Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Xu Y et al. | [The effect of combined use of gossypol and tripterygium wilfordii on the fertility of male rats]. | 1987 | Yao Xue Xue Bao | pmid:3452960 |
Zhou RH and Lin XD | [Isolation of (-)-gossypol from natural plant]. | 1987 | Yao Xue Xue Bao | pmid:3450165 |
Guo ZM et al. | [Synthesis of mono-aldehyde gossypol and its analogues]. | 1987 | Yao Xue Xue Bao | pmid:3450164 |
Lin YC et al. | Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats. | 1987 | Contraception | pmid:3447817 |
Ye WS et al. | Cytological toxicity of gossypol on rat gametogenesis and spermatozoa. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432239 |
Zhang JB et al. | Effect of gossypol on fertilization capacity and chromosome formation of human sperm in vitro. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432238 |
Cheng JX et al. | Effect of gossypol(+/-, +, -) on Leydig cells of rat in vitro. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423013 |
Liu GZ et al. | Effect of K salt and K sparing agent in preventing gossypol-induced hypokalemia. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423005 |
Zhao Y et al. | Studies on frequencies of sister chromatid exchange in peripheral blood lymphocytes before and after gossypol treatment. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3422992 |
Rikihisa Y and Lin YC | Ultrastructure of the testis and epididymis of Japanese quail (Coturnix coturnix japonica) administered gossypol. | 1988 | Poult. Sci. | pmid:3413024 |
Den Boer PJ and Grootegoed JA | Differential effects of (+)- and (-)-gossypol enantiomers on LDH-C4 activity of hamster spermatogenic epithelium in vitro. | 1988 | J. Reprod. Fertil. | pmid:3411560 |
Den Boer PJ and Grootegoed JA | Mechanism of action of (-)gossypol on ATP production in isolated hamster spermatids. | 1988 | J. Reprod. Fertil. | pmid:3411559 |
Zakhidov ST et al. | [Clastogenic action of gossypol on spermatogenic cells in rats studied by counting micronuclei]. | 1988 May-Jun | Izv Akad Nauk SSSR Biol | pmid:3411013 |
Reynolds JM and Tone JN | Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats. | 1988 | Drug Chem Toxicol | pmid:3402348 |
Hudson LM et al. | Gossypol toxicosis in a herd of beef calves. | 1988 | J. Am. Vet. Med. Assoc. | pmid:3391858 |
Liu DY et al. | Mutagenicity of gossypol analyzed by induction of meiotic micronuclei in vitro. | 1988 | Mutat. Res. | pmid:3380110 |
Morgan S et al. | Clinical, clinicopathologic, pathologic, and toxicologic alterations associated with gossypol toxicosis in feeder lambs. | 1988 | Am. J. Vet. Res. | pmid:3377308 |
Royer RE et al. | Binding of gossypol derivatives to human serum albumin. | 1988 | J Pharm Sci | pmid:3373428 |
Hoffer AP et al. | Antifertility, spermicidal and ultrastructural effects of gossypol and derivatives administered orally and by intratesticular injections. | 1988 | Contraception | pmid:3371001 |
Teng CS and Fei RR | The effects of gossypol on nuclear protein in rat testes. II. The synthesis of histones and testis-specific proteins after gossypol treatment. | 1988 | Contraception | pmid:3371000 |
Fei RR and Teng CS | The effects of gossypol on nuclear protein in rat testes. I. Reduction in the content of basic proteins in the spermiogenic cells. | 1988 | Contraception | pmid:3370999 |
Stumpf WE et al. | Sites of action of gossypol studied by autoradiography and enzyme histochemistry. | 1988 | Contraception | pmid:3370998 |
Sonenberg M et al. | Anti-fertility and other actions of gossypol analogues. | 1988 | Contraception | pmid:3370997 |
Zhou RH and Lin XD | Isolation of (-)-gossypol from natural plant. | 1988 | Contraception | pmid:3370996 |
Matlin SA et al. | Large-scale resolution of gossypol enantiomers for biological evaluation. | 1988 | Contraception | pmid:3370995 |
Benz C et al. | Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy. | 1988 | Contraception | pmid:3370994 |
Beaudoin AR | A developmental toxicity evaluation of gossypol. | 1988 | Contraception | pmid:3370993 |
Wang RL et al. | Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships. | 1988 | Contraception | pmid:3370992 |
Heywood R | The toxicology of gossypol acetic acid and (-)-gossypol. | 1988 | Contraception | pmid:3370991 |
van Ypersele de Strihou C et al. | Effects of gossypol on the kidney with special emphasis on potassium (K) excretion. | 1988 | Contraception | pmid:3370990 |
Xue SP et al. | Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. | 1988 | Contraception | pmid:3370989 |
Frick J et al. | Clinical microdose study of gossypol: effect on sperm motility and renal function. | 1988 | Contraception | pmid:3370988 |
Duo X et al. | Clinical safety of long-term administration of gossypol in 32 cases. | 1988 | Contraception | pmid:3370987 |
Liu GZ et al. | Effects of K salt or a potassium blocker on gossypol-related hypokalemia. | 1988 | Contraception | pmid:3370986 |
International Symposium on Gossypol Research for Fertility Regulation. Wuhan, China, 15-17 October 1986. Representative papers. | 1988 | Contraception | pmid:3370985 | |
Othman MA and Abou-Donia MB | Pharmacokinetic profile of (+/-)-gossypol in male Sprague-Dawley rats following single intravenous and oral and subchronic oral administration. | 1988 | Proc. Soc. Exp. Biol. Med. | pmid:3368474 |
Eid JE et al. | Gossypol-induced death of African trypanosomes. | 1988 | Exp. Parasitol. | pmid:3366212 |
Busse R et al. | Vasomotor activity of diadenosine triphosphate and diadenosine tetraphosphate in isolated arteries. | 1988 | Am. J. Physiol. | pmid:3364587 |
Holmberg CA et al. | Pathological and toxicological studies of calves fed a high concentration cotton seed meal diet. | 1988 | Vet. Pathol. | pmid:3363792 |
Meng GD et al. | Recovery of sperm production following the cessation of gossypol treatment: a two-centre study in China. | 1988 | Int. J. Androl. | pmid:3356480 |
Reyes J and Benos DJ | Specificity of gossypol uncoupling: a comparative study of liver and spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354655 |
Reyes J et al. | A bioenergetic model of gossypol action: effects of gossypol on adult rat spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354654 |
Lei HP | Future research priorities of gossypol in the field of fertility regulation. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3321051 |
Liu GZ et al. | Experiences with gossypol as a male pill. | 1987 | Am. J. Obstet. Gynecol. | pmid:3314523 |
Yu YW | Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)- and (-)-stereoisomers. | 1987 | J Ethnopharmacol | pmid:3306161 |
Liu GZ and Lyle KC | Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study. | 1987 | Fertil. Steril. | pmid:3305088 |
Liu GZ et al. | Clinical trial of gossypol as a male contraceptive drug. Part I. Efficacy study. | 1987 | Fertil. Steril. | pmid:3305087 |
Coutinho EM and Melo JF | Clinical experience with gossypol in non-Chinese men: a follow-up. | 1988 | Contraception | pmid:3286112 |
Wu DF et al. | [Determination of (+)- and (-)-gossypol in human plasma using high performance liquid chromatography with pre-column chemical derivatization]. | 1988 | Yao Xue Xue Bao | pmid:3256191 |
Radigue C et al. | Early effects of gossypol on the testis and epididymis in the rat. | 1988 | Reprod Nutr Dev | pmid:3253903 |