Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vander Jagt DL et al. | Gossypol: prototype of inhibitors targeted to dinucleotide folds. | 2000 | Curr. Med. Chem. | pmid:10702620 |
Coutinho EM et al. | Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive. A multicenter, international, dose-finding study. | 2000 | Contraception | pmid:10745071 |
Jan CR et al. | Novel effects of gossypol, a chemical contraceptive in man: mobilization of internal Ca(2+) and activation of external Ca(2+) entry in intact cells. | 2000 | Biochim. Biophys. Acta | pmid:10771095 |
Sharma S et al. | Reversible antispermatogenic effect of gossypol in langur monkeys (Presbytis entellus entellus). | 1999 | Adv Contracept | pmid:10794043 |
Chenoweth PJ et al. | Characterization of gossypol-induced sperm abnormalities in bulls. | 2000 | Theriogenology | pmid:10798496 |
Heiser V et al. | Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10829068 |
Shelley MD et al. | Structure-activity studies on gossypol in tumor cell lines. | 2000 | Anticancer Drugs | pmid:10831280 |
Nagalakshmi D et al. | Pathological lesions in lambs fed raw or processed cottonseed meal. | 2000 | Vet. Res. Commun. | pmid:10868552 |
Luginbuhl JM et al. | Effect of level of whole cottonseed on intake, digestibility, and performance of growing male goats fed hay-based diets. | 2000 | J. Anim. Sci. | pmid:10875652 |
Brandes AA et al. | New drugs in recurrent high grade gliomas. | 2000 May-Jun | Anticancer Res. | pmid:10928126 |
Razakantoanina V et al. | Antimalarial activity of new gossypol derivatives. | 2000 | Parasitol. Res. | pmid:10952267 |
Dao VT et al. | Synthesis and cytotoxicity of gossypol related compounds. | 2000 | Eur J Med Chem | pmid:11006482 |
Quintana PJ et al. | Gossypol-induced DNA breaks in rat lymphocytes are secondary to cytotoxicity. | 2000 | Toxicol. Lett. | pmid:11033237 |
Wang X and Plhak LC | Production, characterization, and application of anti-gossypol polyclonal antibodies. | 2000 | J. Agric. Food Chem. | pmid:11087445 |
Bailey CA et al. | Cottonseed with a high (+)- to (-)-gossypol enantiomer ratio favorable to broiler production. | 2000 | J. Agric. Food Chem. | pmid:11087540 |
Noftsger SM et al. | Effect of whole and expanded-expelled cottonseed on milk yield and blood gossypol. | 2000 | J. Dairy Sci. | pmid:11104273 |
Wang X et al. | Cytotoxic effect of gossypol on colon carcinoma cells. | 2000 | Life Sci. | pmid:11105982 |
Gupta GS and Syal N | Newly exposed immunochemically cross-reactive epitopes in sperm-specific LDH after glucosylation and gossypol interaction. | 2000 | Am. J. Reprod. Immunol. | pmid:11125794 |
Yuan YY and Shi QX | Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity. | 2000 | Contraception | pmid:11137075 |
Braham JE and Bressani R | Effect of different levels of gossypol on transaminase activity, on nonessential to essential amino acid ratio, and on iron and nitrogen retention in rats. | 1975 | J. Nutr. | pmid:1117346 |