Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yuan JR | [Methods of extraction and purification of gossypol]. | 1984 | Shengzhi Yu Biyun | pmid:12339570 |
| Wang R | [Sister chromatid exchanges in gossypol formic acid users after its discontinuation]. | 1986 | Shengzhi Yu Biyun | pmid:12341303 |
| Zhong CQ | [The morphology and formation of micronuclei of blood lymphocytes in man after cessation of gossypol administration]. | 1986 | Shengzhi Yu Biyun | pmid:12314624 |
| Zhong CQ | [Studies on sperm function in man long after cessation of gossypol administration]. | 1988 | Shengzhi Yu Biyun | pmid:12315492 |
| Wang YX and Chen ZX | [A possible mechanism of gossypol-induced hypokalemia and its relation to gossypol dose]. | 1991 | Shengzhi Yu Biyun | pmid:12317367 |
| Guo Z et al. | [Gossypol acetic acid induces DNA double-strand breaks in human mucoepidermoid carcinoma cell MEC-1]. | 2011 | Sheng Li Xue Bao | pmid:21505732 |
| Anderson MA et al. | Targeting BCL2 for the treatment of lymphoid malignancies. | 2014 | Semin. Hematol. | pmid:25048785 |
| Cui X et al. | [Determination of free gossypol in meat by reversed-phased high performance liquid chromatography]. | 2004 | Se Pu | pmid:15706952 |
| Gadelha IC et al. | Gossypol promotes degeneration of ovarian follicles in rats. | 2014 | ScientificWorldJournal | pmid:25540815 |
| Gadelha IC et al. | Gossypol toxicity from cottonseed products. | 2014 | ScientificWorldJournal | pmid:24895646 |
| Baugher WL and Campbell TC | Gossypol detoxication by fungi. | 1969 | Science | pmid:5786644 |
| Maugh TH | Male "pill" blocks sperm enzyme. | 1981 | Science | pmid:7193910 |
| Eagle E | Chronic Toxicity of Gossypol. | 1949 | Science | pmid:17742136 |
| Montamat EE et al. | Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. | 1982 | Science | pmid:6750791 |
| Fishbein L | Natural non-nutrient substances in the food chain. | 1972 | Sci. Total Environ. | pmid:4121147 |
| Xue SP et al. | Subcellular site of antispermatogenic effect of gossypol and its possible molecular mechanism of action. | 1983 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:6623054 |
| Wu YW et al. | Effect of gossypol on the potential difference of rat seminiferous tubules. | 1985 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:4012264 |
| Shepu X et al. | Antispermatogenic effect of gossypol on the germinal epithelium of the rat testes. A cytological, autoradiographical and ultrastructural observation. | 1980 | Sci. Sin. | pmid:7403840 |
| Bi XF et al. | The effect of gossypol on ATPase activity of the kidney. | 1981 | Sci. Sin. | pmid:6266011 |
| Wu G et al. | Temporal allocation of metabolic tolerance in the body of beet armyworm in response to three gossypol-cotton cultivars. | 2009 | Sci. China, C, Life Sci. | pmid:20016971 |