 | Blood | pmid:26045609 |
Maji S et al. | Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. | 2015 | Oncotarget | pmid:26009874 |
Lan L et al. | Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. | 2015 | Mol Oncol | pmid:25933687 |
Sarkar S et al. | Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic. | 2015 | Oncotarget | pmid:25926554 |
Mani J et al. | Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). | 2015 | BMC Cancer | pmid:25885284 |
Zeng QF et al. | The response of meat ducks from 15 to 35 d of age to gossypol from cottonseed meal. | 2015 | Poult. Sci. | pmid:25834247 |
Hanus J et al. | Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway. | 2015 | Mol. Cell. Biol. | pmid:25802279 |
Zhan W et al. | Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. | 2015 | Mol Med Rep | pmid:25672487 |
Zhang H et al. | Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs). | 2015 | Biomaterials | pmid:25468367 |
Sorokina EV et al. | [Features of dynamics of sera cytokines in patients with erythema multiforme during immunotherapy]. | 2014 Jan-Feb | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:24738292 |
Gawande ND et al. | Molecular screening of insecticides with sigma glutathione S-transferases (GST) in cotton aphid Aphis gossypii using docking. | 2014 | Bioinformation | pmid:25512683 |
Ren T et al. | Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. | 2014 | Drug Des Devel Ther | pmid:25548514 |
Gadelha IC et al. | Gossypol promotes degeneration of ovarian follicles in rats. | 2014 | ScientificWorldJournal | pmid:25540815 |
Jarzabek MA et al. | Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models. | 2014 | Br. J. Cancer | pmid:25375271 |
Sadahira K et al. | Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. | 2014 | Int. J. Oncol. | pmid:25231749 |
Xu R et al. | Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. | 2014 | Biomed Res Int | pmid:25197664 |
Kogan P and Wald M | Male contraception: history and development. | 2014 | Urol. Clin. North Am. | pmid:24286773 |
Paulus A et al. | AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia. | 2014 | Br. J. Haematol. | pmid:24236538 |
Keshmiri-Neghab H and Goliaei B | Therapeutic potential of gossypol: an overview. | 2014 | Pharm Biol | pmid:24073600 |
Soderquist RS et al. | Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. | 2014 | J. Biol. Chem. | pmid:24778183 |
Zeng QF et al. | Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks. | 2014 | Poult. Sci. | pmid:24902707 |
Anderson MA et al. | Targeting BCL2 for the treatment of lymphoid malignancies. | 2014 | Semin. Hematol. | pmid:25048785 |
Schelman WR et al. | A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer. | 2014 | Invest New Drugs | pmid:23860642 |
Lima Pde M et al. | Methane emission of Santa Inês sheep fed cottonseed by-products containing different levels of gossypol. | 2014 | Trop Anim Health Prod | pmid:24132456 |
Mei H et al. | Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer. | 2014 | Neoplasma | pmid:24299314 |
Spijkers-Hagelstein JA et al. | Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101. | 2014 | Eur. J. Cancer | pmid:24703900 |